ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Kai Li,Wenjing Yang,Jiqing Hao,Yun Gong
In this work, a Co/Mo metal–organic framework (MOF)-modified filter paper (Co–Mo-MOF@FP) was designated as the separator of sodium metal batteries (SMBs). The Co–Mo-MOF, formulated as [Co(4,4′-bpy)0.5MoO4] (4,4′-bpy = 4,4′-bipyridine), features a three-dimensional (3D) porous architecture with two-dimensional (2D) inorganic bimetallic Co–O–Mo layers bridged by the 4,4’-bpy pillars, leading to a large interlayer spacing of 13.1 Å with a confined pore window of ca. 3.3 Å × 8.1 Å, which provides channels only for the Na+ transport. Therefore, the electrolyte-impregnated Co–Mo-MOF@FP behaves like a single-ion conductor with an ion transference number of 0.76 and a diffusion barrier of 0.27 eV. Meanwhile, the Mo centers with multiple valence states and the rich Co–O–Mo linkages can tolerate electron attack and display excellent electrochemical durability. As a result, the Na |Co–Mo-MOF@FP| Na symmetric cell exhibits a considerable cycling life for over 500 h at 0.5 mA cm–2, and the Na |Co–Mo-MOF@FP| Na3V2(PO4)3 full cells present an initial capacity of ∼100 mAh g–1 with a capacity retention of 81.8% over 1000 cycles at 0.1 A g–1, which are much superior to those with the blank filter paper (FP) separator. This work proposes a strategy of “two-in-one”, in which the confined channel of the Co–Mo-MOF coating on a cheap FP separator and the resultant ion-sieving effect can accelerate uniform Na plating, suppress Na dendritic growth, induce the formation of a stable solid electrolyte interphase (SEI), and promote the desolvation of Na+, thus boosting diffusion kinetics.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Daiyan Wu,Ziwei Liu,Yangyang Feng,Feng Tang,Sheng Li,Xinnan Zhang,Hangyu Li,Qianqian Liu,Linzi Zhang,Qun Liu,Xiaonong Yang,Haibo Feng
Potentilla anserina L polysaccharide (PAP) is known to regulate immunity. Poly(lactic- co -glycolicacid) (PLGA) is a type of drug carrier with biocompatibility and biodegradable USFDA approved polymer, which possesses the advantages of high safety and good sustained-release effect. The DEC205 receptor, a type I membrane protein, is widely distributed on the surface of macrophages and dendritic cells (DCs) and plays a key role in antigen recognition and presentation. In this study, we prepared Potentilla anserina L polysaccharide PLGA nanoparticles targeting DEC205 receptor (DEC205-PAPP) and characterized the nanoparticles with regards to their effects on immune activation in vitro and in vivo . In vitro , DEC205-PAPP promoted the uptake activity of macrophages and increased the secretion of NO and cytokines (IFN-γ, IL-4, IL-6, and GM-CSF), up-regulated the expression of CD80 + , CD86 + . In vivo , DEC205-PAPP elevated the immune organ index, induced DC maturation, promoted T lymphocyte proliferation and differentiation, and increased the levels of antigen-specific IgG antibody and cytokines (IFN-γ, IL-4), which prolonged the residence time of the OVA antigen in the immune organs and the lymph nodes. In conclusion, DEC205-PAPP had a slow-release effect, induced humoral and cellular immune responses, and could potentially be used as an effective antigen-targeted delivery system.
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Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Yu Chen,Yangfei Ou,Chunxing Xian,Hao Wu,Guoqing Pei,Wei Li,Ling Wang,Lei Shi
Osteonecrosis of the femoral head (ONFH) is a common condition that greatly affects patients’ quality of life, yet current treatments often have limited effectiveness. This study aimed to explore how a porous titanium alloy scaffold coated with barium titanate (BaTiO3) could promote bone regeneration in ONFH. We employed various research methods including cell culture, piezoelectric property measurements, tissue-engineered scaffold fabrication, and in vitro and in vivo biocompatibility assessments. Our results showed that macrophages had better attachment and growth on the BaTiO3-coated porous titanium alloy (PTB) scaffold than on the uncoated porous titanium alloy (PT) scaffold, with no significant differences in apoptosis rates between the two groups. Furthermore, the PTB scaffolds reduced the expression of bone resorption markers, such as Cathepsin K, TRAP, and RANK, under dynamic loading conditions. This finding indicates their potential to inhibit osteoclast differentiation. Moreover, the BaTiO3 coating enhanced the mechanical properties and biocompatibility of the scaffolds, evidenced by significantly higher alkaline phosphatase activity and calcium nodule formation in MC3T3-E1 osteoblasts cultured on PTB scaffolds. These findings underscore the dual role of BaTiO3 in facilitating cellular responses and modulating signaling pathways involved in bone metabolism. Our study highlights the promise of BaTiO3-coated titanium alloy scaffolds as an innovative approach to enhance bone regeneration in ONFH, paving the way for future clinical applications and the development of advanced biomaterials for bone healing.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2024
·
IF 4.8
Jun Liu,Jing Ren,Linlan Zhou,Kaiyue Tan,Donglin Du,Lei Xu,Wenfu Cao,Yudi Zhang
Ethnopharmacological relevance The limitations of modern medicine in mitigating the pathological process of diabetic kidney disease (DKD) necessitate novel, precise, and effective prevention and treatment methods. Huangqi, the root of Astragalus membranaceus Fisch. ex Bunge has been used in traditional Chinese medicine for various kidney ailments. Astragaloside IV (AS-IV), the primary pharmacologically active compound in A. membranaceus , is involved in lipid metabolism regulation; however, its potential in ameliorating renal damage in DKD remains unexplored. Aim of the study To elucidate the specific mechanism by which AS-IV moderates DKD progression. Materials and methods A murine model of DKD and high glucose-induced HK-2 cells were treated with AS-IV. Furthermore, multiomics analysis, molecular docking, and molecular dynamics simulations were performed to elucidate the mechanism of action of AS-IV in DKD, which was validated using molecular biological methods. Results AS-IV regulated glucose and lipid metabolism in DKD, thereby mitigating lipid deposition in the kidneys. Proteomic analysis identified 12 proteins associated with lipid metabolism regulated by AS-IV in the DKD renal tissue. Additionally, lipid metabolomic analysis revealed that AS-IV upregulated and downregulated 4 beneficial and 79 harmful lipid metabolites, respectively. Multiomics analysis further indicated a positive correlation between the top-ranked differential protein heme oxygenase (HMOX)1 and the levels of various harmful lipid metabolites and a negative correlation with the levels of beneficial lipid metabolites. Furthermore, enrichment of both ferroptosis and hypoxia-inducible factor (HIF)-1 signaling pathways during the AS-IV treatment of DKD was observed using proteomic analysis. Validation results showed that AS-IV effectively reduced ferroptosis in DKD-affected renal tubular epithelial cells by inhibiting HIF-1α/HMOX1 pathway activity, upregulating glutathione peroxidase-4 and ferritin heavy chain-1 expression, and downregulating acyl-CoA synthetase long-chain family member-4 and transferrin receptor-1 expression. Our findings demonstrate the potential of AS-IV in mitigating DKD pathology by downregulating the HIF-1α/HMOX1 signaling pathway, thereby averting ferroptosis in renal tubular epithelial cells. Conclusions AS-IV is a promising treatment strategy for DKD via the inhibition of ferroptosis in renal tubular epithelial cells. The findings of this study may help facilitate the development of novel therapeutic strategies.
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Advanced Science
·
2026
·
IF 14.1
Kaiyuan Jiang,Fen Xiong,Yiwen Peng,Lingfei Meng,Xinran Wang,Yingruo Xu,Tian Tang,Hongchang Gao
Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes with limited effective interventions. Using a streptozotocin-induced insulin-deficient, type 1 diabetes-like DCM mouse model, we show that intermittent fasting (IF) improves cardiac function and attenuates myocardial remodeling. Antibiotic-mediated microbiota depletion largely abolished these benefits, whereas fecal microbiota transplantation from IF-treated donors recapitulated cardioprotection, supporting a causal role of the gut microbiota. Metagenomic profiling identified Akkermansia muciniphila ( A. muciniphila ) as a prominent IF-responsive taxon, and A. muciniphila supplementation alleviated cardiac injury without obvious improvement in glycaemia. Integrated serum and heart metabolomics identified 1-methyl-L-histidine as a microbiota-associated metabolite reduced in diabetes but restored by IF and A. muciniphila . In vitro and ex vivo assays further supported an L-anserine-linked microbial route for 1-methyl-L-histidine generation. Importantly, oral 1-methyl-L-histidine supplementation recapitulated key cardioprotective effects, remodeled cardiac lipid homeostasis, and reduced lipid peroxidation and oxidative injury. Together, these findings support a gut microbiota–metabolite–lipid axis associated with IF-related cardioprotection in DCM and highlight microbial metabolites as tractable targets to complement dietary intervention.
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BIOSENSORS & BIOELECTRONICS
·
2026
·
IF 11.8
Ziqian Zhang,Min Cui,Junru Li,Shuai Wang,Nianxing Wang,Yingshu Guo
The reusability of molecularly imprinted polymer (MIP)-based biosensors is severely limited by inefficient template removal suppressing in situ regeneration and surface fouling in complex matrices. While recent work demonstrated the feasibility of in situ electrostatic regeneration for MIPs, no study has yet integrated antifouling capability with regeneration ability in a single MIP platform. Here, we reported the first integration of antifouling and ultrahigh in situ regeneration capabilities in a single MIP biosensor for electrochemical cortisol detection in complex biological sweat and real pharmaceutical formulations. The interface exhibited robust antifouling capability against high concentrations of oppositely charged proteins and complex serum, which was primarily attributed to high hydrophilicity of oligochitosan-based surface. Meanwhile the highly hydrated surface effectively preserved structural integrity of biosensing surface and recognition cavities during repeated electrochemical template extraction. As a result, the biosensor achieved 23 regeneration cycles in buffer, a 4.6-fold improvement over previous report, and, more importantly, 12 cycles in sweat and over 15 cycles in pharmaceuticals. Unlike prior works that addressed only regeneration in buffer without antifouling consideration, this new platform simultaneously tackled both long-standing challenges within a single MIP architecture. The biosensor enabled sensitive cortisol detection with a linear range of 0.1 pM to 1 μM and a detection limit of 0.038 pM, with accurate quantification verified in human sweat and pharmaceutical samples. By integrating antifouling and regeneration, this work established a new strategy for robust and reusable MIP biosensors, addressing a key barrier to their practical application.
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CHINESE JOURNAL OF CHEMISTRY
·
2026
·
IF 5.7
Shuai He,Man Zhao,Ze Wang,Shili Fang,Yuhong Chang,Junming Zhang,Li Zhang,Haishun Wu,He Xiao,JianFeng Jia
Comprehensive Summary The selective electrooxidation of methanol to formate is a kinetically complex process involving multiple intermediates ( e.g ., *CH 3 O, *CHO, *OH), whose adsorption energies are difficult to regulate simultaneously. Here, we report a conceptually new electric-field-directed relay catalysis strategy based on a Ni 4 Mo/MoO 2 Mott-Schottky heterojunction. Using a combination of UPS, XPS, and XAFS, we demonstrate that the built-in electric field (BIEF) drives directional electron transfer from metallic Ni 4 Mo to semiconducting MoO 2 , creating spatially separated electron-deficient Ni sites and electron-rich MoO 2 interfaces. Operando FTIR and Raman spectroscopy directly visualize the dynamic evolution of intermediates, revealing a relay mechanism: Ni sites promote *CH 3 O adsorption and C–H/O–H bond cleavage, while MoO 2 enhances *OH supply to accelerate *CHO oxidation. DFT calculations confirm that this BIEF-mediated spatial decoupling lowers the energy barrier of the potential-determining step (*CHO → *HCOOH) from 1.96 eV (Ni 4 Mo) to only 0.76 eV. Consequently, the obtained catalyst achieves a peak current density of 345.2 mA·cm –2 with >97% Faradaic efficiency for formate. This work establishes a new paradigm for designing heterojunction electrocatalysts that leverage interfacial electric fields to orchestrate multi-step reaction pathways with high selectivity.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Gao Ming,Zeng Qin,Wang Xuan,He Xin,Sun Feiyun,Li Bing,Li Xiao-yan,Lin Lin
The exponential growth of the new energy vehicle market
has precipitated
an urgent demand for sustainable lithium iron phosphate (LiFePO 4 ) precursors. While recovering iron phosphate (FePO 4 ) from phosphorus-rich wastewater presents a viable supply chain
solution, conventional precipitation and adsorption methodologies
are critically limited by low product purity and inefficient separation.
This study introduces an innovative electro-driven membrane separation
technology that employs Fe 2 (SO 4 ) 3 as the anode electrolyte to achieve simultaneous phosphorus concentration
and in situ FePO 4 recovery. The process exploits the electric
field to drive PO 4 3– migration into the
anode chamber, where it precipitates with Fe 3+ . Under the
optimized conditions, using a mixed Fe 2 (SO 4 ) 3 /Na 2 SO 4 anolyte and an activated-carbon-containing
catholyte at a current density of 2.6 A m –2 , the
system achieved phosphate removal and recovery efficiencies of 82.4%
and 74.1%, respectively. Mechanistic investigations, corroborated
by mass transport simulations, reveal that the continuous in situ
precipitation strategy effectively maintains a steep concentration
gradient. When applied to actual wastewater, the system yielded a
recovered FePO 4 product with a near-stoichiometric Fe/P
molar ratio of 0.99 and substantially lower cationic impurity levels
than those obtained by direct ferric-salt precipitation. The acidic
anodic environment and ion-selective membrane jointly limited the
association of coexisting cations with the recovered product and suppressed
the formation of Fe(OH) 3 impurities. The strategy addresses
the challenge of impurity incorporation and demonstrates the potential
for value-added FePO 4 precursor recovery from phosphorus-rich
wastewater.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Wei Gan,Ruixin Chen,Li Zhang,Jun Guo,Naidong Chen,Wei Liu,Minfu Zhao,Zhaoqi Sun,Haihong Niu,Xucheng Fu
The combination of peroxymonosulfate (PMS) activation and photocatalytic process was an ideal approach for removing persistent organic pollutants. Here, we constructed a single-atom Co-modified S-scheme heterojunction (0.5CoCN/TiO 2 ) to achieve efficient photoexcitation synergistic PMS activation. Comprehensive characterization and theoretical calculation verified that the addition of Co atoms could strengthening the built-in electric field (BIEF) in heterojunction, which accelerates the rearrangement of Co(III)/Co(II). Meanwhile, the Co atoms bonded with the O in PMS accelerate the adsorption of PMS and facilitate the migration of photoexcitation electrons from CoCN to PMS, thereby boosting the generation of reactive oxygen species (ROS). Furthermore, Co atoms optimized the configuration of active sites, facilitating the simultaneous occurrence of non-radical pathways. Driven by the synergistic effects of Fenton-like reactions and photocatalytic reactions, the optimal heterojunction delivered outstanding catalytic activity, degrading 97.2% of sulfadiazine at a low PMS concentration. This research provides a novel strategy to promote the removal of environmentally persistent pollutants via photo-assisted PMS activation.
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INORGANIC CHEMISTRY
·
2026
·
IF 4.6
Qunmei Zhang,Haiyan Zhu,Tingjie Mao,Mengxiao Yan,Shun Wang,Xiaofang Song,Juan Wang,Huile Jin
Electrochemical CO2 reduction reaction (CO2RR), which enables the directional conversion of CO2 into high-value-added fuels and chemicals, has emerged as a highly promising cutting-edge approach to mitigating fossil fuel consumption and curbing carbon emissions. Copper (Cu)-based catalysts have been extensively studied in the CO2RR, yet the in situ reconstruction mechanism of the catalysts remains an overlooked critical aspect. In this study, we employed diverse metal salt precursors to synthesize CuO catalysts, aiming to investigate the influence of residual elements on the surface reconstruction of catalysts during the CO2RR. Furthermore, with the aid of in situ Fourier transform infrared (FTIR) spectroscopy, the key intermediates in the CH4 formation pathway (*CH2O) and the characteristic intermediate in the C2H4 generation pathway (*OCCHO) were successfully captured, thereby elucidating the impact of residual elements on the CO2RR pathways. This study provides in-depth insights into catalyst surface reconstruction and offers effective strategies for the design of CO2RR catalysts.
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Journal of Energy Storage
·
2026
·
IF 10.7
Yaxin Zhang,Zhaodong Wang,Hao Xiong,Xinren Zhang,Fei Xu,Hongqiang Wang
Currently, protective layers for Zn metal anodes are commonly employed to suppress side reactions triggered by water solvent. However, their complex extra-treatment procedure and suboptimal structural stability remain unsatisfactory, hindering widespread deployment. Herein, the introduction of trimethyl phosphate (TMP) in the electrolyte enables in-situ formation of a Zn 3 (PO 4 ) 2 ·4H 2 O passivation layer, reducing water reactivity and ensuring uniform plating/stripping. Moreover, the oxygen-rich TMP molecules alter the original hydrogen bond structure by increasing strong hydrogen bonds from 42.1% to 63%, leading to enhanced electrolyte stability. Benefiting from these advantages, the assembled half cells achieve superior cycling stability with 99.68% Coulombic efficiency over 1700 cycles under 0.5 mA cm −2 , lasting 48 times longer than TMP-free cells. In the low-temperature environment, the addition of TMP significantly increases the cycle life of the Zn||active carbon capacitor by nearly 70 times. Proof-of-concept pouch cells deliver a robust cycling performance over 1300 cycles with 90.9% capacity retention. These findings provide an impetus for the practical utilization of Zn-based aqueous energy storage systems.
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Polymers
·
2026
·Vol. 18
·期 16
·1932
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IF 5.8
Zhiwei Jiang,Xiang Xiao,Meng Yu,Qiyang Wang,Ping Fang
Herein, a novel chitosan-polydopamine hydrogel was constructed through the in situ self-polymerization of dopamine in a chitosan/alkali aqueous solution. Solid-state13C NMR, FTIR, and SEM confirmed that the formed polydopamine (PDA) particles easily wrapped on chitosan chains to fabricate homogeneous porous hydrogels with pearl-like PDA-chitosan nanofibrils. Thus, the hybrid hydrogels exhibited homogeneous architecture with a high compressive strength of 0.43 MPa. At elevated dopamine (DA) content, the size of PDA particles gradually enlarged from 14 to 32 nm, and a denser network structure was formed because chitosan and DA were partially crosslinked by epichlorohydrin (ECH). Furthermore, PDA endowed the hybrid hydrogels with excellent drug-loading capacity, radical scavenging, and antibacterial activities, which displayed great potential for biomedical and therapeutic applications. Therefore, we provide a new avenue for the creation of polymeric hybrid biomaterials from an alkali aqueous solution.
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