JOURNAL OF THERMAL SPRAY TECHNOLOGY
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2025
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IF 3.3
Li Ting,Bai Yu,Zhang Chennan,Gao Yuanming,Ma Wen
Ion doping of hydroxyapatite (HA) has been increasing in popularity as a chemical approach to endow it with new properties. In this work, the solution precursor plasma spraying (SPPS) technique was used to prepare the magnesium (Mg)-doped HA coating on the titanium substrate. SPPS is a relatively new one-step deposition technique that allows ion doping and coating deposition to occur synchronously, saving time and costs. The XRD and FT-IR analysis confirm that Mg ions were incorporated into the HA structure and the main phase of the coatings belongs to the HA phase. The results demonstrate the feasibility of using the SPPS technique to prepare the doped HA coating. The addition of Mg ions causes lattice distortion of HA, which leads to a reduction in the chemical and thermal stability of the HA coating. The dissolution behavior of the coatings was investigated by immersing them in phosphate-buffered saline solution for different durations. The Mg-doped HA coating shows relatively higher solubility than the undoped HA coating. With the increase of Mg doping amount, more Ca 2+ and Mg 2+ are released from the coating samples. The adhesion strength of the coating is measured by scratch tests. The 5% Mg doped-HA coating shows the strongest bonding to the substrate. An improvement of 19.6 N is achieved compared to the undoped HA coating. The biocompatibility and bioactivity of the coating samples were evaluated based on the behavior of osteoblasts (MC3T3-E1) in vitro . Cell staining and MTT assay show better cell attachment and proliferation ability on the Mg-doped HA coatings. The presence of Mg in the coating also stimulates the expression of alkaline phosphatase (ALP) and the formation of mineralized nodules in MC3T3-E1 cells. Therefore, the Mg-doped HA coatings prepared by SPPS can be used as a promising implant coating material for orthopedic applications.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Han Yan-Chun,Li Fang-Shuo,Zhang Jian-Chao,Wang Quan,Yang Guo-Hui,Yu Miao,Wang Feng,Duan Yong-Xin,Zong Lu,Li Bo-Xiao,Zhang Jian-Ming
Silica aerogels (SAs) impart low density and excellent thermal insulation to polymer systems, yet incorporating hydrophobic SAs into aqueous rubber latex systems remains challenging owing to their poor dispersibility and potential to destabilize the latex. Although previous studies have dispersed SAs in aqueous poly(vinyl alcohol) (PVA), the stability of such dispersions and their effectiveness as bridging media for latex integration have not been thoroughly evaluated, which limits their practical application in latex compounding. This study systematically examined how the surface chemistry governs hydrolytic stability, interfacial behavior, and latex compatibility in PVA-assisted aqueous processing. Two hydrophobic SAs were prepared: ethoxy-modified SA (E-SA) and methyl-modified SA (M-SA). Both initially formed a homogeneous PVA slurry, but E-SA rapidly hydrolyzed its surface —OCH 2 CH 3 groups, releasing ethanol, becoming hydrophilic, and undergoing irreversible nanopore collapse. In contrast, M-SA maintains its structural integrity and hydrophobicity because its —Si(CH 3 ) 3 groups are highly resistant to hydrolysis. This divergence dictates the behavior during latex blending. The ethanol released from E-SA disrupts electrostatic and steric stabilization, inducing latex coagulation, whereas M-SA/PVA dispersions preserve colloidal stability across diverse latex systems. As a practical demonstration, M-SA-reinforced chlorosulfonated polyethylene (CSM) rubber latex composites show more than a 50% reduction in thermal conductivity while maintaining chemical resistance, enabling high-performance insulating protective gloves and coatings. This work establishes a critical link between aerogel surface chemistry and aqueous processing stability, providing a mechanistic foundation for the rational design of water-based rubber/silica aerogel composites and next-generation thermal insulation materials.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Zhang Di,Shao Meng-Di,Wang Xin,Gui Zhou
Nanoscale red phosphorus (NRP) was synthesized via a phosphorus-amine dissolution method and immobilized onto mesoporous silica nanospheres (MSNs) to obtain hybrid NRP@MSN particles with improved dispersion stability. Epoxy resin (EP) composites containing 2 wt% fillers were prepared to evaluate their thermal and flame-retardant behaviors. Compared with EP, the NRP@MSNs/EP composite significantly enhanced fire safety, resulting in a 52.8% reduction in the peak heat release rate, a 13.9% decrease in total smoke production, and a 165% increase in char yield. Mechanical testing revealed a notable toughening effect under impact loading. The improved flame retardancy originates from the combined nano-barrier effect of MSNs and the catalytic charring and radical-quenching functions of NRP. This work demonstrates an efficient strategy for stabilizing NRP and highlights its strong potential as an environmentally friendly flame retardant for EP systems.
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JOURNAL OF PLANT GROWTH REGULATION
·
2026
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IF 4.2
Ren Yong,Lu Enke,Li Qingqing,Sun Kang,Yang Longhui,Li Ruosen,Nurdawuleiti Shawulie,Liu Lu,Cheng Siren
Rice seedlings, with immature defense systems, are highly susceptible to adverse conditions, severely hindering establishment and yield. While exogenous riboflavin regulates rice growth and stress resistance, its role in modulating comprehensive seedling quality (a core yield-determining trait) remains understudied. This study systematically evaluated riboflavin’s effects on two fragrant rice varieties (Meixiangzhan, Nanjingxiangzhan) with four concentrations (0, 10, 20, 40 mg·L⁻¹) at the seedling stage. The key results showed that 20 mg·L⁻¹ riboflavin (optimal concentration) significantly enhanced root architecture (length, surface area, volume, diameter) and coordinated biomass accumulation (leaf/root fresh/dry weights) across three sampling stages (3d, 6d, 9d after treatment). It also elevated chlorophyll a/b, carotenoid contents, antioxidant enzyme (SOD, POD, CAT) activities, and osmolyte (soluble protein, proline) levels, while reducing oxidative damage (MDA, H 2 O 2 )-except for transient leaf-specific fluctuations at 3d. Meixiangzhan showed stronger responsiveness than Nanjingxiangzhan, linked to varietal differences in root traits and redox sensitivity. This study elucidates that riboflavin improves rice seedling quality via synergistic regulation of root development, photosynthetic capacity, and antioxidant homeostasis. As an eco-friendly, cost-effective biostimulant, it offers a practical strategy to enhance transplanting survival, stress tolerance, and yield potential in rice production.
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Journal of the Australian Ceramic Society
·
2026
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IF 2.6
Chen Yuan,Wang Shu,Li Xin
Heavy metal pollution is a globally environmental crisis as the demand for electronic products being steadily on the increase. In our work, a novel transition metal Sn-doping strategy has been proposed to reconstruct the valence band of CdS by s-p orbit hybridization. An easy and mild solvothermal method was employed to synthesize the Sn-doped CdS nanoparticles, in which Sn 2+ ions substitute Cd 2+ ions to occupy CdS lattice. This Sn-doping modification effectively narrows the bandgap and regulates the energy band structure of CdS. In this case, it has caused an extension of the visible light absorption range, an enhancement of photogenerated carrier separation efficiency, and an improvement of thermodynamic potential, as well as a photostability from photocorrosion. For the optimization effect of Sn doping, the 4 at% Sn-doped CdS sample has performed the highest efficiency of photocatalytic reduction Cr (VI) degradation, achieving 84.8% Cr (VI) removal within 10 min, as 1.3 times higher than that of bare CdS. This research establishes an experimental framework for the advancement of efficient and stable nano-photocatalysts, with implications for band engineering in metal dichalcogenide semiconductors.
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NATURE
·
2026
·
IF 56.1
Wang Xukang,Ma Yuanzhu,Niu Yihan,Xiong Bo,Zhang Anke,Zhang Guoxun,Chen Yifan,Wei Wei,Fang Lu,Wu Jiamin,Dai Qionghai
Volumetric additive manufacturing has emerged as a promising technique for the flexible production of complex structures, with diverse applications in engineering, photonics and biology 1 , 2 . However, present methods still face a trade-off between resolution and volumetric build rate, restricting efficient and flexible production of high-resolution 3D structures. Here we propose a method, called digital incoherent synthesis of holographic light fields (DISH), to generate high-resolution 3D light distributions through continuous multi-angle projections with a high-speed rotating periscope without the requirement of sample rotation. The iterative optimization of the holograms for different angles in DISH maintains 19-μm printing resolution across the 1-cm range that is far beyond the depth of field of the objective and enables high-resolution in situ 3D printing of millimetre-scale objects within only 0.6 s. Acrylate materials in a range of viscosities are used to demonstrate the general compatibility of DISH. Integrating DISH with a fluid channel, we achieved mass production of complex and diverse 3D structures within low-viscosity materials, demonstrating its potential for broad applications in diverse fields.
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Drug Delivery and Translational Research
·
2026
·
IF 6.9
Li Jiaqi,Long Meng,Xu Fanjun,Abudureyimu Zulalan,Li Jing,Guo Teng,Feng Nianping,Zhang Yongtai
In the current study, polysaccharides (APS) extracted from the dried roots of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao were demonstrated to promote hair regeneration. However, with an average molecular weight of 20,000, they exhibit poor transdermal absorption. To enhance local efficacy, we synthesized chemically crosslinked hyaluronic acid (cHA) and prepared γ-cyclodextrin-modified potassium metal–organic frameworks (MOFs) loaded with minoxidil (MDX) (MDX@MOF).The aforementioned materials were mixed with APS to form soluble microneedles (MDX@MOF-APS/cHA-MNs). Their oblique spike structure facilitates local fixation after skin penetration. MOF-based drug loading increased MDX water solubility by ninefold, while cHA provided significant sustained-release effects.Furthermore, APS enhances the mechanical properties of hydrogel microneedles and optimizes drug delivery. Notably, APS promotes human hair follicular papilla cell proliferation in a dose-dependent manner and exhibits synergistic effects with MDX. Concurrently, MDX@MOF-APS/cHA-MNs significantly prolong drug retention time in the skin, effectively improving hair coverage and growth rate in androgenetic alopecia mice. In summary, APS emerges as a clinical candidate for treating androgenetic alopecia, while novel microneedles with unique composition and structure enrich topical delivery strategies. Graphical abstract
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BMC Veterinary Research
·
2026
·
IF 3.1
Yao Lulu,Kang Yunzhe,Zhao Xuyang,Wang Lucai,Lv Lijie,Zhu Wenhui,Yang Xiuwen,Zhuang Guoqing,Sun Aijun
Background N6-methyladenosine, the most prevalent post-transcriptional modification in eukaryotes, plays a critical role in regulating gene expression and disease pathogenesis. Concurrently, G-quadruplex structures are implicated in key biological processes, including the regulation of transcription and post-transcriptional events. Emerging evidence suggests that m 6 A modifications and G4 structures colocalize within viral genomes and human pre-mRNAs; however, their functional interplay remains poorly understood. Results Using existing MeRIP-seq data from Marek’s disease virus (MDV)-infected samples, we investigated the colocalization pattern and its potential role in viral infection. Our bioinformatic analyses revealed that the predicted G4 structures were predominantly two G-tetrad G-quadruplexes. Genes with m 6 A-G4 colocalization were significantly enriched in pathways related to immune response and tumorigenesis. Then we verified the presence of co-localization on the CCL4 , which inhibited CCL4 expression. Co-localization also affected viral replication and regulated ICP4 expression. Conclusions We systematically characterized the features of G4 structures co-localized with m 6 A modifications during MDV infection, investigated the role in viral replication and gene regulation, and provided experimental evidence for m 6 A-G4 co-localization. These findings shed new light on the epitranscriptomic regulatory mechanisms employed by an oncogenic virus and may inform the development of novel antiviral and anti-tumor therapeutic strategies.
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CELL BIOLOGY AND TOXICOLOGY
·
2026
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IF 5.7
Peiqi Wang,Haoxin Fu,Jun Wu,Ruibin Li,Lu Cao,Ren-Ai Xu,Weihong Lin
Acalabrutinib is a frontline agent for chronic lymphocytic leukemia (CLL). The objective of this experiment was to screen 21 cardiovascular drugs with a focus on elucidating the metabolic inhibition of acalabrutinib by finerenone in vitro and in vivo. The ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was applied to quantify acalabrutinib and its major active metabolite ACP-5862 in liver microsomes in vitro and in rats in vivo. The half-maximal inhibitory concentrations (IC 50 ) of finerenone in rat liver microsomes (RLM), human liver microsomes (HLM) and recombinant human CYP3A4 (rCYP3A4) were 7.00, 21.29 and 3.52 μM, respectively. In RLM and rCYP3A4, finerenone inhibited the metabolism of acalabrutinib via mixed-type inhibition (competitive and non-competitive), with a non-competitive inhibition observed in HLM. Compared with the control group, in vivo pharmacokinetic analysis indicated that finerenone co-administration increased acalabrutinib exposure, as reflected by 4.08-, 7.16-, and 3.96-fold increases in AUC (0-t) , AUC (0-∞) , and half-life (t 1/2 ), respectively, accompanied by an 86.02% reduction in the clearance (CL z/F ). Its metabolite ACP-5862 demonstrated a 57.47% and 65.12% decrease in AUC (0-t) and the maximum concentration (C max ), respectively, while CL z/F was increased by 0.79-fold. Finally, acalabrutinib and finerenone were evaluated for binding to cytochrome P450 3A4 (CYP3A4) by molecular docking, yielding binding energies of -2.36 and -2.19 kcal/mol, respectively. Thus, in vivo and in vitro results consistently indicated that finerenone inhibited the metabolism of acalabrutinib, providing the basis for individualized dosing considerations.
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FIBERS AND POLYMERS
·
2026
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IF 3.1
Cui Jie,Deng Hangjun,Qi Dongming,Zhou Guiyang,Chen Tao
To enhance the surface hydrophilicity of polyphenylene sulfide (PPS) fibers and expand their industrial applications in fire-resistant/radiation-resistant workwear, water electrolysis hydrogen production diaphragms, and fiber paper, this study modified PPS nonwovens using three polyphenols: dopamine, gallic acid, and tannic acid. Specifically, the catechol groups in polyphenols were utilized to adsorb hydrolyzed titanium dioxide (TiO 2 ) from an aqueous solution of ammonium hexafluorotitanate, thereby forming polyphenol/PPS/TiO 2 composites materials. The physicochemical properties (e.g., morphology, elemental composition) and surface properties (e.g., hydrophilicity, mechanical performance, etc.) of modified and unmodified fabrics were characterized using a suite of analytical techniques, including Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), contact angle measurement, water absorption testing, thermogravimetric analysis (TGA), and stress–strain testing. Additionally, the effects of polyphenol type, polyphenol concentration, and reaction time on hydrophilicity of the modified nonwovens were investigated to determine the optimal modification conditions. Results showed that polyphenol modification, combined with subsequent TiO 2 treatment, significantly improved the surface hydrophilicity of PPS nonwovens while preserving their favorable mechanical properties and friction resistance. Among the three polyphenols, the dopamine/PPS/TiO 2 composite exhibited the best wettability: when 2% dopamine (mass concentration) and subjected to 18 h of deposition, the water contact angle decreased from 146.0° (for unmodified PPS) to 51.9°, and the water absorption capacity of the PPS nonwovens increased to 508.4 mL/m 2 /s.
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Nature Communications
·
2026
·Vol. 17
·期 1
·3295
·
IF 18.1
Zheng Jialu,Zhu Xiwen,Wang Wei,Xie Songrui,Ma Wenyi,Shao Shishi,Nie Hanbing,Li Yan Jie,Zheng Zheng,Huang Cheng Zhi,Gao Peng Fei
Solid-state molecular motion (SSMM) plays a critical role in enriching material properties and functions, yet visualizing its detailed dynamics including direction, progression, and velocity to thoroughly elucidate its mechanism remains a great challenge. Herein, an intermolecular charge transfer (ICT)-mediated fluorescence strategy is developed to visualize and regulate SSMM in binary cocrystal systems, utilizing 6-methoxy-2-acetylnaphthalene (MA)/1,2,4,5-tetracyanobenzene (TCNB) as modeling platform. This approach leverages the reversible transformation between MA/TCNB = 1/1 (MT1, yellow emission) and MA/TCNB = 1/2 (MT2, green emission) crystalline phases, enabling real-time visualization of detailed SSMM information via localized dichromatic fluorescence signatures. It reveals an unexpected significant disparity in diffusion rates between electron donor MA and electron acceptor TCNB during the diffusion process at their interface, even exhibiting unidirectional diffusion from MA to TCNB within a restricted time. Applications demonstrated include pretreatment-free impurity analysis of MA (a key impurity in naproxen) down to 0.1% leveraging the fluorescence shift, and real-time monitoring of transesterification reactions based on the differing interaction capabilities of various naproxen esterification derivatives with TCNB. This study not only provides fundamental insights into SSMM and cocrystallization mechanisms but also demonstrates the potential of charge transfer cocrystallization for molecular sensing and dynamic reaction monitoring.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
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IF 4.1
Wei Yuqing,Zhong Chao,Zhao Hongwei,He Qifang,Zhang Bo,Qiu Hongdeng
The selective separation and precise analysis of rare earth elements (REEs) in impurity-laden matrices constitute persistent challenges. Among available separation techniques, ion-exchange chromatography has gained prominence as an effective approach for REE purification. However, the quest for a high-performance stationary phase preparation method continues to be a focal point. Herein, a propylsulfonic acid-functionalized stationary phase (Sil-SH-SCX) was developed through γ-mercaptopropyl trimethoxysilane (MPTS) grafting followed by oxidation. The Sil-SH-SCX demonstrated excellent chromatographic performance, achieving efficient separation of REEs with resolution ranging from 4.2 to 12.6 for adjacent lanthanides. Besides, the Sil-SH-SCX column displayed high repeatability (RSD < 0.99%, n = 10) and stability (RSD < 1.5%, n = 30). Taking advantage of its excellent separation performance, Sil-SH-SCX was successfully applied for the sensitive determination of REEs with excellent linearity ( R 2 = 0.996–0.999, 1–500 mg L −1 ). This work provided an insight into the design of a chromatography stationary phase and expanded its potential application in REE analysis and purification. Graphical abstract
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