RSC Advances
·
2015
·Vol. 5
·期 95
·77986-77995
·
IF 3.84
Nuannuan Li,Pei Zhang,Chunzhi Huang,Yunmei Song,Sanjay Garg,Yuxia Luan
In this paper, we synthesized the pH-sensitive and biodegradable amphiphilic polypeptide-based block copolymer methoxy-poly(ethylene glycol)2K-poly(ε-caprolactone)4K-poly(glutamic acid)1K (mPEG2K-PCL4K-PGA1K). mPEG2K-PCL4K-PGA1K had low critical aggregation concentration and could self-assemble into polymersomes in aqueous solution revealed by transmission electron microscopy. Therefore, two hydrophilic drug doxorubicin hydrochloride (DOX) and verapamil hydrochloride (VER) were encapsulated into the mPEG2K-PCL4K-PGA1K polymersomes to form poly(DOX + VER) co-delivery system to reverse the multidrug resistance by inhibiting the expression of P-glycoprotein and improve the anti-cancer effect of DOX. The in vitro cytotoxicity experiments indicated the obviously higher inhibition ratio to MCF-7/ADR resistant cells of poly(DOX + VER) compared with that of free DOX solution and polyDOX. The release rate of the two drugs from poly(DOX + VER) were much slower than that from the free drug solutions, and their release behaviors exhibited high pH-sensitive character. Furthermore, the low hemolysis ratio of mPEG2K-PCL4K-PGA1K confirmed that the copolymer could be applied for intravenous injection safely. Therefore, all these findings indicated that the co-delivery of DOX and VER by mPEG2K-PCL4K-PGA1K polymersomes is very promising for cancer therapy.
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INDUSTRIAL CROPS AND PRODUCTS
·
2021
·
IF 5.645
Xiaoxu Yang,Shiyao Hou,Tingting Chu,Jiazhi Han,Runsen Li,Yanzhu Guo,Yumei Gong,Haiming Li,Zhiwei Wan
Eco-friendly, renewable and green biomass materials are considered as the superior carbon precursors for producing carbon quantum dots (CQDs) in large scale. A major challenge is the limited contents of fluorophores in biomass, which then results in low quantum yields (QYs) and inferior fluorescence emission ability of the obtained CQDs. Herein, lignin with amounts of unsaturated aromatic and carbonyl fluorophores was employed as the carbon precursors to prepare CQDs through a green, facile approach. The magnesium and nitrogen elements were successfully introduced into CQDs with the aim of enhancing their QYs and extending their emission wavelengths. The prepared magnesium, nitrogen-doped CQDs (Mg, N-CQDs) could emit green fluorescence with a quantum yield (QYs) up to 46.38 %. The mechanism of their fluorescence ability was discussed extensively. More interestingly, the Mg, N-CQDs displayed a fluorescence transition between green and yellow color at pH value of 5.4, indicating their potential application as a probe to detect pH values of complicated environments. The findings in this paper would provide a viable strategy to converse lignin biomass waste into high-quality fluorescence nanomaterials.
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CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2022
·
IF 1.193
Xiao-Ping CHEN,Ya-Feng ZHUANG,Jian-Wei LIN,Jing-Hua CHEN,Zhi-Zhong HAN
Using citric acid and thiourea as precursors, sulfur-nitrogen co-doped dual emission carbon dots (DECDs) were prepared by a simple solvothermal method. At the excitation wavelength of 360 nm, DECDs have two emission peaks located at 465 nm (blue) and 592 nm (yellow-green) which are attributed by core and surface of DECDs. It is found that Fe 3+ ions can coordinate with oxygen-containing groups on DECDs, and then the electrons transfer from DECDs to Fe 3+ ions, which quench the fluorescence of DECDs. The fluorescence intensity is linear with the concentration of Fe 3+ ions in the range of 0–100 μM and the detection limit is 0.77 μM. Moreover, the designed sensor can be applied to detect Fe 3+ ions in tap water with high selectivity, which provides a basis for the quantitative detection of Fe 3+ ions. At the same time, DECDs can be used as a pH fluorescence probe. In the pH 2.5–11.5 range, the fluorescence increases with pH whilst the solution color changes, providing a visualization platform for pH detection. Moreover, the pH fluorescence probe can be used for intracellular pH fluorescence imaging in living cells, and DECDs have an excellent biocompatibility (e.g., cell viability remains about 80% after treatment for 24 h at 200 μg·mL −1 of DECDs). Therefore, DECDs has a certain application prospect in food detection, biological detection and determination of intracellular pH change.
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JOURNAL OF CONTROLLED RELEASE
·
2014
·
IF 7.261
Shixian Lv,Zhaohui Tang,Dawei Zhang,Wantong Song,Mingqiang Li,Jian Lin,Huaiyu Liu,Xuesi Chen
The synthesis of polymer–drug conjugate (PDC) capable of convenient preparation and controlled release of therapeutic agents is still an urgent requirement in drug delivery field. Herein, we develop a novel anti-cancer PDC engineered with side groups of disulfide and ester bonds for on-demand delivery of paclitaxel (PTX) with redox and pH dual sensitive behaviors. A simple polymer, 3,3′-dithiodipropionic acid functionalized poly(ethylene glycol)- b -poly( l -lysine) (mPEG- b -P(LL-DTPA)), was synthesized and PTX was directly conjugated to the carboxyl groups of mPEG- b -P(LL-DTPA) to obtain the disulfide-containing polymer–PTX conjugate (P(L-SS-PTX)). Another structural similar polymer–PTX conjugate without disulfide bonds (P(L-PTX)) was also prepared to verify the function of disulfide linkages. The P(L-SS-PTX) micelles showed rapid drug release under tumor-relevant reductive conditions as designed. Interestingly, the PTX release from P(L-SS-PTX) micelles could also be promoted by the increased acidity (pH ≈ 5). In vitro cytotoxicity study showed that the P(L-SS-PTX) micelles exhibited significantly enhanced cytotoxicity against a variety of tumor cells compared to the non-sensitive P(L-PTX) micelles. The in vivo studies on B16F1 melanoma bearing C57BL/6 mice demonstrated the superior antitumor activity of P(L-SS-PTX) over both free PTX and P(L-PTX). This dual-sensitive prodrug provides a useful strategy for anti-tumor drug delivery.
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高影响因子
LANGMUIR
·
2024
·
IF 3.7
Kang Wang,Jia-Qing Li,Jun Lu,Dan Wang,Shun He,Jie-Xin Wang,Jian-Feng Chen
An intelligent delivery nanoformulation could enhance the utilization efficacy, uptake, and translocation of pesticides in plants. Herein, a redox/pH-triggered and fluorescent smart delivery nanoformulation was designed and constructed by using hollow mesoporous organosilica nanoparticles (HMONs) and ZnO quantum dots as the nanocarrier and capping agent, respectively. Boscalid was further loaded to generate Boscalid@HMONs@ZnO with a loading rate of 9.8% for controlling Botrytis cinerea (B. cinerea). The quantity of boscalid released by Boscalid@HMONs@ZnO in a glutathione environment or at pH 3.0 was 1.3-fold and 1.9-fold higher than that in a neutral condition. Boscalid@HMONs@ZnO has 1.7-fold the toxicity index of boscalid technical against B. cinerea in antifungal experiments. Pot experiments revealed that the efficacy of Boscalid@HMONs@ZnO was significantly enhanced more than 1.27-fold compared to commercially available water-dispersible granules of boscalid. Due to the fluorescence properties of Boscalid@HMONs@ZnO, pesticide transport’s real-time monitoring of pesticide translocation in tomato plants could be observed by confocal laser scanning microscopy. Fluorescence images revealed that HMONs@ZnO had been effectively transported via treated leaves or roots in tomato plants. This research showed the successful application of HMONs@ZnO as a nanocarrier for controlling disease and offered an effective avenue to explore the real-time tracking of pesticide translocation in plants.
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高影响因子
POLYMER
·
2024
·
IF 4.1
Yong Chen,An Liu
As a natural isoflavone compound, glabridin (GLD) has excellent skin-whitening properties, but its biomedical applications are greatly limited due to its poor water solubility and low skin permeability. In the current work, GLD was complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD) to form a GLD/HP-β-CD inclusion complex that would improve the water solubility and skin permeability by changing the physicochemical properties of GLD, including the formation of intermolecular hydrogen bonds and amorphous transformation. The cytotoxicity of GLD/HP-β-CD on HaCaT keratinocytes is lower than that of GLD, while it has a more substantial inhibitory effect on melanin than GLD. Furthermore, a dual thermo- and pH-responsive hydrogel called PCG was established as the carrier of GLD/HP-β-CD. The PCG hydrogel presented a porous structure, biodegradability, and excellent biocompatibility. GLD had a dual thermo- and pH-responsive release behavior from the PCG hydrogel and displayed an accelerated release rate at weakly acidic pH conditions compared to the neutral pH environment. Moreover, GLD/HP-β-CD/PCG hydrogel can significantly inhibit melanin deposition in vivo . Taken together, this study provides a low toxicity and high efficiency new method for the application of GLD in biomedical fields, demonstrating its enormous potential in skin-whitening.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xueyi Liu,Pei Zhang,Huijia Song,Xiaoshuang Tang,Yi Hao,Yibing Guan,Tie Chong,Sameer Hussain,Ruixia Gao
Prostate cancer is the most common malignancy diagnosed in men. Androgens are directly related to its pathogenesis. Inhibition of the androgen receptor (AR) is considered to be the most promising therapeutic approach for the treatment of prostate cancer. In this study, a new type of pH-responsive dual androgen-blocking nanodrug (FASC MIPs) based on a molecularly imprinted polymer has been designed and synthesized. The nanodrug could selectively sequester testosterone from the prostate tumor through specific molecular imprinting sites and simultaneously deliver the AR inhibitory drug bicalutamide, which ultimately leads to enhanced synergistic therapy of prostate cancer. FASC MIPs demonstrate excellent pH responsiveness in a simulated tumor microenvironment due to the presence of chitosan and significantly inhibit the growth of prostate cancer cells (LNCaP cells) by blocking the G1 phase of cytokinesis. Additionally, the nanodrug also displayed excellent antitumor properties in a xenograft mouse model of prostate cancer without any sign of detrimental effects on healthy tissues and organs. Both in vitro and in vivo studies verified the augmented and synergistic therapeutic effects of FASC MIPs, and the proposed dual-androgen-blocking strategy could explore novel avenues in prostate cancer treatment.
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高影响因子
Small
·
2024
·Vol. 20
·期 47
·2404830
·
IF 13
Xueying Luan,Lingfei Guo,Hongdong Li,Weiping Xiao,Guangrui Xu,Dehong Chen,Caixia Li,Yunmei Du,Zexing Wu,Lei Wang
The developed strategies for synthesizing metal phosphides are usually cumbersome and pollute the environment. In this work, an ultrafast (30 s) quasi-solid-state microwave approach is developed to construct cobalt–molybdenum phosphide decorated with Ru (Ru/Co x P-MoP) featured porous morphology with interconnected channels. The specific nanostructure favors mass transport, such as electrolyte bubbles transfer and exposing rich active sites. Moreover, the coupling effects between metallic elements, especially the decorated Ru, also act as a pivotal role on enhancing the electrocatalytic performance. Benefiting from the effects of composition and specific nanostructure, the prepared Ru/Co x P-MoP exhibits efficient HER performance with a current density of 10 mA cm −2 achieved in 1 m KOH, 0.5 m H 2 SO 4 , seawater containing 1 m KOH and 1 m PBS, with overpotentials of 52, 59, 55, 90 mV, and coupling with good stability. This work opens a novel and fast avenue to design metal-phosphide-based nanomaterials in energy-conversion and storage fields.
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 11
·1-15
·
IF 2.6
Ni Ruixuan,Yang Ziteng,Wang Li,Dai Shanshan,Lu Hongsheng
Hydrogel as a temporary plugging material provides an efficient strategy to replace locally damaged oil pipelines. However, the poor mechanical properties and incomplete gel-breaking severely limit the practical application of this strategy. Herein, a temperature and pH-responsive hydrogel P(ACG-co-AM)-MMT was prepared by copolymerizing a natural amino acid derivative monomer N-acryloyl glycine (ACG) and acrylamide (AM) with montmorillonite (MMT) as filling material. Hydrogen bonding is the main driving force in hydrogel formation, as confirmed by infrared spectroscopy. The introduction of MMT plays a key role in enhancing the mechanical properties of hydrogels. This successfully overcame the issues of inadequate mechanical properties-rapid degradation trade-off in hydrogel temporary plugging materials. The results show that the hydrogel can withstand the pipeline pressure up to 84 kPa and effectively plug the pipeline. Due to the reversibility of hydrogen bonds, the hydrogel can realize the transformation of sol-gel-sol under temperature stimulation. The plugged area of the pipeline is removed by injecting thermal-produced water. When the hot water temperature is 85 ℃, the pipeline changes to the dredging state only 21 min, dramatically simplifying the operation time. P(ACG-co-AM)-MMT hydrogel has great potential as a temporary plugging material in replacing partially damaged oil pipeline plugging operations. Graphical
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2024
·
IF 3.3
Jia-Cheng Liu,Bin Nie,Yu-Qiao Wang,Jia-Nan Yan,Hai-Tao Wu
BACKGROUND Previous studies have investigated complexation and coacervation of scallop Patinopecten yessoensis male gonad hydrolysates (SMGHs) and polysaccharides influenced by pH and blending ratio. It has been found that SMGHs/polysaccharide composite shows better gel properties under strongly acidic conditions. Thus, the complexation and coacervation of SMGHs and gellan gum (GG) were investigated via turbidimetric titration at different pH values (1–12) and biopolymer blending ratios (9.5:0.5–6:4). RESULTS Both pH c and pH φ1 exhibited ratio-independent behavior with constant values at approximately pH 5.8 and pH 3.8, respectively, dividing SMGHs/GG blends into three phases named mixed polymers, soluble complexes and insoluble coacervates, respectively. Overall, SMGHs and GG exhibited synergistic gelation under neutral and acidic conditions, with the initial storage modulus ( G' ) increasing by approximately 42.5-, 573.7- and 3421-fold and 97.7-, 550.3- and 0.5-fold, respectively, at pH 7, 5 and 3, compared with SMGHs and GG. As pH decreased from 7 to 3, the initial G' and viscosity η values of SMGHs/GG gels increased by 20.1- and 2.3-fold, respectively, exhibiting the greatest increase in gel strength. Moreover, the free water in the SMGHs/GG system significantly shifted toward lower relaxation times attributed to the immobilization of the outer hydration layers. SMGHs/GG gels in the insoluble phase exhibited denser networks and rougher surfaces, supporting the enhanced rheological properties and water retention capacity of the gel. CONCLUSION This work provides a basic foundation for the development of pH-driven SMGHs/GG gelation by examining complexation and coacervation processes. © 2024 Society of Chemical Industry.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jiaying Chen,Yilin Wang,Mingxia Pu,Shan He,Neethu Ninan,Ming Cheng
Soybean protein isolate (SPI) exhibits limited functional properties in processing applications due to environmental stressors such as pH, salt ion, and temperature. The present study was devoted to exploring the non-covalent assembly of SPI with chitosan (CS), glucan (GL) and sodium alginate (SA) under different pH conditions. At a fixed mixing ratio (1:1), the phase behavior, protein solubility, and surface hydrophobicity (H 0 ) of the resulting protein-polysaccharide complexes (PPCs) exhibited great differences due to the diversity of polysaccharide charge density and structure. Specifically, CS and SA primarily incorporated with SPI through electrostatic interactions, resulting in a pronounced enhancement of SPI solubility near the isoelectric point, with increases of 37.1 % and 51.6 %, respectively. In contrast, the combination of GL with SPI dominated by hydrophobic interactions and hydrogen bonds, yielding a similar protein solubility and H 0 to SPI itself under different pH. Further analysis in charge density indicates that heat treatment promotes the electrostatic complexation of proteins with polysaccharides, whereas an increase in ionic strength inhibits the non-covalent assembly, and this effect was pronounced in the anionic polysaccharide system. In addition, the formation of electrostatic complexes exerted a positive effect on the stability of the emulsions, while the co-soluble systems tended to produce emulsion particles with smaller particle sizes. In summary, the charged polysaccharides showed great potential to modulate protein structure and enhance the stability of protein emulsions compared with the nonionic polysaccharides.
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高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2024
·
IF 5.5
Peng Xu,Jiawei Bao,Qun Li,Weishan Shi,Gang Xing,Zhaogang Teng
Background Smart pesticides, capable of responding to environmental stimuli, hold promise for achieving precise and on-demand release of pesticides, thereby reducing environmental risks and optimizing pesticide utilization. Methods Herein, we prepared a novel composite nanoparticle with a core-shell structure of poly(acrylic acid)-coated mesoporous silica by distillation precipitation polymerization method, which is simple and efficient. Then, abamectin was successfully loaded by impregnation adsorption, and a novel pH-responsive controlled-release pesticide formulation, Abamectin-MSN@PAA, was prepared. Significant Findings In this work, Abamectin-MSN@PAA exhibited a loading content of 23.79 % and an average particle size of approximately 272.1 nm. Notably, the formulation demonstrated acid-responsive release kinetics, with cumulative release percentages of 85.91 %, 69.03 %, and 53.44 % observed at pH values of 5, 7, and 9, respectively, after 96 h. Moreover, Abamectin-MSN@PAA effectively preserved abamectin from degradation under UV light exposure. In comparison with abamectin suspension, Abamectin-MSN@PAA exhibited superior adhesion to radish leaves and demonstrated increased aphid mortality in bioassay experiments. Following 7 days of drug spraying, the aphid survival rate was 26.67 % for Abamectin (40 mg L −1 ) and only 18.3 % for Abamectin-MSN@PAA (40 mg L −1 ). These findings underscore the potential of pH-responsive poly(acrylic acid)-coated mesoporous silica nanoparticles as a versatile platform for controlled pesticide delivery, thereby enhancing pesticide bioavailability and efficacy in agriculture.
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危险品化学品经营许可证（带存储）