ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2025
·
IF 3.8
Zhang Wenqi,Wang Xiaotong,Wen Shengye,Ge Wei,Deng Jianbo,Zhou Zeyang,Jiang Junhong,Yang Xiaodong,Wang Yan,Yang Shuang
Colorectal cancer (CRC) remains a global health concern, with an urgent need for better early detection and targeted therapies. Our glycoproteomics analysis comparing CRC to paracancerous (PCA) tissue revealed significant alterations. Global proteomic analysis showed more unique proteins in CRC, with differential expression across CRC stages, especially in protein synthesis, translation, and degradation pathways. Despite overall proteomic differences, intact glycopeptide analysis showed high glycosylation similarity between CRC and PCA, with 722 shared glycosites, 2102 shared glycopeptides, and 435 shared glycoproteins. However, a significant shift in CRC’s N -glycan composition was observed: an upregulation of high-mannose N -glycans and a decrease in complex N -glycans, including sialoglycans and fucosylated sialoglycans. While glycosylation motif analysis showed conserved peptide sequences, the attached N -glycan types differed remarkably. KEGG pathway analysis suggested that extracellular matrix and lysosomal glycoproteins like COL1A1 and LAMP1 might modulate the PI3K/Akt signaling pathway via TGFβ1-mediated mechanisms, potentially contributing to tumor progression. These findings suggest that while global protein expression changes significantly in CRC, subtle but crucial changes in N -glycan composition, specifically the increase of high-mannose N -glycans and the decrease of complex N -glycans, may play a significant role in tumor progression and metastasis, potentially through modulation of key signaling pathways. Graphical
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 18
·1-11
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IF 2.8
Liu KunLei,Liu Xumin,Dong Qingchen,Song Lijun,Liang Xinhui,Hu Dianfang,Yu Shihui
Flexible transparent conductive films based on copper nanowires (Cu NWs) are used in a variety of optoelectronic devices. However, their use is limited due to poor stability and adhesion. Herein, highly reliable flexible transparent conductive thin films consisting of SrSnO 3 (STO) and Cu NWs are fabricated using a combination of spin-coating and radio frequency magnetron sputtering techniques. The optical and electrical properties can be modified by changing the number of spin-coating cycle of Cu NWs. The STO thin films can effectively improve optical–electric performance of Cu NWs (before coating STO: 22.1 Ω/sq. at 81.5%, after coating STO: 18.7 Ω/sq. at 82.8%). Furthermore, after 20 tape tests and 2000 bending cycles (with a bending radius of 5.0 mm), the resistance of STO/Cu NW composites remains unchanged, demonstrating exceptional mechanical flexibility and adhesion retention. In addition, the composites show higher stability to high-temperature and high-humidity conditions, oxidation, corrosion, and sulfidation compared with that of Cu NW networks, which is due to the effective covering of STO layer. The combination of these characteristics makes the composite thin films an excellent candidate for substrates of novel flexible optoelectronic devices.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 30
·1-21
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IF 2.8
Yang Minjie,Zou Congyang,Ji Yufeng,Liu Ruijie,Xu Ying
A novel MIL-101(Fe)/Bi₂S₃ Z-scheme heterojunction with a metal–organic framework (MOF) structure was synthesized via a solvothermal method. Compared with pristine MIL-101(Fe) and pristine Bi₂S₃, this composite exhibits a significant breakthrough in degradation performance toward rhodamine B (RhB) and tetracycline hydrochloride (TCH). Specifically, it achieves a degradation efficiency of 95.7% for 20 mg/L TCH within 120 min and 98.6% for 40 mg/L RhB within 90 min.Characterizations including X-ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet–visible diffuse reflectance spectroscopy (UV–Vis DRS), and electrochemical impedance spectroscopy (EIS) confirm that the MOF structure of MIL-101(Fe) provides a stable support matrix for Bi₂S₃. Moreover, the construction of the Z-scheme heterojunction can effectively suppress the recombination of photogenerated electron–hole pairs while retaining the strongly oxidizing hydroxyl radicals (・OH) and strongly reducing superoxide radicals (・O₂⁻). More importantly, after five recycling cycles, the degradation efficiencies of the composite for TCH and RhB remain at 86.8% and 88.6%, respectively, with no obvious damage to its crystal structure after cycling. This demonstrates superior structural stability and reusability compared to most reported MOF-based photo-Fenton catalysts.
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CHEMICAL PAPERS
·
2025
·
IF 2.5
Li Liuqing,Wei Zhengwen,Lü Xiang-fei,Jiang Zhen-Yi,Wang Wei
By utilizing the in situ polymerization reaction of o-tolidine and p-phthalaldehyde, magnetic inorganic/organic hybrid materials were synthesized. Various characterization techniques were employed to analyze the morphology and phase composition of the materials. Using Rhodamine B as a characteristic pollutant, it was found that the maximum adsorption capacity of the materials reached 171.59 mg/g. Density functional theory (DFT) calculations were conducted on different adsorption configurations, revealing that the adsorption process is primarily dominated by π–π interactions, alongside electrostatic attraction and donor–acceptor interactions. This provides a theoretical basis for the subsequent design and preparation of more efficient adsorption materials.
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CHROMATOGRAPHIA
·
2025
·
IF 1.3
Yang Yali,Quan Kaijun,Takafuji Makoto,Chen Jia,Liu Xiuhui,Qiu Hongdeng
C18-modified bipyridinium-functionalized silica was prepared and further modified with tetras(4-sulfonatophenyl)styrene (TPE-SO 3 H) via ion bonding. Thus, two novel stationary phases, including C18-modified bipyridinium stationary phase (Sil-DPC18) and TPE-SO 3 H-functionalized C18-modified bipyridinium stationary phase (Sil-DPC18-TPES) were obtained. The stationary phases were characterized by elemental analysis and Fourier transform infrared spectroscopy (FT-IR). The reversed-phase chromatographic performance of Sil-DPC18 and Sil-DPC18-TPES were evaluated using the Tanaka test mixture, alkylbenzenes, and linear polycyclic aromatic hydrocarbons (PAHs). Compared to an in-house Sil-C18, Sil-DPC18-TPES and Sil-DPC18 exhibited stronger aromatic selectivity and shape selectivity, but weaker hydrophobicity and hydrophobic selectivity. Furthermore, Sil-DPC18-TPES demonstrated better hydrophobicity, hydrophobic selectivity, aromatic selectivity and shape selectivity compared to Sil-DPC18. The enhancement could be due to the introduction of TPE-SO 3 H. In addition, Sil-DPC18-TPES and Sil-DPC18 exhibited good separation selectivity for PAHs, phenylesters, phenols, and phenylamines compared to Sil-C18.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-15
·
IF 12.6
He Jianan,Cai Jianxun,Zhang Jingjing,Li Yang,Wei Kunpeng,Liu Chenshu,Yan Leye,Hu Xinyan,Huang Lin,Gan Hairun,Wang Dashuai,Li Bing,Zhang Huitao,Pang Pengfei
Intraluminal drug coated devices, such as paclitaxel (PTX)-coated balloons, are commonly used to treat arterial occlusive diseases caused by atherosclerosis. However, their efficacy is limited by drug loss, poor drug retention, insufficient penetration and high costs. Nanoparticles with molecular targeting capabilities offer a promising solution to these challenges. Collagen hybridizing peptide (CHP) specifically binds to degraded collagen in atherosclerotic plaques, enabling precise molecular imaging and targeted therapy. In this study, we demonstrated that collagen degradation was significantly elevated in atherosclerotic plaques and could be effectively identified by CHP in both atherosclerosis patients and mice models. Using the emerging copper-free click chemistry reaction, we functionalized the widely used albumin-based indocyanine green nanoparticles and albumin-bound paclitaxel nanoparticles with CHP, developing a targeted nanoplatform for molecular imaging and therapy. In vivo photoacoustic (PA) imaging and ex vivo fluorescence (FL) imaging revealed significantly enhanced PA and FL signals in carotid artery and aorta plaques with CHP functionalized nanoparticles engaging. Furthermore, therapeutic evaluations showed that CHP significantly improved the plaque-targeting capability of albumin-bound paclitaxel nanoparticles, thereby enhancing their therapeutic efficacy against atherosclerotic plaques. These findings highlighted CHP-functionalized albumin nanoparticles as a promising strategy for precise and effective atherosclerosis molecular imaging and treatment. Graphical Albumin nanoparticles functionalized with CHP by copper-free click chemistry reaction, enhancing the imaging ability and therapeutic efficacy for atherosclerosis by elevated plaque targeting capability.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 11
·1-12
·
IF 5.3
Xiao Wenxiang,Hu Yunqin,Shao Liuwen,Liu Jiannan,Wang Dong,Li Hua
Ultra-stable copper nanoclusters were fabricated for the sensitive determination of cholesterol based on fluorescence turn-off. Red-emitting copper nanoclusters capped with cysteine were first synthesized with a short storage time (15 d). Then, the addition of chitosan and the adjustment of media pH were applied to modulate the unstable clusters into exceptionally stable aggregates with cyan-green emission possessing a long lifetime over 180 days. The aggregation-induced emission (AIE) of chitosan-modified copper nanoclusters (Cys-CuNCs) can be significantly quenched by cholesterol due to the interaction between cholesterol and chitosan. The fluorescence response of Cys-CuNCs to cholesterol exhibits a rapid equilibrium (1 min), high sensitivity with a detection limit of 19.63 μmol·L⁻ 1 (3σ, n = 3), and a wide linear concentration range of 25.0 ~ 1000.0 μmol·L⁻ 1 . The proposed method has good stability and can be employed for cholesterol determination in biofluids. Graphical
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IONICS
·
2025
·
IF 2.6
Zhao Chenhao,Fan Jianming,Hu Zhibiao,Tu Fengzhang
Nickel selenides’ structural and composition diversity offers promising avenues for advanced battery anodes, yet their practical implementation faces persistent challenges of structural instability and sluggish kinetics. Addressing these limitations, We developed a spatially confined architecture using a template-directed hydrothermal method. This approach readily produced uniform Ni 3 Se 4 nanoparticles (size ~ 110 nm) encapsulated within conductive carbon nanoplates. Time-dependent XRD analysis confirms continuous selenization-driven phase evolution, while XPS/TGA verify the composite (26.8 wt% carbon) comprises Ni 2+ , Se 2 2− , and Se 2− species. This dual-role design—where carbon simultaneously serves as electron highway and volume-change buffer—enables breakthrough lithium storage performance: 586.2 mAh g −1 after 100 cycles (0.2 A g −1 ) with exceptional 375.5 mAh g −1 retention at ultrahigh 5 A g −1 . Electrochemical analysis demonstrates carbon spacers reduce charge-transfer resistance by > 40% versus bare counterparts. The strategically engineered interface provides critical insights for stabilizing conversion-type anodes. This is significant because, although the sodium storage performance remains challenging (167.9 mAh g −1 after 100 cycles), our study reveals fundamental differences when nickel selenide/carbon composites are employed as its anode materials.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Huang Qi,Duan Jingjing,Antonietti Markus,Chen Sheng
Replacing energy- and cost-intensive Solvay process with innovative manufacture protocol, such as operando -electrified synthesis, would provide a simpler, scale-flexible pathway to produce NaHCO 3 . However, the commercialization of such technique is hampered by the bottleneck problem of small productivity, which is two orders of magnitude below traditional Solvay process. This might be attributed to the gap in conditions between embedded processes inside the system, especially low concentrations of local alkaine, which are generated relatively slowly from one-electron hydrogen chemistry, leading to a small CO 2 –to–HCO 3 − conversion ratio. Guided by octet rule, here we embed eight-electron nitrogen chemistry into Solvay process, maximizing local alkalines generation for CO 2 conversion. By further breaking the stumbling scaling relationship with a liquid metal-derived catalyst, the system achieves productivity up to 3.63 mol L −1 h −1 .
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POLYMER BULLETIN
·
2025
·
IF 4
Xue Baoxia,Feng Jiaxin,Zhang Chunyan,An Zhao,Shao Ziyang,Liu Jing,Niu Mei,Zhang Li
As one of the most common medical dressings, imparting effective antibacterial properties to cotton (COT) fabric is a crucial strategy for preventing bacterial infections. To achieve the continuous release of silver ions, a novel one-step hydrothermal approach was developed by integrating reduced graphene oxide (rGO) and silver nanoparticles (AgNPs) into the fabric, resulting in the in situ growth of rGO/Ag aerogel on the surface of the cotton fabric (rGO/Ag/COT), and forming a new type of structured medical antibacterial dressing. Various analytical methods (including SEM, XRD, plate counting method, flow cytometry, and cytotoxicity) were employed to investigate the structure and properties of the rGO/Ag/COT dressing. The results indicated that, the rGO/Ag aerogel has been embedded within COT fabric via ester-based bonding. The rGO/Ag/COT dressing demonstrated a remarkable antimicrobial efficacy of 99.9% against Escherichia coli and Staphylococcus aureus, owned the ability to continuously release silver ions over a period of several days, and generated a significant amount of reactive oxygen species within the bacterial cells. Additionally, the rGO/Ag/COT dressing displayed the in vitro cytotoxicity of grade 1 and excellent biocompatibility. These implied this strategy provides more ideas for the field of medical dressings through the combination of aerogels and textiles.
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 10
·1-16
·
IF 3
Li Jiatong,Song Lei,Zhang Hao,Wang Runnan,Zhu Bo,Lou Dawei
In this study, a novel composite flocculant was prepared using sodium silicate, aluminum sulfate, and thiosemicarbazone as experimental raw materials. The successful synthesis of the composite flocculant was verified through Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM–EDS), and X-ray photoelectron spectroscopy (XPS). The influence of pH levels in water samples, initial heavy metal ion concentrations, and flocculant dosage on copper ions removal efficiency was systematically studied. The experimental results demonstrate that the removal of Cu 2+ under optimum conditions reached 96.88%. The Langmuir isotherm model predicts a maximum Cu 2+ adsorption capacity reaching 1568.6 mg/g. The adsorption kinetics indicate that the removal of heavy metal ions by this flocculant is dominated by chemisorption. When combined with zeta potential analysis of the flocculation mechanism, charge neutralization emerged as the controlling factor during flocculation, and additional mechanisms such as chelating and precipitation, adsorption and bridging, and sweep flocculation are also involved.
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ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
·
2025
·Vol. 47
·期 7
·1-12
·
IF 3.8
Xue Jinfeng,Ma Yixue,Feng Zhihui,Ji Congbo,Wang Qiao
The atmospheric pollutants polycyclic aromatic hydrocarbon (PAHs) and phenols emitted by the coking industrial area (CIA) have seriously polluted the surrounding soil. Therefore, localized soil screening levels (SSLs) around CIA in Shanxi Province were derived and used for the assessment of soil health risk and groundwater pollution risk. Meanwhile fine-scale spatial probabilistic health risk assessment (PHRA) was conducted based on localized parameters. The results indicated that children under the age of 12 are at a significantly higher carcinogenic exposure risk. The concentration of phenol emitted by CIA into the surrounding soil via atmospheric deposition is higher than those of PAHs, posing a threat to groundwater quality. Groundwater conservation-based SSLs derived from wastewater discharge standards can be used to evaluate the potential pollution of phenols on groundwater. The highest risk for phenol and p-cresol was found to be located within the range of 0.9–1.3 km and 200°–260°, while for PAHs it was within 0.9 km and 90°–200°, neither in line with the prevailing wind direction or areas of high wind speed. BaP, the only substance with an acceptable carcinogenic risk, was primarily concentrated within 0.9 km and 145°–200°. Fine-scale spatial PHRA provides a more accurate understanding of the diverse risk distributions and offer reliable support for precise risk management strategies.
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