CHEMOSPHERE
·
2023
·
IF 8.8
Hao Cheng,Liwen Zhang,Jun Feng,Tingfan Tang,Danfeng Qin
A novel, sensitive Ti 3 C 2 MXene/Co 3 O 4 /carbon nanofibers (Ti 3 C 2 MXene/Co 3 O 4 /CNFs) composite was synthesized via a HF exfoliating Ti 3 AlC 2 strategy, followed by doping Co 3 O 4 and Ti 3 C 2 MXene into the CNFs via a combination electrospinning and thermal annealing process. Ti 3 C 2 MXene/Co 3 O 4 /CNFs composite exhibits higher catalytic effect, conductivity, chemical stability, and electrochemical performance than Co 3 O 4 and Ti 3 C 2 MXene in electrochemical impedance, differential pulse stripping voltammetry, chronocoulometry, and cyclic voltammetry tests. This Ti 3 C 2 MXene/Co 3 O 4 /CNFs hybrid modified electrode provides fast analysis of 4-aminophenol (4-AP) with ultrahigh sensitivity, enhanced reproducibility and strong anti-interference capability. Furthermore, the level of 4-AP was quantified by this electrode with a wide linear range from 0.5 to 150 μM (R 2 > 0.99) and a low detection limit about 0.018 μM was achieved. Finally, the fabricated electrode was used for fast and sensitive analysis of 4-AP spiked in tap water and blood serum samples. This work presents the new Ti 3 C 2 MXene/Co 3 O 4 /CNFs electrode provides a platform for 4-AP monitoring and has the advantages of high selectivity , accuracy, simplicity, and rapid analysis.
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高影响因子
Biomedical Materials
·
2023
·Vol. 18
·期 5
·055024
·
IF 4
Lihong Qiao,Xiaoxia Li,Chuanqi Wei,Zhongjun Li,Shisong Han,Du Cheng
Chemodynamic therapy (CDT) is a rising technology for cancer therapy by converting intracellular hydrogen peroxide (H2O2) into hydroxyl radical (•OH) via transition-metal-containing nanoparticles (NPs) catalysis reaction (i.e. Fenton reaction) to kill tumor cells. Highly efficient Fenton reaction and favorable delivery of the catalytic NPs 'nanoenzyme' are the key for successful treatment of cancer. In this work, we developed a novel nanoenzyme MnFe2O4@GFP for in vitro and in vivo antitumor therapy. A new MnFe2O4 nanoparticle containing two transition-metal-element Fe and Mn was synthesized for enhanced Fenton reaction and used to co-deliver protein with high biocompatibility through post-modification with dopamine polymerization, green fluorescent protein adsorption, and PEG coating. The enrichment of H2O2 and glutathione (GSH) in tumor tissue provided a favorable microenvironment for in situ generation of toxic free radicals. Fe3+ and GSH triggered a redox reaction to produce Fe2+, which in turn catalyzed H2O2 into •OH, with the consumption of antioxidant GSH. By combining Fe3+ with another catalyzer, the catalytic efficiency of the nanoenzyme were greatly improved. Consequently, the nanoenzyme showed efficient antitumor ability both in vitro and in vivo. Thus, the multifunctional CDT nanoenzyme platform shows great promising for antitumor therapy through the combination of catalyzers Fe3+ and Mn2+ and codelivery of protein cargo.
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DRUG RESISTANCE UPDATES
·
2023
·
IF 24.3
Wei Zhang,Yibao Fan,Jinze Zhang,Dan Shi,Jiahui Yuan,Milad Ashrafizadeh,Wei Li,Man Hu,A.M. Abd El-Aty,Ahmet Hacimuftuoglu,Michael Linnebacher,Yongxian Cheng,Weiguang Li,Shuo Fang,Peng Gong,Xianbin Zhang
Aims Multidrug resistance in pancreatic cancer poses a significant challenge in clinical treatment. Bufalin (BA), a compound found in secretions from the glands of toads, may help overcome this problem. However, severe cardiotoxicity thus far has hindered its clinical application. Hence, the present study aimed to develop a cell membrane-camouflaged and BA-loaded polylactic-co-glycolic acid nanoparticle (CBAP) and assess its potential to counter chemoresistance in pancreatic cancer. Methods The toxicity of CBAP was evaluated by electrocardiogram, body weight, distress score, and nesting behavior of mice. In addition, the anticarcinoma activity and underlying mechanism were investigated both in vitro and in vivo . Results CBAP significantly mitigated BA-mediated acute cardiotoxicity and enhanced the sensitivity of pancreatic cancer to several clinical drugs, such as gemcitabine, 5-fluorouracil, and FOLFIRINOX . Mechanistically, CBAP directly bound to nucleotide-binding and oligomerization domain containing protein 2 (NOD2) and inhibited the expression of nuclear factor kappa-light-chain-enhancer of activated B cells. This inhibits the expression of ATP-binding cassette transporters, which are responsible for chemoresistance in cancer cells. Conclusions Our findings indicate that CBAP directly inhibits NOD2. Combining CBAP with standard-of-care chemotherapeutics represents a safe and efficient strategy for the treatment of pancreatic cancer.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Jiahe Zhang,Linna Chang,Ran Hao,Gangwan Zhang,Tao Liu,Zekai Li,Tianyou Wang,Leyong Zeng
Porphyrinic metal–organic frameworks (MOFs) had promising applications in the photodynamic therapy (PDT) and chemodynamic therapy (CDT) of cancers, but the insufficient reactive oxygen species restricted the efficacy. Herein, by coordinating Cu 2+ and coating ultrasmall gold nanoparticles (AuNPs), a bi-functional porphyrinic MOFs (PCN-224) nanoplatform (PCN-224(Cu)-Au) was designed, achieving the dual-enhancement of PDT/CDT. The results indicated that the Cu 2+ was doped in the core of porphyrin ring, and the singlet oxygen ( 1 O 2 ) generation increased from 79.9% to 85.7%, owing to the enhanced capture capability of photogenerated electrons by Cu 2+ . Using the glucose oxidase-like property of ultrasmall AuNPs, the produced hydrogen peroxide (H 2 O 2 ) promoted the Fenton-like reaction of Cu + , by which the hydroxyl radicals ( OH) generation increased from 63.2% to 80.3%, exhibiting the enhanced CDT performance. Under the combination of enhanced PDT/CDT, the cell viability reduced to 9.1%, and the tumors disappeared completely, demonstrating the dual-enhancement effect of PCN-224(Cu)-Au nanoprobe .
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Zhen Lin,Chuangui Cai,Wei Chen,Qian Deng,Jialin Yang,Kaiyuan Huang,Haohua Deng,Xinhua Lin,Wei Chen,Wensong Yao
Chemiluminescence (CL) intensity of luminol-H 2 O 2 system was dramatically enhanced by cetyltrimethylammonium bromide (CTAB) micelle-mediated 6-aza-2-thiothymine-protected gold nanoclusters (ATT-AuNCs). It is proved that spherical micelles of CTAB in aqueous solution improved the dispersity of ATT-AuNCs, thus enhancing their catalytic activity, which brought in the increased CL intensity of luminol-H 2 O 2 system. Carbazochrome sodium sulfonate (CSS) with a hemostatic containing tetrahydroindole structure broke the spherical micelles and notably quenched the CL intensity of luminol-H 2 O 2 -CTAB-ATT AuNCs system. Based on these results, a simple, fast, and sensitive CL method has been developed for the detection of CSS with a linear range of 0.25–25 μM and a detection limit of 0.11 μM. The method has also been successfully applied to the determination of CSS in serum with satisfied recoveries in the range of 89.6 % to 103.7 %. This study not only provides an effective approach for CSS detection but also paves the way for AuNCs-based CL applications.
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DYES AND PIGMENTS
·
2023
·
IF 4.5
Zekun Shi,Yongning Wu,Xue Zhang,Yanyan Gao,Luqin Qiao,Qin Hou,Minglin Wang
Fluorescent cuprous iodide (CuI)-based coordination polymers (CuI-CPs) were widely used in the sensor field for high selectivity and sensitivity. Here, a new CuI-CP fluorescent probe was fabricated for the detection of spermine, spermidine and cysteine with dual-mode, which was capable of both convenient colorimetric analysis and ratiometric fluorescent detection. The fluorescence of CuI-CP solution was quenched and the solution changed from white to purple upon addition of spermine or spermidine, while the solution changed from white to yellow for cysteine. This probe exhibited selective, sensitive, rapid and linear response to spermine, spermidine and cysteine with a limit of detection of 0.57, 1.06 and 1.18 μM, respectively. Furthermore, cellulose acetate was used as the matrix to fabricate intelligent fluorescent film for real-time and visual monitoring the freshness of pork samples based on distinct fluorescence changes under UV light. This work realized a rapid, efficient, and profitable method for visually evaluating food quality.
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高影响因子
MACROMOLECULES
·
2023
·
IF 5.5
Dianyu Dong,Yuzhang Zhu,Wangxi Fang,Jian Jin
Ultrathin membranes by interfacial polymerization can efficiently purify high-salinity water, but the variety beyond classic polyamide is limited yet. Based on the modular and rapid feature of click chemistry, this work for the first time reports a “clickable” IP strategy to prepare polythioether ultrathin membranes for ion separation. Multiple sets of multifunctional thiol and alkene/alkyne monomers are proven to react at the water–oil interface via thiol–ene/yne addition polymerization. In particular, triallyl cyanurate-DL-dithiothreitol and triallyl isocyanurate-DL-dithiothreitol ultrathin membranes prepared on polyether sulfone substrates reach the separation accuracy of nanofiltration with rejections to Na2SO4 of over 95%. Their surfaces remain negatively charged in both acidic and alkaline environments, and thioether linkages even stand the challenge of long-term acid treatment with high concentration. This strategy would thus motivate growing attempts at developing new-type ultrathin membranes for ion removal or desalination.
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Chemosensors
·
2023
·Vol. 11
·期 8
·431
·
IF 4.2
Yushuang Guo,Mingli Chen,Ting Yang,Jianhua Wang
As the most abundant catecholamine neurotransmitter in the brain, dopamine plays an important role in the normal physiological process, and its level in urine also changes during human pathological processes. In clinic, the detection of dopamine in urine is a potential marker for the diagnosis and the treatment of endocrine-related diseases. In this work, a copper metal organic framework with catecholase-like activity was prepared via the precipitation of Cu2+and imidazole, simulating the N-Cu coordination environment in the active site of catecholase. Cu-MOF (the copper–metal organic framework) can catalyze the oxidation of DA (dopamine) to dopaquinone using O2in the air. The oxidation product can further react with 1,3-dihydroxynaphthalene to produce a fluorophore product. Based on the above reaction, a multimodal sensing platform with three signal outputs, including ratio-metric fluorescence, absorbance and digital information extracted from smartphone images for simple and sensitive determination of DA, was proposed, with detection limits of 0.0679, 0.3206, and 0.3718 μM, respectively. This multimodal sensing platform was able to detect DA in body fluid in a self-correcting way, as demonstrated by the successful determination of DA in normal human urine samples, and samples with a high level of interference.
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MOLECULAR CELL
·
2023
·
IF 16
Chenchen Xu,Xiaoqing Pan,Dong Wang,Yuanyuan Guan,Wenyu Yang,Xing Chen,Ying Liu
The mechanistic target of rapamycin complex 1 (mTORC1) regulates metabolism and cell growth in response to nutrient levels. Dysregulation of mTORC1 results in a broad spectrum of diseases. Glucose is the primary energy supply of cells, and therefore, glucose levels must be accurately conveyed to mTORC1 through highly responsive signaling mechanisms to control mTORC1 activity. Here, we report that glucose-induced mTORC1 activation is regulated by O-GlcNAcylation of Raptor, a core component of mTORC1, in HEK293T cells. Mechanistically, O-GlcNAcylation of Raptor at threonine 700 facilitates the interactions between Raptor and Rag GTPases and promotes the translocation of mTOR to the lysosomal surface, consequently activating mTORC1. In addition, we show that AMPK-mediated phosphorylation of Raptor suppresses Raptor O-GlcNAcylation and inhibits Raptor-Rags interactions. Our findings reveal an exquisitely controlled mechanism, which suggests how glucose coordinately regulates cellular anabolism and catabolism.
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高影响因子
ANALYST
·
2023
·
IF 4.2
Jing Liu,Bing Yin,Xiaobo Liu,Cheng Yang,Shiyu Zang,Shuo Wu
The zeolitic imidazole framework with leaf-shaped morphology (ZIF-L) has a wide range of promising applications in gas storage, battery materials, catalytic reactions, and optoelectronic devices due to its planar leaf-like structure and large surface area. However, the low conductivity, weak catalytic activity, and poor stability in the water dielectric of ZIF-L limited its further practical application. To solve the problems, we added the conductive polymer heterocyclic poly (3,4-ethylenedioxythiophene): poly (styrenesulfonate) (PEDOT: PSS) in ZIF-L for the sensitive detection of dopamine (DA). The synthesized composite ZIF-L/PEDOT: PSS (ZIF-L/PEDOT) not only retained the surface morphology of ZIF-L but also exhibited excellent electrochemical properties. The higher electrical conductivity of ZIF-L/PEDOT compared to ZIF-L was due to the enhanced electron transfer at the interface between ZIF-L and PEDOT: PSS. As a result, we developed an electrochemical biosensor based on the ZIF-L/PEDOT composite, which had a limit of detection of 7 nM for DA and a wide linear range from 25 nM to 500 μM. Furthermore, the current dropped was negligible after 28 days, proving the biosensor had excellent stability. Based on the above outstanding performance, the ZIF-L/PEDOT-based biosensor was successfully used to detect DA in human serum samples. These results demonstrated that ZIF-L/PEDOT was expected to play an essential role in disease detection.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Zhongwei Wang,Xiangqian Chen,Yisheng Sun,Dongliang Hua,Shuangxia Yang,Laizhi Sun,Tianjin Li,Lei Chen
Designing highly active and stable catalysts for the selective cleavage of the C-O bond of lignin is important to convert it into high-valued aromatic compounds. Herein, a facile synthetic strategy was developed using melamine as a soft template to prepare a highly active catalyst consisting of highly dispersed Ni nanoparticles on defective N-doped carbon support. The results indicated that the decomposition of melamine during the pyrolysis process induced the nitrogen atoms into aromatic carbon. The introduction of N-doped carbon support acted as anchor points for the Ni nanoparticles, strengthening the metal-support interaction. Approximately 100 conversion of the representative lignin model compounds, including 2-phenylethyl phenyl ether, were converted into their aromatic monomers under mild conditions. The as-prepared catalyst was stable and reusable after five cycles with no apparent signs of deactivation. Moreover, the theoretical calculation revealed that N-doped carbon supported Ni-based catalyst possessed a lower activation energy of C-O bond than only carbon supported Ni-based catalyst for the C-O bond cleavage in hydrogenolysis of lignin and its model compounds.
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PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Yonghong Pan,Daofeng Zhou,Tingting Cui,Yu Zhang,Lei Ye,Ye Tian,Ping Zhou,Yi Liu,Hidetoshi Saitoh,Botao Zhang,Hua Li
The diversity of medical application scenarios demands fine-tuning of drug release profiles for better patient care. Here we report a facile strategy to construct composite coatings as universal drug delivery systems with tunable release efficacy. A poly-L-lactic acid (PLLA)-polycaprolactone (PCL) coating was fabricated by liquid flame spray and its performance was verified by loading chloramphenicol (CAM) as bactericidal component. Physiochemical analyses revealed the homogeneity of chemistry and integrity of functional groups of the composite coatings. Release of CAM was enhanced by the increase of the PCL content in the composite coatings, showing a controllable manner. Kinetics analysis suggested the release mechanism of Korsmeyer-Peppas model for both the PLLA-CAM and the PCL-CAM coatings, and the release regime for the PLLA-PCL composite coatings transited from the Higuchi model to the Korsmeyer-Peppas model when the PCL content increased from 30 % to 70 %. Further antibacterial testing revealed tailorable antibacterial activity of the coatings against both Escherichia coli and Staphylococcus aureus . Regulating the release of the drug CAM through altering PCL content in the PLLA-PCL coating would give inspiring insight into green fabrication of polymeric coatings with tunable drug release for versatile applications.
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