PHYTOTHERAPY RESEARCH
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2026
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IF 8.1
Yubo Zhang,Na Du,Yingqian Ci,Shuai Lu,Shasha Xu,Huajun Li,Chang Qing,Qiaoling Chen,Yongfei Wang,Feifei Chen,Jinping Qiao,Mei Han
Green tea, a commonly consumed beverage worldwide, is extensively used as dietary supplements for cancer prevention. However, the interaction between green tea and paclitaxel is still unknown. This study aimed to systematically investigate the herb-drug interaction of green tea consumption on the pharmacodynamics and pharmacokinetics of paclitaxel. The ATP assay results indicated that green tea extract (GTE) significantly enhanced the cytotoxicity of paclitaxel in both human and murine breast cancer cells. Further, the 4T-1 tumor model testified that daily green tea consumption could improve the therapeutic effects of paclitaxel on breast carcinoma. The pharmacokinetic profiles revealed that in the group with short-term green tea consumption (0.5 h), there was a more than 55.87% increase in the maximum plasma concentration ( C max ) of paclitaxel and a 38.49% increase in the area under the plasma concentration curve (AUC). In the long-term green tea consumption group (2 weeks), there was a 23.80% increase in the C max of paclitaxel and a 28.29% increase in the AUC. Moreover, long-term green tea consumption significantly reduced hepatic microsomal protein level. Taken together, green tea consumption enhances the anticancer efficacy and increases the pharmacokinetic profile of paclitaxel, which provides information to study the interaction between herbs and chemotherapy.
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Mengyan Duan,Long Cao,Ni Wang,Jianxin Liu,Lulu Zhang,Jiancheng Wang
Photocatalytic water splitting is hindered by flammable H 2 /O 2 cogeneration and energy-intensive post-separation. Herein, a Ru/WO 3 -MWCNTs ternary composite is designed to address these bottlenecks via a hydrogen spillover-based strategy: direct H* storage instead of gaseous H 2 generation to achieve H 2 /O 2 separation. Photogenerated H* from Ru active sites migrate through WO 3 , then is immobilized on MWCNTs as C H bonds for hydrogen storage, enabling exclusive O 2 release during photocatalysis. This composite exhibits an oxygen evolution rate (OER) of 645.28 μmol g −1 h −1 (outperforming binary counterparts) with no detectable gaseous H₂ during irradiation, alongside a stable H₂ storage capacity of 2.23 wt%. The stored hydrogen is thermally releasable, and the entire cycle of photocatalytic water splitting (hydrogen storage with O 2 evolution) and thermal H 2 release maintains excellent cyclic stability. This work establishes hydrogen storage-aided in-situ H 2 /O 2 separation as a universal strategy for addressing the core bottlenecks in photocatalytic water splitting.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Shixuan He,Dongdong Li,Guizhao Zhu,Xingqing Duan,Jinting Chen,Bogu Liu,Yawei Li,Haixiang Huang,Haoyuan Zheng,Xinhua Wang,Hong Li,Ying Wu
The practical application of LiBH 4 for solid-state hydrogen storage is hindered by its sluggish kinetics and high thermodynamic stability. To address these challenges, we constructed a multiphase catalytic system within LiBH 4 by incorporating nano-BaTiO 3 and carbon nanotubes (CNTs) through ball milling. The composite of LiBH 4 , 20 wt% BaTiO 3 and 20 wt% CNTs exhibits significantly enhanced dehydrogenation properties, with an initial temperature as low as 223 °C and a peak desorption temperature of 353 °C, releasing 8.2 wt% H 2 at 500 °C. The modified composite demonstrates markedly improved reversibility and kinetics, evidenced by a retained capacity of 4.1 wt% after the 6th cycle and a substantially decreased activation energy of 123 kJ mol −1 . During the first dehydrogenation, LiBH 4 reacts in-situ with BaTiO 3 to form Li 3 BO 3 , BaB 6 , and TiO 2 phases. These products, in conjunction with CNTs, form a multifunctional catalytic framework. Among them, BaB 6 serves as the nucleation site, TiO 2 acts as the active catalyst, and Li 3 BO 3 facilitates ion transport, collectively enhancing the reaction kinetics and cycling stability of LiBH 4 . Meanwhile, the CNTs provides dual functions of confinement and excellent thermal conductivity, which suppressing particle aggregation and enhancing thermal diffusion rate. Consequently, the composite exhibits a lower decomposing temperature, rapider kinetics, and enhances reversibility compared with the as-milled LiBH 4 . This work provides an effective strategy of in-situ engineering a multiphase interface to attain high-performance solid-state hydrogen storage materials.
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高影响因子
FOOD CHEMISTRY
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2026
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IF 10.4
Luyao Chen,Ranran Xu,Jiahua Zhou,Weibo Jiang,Baogang Wang
Pectins, as health-promoting factors, often degrade during fruit post-harvest storage. Changes in structure and physicochemical properties of pectic polysaccharides from ‘Huangguan pear’ after 0, 3, and 5 months of 4 °C storage and their lipid-lowering activity were studied. The degree of methylation of pectic polysaccharides decreased from 79.31% to 71.88%. Galacturonic acid content decreased while side chains, molecular weight and viscosity increased, and surfaces became rougher. Decreased binding ability on four bile salts but enhanced inhibitory ability on cholesterol micelles, pancreatic lipase, and cholesterol esterase were displayed. Cell experiments showed pectic polysaccharides reduced total cholesterol and triglycerides levels by downregulating relative mRNA expression of fatty acid synthase (FAS) and sterol regulatory element-binding protein-1c (SREBP-1c), and pears with shorter storage exhibited higher protection against oxidative stress and lipid accumulation in HepG2 cells. Overall, pectin in fresher pears showed more comprehensive lipid-lowering effects, but pears with longer storage still have specific lipid-lowering values.
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DOI
PubMed
高影响因子
LANGMUIR
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2026
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IF 4.4
Lu Yang,Linting Jiang,Yuxin Peng,Xianli Yi,Bin Gu,Hongru Li,Xiaozhuan Qin,Fang Gao
This study investigates the use of trace nitrogen-doped carbon dots (N-CDs) that are synthesized by low-cost natural molecules of citric acid and β-alanine as an additive in the ZnSO4 electrolyte for augmenting the zinc anode in aqueous zinc-ion batteries. A variety of experimental results demonstrate that an inclusion of N-CDs could facilitate the desolvation of zinc ions through coordination interactions, thereby regulating zinc-ion nucleation, improving uniform deposition of zinc ions, and inhibiting hydrogen precipitation on the zinc electrode surface. Various in situ and ex situ measurements of interfacial and surface engineering suggest that the N-CDs additive in the electrolyte could show intense affinity with zinc ions and form a self-assembled adsorption film on the zinc electrode film, thus inhibiting zinc anode corrosion and effectively suppressing side reactions. It is shown that zinc dendrite growth during the zinc-ion plating/stripping process during cycling of zinc-ion batteries could be prevented by the added N-CDs, thereby boosting the long reversible stability of the zinc anode. Hence, the notable improvement of the cycling performance of zinc-ion batteries could be achieved by an introduction of N-CDs in the electrolyte. This study provides deep insights into the use of low-cost and eco-friendly N-doped carbon quantum dots in aqueous zinc metal batteries, displaying great promise for practical applications.
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DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Tao Zhang,Xu Zhang,Yu Luo,Yuan Xu,Taoming Hu,Deyan Wang,Qianru Wang,Wen Xiong,Xiurong Gao
A long-acting, sustained-release suspension of aprepitant (APT) nano/micron subcutaneous injection was prepared to enhance the bioavailability of APT, achieve a long-acting, sustained-release effect, and improve suitability for patients with vomiting, thereby improving the anti-vomiting effect of APT. APT nano suspension (APT-NPs, 64.65 ± 2.54 nm; PDI = 0.135 ± 0.007; Zeta potential = −28.27 ± 0.91 mV) and micron suspension (APT-MPs, 1.94 ± 0.14 μm, Zeta potential = −44.50 ± 0.85 mV) were prepared by high-pressure homogenization and antisolvent precipitation methods, respectively. Crystal characterisation confirms that APT-NPS retains part of the APT structure, whereas the crystalline state of APT-MPS has undergone alteration. APT-NPs showed a 1.8-fold increase in solubility (17.12 μg/mL) and a cumulative release (72 h) of 85.12 ± 2.33% compared to APT-MPs (56.60 ± 1.40%). The subcutaneous injection of the nano/micron suspension was non-irritating, and APT-NPs demonstrated comparable efficacy and a longer duration of action compared to APT-MPs, administered via gavage, and Orkoping. A single subcutaneous injection into rats resulted in a sustained release for 21 d, and the relative bioavailability of APT-NPs and APT-MPs was approximately 460% and 190%, respectively. It indicates that the smaller the particle size, the higher the bioavailability of APT. This study mechanistically validates particle size engineering as a strategic approach to develop long-lasting antiemetic formulations. These findings validate that a smaller particle size improves the bioavailability and solubility of APT, providing a new strategy for developing clinically long-acting antiemetic formulations.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Chunyu Wang,Yixin Zheng,Qingwen Cui,Yuxin Jiang,Jinhe Wang,Tianyu Zhang,Yuxin Song,Xiao Guo,Manli Wang,Liping An
Portulaca oleracea acidic polysaccharide (POPW-A) demonstrates significant efficacy in anti-inflammatory and immune-enhancing properties. Intervention with POPW-A reduced blood uric acid levels and significantly up-regulated uric acid transporter expression in hyperuricemic (HUA) model mice. Additionally, it suppressed the activation of the NLRP3 inflammasome by down-regulating AIF-1 and CMPK2 protein expression, thereby alleviating renal inflammation. The polysaccharide components of POPW-A were screened after purifying. Among them, the POPW-Ab component effectively enhanced the expression of uric acid transport proteins and suppressed the activation of the NLRP3 inflammasome. Structural analysis confirmed that POPW-Ab is a pectin polysaccharide composed primarily of a homogalacturonan (HG) domain with a backbone of →4)-α-D-GalpA-(1→, along with a minor rhamnogalacturonan-I (RG-I) domain containing side chains of →5)-α-L-Araf-(1→. After silencing the CMPK2 gene in model cells, the protective effects of POPW-Ab were counteracted. Conversely, overexpression of the CMPK2 gene restored the intervention efficacy of POPW-Ab. Therefore, POPW-Ab is likely the fundamental material basis for the bioactivity of Portulaca oleracea polysaccharides. The underlying mechanism involves targeted down-regulation of CMPK2 gene expression, thereby inhibiting NLRP3 inflammasome activation and subsequent release of pro-inflammatory cytokines. These findings suggest that POPW-Ab holds promise as a potential therapeutic agent for HUA and its associated renal complications.
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高影响因子
FOOD CHEMISTRY
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2026
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IF 10.4
Ruoyu Cao,Ning Zhang,Chang Lu,Xuelian Hu,Wenxiu Wang,Tianyi Ma,Shuo Wang,Yiwei Tang
A magnetic-fluorescent integrated platform (Fe 3 O 4 -COOH@MIL-101(Cr)@MIPs/b-BCDs), designed for the magnetic separation, biomimetic recognition, and fluorescence detection of doxycycline, was proposed. In this proposal, Fe 3 O 4 -COOH@MIL-101(Cr)@MIPs were synthesized through layer-by-layer self-assembly modification of MIL-101(Cr) onto the surface of Fe 3 O 4 -COOH and coupling with MIPs. The introduction of MIL-101(Cr) endowed Fe 3 O 4 -COOH@MIL-101(Cr)@MIPs with superior binding capacity and mass-transfer rate. High-affinity imprinting layer boosted the precise identification of Fe 3 O 4 -COOH@MIL-101(Cr)@MIPS towards doxycycline in complex environments. Benefiting from inherent merits, Fe 3 O 4 -COOH@MIL-101(Cr)@MIPs demonstrated an appealing adsorption capacity ( Q e = 13.19 mg g −1 ), favorable mass-transfer rates ( h = 9.22 mg g −1 min −1 ), and specificity. Biomass-based carbon dots (b-BCDs) were introduced to construct Fe 3 O 4 -COOH@MIL-101(Cr)@MIPs/b-BCDs-based sensing platform, which demonstrated satisfactory analytical performance, with a linear range of 0.05–2 mg/L, a limit of detection of 3.86 ng/mL, and recoveries of 90.24–98.85% in water, milk, and chicken samples. The platform offers high accessibility for ultrasensitive and selective doxycycline measurement in samples and a novel perspective for three-in-one detection method development.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Bo Li,Kaixuan Ma,Tao Yuan,Haoran Wu,Yiming Huo,Haojue Wang,Xiao Xu,Yang Liu,Lei Yang,Kai Chen
Repairing spinal cord injury (SCI) remains hindered by two major unmet challenges: the inability to precisely reconstruct irregular lesion cavities, where tissue contraction and collapse disrupt anatomical continuity, and the lack of effective platforms for stable and localized delivery of fragile therapeutics such as exosomes, whose rapid clearance severely limits efficacy. Addressing these bottlenecks requires biomaterials that can simultaneously rebuild three-dimensional structure and orchestrate a pro-regenerative microenvironment. Here, we present a morphology-adaptive injectable microporous annealed particle scaffold (MS) for localized and long-term release of human umbilical cord MSC-derived exosomes (hucMSC-Exo). GelMA/SFMA microspheres were fabricated via solvent-free microfluidic electrospraying combined with liquid nitrogen-assisted cryo-processing, preserving exosome bioactivity. This “disassemble-and-reassemble” approach enables minimally invasive injection of microspheres into irregular lesion cavities, followed by body temperature-induced annealing and in situ photocuring to form a mechanically stable, interconnected three-dimensional scaffold, which supports cell infiltration, nutrient diffusion, and sustained exosome release. In vivo , MS@Exo suppressed inflammation and scar formation, enhanced angiogenesis, and promoted neuronal survival, axonal regeneration, and myelination, ultimately achieving superior functional recovery over MS or Exo alone, demonstrating a clear synergistic effect. Transcriptomic profiling further revealed that MS@Exo reprogrammed gene expression by downregulating extracellular matrix- and collagen-related pathways while upregulating neuronal, synaptic, and ion channel signaling networks, thereby shifting the repair process from an inflammatory-proliferative phase toward a differentiation-remodeling phase. Collectively, MS@Exo acts as an intelligent multifunctional scaffold that couples advanced fabrication with exosome-based therapy to overcome fundamental limitations in SCI repair, offering a broadly applicable strategy for reconstructing irregular tissue defects in regenerative medicine.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2026
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IF 3.9
Xingyu Lin,Ruoxin Zhang,Ziteng Yang,Yulong Zhao,Hongsheng Lu
Early gas breakthrough during CO2 flooding is often aggravated by dominant flow channels formed in prior waterflooding. We developed a CO2-triggered silicate system (SAS) for proactive profile control in high-temperature and high-salinity reservoirs. Owing to its low initial viscosity, SAS can be preferentially placed in high-permeability channels before CO2 injection. Dissolved CO2 then lowers pH and triggers silicate condensation, leading to in situ formation of silica particles that selectively plug dominant flow paths. The generated inorganic Si–O–Si network endows the system with strong thermal and salinity tolerance. Characterizations including FTIR, XPS, TGA, SEM, particle size analysis, pH/conductivity monitoring, HOMO–LUMO analysis and molecular dynamics simulations were conducted to reveal the acid-triggered structural evolution induced by CO2 dissolution. Sand-pack displacement experiments further demonstrate that SAS pretreatment increases total oil recovery from 49.5% to 67.2%. This CO2-triggered in situ particle system provides a simple and effective strategy for mitigating gas channeling and enhancing CO2 flooding performance in harsh reservoirs.
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高影响因子
ANALYTICA CHIMICA ACTA
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2026
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IF 6.1
Xueliang Li,Lingxia An,Yunna Li,Yuming Chang,Yan Wang,Kezhi Jiang
Background The monitoring of perfluorocarboxylic acids (PFCAs), a new class of persistent pollutants, has attracted widespread public concern. However, achieving highly selective enrichment of trace PFCAs in environmental samples remains a challenge for analysts. Results In this work, we have successfully prepared a new superhydrophobic fluorine-containing magnetic particles, Fe 3 O 4 @SiO 2 @CF&TMS, by modifying the surface of Fe 3 O 4 particles. By sealing their residual silanol groups, this material exhibited exceptional hydrophobicity, enabling efficient extraction of PFCAs. Using magnetic solid phase extraction (MSPE) with the prepared magnetic particles, a recovery rate of above 95.5% was achieved for PFCAs from real water within 5 min. Extraction recovery rates remained at 85%-112% for PFCAs in water in 5 consecutive extractions. Based on the MSPE method with this material, in combination with methylation with trimethylsilane diazomethane, and GC-MS analysis, a selective analytical method was developed for determining of 9 PFCAs in various real water samples, including surface water and sewage plant water. This method demonstrated good reproducibility, sensitivity, and anti-interference capability, with the intra-day relative standard deviation (RSD, n = 3) in the range of 0.15-4.87% and a limit of quantification of 0.020 ng/mL, even in the presence of humic acid (5 μg/mL). Experimental results revealed that the detected content of medium- and long-chain PFCAs in various surface water samples ranged from
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Yu Wu,Arul Murugesan,Yaru Han,Juan Han,Yiping Chen,Huanhuan Li
An injectable BZUCNPs-PACMSNs/PGB sensor was proposed to detect AFB 1 . • BPEI was coated on ZUCNPs to improve the water-soluble ability of ZUCNPs • A dual-gated strategy was presented to improve the stability of UCNPs sensor. • BPEI@Cu 2+ can effectively quench the fluorescence of ZUCNPs due to IFE. • Injectable PGB hydrogel was utilized for stable and on-site AFB 1 detection. An expanding presence of aflatoxin B 1 (AFB 1 ) contamination across the global food supply represents a serious threat to public health. This work developed a portable sensor using Zn 2+ -doped upconversion nanoparticles (ZUCNPs) that Cu 2+ -induced fluorescence quenching with an injectable polyvinyl alcohol/gelatin/borax (PGB) hydrogel. First, ZUCNPs exhibiting enhanced fluorescence were modified with branched polyethylenimine (BPEI) to form signal probes known as BZUCNPs. Additionally, mesoporous silica nanoparticles (MSNs) were fabricated via sol-gel methods, loaded with Cu 2+ and coated with aptamer (Apt) and polydopamine (PDA) to create dual-gated capture probes (PACMSNs). Afterwards, BZUCNPs and PACMSNs were mixed to form sensing probes and then integrated into the PGB hydrogel, forming the final sensor (BZUCNPs-PACMSNs/PGB). In the presence of AFB 1 at pH 5.5, the AFB 1 diffused into the PGB hydrogel, disrupting the PDA and Apt layer due to acid environment and changing the structure of Apt as AFB 1 specifically bound to it. Then, Cu 2+ released and facilitated the formation of BPEI@Cu 2+ complex on the surface of ZUCNPs, which produced inner filter effect (IFE) that quenched fluorescence. When experimental conditions were optimized, a pronounced linear calibration curve ( R 2 = 0.994) was observed, linking fluorescence to the logarithm of AFB 1 levels across a 0.1–100 μg/kg AFB 1 range. And its sensitivity was characterized with a detection limit of 0.03 μg/kg. Furthermore, the sensor's applicability was confirmed through analysis of food matrices, including wheat, corn, peanuts, and water, yielding high analytical accuracy with relative standard deviations below 6.08% and recovery rates ranging from 93.77% to 107.67%.
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高影响因子
危险品化学品经营许可证（带存储）