Materials Today Bio
·
2025
·
IF 10.2
Changjiang Pan,Naiquan Yang,Jie Chen,Qiuyang Zhang,Linhong Deng,Teng Luo,Lingjie Meng
Magnesium and its alloys are undoubtedly ideal candidates for manufacturing new bioabsorbable vascular stents thanks to their good bio-absorbability and better mechanical characteristics. However, the bottlenecks that restrict their clinical application, such as fast corrosion in vivo , poor hemocompatibility, and inferior surface endothelial regeneration ability, have not been resolved fundamentally. In this study, a polydopamine (PDA) intermediate layer covalently linked with acrylamide was first constructed on the alkali-heat-treated magnesium alloys, followed by in-situ polymerizing methacryloyloxyethyl sulfonyl betaine (SBMA) and acrylamide (AAM) to fabricate a hydrogel coating on the surface by ultraviolet (UV) polymerization. Finally, bivalirudin and selenocystamine were sequentially grafted onto the hydrogel coating surface to construct a multifunctional bioactive corrosion-resistant coating with excellent antifouling, anticoagulant performance, and catalytic liberation of NO (nitric oxide) to facilitate endothelial cell (EC) growth. The outcomes verified that the bioactive coating could not only significantly resist corrosion of magnesium alloys, but also had excellent hydrophilicity and the ability to selectively promote albumin adsorption, which could prevent platelet adhesion and activation and significantly diminish the hemolysis occurrence, thereby considerably facilitating its anticoagulant properties. At the same time, due to the hydrophilicity and extracellular matrix-like characteristics of the hydrogel coating, the coating could promote EC growth and upregulate the secretion of vascular endothelial growth factor (VEGF) and NO of endothelial cells (ECs). In the case of catalytic NO-liberation, the catalytic release of NO could further significantly improve blood compatibility, EC growth, and functional expressions of ECs. Therefore, the method in this study provides an effective strategy to fabricate the bioactive hydrogel coating that can simultaneously resist corrosion and enhance the biocompatibility of magnesium-based alloys, thereby effectively promoting research and application of magnesium alloy in intravascular stents.
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ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Yu Dong,Jiaojiao Tao,Bingjie Wang,Aijia Zhang,Guangli Xiang,Shuang Li,Tianze Jiang,Xia Zhao
Photothermal therapy (PTT) shows promise in cancer treatments due to its good spatiotemporal selectivity and minimal invasiveness. However, PTT has some problems such as excessive heat damage to normal tissues, tumor thermo-resistance caused by heat shock proteins (HSPs), and limited efficacy of monotherapy. Here, we construct a patch named “partitioned microneedles” (PMN-SNAP/CuS), which separates the “catalyst” bovine serum albumin-based copper sulfide nanoparticles (CuS@BSA NPs) and the “reactant” S-nitroso-N-acetylpenicillamine (SNAP) into different regions of microneedles, for enhancing mild PTT (mPTT) of melanoma. PMN-SNAP/CuS showed an excellent photothermal effect, Fenton-like catalytic activity, and nitric oxide (NO) generation ability. The combination of NO and reactive oxygen species (ROS) produced by PMN-SNAP/CuS effectively blocked the synthesis of HSPs at the source and enhanced the efficacy of mPTT. Both in vitro and in vivo results proved that PMN-SNAP/CuS significantly enhanced the inhibition of melanoma under 808 nm laser irradiation. In conclusion, our partitioned microneedle strategy based on the combination of enhanced mPTT and gas therapy (GT) provides a promising approach to enhance the therapeutic effect on melanoma.
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Pharmaceutics
·
2024
·Vol. 16
·期 9
·1166
·
IF 4.9
Kadireya Aikelamu,Jingya Bai,Qian Zhang,Jiamin Huang,Mei Wang,Chunhong Zhong
The combination of photodynamic therapy (PDT) and pneumatotherapy is emerging as one of the most effective strategies for increasing cancer treatment efficacy while minimizing side effects. Photodynamic forces affect nitric oxide (NO) levels as activated photosensitizers produce NO, and NO levels in the tumor and microenvironment directly impact tumor cell responsiveness to PDT. In this paper, 3-benzenesulfonyl-4-(1-hydroxy ether)-1,2,5-oxadiazole-2-oxide NO donor–silicon phthalocyanine coupling (SiPc–NO) was designed and prepared into self-assembled nanoparticles (SiPc–NO@NPs) by precipitation method. By further introducing arginyl-glycyl-aspartic acid (RGD) on the surface of nanoparticles, NO-photosensitizer delivery systems (SiPc–NO@RGD NPs) with photo-responsive and tumor-targeting properties were finally prepared and preliminarily evaluated in terms of their formulation properties, NO release, and photosensitizing effects. Furthermore, high reactive oxygen species (ROS) generation efficiency and high PDT efficiency in two breast cancer cell lines (human MCF-7 and mouse 4T1) under irradiation were also demonstrated. The novel SiPc–NO@RGD NPs show great potential for application in NO delivery and two-photon bioimaging-guided photodynamic tumor therapy.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Hui Wang,Duohang Bi,Bowen Yu,Qiang Chen,Shuo Du,Ge Xie,Jintao Zhu,Lianbin Zhang
Photodynamic therapy (PDT) offers potential for combating bacterial infections through the generation of reactive oxygen species (ROS). However, the antibacterial efficiency of PDT is largely impeded by the limited photon absorption of photosensitizers and the short diffusion length and lifespan of ROS. Herein, we present a light-harvesting platform based on l -arginine-modified photonic hydrogels loaded with new indocyanine green (PG@Arg/IR820) for synergizing the slow photon effect with NO gas therapy to enhance PDT antibacterial efficiency. Upon near-infrared (NIR) light irradiation, PG@Arg/IR820 can maximize the utilization of photons via the slow photon effect to generate sufficient ROS, which not only acts as the primary bactericidal agent in PDT but also triggers l -arginine to generate NO. NO exhibits a long diffusion distance and lifespan and can freely diffuse to inhibit distant bacterial growth, demonstrating a vital complementary advantage in bacterial inactivation by ROS. The synergistic effect of the slow photon effect combined with NO gas therapy allows PG@Arg/IR820 to intensify bacterial destruction and enhance PDT antibacterial efficiency. This antibacterial system sheds light on an advisable design principle for efficient antibacterial activities in photodynamic inactivation.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Hongxia Liu,Minggang Zhang,Zhipeng Jin,Hui Mei,Gangqiang Zhu,Longkai Pan,Laifei Cheng,Litong Zhang
Photocatalysis is recognized as one of the most promising techniques for environment purification. However, the inconvenient recovery of powder photocatalysts significantly impeded their practical applications. Immobilization of the photocatalysts on supports to form monolithic photocatalysts is an effective method to solve this problem. Herein, a monolithic photocatalyst Bi 12 TiO 20 /Bi 4 Ti 3 O 12 /SiOC is fabricated by growing optimal Bi 12 TiO 20 /Bi 4 Ti 3 O 12 S-scheme heterojunction onto 3D-printed porous SiOC support. On one side, S-scheme heterojunction facilitates the separation of photoinduced electrons and holes while retaining their strong redox ability. On the other side, the porous structure favors mass transport and improves light harvesting by reflecting the light several times. Under simulated solar light irradiation, the NO removal efficiency of the monolithic photocatalyst Bi 12 TiO 20 /Bi 4 Ti 3 O 12 /SiOC is 16.4 %. Furthermore, the composite has good stability and reusability, suggesting its great potential in practical application. The possible photocatalytic mechanism is proposed according to systematic experiments and density functional theory (DFT). This work provides a rational reference for constructing efficient photocatalysts for environmental purification.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
·
IF 15.7
He Wenyan,Huan Xueting,Li Yinchuan,Deng Qisen,Chen Tao,Xiao Wen,Chen Yijun,Ma Lingman,Liu Nan,Shang Zhuo,Wang Zongqiang
The rapid emergence of difficult-to-treat multidrug-resistant pathogens, combined with the scarcity of antibiotics possessing novel mechanisms, poses a significant threat to global public health. Here, we integrate the synthetic-bioinformatic natural product approach with peptide optimization to unveil the antibiotic-producing potential of Paenibacillaceae bacteria. Our culture-independent approach led to the discovery of paenimicin, a novel 11-mer depsi -lipopeptide featuring an unprecedented dual-binding mechanism. By sequestering the phosphate and hydroxyl groups of lipid A in Gram-negative bacteria, as well as the phosphate groups of teichoic acids in Gram-positive bacteria, paenimicin exhibits potent and broad-spectrum efficacy against MDR pathogens in vitro and in vivo models. Paenimicin demonstrates no detectable resistance, favorable pharmacokinetics and low nephrotoxicity, positioning it as a promising candidate for treating severe and urgent MDR infections.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zhijian Xiao,Wenda Yang,Jing Wang,Shuang Cao,Jingling Yang,Mingshan Zhu
Photocatalysis is a promising technology for removing low concentrations of nitric oxide (NO) from the atmosphere. However, the unsatisfactory photocatalytic NO removal efficiency and the high selectivity for NO 2 in catalysts limit the development of this technology. In this work, we used an in-situ synthesis method to incorporate Cs 3 Bi 2 Br 9 into UiO-66 for efficient and robust photocatalytic NO removal. The Cs 3 Bi 2 Br 9 /UiO-66 catalyst exhibits a 77.6 % NO removal efficiency and low NO 2 selectivity under visible light irradiation at a WHSV of 1,650,000 mL h −1 g −1 , exceeding the efficiencies of Cs 3 Bi 2 Br 9 (36.4 %) and UiO-66 (2.3 %), as well as those of most reported MOF-based photocatalysts. The synergy of weak Lewis acid sites from Cs 3 Bi 2 Br 9 in Cs 3 Bi 2 Br 9 /UiO-66 and the strong Lewis acid sites from UiO-66 promotes the enrichment of NO on the catalyst surface and act as electron traps to induce carrier separation, thereby promoting the generation of O 2 − to achieve high efficiency. This work provides a new idea for the development of catalysts in NO elimination.
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Food Bioengineering
·
2025
·Vol. 4
·期 2
·166-181
·
IF 2.3
Baoming Tian,Xue Zhou,Shuo Pan,Wei Liu
Tea polysaccharides have attracted widespread attention in regulating gut microbiota. A highly efficient enzymolysis and ultrasonic-assisted extraction method was developed and optimized for the extraction of polysaccharides from Zhonghuang No. 1 etiolated-green tea (GTP) with a-single factor and response surface methodology, i.e, with a pH of 5.5, an enzyme concentration of 7%, an ultrasonic time of 2.5 h, a solid-liquid ratio of 1:20 g/mL, and an ultrasonic temperature of 80°C. GTP exhibited a triple helix structure and demonstrated the ability to bind with Congo red. Its surface was observed to be spherical with slender chain fragments. GTP remained intact throughout the simulated in vitro digestive process, which encompassed the oral, gastric, and small intestinal phases. The relative abundance of Bacteroidota was significantly increased, while the Firmicutes/Bacteroidota ratio was reduced following the administration of GTP. The contents of Faecalibacterium and Bacteroides were increased, while the contents of Escherichia_Shigella and Dorea were reduced after GTP treatment. Furthermore, GTP were degraded and utilized by gut microbiota to produce SCFAs and reducing pH value. GTP regulated the composition of the gut microbiota and has the potential to act as a prebiotic, with the possibility of its use as a functional food.
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CELLULOSE
·
2025
·
IF 4.8
Ge Xinchang,Fang Kuanjun,Fang Lei,Zhang Longxue,Li Hanyu,Gao Hongguo,Bao Wei
Sustainable lyocell fiber is widely used to manufacture various high-end low carbon and green textile products. However, fibrillation usually occurred during wet processing, causing severe pilling and poor appearance. The current anti-fibrillation methods still suffer from strength loss or unsatisfactory anti-fibrillation performance, and the functional modification of lyocell fibers is generally a distinct processing stage, which causes more water consumption. The present study reported a new strategy for fabricating multifunctional lyocell textiles using cationic P(St-BA-DMC) nanospheres with an average diameter of 90.9 nm and zeta potential of + 49.4 mV. The nanospheres were adsorbed on the negatively charged lyocell fiber surfaces through electrostatic forces when the fibers were treated with the nanosphere suspension. FTIR, SEM, and XPS revealed that when cured at 150 °C, the core–shell-structure nanospheres on the fibers spread into dot membranes like frying eggs, which made the fiber much more hydrophobic through the lotus effect. As a result, the fiber swelling rate reduced from 23.7% to 7%, while the bursting strength of the knitted fabric was not changed significantly. The air permeability at the wet state increased by 30.5% compared to the original fabric. Additionally, the treated fabric’s antibacterial rate against S. aureus reached 97%. The lyocell fabric was endowed with anti-fibrillation, higher air permeability, and anti-bacterial functions without significant strength loss. Moreover, the dyeability of treated fabric was greatly enhanced. This work provides a new strategy for the anti-fibrillation and functionalization of low-carbon lyocell textiles.
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ADVANCED MATERIALS
·
2024
·
IF 27.4
Shuyu Wang,Miaomiao Cheng,Shenghui Wang,Wei Jiang,Feifei Yang,Xiaomei Shen,Lirong Zhang,Xiyun Yan,Bing Jiang,Kelong Fan
Radiotherapy (RT), essential for treating various cancers, faces challenges from tumor hypoxia, which induces radioresistance. A tumor-targeted “prosthetic-Arginine” coassembled nanozyme system, engineered to catalytically generate nitric oxide (NO) and oxygen (O 2 ) in the tumor microenvironment (TME), overcoming hypoxia and enhancing radiosensitivity is presented. This system integrates the prosthetic heme of nitric oxide synthase (NOS) and catalase (CAT) with NO-donating Fmoc-protected Arginine and Ru 3+ ions, creating HRRu nanozymes that merge NOS and CAT functionalities. Surface modification with human heavy chain ferritin (HFn) improves the targeting ability of nanozymes (HRRu-HFn) to tumor tissues. In the TME, strategic arginine incorporation within the nanozyme allows autonomous O 2 and NO release, triggered by endogenous hydrogen peroxide, elevating NO and O 2 levels to normalize vasculature and improve blood perfusion, thus mitigating hypoxia. Employing the intrinsic O 2 -transporting ability of heme, HRRu-HFn nanozymes also deliver O 2 directly to the tumor site. Utilizing esophageal squamous cell carcinoma as a tumor model, the studies reveal that the synergistic functions of NO and O 2 production, alongside targeted delivery, enable the HRRu-HFn nanozymes to combat tumor hypoxia and potentiate radiotherapy. This HRRu-HFn nanozyme based approach holds the potential to reduce the radiation dose required and minimize side effects associated with conventional radiotherapy.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Yinghao Jia,Xin Hu,Hengjie Huang,Yangcan Deng,Wenning Cao,Ying Zhou,Xinghui Hou
CS- x ( x = 1, 2, 4, 6) nanoparticles have been successfully prepared by simple hydrothermal method combined with calcination process, and the calcination time is adjusted to optimize micro-structure characterization for their enhanced NO-sensing. The techniques of XRD, Raman, SEM, TEM, TGA, DSC, BET, and XPS are used to study their phase structure, micro-morphology, thermal decomposition process and surface states, then the possible gas-sensitive mechanism is analyzed. Results show that the typical CS-2 sensor has the maximum response of 130–50 ppm NO at 90 ℃, the short response/recovery time of 40/45 s, and the low detection limit of 0.1 ppm (1.18). It also has the reliable NO selectivity against to other interfering gases, good repeatability and high stability. Its enhanced NO-sensing performance may be due to the optimization of pore structure by adjusting the calcination process based on particles adhesion and mass transfer, which increases the pore size and specific surface area that could provide the channel and active sites for gas diffusion and adsorption, thus further promoting the gas-sensing reaction. The experimental methods and ideas of pore structure regulation provide a new way for the design of high-performance sensitive materials.
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Yuzheng Wu,Xiaoxue Ren,Dezhi Xiao,Pei Liu,You Ke,Wenqiang Cui,Paul K. Chu,Huaiyu Wang
Biofilm infections present escalating clinical challenges due to their intrinsic resistance to conventional treatments, underscoring the urgent need for innovative therapeutic strategies. Here, we show a pioneering approach that leverages sacrificial nitric oxide (NO) to enhance hydrogen peroxide (H 2 O 2 ) retention for antibiofilm therapy. H 2 O 2 has the ability to produce hydroxyl radicals (•OH), the most potent oxidants in nature, but it is often neutralized by H 2 O 2 scavengers before •OH formation. Our design utilizes ultrasound irradiation to release NO from the biofilm-anchoring nano-xanthiums (G-B@NXs), which subsequently interact with biofilm-associated H 2 O 2 scavengers, including catalase and glutathione, to suppress the decomposition ability toward H 2 O 2 . Additionally, glucose oxidase on the surface of G-B@NXs supplements H 2 O 2 production, facilitates its conversion into •OH, and exhibits effective biofilm sterilization in different infection models. Our strategy not only shows the promise for advancing antibiofilm applications but also provides novel insights into the development of NO-assisted biomaterials.
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