ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
·
2026
·Vol. 119
·期 9
·205
·
IF 2
Raj Pranay,Sharma Harshit Kumar,Selvaraj Venkatesan,Pandey Abhay Kumar
The present research investigates the chemical profile of secondary metabolites produced by Bacillus paramycoides BOK01 and Microbacterium barkeri BPATH02 rhizospheric bacteria originating from the tea rhizosphere and their antifungal activity against major tea pathogens. GC–MS analysis revealed that dimethyl sulphate (77.09%) was a major compound (Compound I ) of B. paramycoides BOK01 and 1H-Purin-6-amine, [(2-fluorophenyl) methyl- (CAS) (Compound II; 16.88%), and docosane (Compound III; 11.75%) as putative major compounds in M. barkeri BPATH02. Furthermore, the ethyl acetate extract of both bacterial antagonists and compounds I, II , and III were evaluated for their efficacy against major tea pathogens, namely Exobasidium vexans , Pseudopestalotiopsis theae, and Fusarium concentricum causing respective blister blight, gray blight, and Fusarium dieback in tea crops using two-sealed-base-plate method. Laboratory screening of ethyl acetate (EA) extracts of both bacterial antagonists at 200 µg/mL provided a 65.95 to 82.5% range of growth inhibition of tested pathogens. At similar dose, compounds I, II, and III provided 70.88 to 77.53%, 67.7 to 78.0% and 71.8 to 73.07% range of growth inhibition of tested pathogens, respectively. Thus, this study shows that bacterial metabolites and their compounds are sources of putative antifungal agents, which can be harnessed for bio-fungicides development against tea diseases.
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Nature Communications
·
2026
·
IF 18.1
Zheng Guang-Song,Lou Qing,Shen Cheng-Long,Jiang Tian-Ci,Song Run-Wei,Cheng Zhe,Dong Lin,Shan Chong-Xin
Ultrasound-induced afterglow has emerged as a promising modality for in vivo imaging, yet achieving sufficient afterglow brightness remains a challenge. Here, we report the inaugural realization of ultrasound-induced afterglow from carbon nanodots using engineered carbon nanodots, the elucidation of the resonance amplification mechanism during the ultrasound process, and the facilitation of high-contrast tumor imaging and precise resection. Through ultrasound frequency matching, we achieved up to 51-fold enhancement in sonoluminescence from carbon nanodots as fluorophore matrice, far surpassing the ultrasound-induced conventional organic polymer-based afterglow materials. Experimental and finite element analyses reveal an inverse monotonic relationship between ultrasound frequency and matrix dimensions, where resonant ultrasound enhances reactive oxygen species generation, leading to intermediate oxidation-derived near-infrared afterglow lasting over 240 min following a single 2-min ultrasound pulse. With significant amplification in afterglow brightness via precise frequency decoding, this approach evokes a 2.5 cm tissue penetration enabling high-contrast tumor imaging and precise resection in animal models, outperforming conventional optical-excited afterglow agents and fluorescence imaging. Our work elucidates the mutual size-frequency selection mechanism in ultrasound-induced afterglow and establishes a non-invasive, sensitive platform for advanced bioimaging and therapeutic monitoring.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Wang Yifan,Zou Minglang,Cheng Junyao,Chen Cuiping,Zhang Chuyue,Yan Taoxu,Wang Xianzheng,Tian Zheng,Zhang Zhenyue,Mao Kaige,Li Bo,Liu Xuanhui,Liu Haoming,Chi Pengfei,Pan Zhimin,Weng Zuquan,Huang Da,Liu Jianheng,Wang Zheng
Intervertebral disc degeneration, the leading cause of chronic low back pain, remains incurable with traditional conservative therapies limited to symptomatic alleviation. We present an ECM-mimetic injectable hydrogel (HPTC) synthesized via dynamic crosslinking of hyaluronic acid-phenylboronic acid (HA-PBA) and tannic acid-cerium(III) metal-polyphenol networks (TA-Ce³⁺ MPNs), which faithfully recapitulates native nucleus pulposus ECM to enable functional tissue regeneration. In vitro, HPTC presented broad-spectrum reactive oxygen species scavenging and downregulated pro-inflammatory cytokine expression (TNF-α, IL-1β, IL-6), while upregulating anti-inflammatory markers (IL-4, IL-10). Crucially, Ce³⁺ effectively reduced dissolved oxygen levels (to 105% vs. 115% in control at 15 min), thereby promoting HIF-1α signal expression and mitigating nucleus pulposus cells senescence under H₂O₂-induced oxidative stress. In rat and rabbit intervertebral disc degeneration models, a single, minimally invasive injection of the ECM-mimetic HPTC hydrogel preserved the disc height index and magnetic resonance imaging signal intensity, enhanced aggrecan and collagen II deposition, suppressed inflammatory mediators, and elevated HIF-1α while reducing p21 expression in situ. Transcriptomic analysis further implicated HIF-1α pathways in ECM regeneration. All these findings demonstrate that the HPTC hydrogel leverages metal-polyphenol chemistry within an ECM-inspired framework to synergistically modulate oxygen homeostasis, oxidative stress, and inflammation, offering a bifunctional and biomimetic platform for disc regeneration. Graphical
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PubMed
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Food Analytical Methods
·
2026
·Vol. 19
·期 10
·302
·
IF 3
Yu Haichao,Huang Jiayue,Zhao Jinfeng,Luo Wang,Li Jianjun,Liu Xiaojun
With the large-scale development of the food industry, hydrogen peroxide (H₂O₂), a potent oxidizing agent, has been illicitly used by some manufacturers for bleaching, decolorization, and preservation, making it a significant potential risk in the field of food safety. Therefore, elucidating the hazardous mechanisms of H₂O₂ residues in food is of paramount importance for strengthening food safety monitoring systems and safeguarding public health. In this study, a label-free and highly sensitive sensing platform based on 4-cyano-4'-pentylbiphenyl (5CB) liquid crystal (LC) microdroplets was developed for the detection of H₂O₂ and catalase (CAT). The sensor enables the detection of H₂O₂ and CAT by monitoring the distinct optical pattern transitions of dodecanal-doped 5CB liquid crystal microdroplets under various conditions using polarized optical microscopy (POM). The results demonstrate that under pH 11 conditions, the limit of detection (LOD) for H₂O₂ is 0.01% (w/v), and for CAT is 0.01 ng/mL. Fourier Transform Infrared Spectroscopy (FTIR) was employed to characterize the post-reaction system, verifying the chemical transformations. Furthermore, simulated testing on food samples was successfully conducted, suggesting that this sensor holds significant potential for applications in food safety, biomedicine, and analytical detection. However, the optical sensing platform is sensitive to changes in ambient humidity and temperature, which may limit its direct application in complex food matrices. Although the system enables intuitive interpretation of POM textures, future work should investigate matrix interference, quantitative image analysis, portable readout integration, and validation using authentic food samples.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Wenjia Liu,Ying Wang,Xiangyu Hao,Yangxun Wang,Xiaofan Zhang,Jinchao Zhang,Kun Ge,Guoqiang Zhou
Triple-negative breast cancer (TNBC) is associated with rapid progression and poor sensitivity to monotherapies, necessitating combination strategies to enhance tumor immunogenicity, reprogram the tumor microenvironment (TME), and convert immunologically "cold" tumors into "hot" ones. In this study, we develop a pH-responsive, pyroptosis-inducing nanoreactor, ZnS/ZIF-90:Fe/Vk3 (ZZFV), designed to elicit potent antitumor immunity. Under acidic conditions, ZZFV rapidly degrades, releasing Zn 2+ , Fe 2+ , H 2 S, and Vk3. H 2 S promotes glucose uptake and consumption while downregulating cytochrome c oxidase subunit IV (COX IV) expression, whereas Zn 2+ suppresses lactate dehydrogenase (LDH) activity, collectively disrupting glucose metabolism and exacerbating intracellular acidification. Meanwhile, NAD(P)H quinone oxidoreductase 1 (NQO1), highly expressed in tumor cells, catalyzes the conversion of Vk3 to H 2 O 2 , which is subsequently converted to highly toxic •OH through Fe 2+ -mediated Fenton reactions. Additionally, Zn 2+ and H 2 S synergistically disrupt mitochondrial function, thereby amplifying reactive oxygen species (ROS) production. Excessive ROS triggers Caspase-1-dependent pyroptosis, leading to the liberation of damage-associated molecular patterns. These events promote dendritic cell (DC) maturation, robust T-cell activation, M1 macrophage polarization, and expansion of central memory T-cell populations, thereby conferring durable immune protection. Consequently, ZZFV demonstrates potent antitumor efficacy, effectively overcoming immune tolerance in TNBC and achieving robust, sustained antitumor immunity.
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npj Science of Food
·
2026
·
IF 9.7
Li Gaotian,Wang Menglei,Xu Zheyuan,Wang Hongqing,Shen Guofang,Yang Zhi,Xiao Hailong,Yan Jinhua,Ji Xuming,Ruan Jiazhao
Ensuring the safety of widely consumed floral tea requires robust methods for monitoring pesticide residues. Herein, an innovative magnetic effervescence-assisted liquid-liquid extraction (MEALLE) method was developed for the rapid detection of pyrethroids in Chrysanthemum morifolium Ramat ( C. morifolium ). Effervescent tablets containing CO 2 /H + donors, Fe 3 O 4 , and carboxylated multi-walled carbon nanotubes were prepared via one-pot grinding-and-pressing preparation. During extraction, the tablet was introduced into C. morifolium powder pre-moistened with acidified acetonitrile as the extracting solvent. By integrating effervescence, salting-out, and magnetic aggregation, this method simplified the sample preparation procedure, eliminated the need for vortexing and centrifugation, and reduced the total time to approximately 3 min. Coupled with gas chromatography-tandem mass spectrometry (GC-MS/MS), the method exhibited excellent linearity ( R 2 > 0.998), sensitivity (limits of quantification: 1.6–4.1 μg kg −1 ), accuracy (recovery: 73.9–108.7%), and precision (relative standard deviations < 5.7%). Application of the MEALLE method to commercial C. morifolium samples further validated its robustness and versatility. Overall, this approach provide a time-effective, equipment-independent solution for pesticide residue analysis that is independent of auxiliary equipment during the sample pretreatment, thereby serving as a valuable tool for ensuring the safety of processed floral products.
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JOURNAL OF ELECTRONIC MATERIALS
·
2026
·
IF 2.8
Shi Xiaofei,Wang Xi,Zheng Xinzhu,Wang Lei,Tang Xiaoli,Su Hua,Lizhong Song
Ca 2+ -doped Co 1.1 ZnTiO 4 ceramics (0 ≤ x ≤ 0.08) were successfully synthesized via the conventional solid-state reaction route to investigate the doping effects of Ca 2+ on their microwave dielectric properties. X-ray diffraction (XRD) results revealed a distinct crystal structure evolution: a single-phase spinel structure with the Fd-3m space group was maintained at x ≤ 0.04, while the CaTiO 3 secondary phase precipitated at x ≥ 0.06 due to the finite solid solubility of Ca 2+ in the matrix lattice. The optimal comprehensive dielectric performance was achieved at x = 0.04 sintered at 1175°C, achieving Q × f = 73,300 GHz, ε r = 21.46, and τ f = −17 ppm/°C. Notably, H 3 BO 3 addition enabled a 275°C reduction in sintering temperature (down to 900°C) while retaining phase purity, which was fully confirmed by XRD analysis. Scanning electron microscopy (SEM) results verified improved bulk densification (relative density > 93%) and uniform microstructures with a homogeneous grain size of approximately 2.5 μm. Raman spectroscopy further indicated obvious [TiO 6 ] octahedral distortion, and a redshift of the A 1g mode from 720 to 715 cm −1 directly demonstrated lattice expansion after cation doping. The low-temperature-sintered samples at 900°C still exhibited competitive microwave dielectric properties ( Q × f = 30,900 GHz, ε r = 20.21, τ f = −18 ppm/°C), which strongly confirms that H 3 BO 3 serves as an efficient low-temperature sintering aid for the as-prepared titanate ceramics.
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Science China-Materials
·
2026
·
IF 7.7
Ren Mingfei,Ma Jiacheng,Qin Long,Zhang Boyuan,Wang Bokun,Zhang Kaige,Ji Zhanyou,Chen Chaochan,Wu Fan,Kang Yifan,Huang Wenhuan
Rare earth-based electromagnetic wave (EMW) absorbing materials have broad application prospects due to their strong dielectric loss and magnetic loss ability, but the effective enrichment and utilization of rare earth ions are still challenging. In this work, an anionic imidazolium-based metal-organic framework (MOF) was used to realize the enrichment strategy of multiple rare earth ions (La 3+ , Ce 3+ , Pr 3+ , Nd 3+ , Y 3+ ). Thanks to its anionic coordination framework, metal-organic zeolite (MOZ)-200 can uniformly enrich these ions and convert them into highly dispersed high-entropy rare earth alloy nanoparticles in situ during the carbonization process. The obtained HE@C composites have a conductive and graphitized carbon matrix, rich multi-scale polarization centers, and heterogeneous interfaces, which effectively enhance the dipole polarization, interface polarization, and conductive loss. Therefore, the material achieves excellent electromagnetic wave absorption in the Ku band, with a minimum reflection loss of −79.20 dB and a maximum effective absorption bandwidth of 5.23 GHz. Further integrated with the polyurethane matrix, a multifunctional flexible electromagnetic wave absorption device was obtained, including electromagnetic wave absorption, photothermal heating, microwave de-icing, and hydrophobicity. This work provides a feasible strategy for the utilization of rare earth ions and promotes the design of flexible multifunctional EMW absorbing materials.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 20
·1579
·
IF 3.2
Zhang Yuhong,Wu Renjie
In this study, a polyvinyl alcohol/polyacrylamide/carbon nanotubes (PVA/PAAm/CNTs) conductive hydrogel film was prepared through a simple one-pot precursor solution-casting route. The PVA/PAAm/CNTs composite hydrogel exhibited an interconnected porous network, and CNTs were dispersed within the hydrogel matrix to form continuous conductive pathways. The strain-sensing performance of the hydrogel sensor was systematically investigated. The sensor showed a high gauge factor of 6.34 in the low-strain range of 0–10% and low electrical hysteresis of 0.3% ± 0.2% (mean ± SD), indicating good sensitivity and cyclic response stability. The sensor was further applied to human joint motion monitoring and object-grasping recognition, demonstrating its capability to capture dynamic strain signals under wearable conditions. In addition, a proof-of-concept comparison of knee flexion–extension between one healthy volunteer and one stroke patient showed that the sensor could record representative differences in motion amplitude and signal patterns. These results suggest that the PVA/PAAm/CNTs conductive hydrogel sensor has potential for wearable motion monitoring and rehabilitation-oriented signal acquisition, although larger-scale subject studies are still required for clinical validation.
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IONICS
·
2026
·
IF 3.4
Yan Yu,Sun Xiaofei,Yin Shiyu,Chang Qing,Huang Jie,Wang Bei,Le Qinyuan,Jiang Guodong
Cation-disordered rocksalt (DRX) cathodes have emerged as promising candidates for next-generation energy storage due to their high theoretical capacity and reliance on earth-abundant elements. However, their practical implementation is severely limited by inherently sluggish electrical conductivity and restricted Li + diffusion. In this study, we propose a facile structural engineering strategy by incorporating few-layer Ti 3 C 2 T x MXene, prepared via ball-milling, as a multifunctional conductive additive for Li 1.2 Mn 0.4 Ti 0.4 O 2 DRX cathodes. By synergistically coupling 2D MXene nanosheets with conventional 0D carbon black, a robust hierarchical “point-to-surface” conductive network is successfully constructed. Systematic electrochemical characterizations reveal that optimal MXene integration not only serves as a physical protective barrier but also provides accessible sites for transient lithium-ion storage, thereby collectively accelerating Li + /electron transport and mitigating interfacial polarization. Consequently, the optimized composite electrode with 20% MXene additive delivers a remarkably high initial discharge capacity of 203.7 mAh g − 1 at 0.1 C, substantially outperforming the pristine electrode (165.2 mAh g − 1 ), alongside markedly superior rate capability and structural reversibility. This work provides critical mechanistic insights into MXene-mediated modifications and offers a sustainable pathway for the design of high-performance Mn-based DRX cathodes.
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Advanced Composites and Hybrid Materials
·
2026
·Vol. 9
·期 1
·55
·
IF 15.5
Qiao Lei,Zhou Jiazuo,Wang Fangmiao,Gu Yuehe,Ji Xinyao,Liu Yifan,Ma Qichao,Cui Shuting,Li Yudong,Yao Taikun,Yang Haiyue,Wang Chengyu
The emergence of 5G technologies and advanced high-power electronics demands urgently thermal interface materials (TIMs) with superior thermal transport properties for efficient heat dissipation and reliable thermal management. However, existing TIMs suffer from unsatisfactory interfacial heat transfer efficiency due to the inherent trade-off between achieving high thermal conductivity and excellent viscoelasticity. Here, drawing inspiration from wood supramolecular architectures, a viscoelastic thermally conductive plasticine (AL-VTCP) is fabricated via alkali lignin (AL)-induced supramolecular self-assembly, integrating phase change emulsions with boron nitride nanosheets for nanoscale thermal regulation. Attributed to AL-induced dynamic supramolecular interactions, the developed AL-VTCP not only enhances viscoelastic properties and reduces contact thermal resistance by 71.9%, but also optimizes the thermal conductivity pathway, resulting in an 18.8% increase in thermal conductivity compared with VTCP. Consequently, combined with phase-change heat absorption, a CPU device with AL-VTCP achieves an additional temperature reduction of approximately 13.1 °C compared to high-performance commercial TIMs. Additionally, AL-VTCP demonstrates a low compression modulus (170 kPa), excellent interface adaptability, and minimal environmental impact. This work demonstrates the molecular level engineering of TIMs that optimizes heat transport while minimizing interface resistance, enabling advanced electronics thermal management in 5G integrated systems. Graphical abstract In this work, inspired by wood supramolecular architectures, we fabricate a viscoelastic thermally conductive plasticine (AL-VTCP) via alkali lignin-induced supramolecular self-assembly. The interfacial design simultaneously enhances thermal conductivity and viscoelasticity, thereby solving inherent contradiction and enabling superior heat dissipation capabilities. This work demonstrates the molecular level engineering of TIMs optimizing thermal transport while minimizing interfacial resistance, enabling advanced electronics thermal management in 5G integrated systems.
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POLYMER BULLETIN
·
2026
·Vol. 83
·期 10
·561
·
IF 4.2
Sebbar Khaoula,Ibnsouda Saad Koraichi,Damiri Fouad,Fatimi Ahmed,Moudani Nada Al,Aarab Lotfi,Ilhan Elif,Altan Eray,Gunduz Oguzhan,Houmada Amine Ait,Lyamlouli Karim,Elabed Soumya
Argan nutshell lignin (ANS-LIG) is a sustainable biomaterial recognized for its notable antioxidant and antimicrobial properties. This study investigates its application in 3D-printed (3DP) wound dressings, infused with Moroccan essential oils (EOs), specifically Mentha pulegium (MPEO) and Rosmarinus officinalis (ROEO), to reinforce its antibacterial efficacy. ANS-LIG and EOs were integrated into Eudragit RS PO (EudRP) matrices and printed at room temperature to protect the bioactive properties. Analyses using SEM, ATR-FTIR, and XRD revealed the formation of highly porous, lightweight meshes, with ANS-LIG crystallographic planes becoming partially amorphous when combined with EUD and EOs. Thermal analysis demonstrated improved stability for LIG/EUD + EOs compared to LIG/EUD alone. Studies on hydrophilicity and swelling indicated substantial water absorption, while DPPH assays confirmed strong antioxidant activity within 15 min. Antibacterial tests against gram-positive and gram-negative bacterial strains demonstrated significant activity; in particular, Staphylococcus aureus viability was reduced by 93% after 24 h using the LIG/EUD+MPEO 3D printed patch. Lastly, for the in vitro biocompatibility assay, mouse dermal fibroblasts (MTT assay) were utilized, confirming promising cytocompatibility, with ROEO-loaded meshes exhibiting the highest cell viability of 220%, while MPEO demonstrated more efficient antimicrobial results across all tested strains. Ultimately, the obtained 3D-printed scaffolds efficiently integrated sustainable biopolymers mixed with potent antimicrobials and antioxidant agents, alongside impressive biocompatibility, indicating their potential as advanced wound dressings. This study underscores the advantages of incorporating ANS-LIG and EOs into 3D-printed formulations for future biomedical applications. Graphical abstract
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危险品化学品经营许可证（带存储）