CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Guanshu Zhao,Jing Ding,Jiayi Ren,Qingliang Zhao,Qingwei Gao,Kun Wang,Liangliang Wei,Xueqi Chen,Fanyang Zhou,Dionysios D. Dionysiou
A novel Fe-modified g-C 3 N 4 with rich N vacancies (NVs) under N 2 calcination was developed to active sulfite for the efficient removal of contaminants and bacterial inactivation under visible light (VIS). The degradation rates of VIS/sulfite/Fe/g-C 3 N 4 (N 2 ) for acetaminophen (ACT) were 10.94, 4.88, and 2.85 times higher than those of VIS/Fe/g-C 3 N 4 (N 2 ), VIS/sulfite/g-C 3 N 4 (N 2 ), and VIS/sulfite/Fe/g-C 3 N 4 (CO 2 ), respectively. Escherichia coli (E. coli) with an initial concentration of 2.5 × 10 8 CFU/mL decreased by 6.1 and 8.4 log CFU/mL within 60 min and 80 min of inactivation, respectively. The activation of sulfite led to the generation of oxysulfur radicals, and the consumption of hole (h + ) by sulfite inhibited its recombination with electron (e − ), promoting the formation of superoxide radical ( • O 2 – ). The synergistic effect of Fe, NVs, and g-C 3 N 4 in VIS/sulfite/Fe/g-C 3 N 4 (N 2 ) system promoted the generation of oxysulfur radicals. Density functional theory (DFT) calculations indicated that NVs facilitated charge transfer from Fe to g-C 3 N 4 substrate, accelerating the Fe 3+ /Fe 2+ and oxysulfur radical cycles. Fe/g-C 3 N 4 with rich NVs exhibited lower adsorption binding energy, faster charge transfer, and longer S-O bond length than pristine Fe/g-C 3 N 4 during sulfite adsorption. This work unraveled the synergistic mechanism of Fe, NVs, and g-C 3 N 4 , which provides new insights into heterogeneous photocatalysts on sulfite activation for water treatment.
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ACS Biomaterials Science & Engineering
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2022
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IF 5.395
Fei He,Jing Li,Yixi Wang,Zhipeng Li,Lu Wang,Yuchen Li,Huiling Chen,Chenggang Wang,Bin Liu,Peng Ma,Genxi Dong,Ping Zhou
The success rate of dental implants is limited by peri-implant infection and insufficient osseointegration. Therefore, reducing the occurrence of peri-implantitis and promoting osseointegration are in demand. A roughened surface has commonly been applied to improve the osseointegration of implants, but it will accelerate the attachment of bacteria. We have developed novel antibiotic-decorated titanium (Ti) surfaces by the immobilization of dopamine and cefotaxime sodium (CS) simultaneously. Moreover, the surface roughness of the polydopamine (PDA)/CS coating was controlled by the changes in polymerization times as determined by atomic force microscopy. Then, all antibiotic-grafted Ti surfaces could effectively prevent the adhesion and proliferation of both Escherichia coli and Streptococcus mutans in comparison to the pristine control. For the culture and osteogenic differentiation of human umbilical mesenchymal stem cells (hUMSCs) on the substrate surface, PDA/CS coating with polymerization times less than 30 min showed acceptable biocompatibility, but the upregulation of marker genes and proteins was detected when the polymerization time was more than 30 min. Moreover, the best calcium deposition results were found in the 30 min PDA/CS group with or without the addition of osteogenic factors. Therefore, our PDA/CS coating with a polymerization time of 30 min holds great potential to design dental implants with dual bacteriostatic and osteogenic properties.
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Separations
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2022
·Vol. 9
·期 10
·284
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IF 3.344
Jiaxin Huang,Chunxian Tao,Zhenqing Li,Erika Miyake,Qingxiang You,Wen Xiao,Dawei Zhang,Yoshinori Yamaguchi
Capillary electrophoresis (CE) is a versatile analytical separation method in the field of biochemistry. Although it has been proved that the relative molecular mass (Mr) of the polymers determines the threshold concentration of the entangled polymer solution, which will affect the separation performance of DNA molecules, there is still no report on the effect of Mron the separation performance of proteins. Herein, we have thoroughly performed the CE of proteins ranged from 14.3 kDa to 116 kDa in a mixed hydroxyethyl cellulose (HEC) solution. The mixed solution was obtained with various Mrincluding 90,000, 250,000, 720,000, and 1,300,000. Then, we found that the mixed polymer provided a high resolution for small protein molecules while increasing the efficiency of large ones. Results demonstrated that the migration time decreased if HEC (1,300,000) was mixed with the lower Mrone, and the mixed solution (1,300,000/250,000) offered the highest resolution. The resolution was negatively correlated with the electric field strength. Finally, we have employed the optimal electrophoretic conditions to separate proteins in human tears, and it showed that lysozyme, lipocalin, and lactoferrin from human tears were successfully resolved in the mixed HEC. Such work indicates that CE has the potential to be developed as a tool for the diagnosis of xerophthalmia, meibomian gland dysfunction, or other eye diseases.Keywords:capillary electrophoresis;protein separation;hydroxyethyl cellulose;relative molecular mass;flamingo
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Inorganic and Nano-Metal Chemistry
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2022
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IF 1.514
Rong Chen,Fenghe Chen,Mengyang Sun,Renyu Zhang,Songshuai Wu,Chuangang Meng
In this work, we report a controllable green synthesis of gold nanoparticles (AuNPs) using chlorogenic acid (CGA) as the only reducing and stabilizing agent. The well-dispersed AuNPs are obtained due to the protection of CGA against aggregation. The resulting AuNPs are controllable in size and shape mainly by changing the molar ratio of HAuCl4 to CGA in reductive process. With an increase in CGA concentration, the average size of AuNPs increased, which resulted in different morphologies from spherical to flower-like shapes. The dropping speed of gold precursor is also found to influence the size of AuNPs in different trends. Additionally, the advantages of CGA for synergistic biological activities are demonstrated through the enhanced antioxidant activity of AuNPs with CGA for scavenging of DPPH radicals. The controllable size and shape of nanoparticles are potentially important in nanomedical application.
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Energies
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2022
·Vol. 15
·期 19
·7221
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IF 3.252
Mengyao Guo,Shu Yu,Shu Zhang,Juntao Wei,Wenran Gao,Weina Bao,Lei Shi,Hong Zhang,Deliang Xu
In thermal conversion utilization, nitrogen-rich biomass such as waste wood-based panels will release a large amount of NOxinto the atmosphere, causing serious harm to the surroundings. By means of co-pyrolysis, N in waste wood-based panels can be fixed in chars instead of discharging into the atmosphere in the form of volatile matter, which can reduce NOxemission and lay a foundation for the preparation of nitrogen-rich carbon materials with high added value. As the most commonly used adhesive in the production of wood-based panels, urea-formaldehyde resin adhesive (UF) is the main nitrogen source in waste wood-based panels. Therefore, the purpose of this paper is to explore the effects of glucose, ethyl maltol and 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DMHF) on nitrogen migration and conversion during UF pyrolysis by adjusting the different proportions of model compounds and UF. Thermogravimetric analysis showed that ethyl maltol and DMHF had lower thermal stability and the pyrolysis process was concentrated in the range of 90–168 °C, which does not coincide with the mass loss temperature of UF. UF can promote the pyrolysis of these three model compounds at the initial stage to some extent. The elemental analysis showed that the N retention in co-pyrolysis chars increased in varying degrees with the increase of the addition of model compounds; the nitrogen retention in chars of glucose-UF, ethyl maltol-UF and DMHF-UF increased by 28.47%, 3.48% and 16.45% with the increase of the model compound content from 50% to 90%, respectively. The XPS results showed that the relative content of N-6 in chars increased with the increase of ethyl maltol content, and the relative content of N-5 in chars increased with the increased addition of DMHF. Glucose had little effect on the distribution of N-functional groups in chars.Keywords:wood;thermal conversion;model compounds;urea-formaldehyde resin adhesive;char;nitrogen migration and transformation
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Dong Wang,Yumeng Wang,Xuefen Wang
In this work, a thorn ball-like three-dimensional (3D) heterostructured ZIF-67@α-MnO 2 catalyst consisting of ZIF-67 nanocages impaled by α-MnO 2 nanorods were robustly embedded in polyacrylonitrile nanofibers by electrospinning technique for highly efficient removal of low-molecular-weight pollutants (LMWPs, like dyes and antibiotics) from wastewater. Benefiting from abundant active sites and enhanced charge transfer abilities provided by ZIF-67@α-MnO 2 nanoparticles, the optimal ZIF-67@α-MnO 2 nanofibrous membranes (NFMs) showed a significant response towards acid fuchsin (AF) in terms of comparable adsorption capacity (2495 mg/g) and impressive catalytic activity (degradation degree of 99 % AF within 20 min). In addition, the resultant membranes possessed satisfactory versatile catalytic activity toward tetracycline (95.3 %), norfloxacin (98.4 %) and doxycycline hyclate (89.2 %). Besides, the resultant membranes had high permeability of 1302 L·m − 2 ·h − 1 driven by gravity and could efficiently treat 370.5 L·m − 2 AF (20 ppm), which was significantly higher than that of pure ZIF-67 NFMs (141.8 L·m − 2 ). The successful fabricating of such membrane with extraordinary adsorption and catalytic performance provided a promising approach for high-performance catalytic membranes.
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Journal of the American Chemical Society
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2022
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IF 16.383
Yuan Tian,Zhiliang Gao,Ning Wang,Ming Hu,Yi Ju,Qiang Li,Frank Caruso,Jingcheng Hao,Jiwei Cui
Surface modification with poly(ethylene glycol) (PEGylation) is an effective strategy to improve the colloidal stability of nanoparticles (NPs) and is often used to minimize cellular uptake and clearance of NPs by the immune system. However, PEGylation can also trigger the accelerated blood clearance (ABC) phenomenon, which is known to reduce the circulation time of PEGylated NPs. Herein, we report the engineering of stealth PEG NPs that can avoid the ABC phenomenon and, when modified with hyaluronic acid (HA), show specific cancer cell targeting and drug delivery. PEG NPs cross-linked with disulfide bonds are prepared by using zeolitic imidazolate framework-8 NPs as templates. The reported templating strategy enables the simultaneous removal of the template and formation of PEG NPs under mild conditions (pH 5.5 buffer). Compared to PEGylated liposomes, PEG NPs avoid the secretion of anti-PEG antibodies and the presence of anti-PEG IgM and IgG did not significantly accelerate the blood clearance of PEG NPs, indicating the inhibition of the ABC effect for the PEG NPs. Functionalization of the PEG NPs with HA affords PEG NPs that retain their stealth properties against macrophages, target CD44-expressed cancer cells and, when loaded with the anticancer drug doxorubicin, effectively inhibit tumor growth. The innovation of this study lies in the engineering of PEG NPs that can circumvent the ABC phenomenon and that can be functionalized for the improved and targeted delivery of drugs.
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PubMed
高影响因子
FOOD CHEMISTRY
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2022
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IF 9.231
Xinsheng Qin,Qingli Bo,Panzhu Qin,Sufang Wang,Kaiyong Liu
In this study, we demonstrated the role of whey protein isolate (WPI)/(−)-epigallocatechin-3-gallate (EGCG) covalent conjugates/gellan gum double network emulsion gels by duo-induction of glucono-δ-lactone (GDL) and CaCl 2 on the digestion viability of Lactobacillus Plantarum powders. We employed a novel one-step continuous cold gelation strategy to product double network emulsion gels. The gellan gum in continuous phase was first induced by CaCl 2 to form a gel in a short time. Besides, the GDL was improved covalent cross-linking between WPI-EGCG covalent conjugate Pickering particles or particle-coated oil droplets because of the slowly pH reduction. The first cross-linked gellan gum gels could be more closely integrated into the GDL-induced second gel networks with synergistic role, which promoted the formation of compact and homogeneous networks through hydrophobic interactions and disulfide bonds. Thus, the results provide a promising strategy for probiotic powders encapsulation of double network emulsion gels in oral applications of gel type foods.
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高影响因子
Frontiers in Nutrition
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2022
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IF 6.59
Du Qi,Fang Chuangdong,Qi He,Benjakul Soottawat,Aubourg Santiago P.,Zhang Bin
Phosphates and trehalose are widely accepted additives in animal muscle products. In this study, the effects of pre-soaking with sodium tripolyphosphate (STPP) and trehalose under vacuum permeation (VP) conditions on the physicochemical properties of shrimp muscle were evaluated over 120 d of frozen storage. The results indicate the STPP/trehalose-VP treatments significantly reduced the thawing loss and prevented changes in the texture, myofibrillar protein (MP) content, and Ca2+-ATPase activity of shrimp muscle during frozen storage compared with results of control and individual STPP or trehalose soaking treatments. The histological structure analysis revealed the permeated STPP/trehalose distinctly inhibited the dissociation of muscle fibers and reduced physical damage to connective tissues during storage. Furthermore, analysis of the thermal properties indicated STPP/trehalose treatment increased the Tg’ values of shrimp muscle tissues, likely by restricting the mobility of water molecules in muscle tissues and embedding proteins in the glassy matrix. Thus, the physical destruction caused by ice crystal growth was greatly reduced, due to the absence of water molecules around muscle proteins during frozen storage. Accordingly, the combined STPP/trehalose-VP treatment significantly enhanced the stability of frozen shrimp, and the results support the application of traditional cryoprotective additives. The treated shrimp can be stored at comparatively higher temperatures with limited physicochemical reactions during frozen storage.
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高影响因子
CHEMISTRY & BIODIVERSITY
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2022
·Vol. 19
·期 11
·e202200414
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IF 2.745
Xin-Yu Lei,Shao-Huan Liu,Ya-Xian Zhao,Meng-Jia Guo,Ling Tao,Xiang-Chun Shen,Nen-Ling Zhang
A pair of new lignan conformers ( 1 – 2 ), one new flavonoid glycoside ( 3 ), as well as nineteen known compounds were purified from the twigs and leaves of Cajanus cajan (L.) Millsp.. The planar structures of the unknown compounds were determined via NMR and high-resolution mass spectrometry, while their absolute configurations were elucidated via comparison between their experimental and calculated electronic circular dichroism (ECD) values. All the isolated compounds were assayed for their α -glucosidase inhibitory activities. The results demonstrated that compounds 8 – 12 , 15 – 16 , 18 – 19 , 21 – 22 had strong inhibition activities, with compound 10 (IC 50 =0.4±0.21 μM) most active. The structure-activity relationships were preliminarily summarized. Enzyme kinetics showed that compounds 8 , 9 , 15 – 16 , 18 – 19 , 21 – 22 were non-competitive inhibitors and compounds 10 – 12 were anti-competitive ones. Graphical
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Drug Design Development and Therapy
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2022
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IF 4.319
Nianxiu Tian,Yanbin Gao,Xiaolei Wang,Xiaoming Wu,Dawei Zou,Zhiyao Zhu,ZheJi Han,Tao Wang,Yimin Shi
Background Endoplasmic reticulum stress is associated with podocyte apoptosis in the pathogenesis of diabetic nephropathy (DN). A previous study has demonstrated that emodin has a protective effect in the kidney by suppressing proliferation of mesangial cells and inhibiting the renal tubular epithelial-to-mesenchymal transition. However, the effects of emodin on the podocyte apoptosis in DN and its mechanisms are unknown.Aim This study aimed to explore the effect of emodin on DN model KK-Ay mice and high glucose induced podocytes apoptosis via the PERK–eIF2α pathway.Methods KK-Ay mice model of DN were treated with emodin at dose of 40 and 80 mg/kg/day for 8 weeks. Urine albumin, serum creatinine, blood urea nitrogen levels and the renal histopathology in mice were performed. In vitro, conditionally immortalized mouse podocytes exposed to HG (30mM) were incubated with emodin. Cell viability was measured by CCK-8 assay. Additionally, we performed RNA interference and measured the apoptosis in cultured podocytes treated with emodin. Immunohistochemistry, immunofluorescence, western blot, and real-time PCR were used to detect gene and protein expression both in vivo and in vitro.Results The results showed that emodin treatment ameliorated urine albumin, serum creatinine, and blood urea nitrogen of DN mice. The pathological damage of kidney tissue was also improved after treatment with emodin. Moreover, emodin increased nephrin expression. Podocytes apoptosis and endoplasmic reticulum stress markers (GRP78) were significantly reduced upon emodin treatment. Furthermore, emodin treatment decreased the expression of phosphorylated protein kinase RNA-like endoplasmic reticulum kinase (P-PERK), phosphorylated P-eIF2α, ATF4, and CHOP. In vitro, emodin treatment was further found to decrease the GRP78 level induced by high glucose or tunicamycin (TM). Besides, emodin and PERK knockdown inhibited the apoptosis of podocytes cultured in high glucose by counteracting the upregulation of phosphorylated PERK, phosphorylated eIF2α, ATF4, and CHOP.Conclusion Overall, the findings indicate that emodin mitigates podocytes apoptosis by inhibiting the PERK-eIF2α signaling pathway in vivo and in vitro, and, therefore, exerts a protective action on podocytes in DN.
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DIAMOND AND RELATED MATERIALS
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2022
·
IF 3.806
Qian Zhang,Si Chen,Zhi Huang,Yanying Liu,Jun-ming Hong
In this research, a novel insight was provided for oriented low-temperature S and N doping into graphene oxide (GO).Given the gradual concern in the high-temperature dependence of traditional annealing method for the oriented design of heteroatom doping, utilizing O 3 etching-assisted heteroatom doping can simultaneously resolve the problems of energy consumption and doping species design. In this research, with O 3 etching, 100 at.% marginal S (C-SO X -C) and 92 at.% graphitic N co-doped O 3 -S/NGO were successfully synthesized at annealing temperature of 200 °C. Characterization results showed that S and N doping via O 3 etching maintained the sheet-like structure of GO without much stacking (layer thickness of 4–5 nm). In addition, active defects were formed by O 3 etching and S/N atom doping to provide active center for catalytic reaction . The electrocatalytic degradation behavior proved that 100 % bisphenol A degradation efficiency could be achieved by O 3 -S/NGO within 30 min and that the main active species generated during the reaction were O 2 •− , 1 O 2 and active chlorine. The possible pathways of bisphenol A degradation were also determined to complete the discussion. This project was based on the environmental demand of organic pollution control and suggested an optimal preparation strategy for high-performance catalyst preparation and utilization.
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危险品化学品经营许可证（带存储）