APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2024
·
IF 3.1
Yang Yu,Ma Xueliang,Wang Manzhu,Ji Xinyi,Li Long,Liu Ziyu,Wang Jiangyao,Ren Yujin,Jia Lili
In this study, γ-butyrolactone/water (GBL/H 2 O) was explored as a mild, efficient, and cost-effective binary solvent pretreatment to enhance hydrolyzability of corn stover (CS). Key pretreatment parameters—reaction time, temperature, and H 2 SO 4 concentration—were systematically investigated for their effects on the physicochemical properties of CS. Specifically, increased temperature and acid concentration significantly decreased cellulose crystallinity (from 1.39 for untreated CS to 1.04 for CS pretreated by GBL/H 2 O with 100 mM H 2 SO 4 at 120 °C for 1 h) and promoted lignin removal (47.3% for CS pretreated by GBL/H 2 O with 150 mM H 2 SO 4 at 120 °C for 1 h). Acknowledging the cellulase’s limited hydrolysis efficiency, a dual-enzyme scheme using a low cellulase dosage (10 FPU/g) supplemented with β-glucosidase or xylanase was tested, enhancing hydrolysis of CS pretreated under low temperature–long duration and high temperature–short duration conditions, respectively. Optimum sugar release was obtained from CS pretreated with GBL/H 2 O and 150 mM H 2 SO 4 at 120 °C for 1 h, achieving 98% glucan and 82.3% xylan conversion, compared with 53.9% and 17% of glucan and xylan conversion from untreated CS. GBL/H 2 O pretreatment outperformed other binary systems in literature, achieving the highest sugar conversions with lower enzyme loading. These results highlight the potential of GBL/H 2 O pretreatment for efficient biomass conversion, contributing to the goals of the green economy.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-21
·
IF 10.6
Li Fupeng,Mao Zhiyuan,Du Yun,Cui Yuehan,Yang Shengbing,Huang Kai,Yang Jian,Li Zhuoyuan,Liu Yihao,Gu Jinlou,Wang Danru,Wang Chen
Excessive production of reactive oxygen species (ROS) and inflammation are the key problems that impede diabetic wound healing. In particular, dressings with ROS scavenging capacity play a crucial role in the process of chronic wound healing. Herein, Zr-based large-pore mesoporous metal–organic frameworks (mesoMOFs) were successfully developed for the construction of spatially organized cascade bioreactors. Natural superoxide dismutase (SOD) and an artificial enzyme were spatially organized in these hierarchical mesoMOFs, forming a cascade antioxidant defense system, and presenting efficient intracellular and extracellular ROS scavenging performance. In vivo experiments demonstrated that the SOD@HMUiO-MnTCPP nanoparticles (S@M@H NPs) significantly accelerated diabetic wound healing. Transcriptomic and western blot results further indicated that the nanocomposite could inhibit fibroblast senescence and ferroptosis as well as the stimulator of interferon genes (STING) signaling pathway activation in macrophages mediated by mitochondrial oxidative stress through ROS elimination. Thus, the biomimetic multi-enzyme cascade catalytic system with spatial ordering demonstrated a high potential for diabetic wound healing, where senescence, ferroptosis, and STING signaling pathways may be potential targets. Graphical Abstract
Schematic diagram showing the proposed mechanism that S@M@H NPs promoted diabetic wound healing
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CELLULOSE
·
2024
·Vol. 31
·期 10
·6517-6533
·
IF 4.9
Li Qingyi,Zong Yakun,Jiang Yuanzhang,Zhang Jun,Zhao Ruifang,Chen Jianming,Shi Yidong,Tan Lin
Cotton fabrics are widely used in clothing, packaging, and medical applications because of their excellent comfort, breathability, and low cost. However, it poses a threat to use them in specific scenarios, where flame retardance and antibacterial activity are highly desired. In this work, we propose the functionalization route by using layer-by-layer assembly of polyethyleneimine (PEI), phytic acid (PA), iron (Fe 3+ ), and aluminum (Al 3+ ) ions on cotton fabrics. Interestingly, the modified cotton fabric showed good biocompatibility in the cell viability (> 70%) and hemolysis (< 3%) test. In addition to biocompatibility, the antibacterial performance was largely improved for the modified cotton fabric with the antibacterial efficacy of > 99% due to the presence of Fe 3+ and Al 3+ that work in a synergistic manner. In term of flame retardance, the modified cotton fabric exhibited self-extinguishing characteristics in vertical burning experiments, with the Limiting Oxygen Index (LOI) of 35.0%. The excellent flame-retardant property was further supported by the results in cone calorimetry test, thermal gravimetric analysis, and TG-IR test, elucidating the underlying mechanism that rapid formation of dense char layer by the thermal decomposition of PEI/PA/FeAl system is effective to prevent the spreading of flame and thus protect the cotton from burning. This work provides a strategy to achieve multifunctionality on cotton fabrics, which may inspire the design on other types of fabrics or materials for extended applications.
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Microsystems & Nanoengineering
·
2024
·Vol. 10
·期 1
·1-9
·
IF 7.3
Guo Shanlu,Zhu Ruihe,Chen Jingwei,Liu Weilin,Zhang Yuxiang,Li Jianmin,Li Haizeng
With the increasing demand for multifunctional optoelectronic devices, flexible electrochromic energy storage devices are being widely recognized as promising platforms for diverse applications. However, simultaneously achieving high capacitance, fast color switching and large optical modulation range is very challenging. In this study, the MXene-based flexible in-plane microsupercapacitor was fabricated via a mask-assisted spray coating approach. By adding electrochromic ethyl viologen dibromide (EVB) into the electrolyte, the device showed a reversible color change during the charge/discharge process. Due to the high electronic conductivity of the MXene flakes and the fast response kinetics of EVB, the device exhibited a fast coloration/bleaching time of 2.6 s/2.5 s, a large optical contrast of 60%, and exceptional coloration efficiency. In addition, EVB acted as a redox additive to reinforce the energy storage performance; as a result, the working voltage window of the Ti 3 C 2 -based symmetric aqueous microsupercapacitor was extended to 1 V. Moreover, the device had a high areal capacitance of 12.5 mF cm −2 with superior flexibility and mechanical stability and showed almost 100% capacitance retention after 100 bending cycles. The as-prepared device has significant potential for a wide range of applications in flexible and wearable electronics, particularly in the fields of camouflage, anticounterfeiting, and displays.
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Journal of Oceanology and Limnology
·
2024
·
IF 1.3
Ma Xiao,Wang Xueli,Zhou Shaoqi,Ma Jianrong,Wang Jingfu,Chen Jingan,Zeng Yan,Chen Qiao,Qin Boqiang,Li Ming
Genus Microcystis is the most common dominant species of bloom-forming cyanobacteria. Growth and colony formation are critical processes for the occurrence of Microcystis blooms. To identify allelochemicals that can inhibit the growth and colony formation of Microcystis, Microcystis aeruginosa was cultivated and treated with various concentrations of gramine, catechol, berberine, and sanguinarine in laboratory. Results indicate that the growth, colony formation, and extracellular polysaccharides (EPS) content of Microcystis were significantly inhibited when treated with gramine, catechol, and berberine in appropriate concentrations at high iron level (6.8 mg/L). Microcystis growth was inhibited and colony formation and EPS content were promoted when treated with sanguinarine at high iron level. These findings suggest that cyanobacterial blooms can be controlled by regulating the input of gramine, catechol, and berberine. Furthermore, this study revealed that plant allelochemicals could affect the growth and morphology of algae in aquatic ecological restoration, which may be potentially important for improving water quality.
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RARE METALS
·
2024
·Vol. 43
·期 8
·3876-3892
·
IF 9.6
Chai Fei,Zhao Fei-Ping,Hu Zhan,Wen Shi-Yi,Samia Ben-Hammouda,Fu Ze-Lin,Lai Xin-Ting,Liang Yan-Jie,Min Xiao-Bo,Chai Li-Yuan
Arsenic materials have attracted great attention due to their unique properties. However, research concerning iron–arsenic (Fe–As) alloys is very scarce due to the volatility of As at low temperature and the high melting point of Fe. Herein, a new Fe–As alloy was obtained by mechanical alloying (MA) followed by vacuum hot-pressed sintering (VHPS). Moreover, a systematic study was carried out on the microstructural evolution, phase composition, leaching toxicity of As, and physical and mechanical properties of Fe–As alloys with varying weight fractions of As (20%, 25%, 30%, 35%, 45%, 55%, 65%, and 75%). The results showed that pre-alloyed metallic powders (PAMPs) have a fine grain size and specific super-saturated solid solution after MA, which could effectively improve the mechanical properties of Fe–As alloys by VHPS. A high density (> 7.350 g·cm −3 ), low toxicity, and excellent mechanical properties could be obtained for Fe–As alloys sintered via VHPS by adding an appropriate amount of As, which is more valuable than commercial Fe–As products. The Fe-25% As alloy with low toxicity and a relatively high density (7.635 g·cm −3 ) provides an ultra-high compressive strength (1989.19 MPa), while the Fe-65% As alloy owns the maximum Vickers hardness (HV 0.5 899.41). After leaching by the toxicity characteristic leaching procedure (TCLP), these alloys could still maintain good mechanical performance, and the strengthening mechanisms of Fe–As alloys before and after leaching were clarified. Changes in the grain size, microstructure, and phase distribution induced significant differences in the compressive strength and hardness. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 17
·1-15
·
IF 2.8
Min Zhijian,Hu Yuehui,Chen Yichuan,Wu Weimin,Hu Yefu,Liu Huiwen
There are still some problems on the traditional spin-coating preparation of silver nanowire transparent conductive films (AgNWs-TCFs), such as high junction resistance and uneven resistance distribution, due to the random distribution of the AgNWs in network. In this paper, a shear coating method was employed to prepare the aligned AgNWs-TCFs, which is used to reduce the junction resistance. The results revealed a significant anisotropic distribution of resistance, with a maximum transverse-to-longitudinal resistance ratio ( R y / R x ) of 4.31 at a solution temperature of 40 °C. Annealing treatments with twice could effectively eliminate the chemical residue PVP from the samples and resulted in optimal electrical performance, as well as possessed remarkable anisotropic resistance distribution for the aligned AgNWs-TCFs. However, the resistivity anisotropy of the aligned AgNWs-TCFs deteriorated after undergoing more than three annealing treatments. Additionally, this work indicated that the sheet resistivity significantly decreased in the aligned AgNWs-TCFs modified by SnO 2 nanoparticles produced through magnetron sputtering. The resistance’s directivity of aligned AgNWs-TCFs has important potential application in crystal directional growth with electric-field induction.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 26
·期 5
·1-11
·
IF 2.1
Xing Yi,Wu Zhenyu,Li Yaowen,Gong Juntao,Zhang Zhijie,Liu Weili,Song Zhitang
This paper investigates the effect of three different alkalis, namely ammonia (NH 4 OH), ethylenediamine (EDA), and tetrabutylammonium hydroxide (TBAOH) on the stability of colloidal silica, with pH controlled within the range of 8–11. As a result, NH 4 OH greatly promotes the stability of silica sol at first due to the strong solvation ability of NH 4 + and then the stability begins to decrease because the electric double layer of silica is compressed. The addition of EDA into silica system leads to a reduction in the stability evidently followed by a slight increase, which can be explained by the cationic bridging effect of the ethylenediammonium cations. Meanwhile, the effect of TBAOH on silica dispersion is analogous to EDA, mainly caused by the hydrophobic and steric effects. The abovementioned relevant stability mechanisms are involved in non-DLVO theory.
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Cancer Nanotechnology
·
2025
·Vol. 16
·期 1
·1-38
·
IF 4.8
Abd El-Kaream Samir Ali,Mohamad Abed Elrahman Ahmad,El-Kholey Sohier Mahmoud,Ebied Samia Abd El-Moniem
Background In the realm of cancer treatment, sono–X-ray–photodynamic therapy (SXPDT) has garnered significant interest as a novel therapeutic approach. The essential part of SXPDT is the sensitizer, which under X-ray photon and ultrasound sono-irradiation may transform sono and photo-energy into cytotoxic molecules. Photon absorption, targeting, penetration, and oxygen dependence remain challenges in sono–X-ray–photosensitizer (SXPs) design. Rapid advancements in material science have prompted the creation of several SXPs that create cytotoxic species with great selectivity, safety, and noninvasiveness for the treatment of tumors. The current study aims to provide an advanced method of activated cancer treatment by using electroporation to assist the delivery of Roussin salts porphyrin-based conjugated carbon nanoparticles (EP@RRBP-CNP) for the sono–X-ray–photodynamic prostate cancer (PCa) in vivo and in vitro treatment. Materials and methods Human PCa cells (DU-145) were used in the in vitro study, and the in vivo application groups of the study protocol were Swiss albino mice treated with N-methyl-N-nitrosourea (MNU) / testosterone only; they were not given any treatment to induce PCa. The study treatment protocol started only after PCa induction, and involved daily administration of EP@RRBP-CNP as SXPDT sensitizer whether or not to be exposed to photo–(X-ray) or sono–(US) or a combination of them for 3 min for a period of 2 weeks. Results Indicated that CNP is a useful RRBP delivery mechanism that targets PCa cells directly. Furthermore, EP@RRBP-CNP is a promising SXPS that, when used in conjunction with SXPDT, can be very effective in in vitro treating PCa-DU-145 (in a dose-dependent manner cell viability declined, an increase in the cells population during the G0/G1-phase indicates that the cell cycle was arrested, and an increase in cell population in the Pre-G, autophagic cell death, as well as necrosis and early and late apoptosis, indicate that cell death was induced) and MNU/testosterone-PCa-induced mice in vivo (induced antiproliferative genes, p53, Bax, TNFalpha, caspase 3,9, repressed antiangiogenic and antiapoptotic genes, VEGF and Bcl2, respectively), successfully slowing the growth of tumors and even killing cancer cells, as well as lowering oxidative stress (MDA), improving the functions of the kidneys (urea, creatinine), liver (ALT, AST), and antioxidants (GPx, GPx, GST, CAT, GSH, TAC). SXPDT, the X-ray photo- or sono-chemical RRBP activation mechanism, and the antioxidant capacity of non-activated RRBP can all be linked to this process. Conclusion On the bases of the findings, EP@RRBP-CNP shows a great promise as a novel, efficient selective delivery system for localized SXPDT-activated prostate cancer treatment.
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JOURNAL OF FLUORESCENCE
·
2025
·
IF 3.1
Xue Weijian,Ling Xiangyu,Li Huiqian,Liu Yuhang,Zhao Bing,Yin Yanbing
In this work, two chain aromatic hydrocarbon derivatives 1 – 2 , which are constructed by linking two 3 H-imidazo[4,5- b ]pyridine moieties through phenyls and oxygen bridges, were designed and synthesized. The aggregation and disaggregation behavior of these sensors could be modulated by pH, as evidenced by H 1 NMR, fluorescence spectrum and DLS, attributable to the altered deprotonation of the 3 H-imidazo[4,5- b ]pyridine cores. An increase in the sensor concentration leads to the reemergence of aggregation, correspondingly diminishing the fluorescence intensity. Polyaromatic aromatic hydrocarbons (PAHs), known for their luminescent characteristics, demonstrate sustained luminescence even at high concentrations of 10 − 3 M. Notably, the fluorescence of PAHs are effectively quenched upon mixed with 7 × 10 − 5 M aggregated sensor 1 or 10 − 4 M aggregated sensor 2 . Aggregation is identified as the predominant mechanism for fluorescence quenching, the finding corroborated by fluorescence spectroscopy and DLS measurements. Based on computational studies and mechanistic evaluations, sensors 1 and 2 emerge as promising candidates for serving as efficient fluorescence quenchers for polycyclic aromatic hydrocarbons. Graphic
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Chu Juan,Liu Zhaoli,Yu Jie,Wang Heng-Guo,Cui Fengchao,Zhu Guangshan
Two-dimensional conjugated metal organic frameworks (2D c-MOFs) hold significant promise as electrode materials for alkali metal ion batteries while their electrochemical properties still lack reasonable and effective regulation. Here, two representative 2D c-MOFs (M-HHTQ/M-HHTP, M=Cu or Ni) as positive electrodes are used as models to explore the basic/microscopic principles of their complex storage mechanism in sodium ion batteries (SIBs). It is demonstrated that the energy storage mechanism of 2D c-MOFs is determined by the interaction between coordination covalent bonds and organic linkers. Theoretical calculations and experiment results have jointly demonstrated that the redox potential and theoretical capacity can be regulated based on the valence of M-O bond and the utilization of anions and cations, respectively. As a result, Cu-HHTQ achieves a high discharge voltage at 2.55 V (vs. Na + /Na), a higher stable specific capacity of 208 mAh g −1 at 0.05 A g −1 , and long cyclability with the capacity retention rate of 100% at 1 A g −1 after 2000 cycles.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-18
·
IF 15.7
Xue Bin,Xu Zhengyu,Li Lan,Guo Kaiqiang,Mi Jing,Wu Haipeng,Li Yiran,Xie Chunmei,Jin Jing,Xu Juan,Jiang Chunping,Gu Xiaosong,Qin Meng,Jiang Qing,Cao Yi,Wang Wei
Hydrogels are extensively utilized in stem cell-based tissue regeneration, providing a supportive environment that facilitates cell survival, differentiation, and integration with surrounding tissues. However, designing hydrogels for regenerating hard tissues like bone presents significant challenges. Here, we introduce macroporous hydrogels with spatiotemporally programmed mechanical properties for stem cell-driven bone regeneration. Using liquid-liquid phase separation and interfacial supramolecular self-assembly of protein fibres, the macroporous structure of hydrogels provide ample space to prevent contact inhibition during proliferation. The rigid protein fibre-coated pore shell provides sustained mechanical cues for guiding osteodifferentiation and protecting against mechanical loads. Temporally, the hydrogel exhibits tunable degradation rates that can synchronize with new tissue deposition to some extent. By integrating localized mechanical heterogeneity, macroporous structures, surface chemistry, and regenerative degradability, we demonstrate the efficacy of these stem cell-encapsulated hydrogels in rabbit and porcine models. This marks a substantial advancement in tailoring the mechanical properties of hydrogels for stem cell-assisted tissue regeneration.
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