Communications Chemistry
·
2025
·Vol. 8
·期 1
·389
·
IF 6.2
Han Lei,Tan Jingying,Zhang Yucui
Given the promising prospect of nanozymes in colorimetric test strips, it is essential to eliminate the interferences of their multi-activities and various colors on the test strip. Here, white Mn-based metal-organic frameworks (Mn-MOFs) with ultrathin 2D morphology (3 nm thick) were successfully synthesized by a simple ultrasonic approach. The origin of the white optical property in Mn-MOFs was systematically investigated, revealing that it stems from specific metal-ligand coordination polymerization rather than morphological features or defect states. Mn-MOF nanozymes possessed exclusive peroxidase-mimicking activity rather than oxidase-like activity, effectively resisting O 2 interference during colorimetric assay. Moreover, Mn-MOF nanozymes displayed unique substrate selectivity without additional modification. Unlike other colored nanozymes, the whiteness of Mn-MOF nanozymes enhanced the paper’s whiteness, boosting contrast for colorimetric detection on test strip. This study pioneers a systematic investigation into the origin of whiteness in MOF nanozymes. The coordination-defined properties enable interference-free optical design and O 2 -resistant on-site detection.
研究领域:
材料科学
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纳米技术
·
分析化学
·
生物传感器
·
酶模拟
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2025
·Vol. 60
·期 48
·25148-25163
·
IF 3.9
Zhang Zhenyan,Chai Huan,Yu Zhengqian,Li Jinsheng,Li Pengfei,Wu Lei,Li Zhanshuai,Qi Xiwei
TiO 2 -based materials are widely used in high-temperature capacitors and aerospace electronics but face challenges such as high dielectric loss and limited thermal stability in conventional single-component systems. To address these issues, we propose a novel strategy integrating high-entropy doping design and oxygen vacancy engineering. In 2 O 3 -doped (GeMnTiSnMo)O 2 high-entropy ceramics (GMTSMO- x In, x = 0.1–1) were synthesized via solid-state reaction. Experimental results reveal that In 3+ doping generates high-density oxygen vacancies (V o ·· ) through charge compensation, forming [Ti 3+ - V o ·· -Ti 3+ ] and [Mn 3+ - V o ·· -Mn 3+ ] defect-dipole clusters. These clusters enhance electron localization and suppress carrier migration, reducing dielectric loss by threefold. Simultaneously, oxygen vacancy enrichment strengthens interfacial polarization, increasing the dielectric constant by fourfold. The optimal GMTSMO-0.5In exhibits a relative permittivity ( ε r ) of 4.0 × 10 6 and a low loss tangent of 15 at 650 ℃/100 Hz, outperforming traditional TiO 2 -based materials and existing high-entropy oxides. All compositions demonstrate excellent temperature stability (25–400 ℃) and frequency-independent behavior above 10 4 Hz. This work provides a high-entropy-driven approach for dynamic defect engineering, paving the way for advanced dielectric materials in extreme-condition energy storage systems.
研究领域:
材料科学
·
陶瓷与介电材料
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电子材料
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储能技术
·
缺陷化学
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Sipeng Tian,Baobing Tang,Mingzi Sun,Zhangpeng Xu,Tongtong Zhai,Huanhuan Xing,Bolong Huang,Yunling Liu,Jing Li,Erkang Wang
Classic luminol-H2O2 chemiluminescence (CL) systems are plagued by inherent self-decomposition, which compromises detection reliability. Although luminol-dissolved oxygen systems circumvent this issue, their ultralow reactivity necessitates innovative catalytic microreactor design. Herein, we pioneer a hydrogen-bonded organic framework (HOF) constructed from metal–organic square units and 1,2-propanediamine ligands as terminal hydrogen-bonding sites, achieving an unprecedented 4284-fold CL enhancement in luminol-O2 systems. HOF with porous zeolite-like supramolecular assemblies (ZSA) serves as the coreaction accelerator with strong O2 adsorption at tetrahedral Co–N/O sites that activates O2 to generate reactive oxygen species (ROS). And the kinetic confinement effect provided by the ZSA host with suitable channel and hydrogen-bonding contributions efficiently captured the luminol emitter in the nanocages, shortening electron-transfer pathways and reducing nonradiative energy loss. And the synergistic confinement catalysis enhanced CL performance is linearly related to the O2 adsorption capacity of the ZSA series (ZSA-1, ZSA-3, and ZSA-4). Theoretical calculations further confirmed that the adsorption of O2 and luminol in ZSA-1 optimizes the electron-transfer pathways to promote CL emission performances compared with those of zeolitic imidazolate framework-67 (ZIF-67). This work not only expands the application of HOF in the field of CL but also provides new insights for engineering materials to boost the CL photon emission efficiency of weak luminol-O2 systems.
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高影响因子
BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Zepeng Kang,Yi-Heng P. Job Zhang,Zhiguang Zhu
In this study, a novel carbon tube was prepared by carbonizing a rectangular polypyrrole (RPPy) tube at a high temperature for the construction of enzymatic biofuel cells with high performance. SEM and TEM images clearly showed that the initial PPy presented a rectangular tube shape, while the carbonized PPy became a shriveled rectangular tube with a concave surface, which might be beneficial for enzyme immobilization and electrochemical applications. The glucose oxidase (GOx)- or laccase (Lac)-modified electrodes based on carbonized RPPy exhibited excellent bioelectrochemical performance. In addition, a biofuel cell (GOx, glucose/O 2 , Lac) was assembled, and the open-circuit voltage reached 1.16 V. The maximum power density was measured to 0.350 mW cm −2 , which correlated to the gravimetric power density of 0.265 mW mg −1 (per mg of GOx) at 0.85 V. The constant-current discharge method was used to further evaluate the continuous discharge capacity. The discharge time reached 49.9 h at a discharge current of 0.2 mA before the voltage was lower than 0.8 V. Furthermore, three of the fabricated biofuel cells in series were able to continually light up a white light-emitting diode (LED) whose turn-on voltage was ca. 2.4 V for more than 48 h. This study suggests that carbonized conducting polymers may become a useful electrode material for the development of enzymatic biofuel cells.
研究领域:
生物化学
·
材料科学
·
能源科学
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DOI
高影响因子
Energy Storage Materials
·
2022
·
IF 20.831
Yiqiao Wang,Siyuan Pan,Yong Guo,Shichao Wu,Quan-Hong Yang
Li-O 2 batteries require catalysts to solve the problem of sluggish oxygen-related reaction kinetics. However, the solid catalysts and redox mediators are intrinsically deficient due to poor solid contacts and shuttle problems, respectively. Here, we report lithium phthalimide-N-oxyl (LiPINO) as a phase transfer catalyst (PTC) for promoting Li 2 O 2 formation and its reversible decomposition through the solution-phase reactions. The interaction between LiPINO and oxygen species in the electrolyte enables the high dissolution and stability of oxygen species, the fast charge transfer at liquid-solid interfaces and superior kinetics, and the suppressed side reactions. The efficient bidirectional catalytic activity and high stability of LiPINO capacitate batteries with a highly improved discharge capacity (11400 mAh g −1 ), a largely lowered charge potential (3.14 V) and an extended cycle life (more than 200 cycles) both in O 2 and air. Our understanding of the phase-transfer catalysis towards the Li-O 2 electrochemistry and the discovery of the PTC with superior activity and stability provide deep insights into the design of the most reliable catalysts for Li-O 2 batteries.
研究领域:
电化学
·
能源材料
·
物理化学
·
电池技术
·
催化化学
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DOI
高影响因子
ADVANCED MATERIALS
·
2024
·
IF 27.4
Shuyu Wang,Miaomiao Cheng,Shenghui Wang,Wei Jiang,Feifei Yang,Xiaomei Shen,Lirong Zhang,Xiyun Yan,Bing Jiang,Kelong Fan
Radiotherapy (RT), essential for treating various cancers, faces challenges from tumor hypoxia, which induces radioresistance. A tumor-targeted “prosthetic-Arginine” coassembled nanozyme system, engineered to catalytically generate nitric oxide (NO) and oxygen (O 2 ) in the tumor microenvironment (TME), overcoming hypoxia and enhancing radiosensitivity is presented. This system integrates the prosthetic heme of nitric oxide synthase (NOS) and catalase (CAT) with NO-donating Fmoc-protected Arginine and Ru 3+ ions, creating HRRu nanozymes that merge NOS and CAT functionalities. Surface modification with human heavy chain ferritin (HFn) improves the targeting ability of nanozymes (HRRu-HFn) to tumor tissues. In the TME, strategic arginine incorporation within the nanozyme allows autonomous O 2 and NO release, triggered by endogenous hydrogen peroxide, elevating NO and O 2 levels to normalize vasculature and improve blood perfusion, thus mitigating hypoxia. Employing the intrinsic O 2 -transporting ability of heme, HRRu-HFn nanozymes also deliver O 2 directly to the tumor site. Utilizing esophageal squamous cell carcinoma as a tumor model, the studies reveal that the synergistic functions of NO and O 2 production, alongside targeted delivery, enable the HRRu-HFn nanozymes to combat tumor hypoxia and potentiate radiotherapy. This HRRu-HFn nanozyme based approach holds the potential to reduce the radiation dose required and minimize side effects associated with conventional radiotherapy.
研究领域:
肿瘤学
·
纳米技术
·
生物化学
·
治疗学
·
放射肿瘤学
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DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2022
·Vol. 34
·期 40
·2201838
·
IF 32.086
Guiru Sun,Rui Gao,Hailiang Jiao,Dan Luo,Yan Wang,Zexu Zhang,Wei Lu,Ming Feng,Zhongwei Chen
The major challenges for Li-O 2 batteries are sluggish reaction kinetics and large overpotentials due to the cathode passivation resulting from insulative and insoluble Li 2 O 2 . Here, a novel nanodot (ND)-modified electrolyte is designed by employing cobalt bis(trifluoromethylsulfonyl)imide (Co(TFSI) 2 ) as an electrolyte additive. The Co(TFSI) 2 additive can react with discharge intermediate LiO 2 and product Li 2 O 2 to form CoO NDs. The generated CoO NDs are well dispersed in electrolyte, which integrates both the high catalytic activity of solid catalyst and the good wettability of soluble catalyst. Under the catalytis of CoO NDs, Li 2 O 2 is produced and deposits on the cathode together with them. At the recharge process, these well dispersed CoO NDs help to decompose solid Li 2 O 2 at a lower overpotential. The Li-O 2 cells with Co(TFSI) 2 exhibit a long cycle life of 200 cycles at a current density of 200 mA g −1 under a cutoff capacity of 1000 mAh g −1 , as well as a superior reversibility associated with the Li 2 O 2 formation and decomposition. The study is expected to broaden the range of electrolyte additives and provide a new view to developing highly dispersed NDs-based catalysts for Li-O 2 batteries.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 71
·40984-40988
·
IF 2.936
Xiaonan Gao,Wenfei Guo,Lihong Ge,Fanpeng Kong,Kehua Xu,Bo Tang
Sodium selenite (Na2SeO3), as an anti-tumor drug for inducing tumor cells' apoptosis, has been widely studied under normoxic conditions and has been shown to exhibit oxidative stress process-induced apoptosis. However, since the real tumor environment is hypoxic, the actual mechanism is still unclear. Hence, considering the main metabolite of Na2SeO3 in the metabolic process to be hydrogen selenide (H2Se) and also that it can be converted to superoxide anion (O2˙−) instantaneously in the presence of oxygen, a dual-ratiometric fluorescence imaging system for simultaneous monitoring of the changes of H2Se and O2˙− induced by Na2SeO3-guided tumor cell apoptosis under hypoxic conditions was constructed. Two molecular probes NIR-H2Se and dihydroethidium were used to detect H2Se and O2˙−, respectively, whereas Rhodamine 110 was used as the reference fluorophore. Notably, H2Se levels significantly increased under hypoxic conditions, but there was no change in the level of O2˙−, which is inconsistent with the results of the previous researches. Therefore, we hypothesize that the mechanism of Na2SeO3-induced apoptosis for tumor cells is caused by reductive stress; also, this method can be applied for the future study of other anti-cancer selenium compounds.
研究领域:
生物化学
·
医学影像学
·
肿瘤学
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DOI
高影响因子
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
·
2024
·Vol. 121
·期 23
·e2320012121
·
IF 9.4
Xin He,Youxuan Ni,Wenjiao Ma,Qiu Zhang,Zhenkun Hao,Yunpeng Hou,Haixia Li,Zhenhua Yan,Kai Zhang,Jun Chen
Rechargeable sodium-oxygen (Na–O2) battery is deemed as a promising high-energy storage device due to the abundant sodium resources and high theoretical energy density (1,108 Wh kg–1). A series of quasisolid electrolytes are constantly being designed to restrain the dendrites growth, the volatile and leaking risks of liquid electrolytes due to the open system of Na–O2 batteries. However, the ticklish problem about low operating current density for quasisolid electrolytes still hasn’t been conquered. Herein, we report a rechargeable Na–O2 battery with polyvinylidene fluoride-hexafluoropropylene recombination Nafion (PVDF–HFP@Nafion) based quasisolid polymer electrolyte (QPE) and MXene-based Na anode with gradient sodiophilic structure (M-GSS/Na). QPE displays good flame resistance, locking liquid and hydrophobic properties. The introduction of Nafion can lead to a high Na+ migration number (tNa+ = 0.68) by blocking the motion of anion and promote the formation of NaF-rich solid electrolyte interphase, resulting in excellent cycling stability at relatively high current density under quasisolid environment. In the meantime, the M-GSS/Na anode exhibits excellent dendrite inhibition ability and cycling stability. Therefore, with the synergistic effect of QPE and M-GSS/Na, constructed Na–O2 batteries run more stably and exhibit a low potential gap (0.166 V) after an initial 80 cycles at 1,000 mA g–1 and 1,000 mAh g–1. This work provides the reference basis for building quasisolid state Na–O2 batteries with long-term cycling stability.
研究领域:
材料科学
·
电化学
·
能源存储
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Yaying Dou,Xin-Gai Wang,Dashuai Wang,Qinming Zhang,Chengyi Wang,Gang Chen,Yingjin Wei,Zhen Zhou
Large overpotential in oxygen reduction and evolution reactions is the intractable obstruction of Li-O 2 batteries, causing inferior round-trip efficiency and diminished cycle life. Modulating the reaction mechanism of Li 2 O 2 is of crucial importance for a high-performance Li-O 2 battery. Herein, we report a composite of amorphous RuO 2 nanoparticles decorated carbon nanotubes (A-RuO 2 @CNT) as an efficient catalyst for Li-O 2 batteries. The amorphous catalyst contains abundant defects and vacancies as well as distorted atom arrangements, which provide sufficient active sites for reactions and enhance the affinity for LiO 2 intermediates. As a result, the formation/decomposition mechanisms of Li 2 O 2 are reasonably regulated. An amorphous film-like Li 2 O 2 product forms and uniformly deposits on the surface of A-RuO 2 @CNT, thus achieving faster redox kinetics and smaller overpotential. When used in Li-O 2 batteries, the amorphous catalyst affords remarkably decreased charge overpotential and enhanced cyclic stability, which is superior to its crystalline counterpart.
研究领域:
储能
·
电化学
·
材料科学
·
纳米材料
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Linlin Xie,Xingye Ma,Zheng Wang,Caifang Wang,Zhongxin Xiao,Ling-Dong Sun,Chun-Hua Yan,Chen-Jie Fang
Pyroptosis resulted from photodynamic therapy (PDT) plays a crucial role in triggering photoimmunotherapy (PIT). However, visible light-triggered PDT may rise phototoxicity, with low penetration into biological tissues. Crucially, the efficacy of PDT in eliciting pyroptosis remains suboptimal. To address these formidable challenges, we developed a O 2 -supplementing photosensitizer AuNCs@TAT that could efficiently induce pyroptosis upon irradiation with second near-infrared (NIR-II) light in hypoxic tumor microenvironment (TME). Replacing GSH with TAT resulted in a gold nanocluster AuNCs@TAT. The ratio of Au (I) to Au (0) shifted from 1: 0.26 in pristine AuNCs to 1: 1.21 in AuNCs@TAT, which contributed to enhanced catalytic activity of AuNCs@TAT. The superior catalase-like activity of AuNCs@TAT produced 1.9-fold higher O 2 than AuNCs. This O 2 self-supplying capability of AuNCs@TAT not only relieved hypoxic condition in TME but also significantly enhanced the efficiency of AuNCs@TAT to induce pyroptosis upon 1064 nm light irradiation. Western blotting indicated both remarkable upregulation of cleft Caspase-3 and GSDME-N, suggesting GSDME mediated pyroptosis. Further, release of pro-inflammatory cytokines and damage-associated molecular patterns (DAMPs) triggered a strong systematic immune response and reprogrammed the immunosuppressive microenvironment into an immunostimulatory state, which led to a significant suppress of tumor metastasis in mice. Overall, this work sets the stage for future advancements in the design of NIR-II photosensitizer with O 2 -supplementing capability and therefore offers an innovative framework and solid foundation for tumor PIT.
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DOI
高影响因子
Theranostics
·
2026
·Vol. 16
·期 6
·2811
·
IF 13.3
Hanqing Zhao,Wenjun Shao,Man Jiang,Fangyuan Chen,Yingying Li,Xiaoyu Zhang,Tao Ma,Minglong Chen,Baohong Sun,Zekun Wang,Chuanbin Wu,Qingqing Wang
Rationale: Chronic diabetic wounds present significant therapeutic challenges due to biofilm resistance and dysregulated metabolism of glucose, reactive oxygen species (ROS), and nitric oxide (NO), which collectively exacerbate immunosuppression and impair tissue repair. Methods: This study developed a glucose-driven cascade nanozyme-loaded dissolvable microneedle system (PPLG@MN) that enables spatiotemporal regulation of the wound microenvironment through a closed-loop mechanism involving nutrient deprivation, gas modulation, and immune reprogramming. The system consists of porous Prussian blue nanozymes (PPB) loaded with glucose oxidase (GOx) and L-arginine (L-arg), which is precisely delivered into the tissue via microneedles. Results: PPLG@MN initiates a self-sustaining therapeutic cycle within the biofilm microenvironment, in which GOx catalyzes the oxidation of glucose to generate hydrogen peroxide (H 2 O 2 ), inducing bacterial starvation. Subsequently, H 2 O 2 reacts with PPB and L-arg to release oxygen (O 2 ) and biofilm-disrupting NO, thereby alleviating local hypoxia and enhancing antibacterial efficacy. Furthermore, the synergistic action of O 2 and NO reprograms macrophages toward an anti-inflammatory M2 phenotype (approximately 30-fold increase compared to the model group), effectively resolving inflammation and promoting angiogenesis. In vivo studies confirmed that the system achieved > 99.9% biofilm eradication efficiency and accelerated wound healing by 25.6% compared to the model group. Conclusion: This nanoplatform offers a clinically translatable therapeutic strategy for biofilm-associated diabetic wounds by synergistically combining gas therapy and immune reprogramming.
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PubMed
高影响因子
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