ACS Nano
·
2026
·
IF 17.3
Xinhao Li,Weikang Hu,Yao Huang,Yanmei Ma,Zuokun Yin,Tong Wang,Chengzhi Hu
Unraveling the precise kinetics of the intrinsic apoptotic pathway requires resolution of the temporal lag between mitochondrial permeabilization and downstream proteolytic execution. However, dissecting these distinct molecular events within the crowded cytosolic environment of a single live cell remains limited by the lack of nonperturbative, multiplexed sensing tools. Here, we report a dual-channel nanoprobe capable of label-free, simultaneous monitoring of Cytochrome c (Cyt c) translocation and Caspase-3 activation. The nanoprobe features physically isolated nanochannels allowing for orthogonal functionalization: one channel acts as an aptamer-based sensor for Cyt c, while the second functions via the enzymatic cleavage of a specific peptide substrate by Caspase-3. This design enables the synchronous transduction of protein binding and enzymatic activity into independent current signals. The probe exhibited high sensitivity, selectivity, and stability in complex biological fluids. We applied this platform to monitor the dynamics of Cyt c and caspase-3 in breast cancer cells, revealing significant heterogeneity in apoptosis and a spatiotemporal delay between Cyt c release and caspase-3 activation, consistent with the intrinsic apoptosis pathway. This dual-detection methodology provides a minimally invasive approach with high spatial and temporal resolution for probing apoptotic signaling at the single-cell level and enables quantitative assessment of heterogeneous cellular responses to apoptotic stimuli.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Wanyu Li,Yu Xiao,Rui Yao,Jinping Li,Guang Liu
Solution-reduced nano-Mg is uniformly dispersed in flower-like Ni/C(D). • Mg 2 Ni/Mg 2 NiH 4 pump and carbon confinement synergistically enhance kinetics. • 100% capacity retention over 90 cycles after activation. A rationally designed Mg-Ni/C(D) composite was synthesized by calcining a hydrothermally prepared Ni-MOF(BDC) precursor (from Ni 2 + and terephthalic acid, H 2 BDC) into flower-like porous Ni/C(D), followed by Mg loading via lithium-naphthalenide reduction. Spherical Ni/C(T) was prepared similarly using trimesic acid (H 3 BTC). Compared with Ni/C(T), Ni/C(D) possesses an effective hierarchical porous structure, enabling a higher effective reversible hydrogen storage capacity (based on the total composite mass) at a comparable dehydrogenation onset temperature. During hydrogen sorption, in situ-formed Mg 2 Ni acts as a reversible Mg 2 NiH 4 /Mg 2 Ni hydrogen pump, lowering the kinetic barrier and providing nucleation sites for the Mg/MgH 2 transformation, while the carbon matrix confines nanoparticles to prevent agglomeration. Notably, after 10 activation cycles, it retains nearly 100% capacity over the next 90 cycles. This synergy between catalytic pumping and nanoconfinement makes Mg-Ni/C(D) promising for solid-state hydrogen storage. Download: Download high-res image (156KB) Download: Download full-size image Through in situ lithium-naphthalenide reduction, nano-Mg is uniformly embedded in the flower-like Ni/C(D) scaffold. The Mg 2 Ni/Mg 2 NiH 4 hydrogen pump, coupled with carbon nanoconfinement, effectively lowers the kinetic barriers via interfacial electron transfer and hydrogen diffusion, yielding a low onset temperature of 223.38 °C and 100% capacity retention over 90 cycles after activation. This work demonstrates a rational strategy for designing high-performance Mg-based hydrogen storage materials.
✓ 已验证
DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2026
·
IF 3.2
Xiao-Dong Kang,Zhi-Gang Zhu,Guo-Hua Zhang
This study proposed a two-step carbothermal reduction-carburization method for preparing high-quality (Ti, W)C solid solution powders. Through separating the carbothermal reduction deoxygenation from the carburization and solid solution process, stepwise precise control was achieved. Using TiO 2 , WO 3 , and carbon black as raw materials, deoxygenation and most of the solid solution reactions were first completed at 1500 °C under a carbon-deficient condition. Subsequently, precise carbon supplementation was conducted, followed by final carburization and solid solution at 1550 °C. The resulting powders possessed excellent characteristics including elevated purity, fine grain size, homogeneous morphology, and optimal dispersibility. High-frequency spark plasma sintering (HF-SPS) was employed subsequently to fabricate (Ti, W)C-based cermets. A systematic elucidation of the reaction mechanisms in the two-step method was conducted, and the effects of W content on the powder characteristics as well as the microstructure and properties of cermets were explored. Results demonstrated that the grain size of the synthesized powders gradually decreased as W content increased, and (Ti 0.69 , W 0.31 )C showed the finest average grain size (0.38 ± 0.12 μm). Increasing W led to a decline in both hardness and fracture toughness ( K IC ) of cermets. Cermet sintered from (Ti 0.88 , W 0.12 )C powder demonstrated optimal mechanical properties, and possessed a hardness of 2030 ± 21 HV 30 and a K IC of 10.35 ± 0.31 MPa m 1/2 , achieving an excellent combination of hardness and toughness.
✓ 已验证
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 12
·118437
·
IF 6.3
Zhiyuan Xu,Wenhao Li,Rong Li,Bangbang Liu,Jingxuan Luo,Wenjing Luo,Yuan Fang,Qiang Zhen
To meet the requirements of enhanced-performance Al 2 O 3 -SiC-C (ASC) refractories driven by larger modern blast furnaces, a novel in-situ approach to synthesize Al 4 Si 2 C 5 platelets within ASC was developed. Combined thermodynamic and experimental studies demonstrated the formation of Al 4 Si 2 C 5 platelets via AlF 3 -facilitated vapor-phase transport of Si sources to carbon at 1300–1600 °C. First-principles calculations indicate its growth initiates via SiC heterogeneous nucleation on C(002), followed by vapor adsorption of Al 2 O (g) , SiO (g), and SiOF 2(g). With 0.2 wt% AlF 3 , ASC castables exhibited markedly enhanced overall performance, including superior mechanical strength, improved thermal shock resistance, and significantly better oxidation and slag corrosion resistance. These enhancements arise from pore-filling by Al 4 Si 2 C 5 platelets and their role in forming a protective barrier during oxidation, which jointly hinder oxygen/slag penetration and crack propagation. This work provides fundamental insights into the low-temperature synthesis and reinforcement mechanisms of Al 4 Si 2 C 5 , offering a theoretical basis for designing high-performance refractories.
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Bei-Chen Gao,Yu Tian,Run-Ping Liu,Yi-Xin Wang,Yang You,Wei-Ming Guo,Hua-Tay Lin
A two-step method including low-temperature pretreatment and high-temperature homogenization was developed to prepare high-purity (Ti 0.2 V 0.2 Ta 0.2 Nb 0.2 Hf 0.2 )(C 0.75 N 0.25 ) powder. In the first step, the reaction mixture was heated to 1450 ℃ to form intermediate carbonitride phases through carbothermal reduction-nitridation, and the second step at 1700 ℃ produced a single-phase high-entropy carbonitride. The powder prepared by single-step treatment at 1750 ℃ contained 2.28 wt% nitrogen and 0.18 wt% oxygen. In contrast, the two-step powder exhibited higher nitrogen content (2.45 wt%) and lower oxygen content (0.09 wt%), and the formation of a complete single-phase solid solution enabled accurate calculation of its composition (Ti 0.2 V 0.2 Ta 0.2 Nb 0.2 Hf 0.2 )(C 0.78 N 0.21 O 0.01 ). The ceramic prepared from the two-step powder achieved 99.8% relative density, with an average grain size of 4.58 ± 0.32 μm, a Vickers hardness of 22.73 ± 0.51 GPa, and a fracture toughness of 3.16 ± 0.30 MPa·m 1/2 , whereas the single-step ceramic reached only 86.5% relative density.
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Zaohong Zhang,Jing Yang,Dmitry V. Bavykin,Carlos Ponce de León,Kai Zhang,Yong-Wei Zhang,Jia Hong Pan
Nanostructured silicon (Si) is a highly promising anode material for next-generation lithium-ion batteries (LIBs) due to its ultra-high theoretical capacity (Li 22 Si 5 , ∼4200 mAh g − 1 ), yet its practical application is hindered by poor conductivity and drastic volume expansion (300–400%). Here, Si nanoparticles are in situ encapsulated within a ZIF-8 framework, guided by a pre-applied carbon coating, forming a porous core–shell architecture that simultaneously enhances ionic/electronic transport and buffers volumetric changes. The resulting Si@C@ZIF anode delivers a reversible capacity of 1030 mAh g − 1 after 500 cycles at 1.0 A g − 1 . In a full cell with LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811), 76.8% capacity retention is maintained at 0.5 C over 260 cycles. Post-cycling analysis reveals a robust solid electrolyte interphase (SEI) enriched in Li 3 N and LiF. Density functional theory (DFT) calculations indicate that preferential LiPF 6 adsorption facilitates conductive SEI formation, accelerating Li + diffusion and enhancing interfacial stability, demonstrating a low-cost route to highly durable Si/C nanocomposite anodes for practical high-energy LIBs.
✓ 已验证
DOI
高影响因子
ChemistrySelect
·
2026
·Vol. 11
·期 15
·e07225
·
IF 2.3
Feng Zhou,Danquan Bi,Xinzhi Liu,Suhaidi Shafie,Xiongtao Yu,Danfeng Qin
Environmental analysis and food safety control still depend on quick, precise nitrite monitoring. In response, the current work uses a one-step hydrothermal process to create a hollow SiO 2 @C core-shell material, which is then integrated into an electrochemical nitrite sensor. X-ray diffraction, high-resolution transmission electron microscopy, and scanning electron microscopy all confirm the homogeneous carbon coating and hollow structure, creating a strong foundation for charge transfer. The SiO 2 @C-modified electrode maintains linearity between 0.5 and 4650.0 µM and achieves a detection limit of 0.17 µM. Strong operational stability is demonstrated by the high repeatability (RSD = 1.23%) and the retention of 90.66% of the initial signal after 17 days at 4°C. Reliable performance in complex food matrices is confirmed by standard-addition assays in sausage and fermented bean curd, which provide recoveries of 95.53–100.03% and 98.15–99.83%, respectively. These findings establish the hollow SiO 2 @C sensor as a useful, highly sensitive instrument.
✓ 已验证
DOI
高影响因子
C-Journal of Carbon Research
·
2026
·Vol. 12
·期 1
·
IF 4.3
Qi Qiang,Kezhi Li,Tianzhan Shen,Haibo Ouyang
The pantograph slider is a key friction component in high-speed train systems, and its performance directly affects the safety and efficiency of operation. In this study, Cf/C/CuNi composites with carbon fiber contents of 1 wt.%, 3 wt.%, 5 wt.%, and 7 wt.% were prepared by a solvothermal method combined with spark plasma sintering (SPS). The influence of carbon fiber content on the mechanical and friction properties of the composites was systematically studied. The results show that the flexural strength of the composites increases from 20.20 MPa to 38.45 MPa with an increase in the carbon fiber content. However, excessive carbon fiber content can lead to fiber agglomeration and interface defects, thereby reducing the friction stability and increasing the wear rate from 0.64 g/m3to 1.60 g/m3. A carbon fiber content of 1 wt.% helps to form a continuous lubricating film, resulting in a low and stable friction coefficient. This study provides valuable insights for the design and optimization of high-performance pantograph slider materials for high-speed railway applications.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2026
·
IF 9.2
Zhao Meng,Haibo Yang,Yongzhen Ma,Yan Cheng,Yanlong Ma,Binglong Zheng,Hongwei Zhou,Ying Lin
In increasingly complex electromagnetic environments, developing high-performance and dynamically tunable electromagnetic wave (EMW) absorption materials is essential. This study designed a pressure-responsive TiO2/CNFs@Co/C elastic aerogel for efficient EMW absorption. A 3D interpenetrating structure consisting of Ti3C2Tx MXene-derived TiO2 nanosheets, magnetic Co/C frameworks, and carbon nanofibers was constructed via electrospinning combined with in situ synthesis. This 3D interpenetrating structure constructs abundant heterogeneous interfaces, thereby enhancing interfacial polarization. The results demonstrate that the composite achieves an exceptionally broad effective absorption bandwidth (EAB) of 8.17 GHz at a thickness of 2.7 mm, with only 10 wt% filler loading. Additionally, the composite exhibits strong environmental tolerance, including hydrophobicity, stretchability, and thermal insulation. Notably, the alginate-induced elastic aerogels enable dynamic tuning from 6.4 to 18 GHz under compressive strains of 0% to 66%. This work designs dynamically tunable, high-performance EMW absorbers through component optimization and interface engineering, providing a promising strategy for the preparation of next-generation multifunctional intelligent EMW absorbers.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2026
·Vol. 109
·期 5
·e70838
·
IF 4.2
Sheng Li,Rui Zhang,Min Chen,Junjie Shi,Jing Xu,Yueyao Liu,Xiao Zhang,Zhuoying Lian,Yuyan Wu,Yandong Li,Jianzhong Li
Understanding the phase equilibria of the Yb 2 O 3 -MgO-SiO 2 system is crucial to reveal the coating-medium interaction mechanism and guide composition design. In the present work, the isothermal section of the Yb 2 O 3 -MgO-SiO 2 system at 1600°C in air was systematically constructed using high-temperature equilibrium quenching experiment combined with XRD, SEM, and EPMA analyses. Ten phase regions were identified, including one liquid-phase region, four two-phase regions, and five three-phase regions. Comparative analysis with the binary subsystems highlights the restricted solubility of Yb 2 O 3 in MgO (1.61 wt%) and the associated asymmetry, which are rationalized by crystallographic constraints and defect energetics. This study fills a critical knowledge gap and provides essential phase equilibria data for designing advanced Yb-silicate coatings with enhanced CMAS and corrosion resistance, as well as for developing MgO-based refractory materials.
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Hongliang Fu,Wenyao Xue,Shaocong Zhan,Jing Zhao,Yue Lian,Zhifeng Wang,Yongfeng Hu,Huaihao Zhang
Metal active sites are anchored via the coordination effects between V/Co and terephthalic acid. • Co-doping constructs highly active Co-O-V catalytic sites, enhancing reaction activity. • PTA-derived oxygen-containing carbon layer mitigates metal site dissolution, improving stability. Developing highly active and stable catalysts for alkaline electrolytic water oxidation remains a challenge. Here, we prepared highly active, stable and conductive scale like microsheet Co-V 2 O 5 @C through Co-doping and coordination effect between terephthalic acid (PTA) and metal (V/Co). Specifically, Co-doping into V 2 O 5 lattice constructs highly active V-O-Co sites, thus reducing the adsorption energy of oxygen-containing intermediates. Meanwhile, the scale like microsheet Co-V 2 O 5 @C expose abundant active sites, enhancing oxygen evolution efficiency. The coordination effect between PTA and V/Co enables the in-situ formation of carbon layer on V 2 O 5 surface after carbonization, which effectively alleviates the dissolution of active sites and enhances stability. For conductive design, the Co introduction into V 2 O 5 can promote intrinsic conductivity. Moreover, under high-temperature carbonization, PTA evolves into oxygen-containing carbon layer, which boosts Co-V 2 O 5 @C overall conductivity and reaction kinetics. Based on above advantages, Co-V 2 O 5 @C displays good electrochemical performance in oxygen evolution reaction (OER) (low overpotential: 290 mV@10 mA cm −2 ; long stability: 50 h; small charge transfer resistance: 11.7 Ω). Download: Download high-res image (226KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
Small
·
2026
·
IF 11.8
Hang Zhang,Yinuo Wu,Zhen Zhang,Ying Hou,Peizhi Liu,Ting Liao,Bingshe Xu,Yanhui Song,Haixia Zhang,Junjie Guo,Ziqi Sun
M-N-C single-atom catalysts have been demonstrated to be a promising class of non-noble-metal based catalysts, but their activity is largely constrained by the symmetrical electronic density distribution of the M-N 4 moieties. Herein, a ZIF-8 derived Fe/Fe dual-center catalyst (FeN 4 /FeO 5 @NC) is constructed by introducing a O-FeO 4 configuration adjacent to the Fe-N 4 sites to form asymmetric dumbbell-shaped FeN 4 -O-FeO 4 active sites, resulting in improved intrinsic activity of Fe─N─C catalyst. The dumbbell FeN 4 -O-FeO 4 dual-center catalyst features an electron transfer pathway of “FeN 4 → bridged O → FeO 4 ”, which breaks the symmetry of the electronic density distribution of the Fe moiety and regulates the position of the d-band center, increasing the electron transfer efficiency, reducing the desorption energy barrier of the rate-determining step, and enhancing the activation ability of O 2 molecules. The obtained FeN 4 -O-FeO 4 dual-center catalyst exhibits excellent ORR performance in a pH-universal range. The liquid-state Zn-air battery (ZAB) with this FeN 4 -O-FeO 4 dual-center catalyst delivers an outstanding open circuit voltage of 1.502 V and a peak power density of 246 mW cm −2 , superior to the Pt/C-cathode ZAB. This work represents an exploration of ways to improve the ORR performance of Fe─N─C catalysts and provides a paradigm for rationally designing low-cost, highly catalytic, and stable non-noble metal catalysts.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）