JOURNAL OF POLYMER RESEARCH
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2020
·Vol. 27
·期 9
·1-10
·
IF 2.426
Yang Min,Lu Xiaoluan,Tang Luyang,Fu Yangyang,Yang Peixin
The purpose of this work was first to propose a thermosensitive hydrogel incorporating Zn phthalocyanine loaded mixed micelles for drug delivery. The mixed micelles was prepared easily by dialysis method and the thermosensitive hydrogel was prepared by “cold method” using Pluronic F127 as hydrogel matrix. The properties of sol and gel transition caused by F127 temperature response enables the drug loaded micellar hydrogel(DLM-Gel) to gel in situ gelification upon injection providing long-term retention within the tumor. Sodium deoxycholate (SDC) and D-alpha tocopheryl polyethylene glycol succinate (TPGS) were utilized as micelles materials. Micelles resulted in a mean particle size around 106 nm, spherical morphology and loading efficiency up to 92%. The DLM-Gel displayed a three-dimensional network structure, which helps to stabilize ZnPc molecules because it can reduce the rotation and intermolecular collision of the ZnPc molecules, leading to the enhancement of fluorescence intensity and 1 O 2 generation. The production of 1 O 2 from DLM-Gel was more efficient than micelles under the same laser irradiation condition. The DLM-Gel was more photostable than free ZnPc and micelles in the timescale typically used in photodynamic therapy(PDT), only a small photobleaching event(16.91%) was observed after 20 min of light irradiation. Rheology studies demonstrated that DLM-Gel has the potential to be injected at room temperature and to adapt to the deformation of surrounding tissues during human motion. The in vitro drug release studies of DLM-Gel demonstrated slower drug release than mixed micelles. Phototoxicity experiments in A549 cells showed that DLM-Gel had significante toxicity.Therefore the injective micellar hydrogels is a potential drug delivery system for PDT.
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Scientific Reports
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2021
·Vol. 11
·期 1
·1-12
·
IF 4.38
Wu Shibin,Chen Yan,Chen Zhenshou,Wang Jiaqi,Cai Miaomiao,Gao Junkai
Metal microspheres doping porous carbon (MMPC), which was prepared using in-situ pyrolysis reduction strategy, could enhance the thermal conductivity of shape-stabilized phase change material (ss-PCM) prepared by MMPC as the matrix. However, in previous studies that were reported, the preparation of MMPC needed to synthesize porous carbon by pyrolysis firstly, and then porous carbon adsorbed metal ions was pyrolyzed again to obtain MMPC, which was tedious and energy-prodigal. In this study, a one-step pyrolysis strategy was developed for the synthesis of MMPC through the pyrolyzation of wheat bran adsorbed copper ions, and the copper microspheres doping wheat bran biochar (CMS-WBB) was prepared. The CMS-WBB was taken as the supporter of stearic acid (SA) to synthesize the ss-PCM of SA/CMS-WBB. The study results about the thermal properties of SA/CMS-WBB demonstrated that the introduction of copper microspheres could not only improve the thermal conductivity of SA/CMS-WBB, but also could increase the SA loading amount of wheat bran biochar. More importantly, the CMS-WBB could be obtained by only one-step pyrolysis, which greatly simplified the preparation process and saved energy consumption. Furthermore, the raw material of wheat bran is a kind of agricultural waste, which is abundant, cheap and easy to obtain. Hence, the SA/CMS-WBB synthesized in this study had huge potentialities in thermal management applications, and a simplified method for improving the thermal properties of ss-PCMs was provided.
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PubMed
高影响因子
Cancer Nanotechnology
·
2020
·Vol. 11
·期 1
·1-17
·
IF 4.7
Pisano S.,Wang X.,Garcia-Parra J.,Gazze A.,Edwards K.,Feltracco V.,Hu Y.,He L.,Gonzalez D.,Francis L. W.,Conlan R. S.,Li C.
Background Amphiphilic block copolymers used as nanomicelle drug carriers can effectively overcome poor drug solubility and specificity issues. Hence, these platforms have a broad applicability in cancer treatment. In this study, Pluronic F127 was used to fabricate nanomicelles containing the histone deacetylase inhibitor SAHA, which has an epigenetic-driven anti-cancer effect in several tumor types. SAHA-loaded nanomicelles were prepared using a thin-film drying method and characterized for size, surface charge, drug content, and drug release properties. Loaded particles were tested for in vitro activity and their effect on cell cycle and markers of cancer progression.Results Following detailed particle characterization, cell proliferation experiments demonstrated that SAHA-loaded nanomicelles more effectively inhibited the growth of HeLa and MCF-7 cell lines compared with free drug formulations. The 30 nm SAHA containing nanoparticles were able to release up to 100% of the encapsulated drug over a 72 h time window. Moreover, gene and protein expression analyses suggested that their cytoreductive effect was achieved through the regulation of p21 and p53 expression. SAHA was also shown to up-regulate E-cadherin expression, potentially influencing tumor migration.Conclusion sThis study highlights the opportunity to exploit pluronic-based nanomicelles for the delivery of compounds that regulate epigenetic processes, thus inhibiting cancer development and progression.
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JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 56
·期 8
·5143-5160
·
IF 3.553
Bao Yan,Yan Yan,Wei Yanmin,Ma Jianzhong,Zhang Wenbo,Liu Chao
Capsules containing corrosion inhibitors have drawn considerable attention in the field of self-healing corrosion protection because of their appropriate size and high efficiency. ZnO has become a type of promising encapsulants due to its high structural tunability and unique surface chemical property. Meanwhile, carbon dots (CDs) have huge application potential to replace the existing toxic corrosion inhibitors. Herein, a corrosion-resistant microcapsule with nitrogen-doped carbon dots (NCDs) as the core material and ZnO as the wall material (NCD@ZnO MCs) was developed to exert perfectly the advantages of the two materials. The NCDs were first synthesized by solvothermal method, and the NCD@ZnO MCs were then fabricated just by stirring at room temperature. The morphology, microstructure and composition of NCDs and NCD@ZnO MCs were characterized, respectively. The superiority of NCD@ZnO MCs in improving the anti-corrosion resistance of waterborne coatings was also discussed. The results showed that the obtained NCDs had a size distribution of 2–5 nm and the N-doping content was 6.56%. The size distribution and shell thickness of the prepared NCD@ZnO MCs were 100–200 nm and 30–90 nm, respectively. The encapsulation efficiency of NCDs was 34.69 ± 3.04%. The release behavior of NCD@ZnO MCs exhibited a dependence on salt concentration. Electrochemical impedance spectroscopy (EIS) measurements showed that NCD@ZnO MCs as fillers significantly improved the durability of the coating in terms of anti-corrosion resistance in all solutions with different salt concentrations. This smart filler is a promising candidate for application in anti-corrosive coatings, due to its low toxicity, facile synthetic route, near nanoscale size and sensitive environmental responsiveness. Graphical abstract
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Nano Research
·
2020
·Vol. 14
·期 3
·868-878
·
IF 8.183
Lei Zhao,Tan Yangyang,Zhang Zeyi,Wu Wei,Cheng Niancai,Chen Runzhe,Mu Shichun,Sun Xueliang
The construction and design of highly efficient and inexpensive bifunctional oxygen electrocatalysts substitute for noble-metal-based catalysts is highly desirable for the development of rechargeable Zn-air battery (ZAB). In this work, a bifunctional oxygen electrocatalysts of based on ultrafine CoFe alloy (4-5 nm) dispersed in defects enriched hollow porous Co-N-doped carbons, made by annealing SiO 2 coated zeolitic imidazolate framework-67 (ZIF-67) encapsulated Fe ions. The hollow porous structure not only exposed the active sites inside ZIF-67, but also provided efficient charge and mass transfer. The strong synergetic coupling among high-density CoFe alloys and Co-N x sites in Co, N-doped carbon species ensures high oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) activity. First-principles simulations reveal that the synergistic promotion effect between CoFe alloy and Co-N site effectively reduced the formation energy of from O* to OH*. The optimized CoFe-Co@PNC exhibits outstanding electrocatalytic stability and activity with the overpotential of only 320 mV for OER at 10 mA·cm −2 and the half-wave potential of 0.887 V for ORR, outperforming that of most recent reported bifunctional electrocatalysts. A rechargeable ZAB constructed with CoFe-Co@PNC as the air cathode displays long-term cyclability for over 200 h and high power density (152.8 mW·cm −2 ). Flexible solid-state ZAB with our CoFe-Co@PNC as the air cathode possesses a high open circuit potential (OCP) up to 1.46 V as well as good bending flexibility. This universal structure design provides an attractive and instructive model for the application of nanomaterials derived from MOF in the field of sustainable flexible energy applications device.
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COLLOID AND POLYMER SCIENCE
·
2020
·Vol. 299
·期 1
·25-35
·
IF 1.536
Zhang Zhijie,Chu Nini,Shen Yinglin,Li Congling,Liu Rui
In this study, hierarchical porous polyacrylonitrile nanofibers were fabricated via electrospinning zeolitic imidazolate framework-8 (ZIF-8) and polyacrylonitrile (PAN), followed by tannic acid (TA) etching and amidoximation (denoted as p-PAN-AO). The as-prepared p-PAN-AO was utilized to remove radioactive U(VI) from sewage water and simulated seawater. The influence of uranium adsorption on p-PAN-AO was investigated as a function of uranium concentration, pH, and time. Adsorption kinetic experiments indicated that the pseudo-second-order kinetic model was fitted better than the pseudo-first-order model. Benefiting from amidoximation and hierarchical porous structure, the nanoadsorbent exhibited a high U(VI) adsorption capacity of 412.28 mg/g at 298 K. The thermodynamic analysis manifested a spontaneous and endothermic nature of U(VI) adsorption. The results demonstrated a potential application of the reported materials in nuclear wastewater and environmental cleanup.
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Food Analytical Methods
·
2021
·Vol. 14
·期 4
·797-804
·
IF 3.366
Zhang Liqun,Wu Leyi,Wu Pinggu
Pollution of foods with chloropropanol fatty acid esters is a growing international food safety issue, especially contamination with 3-monochloropropane-1, 2-diol (3-MCPD) esters. Traditional GC/MS method using phenylboronic acid (PBA) as a derivatization reagent has been proven to be high selective. However, the disadvantage of this method is that excessive amounts of phenylboronic acid causes the formation of triphenylboroxin that may lead to instrument fouling and reduces the sensitivity of this 3-MCPD detection method. The objective of this study was to optimize a solid phase extraction method after the phenylboronic acid derivatization to illimate the triphenylboroxin formed form excess PBA treatment, and to provide an instrument-friendlier GC-MS method for the detection of 3-MCPD in camellia oil. Different solid phase extraction methods were compared, and (n-propyl)ethylenediamine (PSA) column was selected for its selective in the absorption of fatty acid of ethylenediamine-N-propyl (PSA). Good linearity for 3-MCPD esters detection was found within the concentration range of 0.2 to 10 mg/kg ( r 2 = 0.9992). The limits of detection (LOD) and the limits of quantification (LOQ) were 0.05 mg/kg and 0.10 mg/kg, respectively. The average recoveries of 3-MCPD esters spiked at 0.25 mg/kg, 1 mg/kg, and 5 mg/kg in pressed camellia oil ranged from 98.83 to 108.79% with a relative standard deviation less than 10%. When this method was applied to the detection of 3-MCPD esters in commercially available camellia oil samples, high amounts of 3-MCPD were present in refined camellia oil samples: the mean content was 1.33 mg/kg, ranging from < 0.034 to 5.47 mg/kg.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2021
·Vol. 127
·期 1
·1-13
·
IF 2.584
Xie Ping,Li Bin,Chen Gang,Zheng Weimin,Ma Xiaofeng,Luo Haihan,Liu Dingquan
The dielectric function of phase-change materials (PCMs) presents a tremendous difference for the amorphous and crystalline states. Therefore, the measurement of the mid-infrared transparency of thin films of PCMs will provide a cost-efficient method to reveal the dependence of amorphous-crystalline phase transition on their compositions. Although Sb–Te–Se system has shown the advantages of the high speed, low power consumption and long retention life, the information on the mid-infrared transparency of Sb–Te–Se thin films is still insufficient. In our investigation, combinatorial materials libraries of Sb–Te–Se thin films were synthesized. The composition and mid-infrared spectral transmittance of each pixel of Sb–Te–Se thin film in the library were characterized using the energy dispersive X-ray analysis (EDX) and Fourier-transform infrared (FTIR) spectrometer, respectively. The in-depth chemical composition for randomly selected pixels was identified using secondary ions mass spectroscopy (SIMS). The crystallographic structure of some pixels was also identified using micro-area X-ray diffraction (μ-XRD). It can be found that, with the change of composition in Sb–Te–Se thin films, their mid-infrared spectral transmittance can be organized into three distinctive groups, corresponding to amorphous Sb–Se, Sb 2 Se 3 orthorhombic structure and Sb 2 Te 3 rhombohedral structure, respectively. Therefore, the amorphous-crystalline phase transition and the phase-change from the orthorhombic structure of Sb 2 Se 3 to the rhombohedral structure of Sb 2 Te 3 can be completely reflected in the mid-infrared spectral transmittance of Sb–Te–Se thin films.
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Nano Research
·
2020
·Vol. 14
·期 7
·2337-2344
·
IF 8.183
Hou Chuang,Tai Guo’an,Liu Bo,Wu Zenghui,Yin Yonghe
Heterostructure has triggered a surge of interest due to its synergistic effects between two different layers, which contributes to desirable physical properties for extensive potential applications. Structurally stable borophene is becoming a promising candidate for constructing two-dimensional (2D) heterostructures, but it is rarely prepared by suitable synthesis conditions experimentally. Here, we demonstrate that a novel heterostructure composed of hydrogenated borophene and graphene can be prepared by heating the mixture of sodium borohydride and few-layered graphene followed by stepwise and in situ thermal decomposition of sodium borohydride under high-purity hydrogen as the carrier gas. The fabricated borophene-graphene heterostructure humidity sensor shows ultrahigh sensitivity, fast response, and long-time stability. The sensitivity of the fabricated borophene-based sensor is near 700 times higher than that of pristine graphene one at the relative humidity of 85% RH. The sensitivity of the sensor is highest among all the reported chemiresistive sensors based on 2D materials. Besides, the performance of the borophene-graphene flexible sensor maintains good stability after bending, which shows that the borophene-based heterostructures can be applied in wearable electronics. The observed high performance can be ascribed to the well-established charge transfer mechanism upon H 2 O molecule adsorption. This study further promotes the fundamental studies of interfacial effects and interactions between boron-based 2D heterostructures and chemical species.
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 12
·1-10
·
IF 6.232
Hu Shuisheng,Lin Yuxia,Teng Jing,Wong Wing-Leung,Qiu Bin
A new electrocatalytic biosensor (MOF-74(Cu) NS-CC) based on the in situ deposition of MOF-74(Cu) nanosheet on carbon cloth via a bottom-up synthetic approach in a glass tube was developed. The electrocatalytic activity of the deposited MOF-74(Cu) NS was demonstrated in the oxidation of glucose to gluconate under alkaline conditions. The results revealed that the proposed method of in situ formation of MOF-74(Cu) NS onto a carbon cloth surface in a multi-layer solution is capable to generate a stable MOF-74(Cu) NS-CC electrode with excellent sensing performance. When the as-synthesized MOF-74(Cu) NS-CC was applied directly as the working electrode for glucose sensing, it showed much higher conductivity and redox activity than MOF-74(Cu) NS-GCE. With the potential applied at 0.55 V (vs. Ag/AgCl), this new electrocatalytic biosensor exhibits an excellent linear relationship between current density and concentration of glucose. Moreover, a wide linear range of detection (1.0 to 1000 μM) was observed. The limit of detection was found to be 0.41 μM (S/ N = 3). The response sensitivity is 3.35 mA mM −1 cm −2 when the concentration of glucose is in the range 1–100 μM and 3.81 mA mM −1 cm −2 for the 100–1000 μM concentration range. This study provides a low-cost, easy to prepare, and reproducible methodology for the synthesis of highly redox-active nanomaterials based on the in situ formation of two-dimensional MOF-74(Cu) NS for the development of new electrocatalytic biosensors.
Graphical abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2020
·Vol. 32
·期 1
·967-976
·
IF 2.22
Pu Zejun,Xia Jialing,Liu Xueyu,Wang Qi,Liu Jingyue,He Xiaohang,Zhong Jiachun
In this work, a series of fluorene-containing fluorinated polyethersulfone (PES-6AF/BHPF) copolymers with high temperature resistance and intrinsic low dielectric constant (low- ε ) have been designed and synthesized from 4,4′-dichlorophenyl sulfone (DCS) and polyphenol. The performance of obtained PES-6AF/BHPF can be controlled and optimized by controlling the copolymers structure. The thermal and dielectric properties of PES-6AF/BHPF were evaluated comprehensively. The obtained PES-6AF/BHPF copolymers show high glass transition temperatures ( T g ) ranging from 200 to 260 °C, and 5% weight loss temperatures ( T d5% ) is stable up to 500 °C. The ε value of PES-6AF/BHPF-0% and PES-6AF/BHPF-100% are as low as 2.1 and 2.3, and the loss tangent (tan δ ) are only 0.0088 and 0.003 at 1 kHz, respectively. In addition, all of PES-6AF/BHPF films show good stability of dielectric properties in high temperature conditions. More importantly, the PES-6AF/BHPF copolymers are soluble in common solvents (such as DMAc, NMP, DMF, THF). The PES-6AF/BHPF copolymers are amorphous and can be easily cast into transparent and flexible films with tensile strength of 62–74 MPa and an elongation at break of 13.3–15.8%. The outstanding comprehensive properties made it possible to be the most promising polymer candidates for high-performance interlayer dielectrics.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2020
·Vol. 32
·期 1
·1061-1072
·
IF 2.22
Wang Yan,Di Xiaochuang,Lu Zhao
Lightweight absorbers with strong broadband microwave absorption are highly desired in military and civil fields. In this work, a 3D interpenetrating network formed from a Co@C@ MWCNTs composite was synthesized via a combined wet chemical and pyrolysis route. Because of strengthening interfacial polarization, suitable impedance matching and synergistic effects, the Co@C@MWCNTs hierarchical composite exhibited outstanding microwave absorption properties. An optimal reflection loss reached − 55.7 dB at 8.7 GHz and its effective bandwidth ( R L < − 10 dB) achieved 4 GHz (7.4–11.4 GHz) at an absorber thickness of 3 mm with a low filler content of 10 wt%. Furthermore, an effective bandwidth of 12.4 GHz (4.5–16.9 GHz) was obtained by varying the thickness from 2 to 4.5 mm. The superior microwave absorption performance originated from the enhanced interfacial polarization, multiple reflections, conductive network, synergistic effects and an improved impedance matching between Co–C and MWCNTs. This work provides a strategy to rationally design novel lightweight absorbers with strong microwave absorption.
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