Theranostics
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2026
·Vol. 16
·期 6
·2811
·
IF 13.3
Hanqing Zhao,Wenjun Shao,Man Jiang,Fangyuan Chen,Yingying Li,Xiaoyu Zhang,Tao Ma,Minglong Chen,Baohong Sun,Zekun Wang,Chuanbin Wu,Qingqing Wang
Rationale: Chronic diabetic wounds present significant therapeutic challenges due to biofilm resistance and dysregulated metabolism of glucose, reactive oxygen species (ROS), and nitric oxide (NO), which collectively exacerbate immunosuppression and impair tissue repair. Methods: This study developed a glucose-driven cascade nanozyme-loaded dissolvable microneedle system (PPLG@MN) that enables spatiotemporal regulation of the wound microenvironment through a closed-loop mechanism involving nutrient deprivation, gas modulation, and immune reprogramming. The system consists of porous Prussian blue nanozymes (PPB) loaded with glucose oxidase (GOx) and L-arginine (L-arg), which is precisely delivered into the tissue via microneedles. Results: PPLG@MN initiates a self-sustaining therapeutic cycle within the biofilm microenvironment, in which GOx catalyzes the oxidation of glucose to generate hydrogen peroxide (H 2 O 2 ), inducing bacterial starvation. Subsequently, H 2 O 2 reacts with PPB and L-arg to release oxygen (O 2 ) and biofilm-disrupting NO, thereby alleviating local hypoxia and enhancing antibacterial efficacy. Furthermore, the synergistic action of O 2 and NO reprograms macrophages toward an anti-inflammatory M2 phenotype (approximately 30-fold increase compared to the model group), effectively resolving inflammation and promoting angiogenesis. In vivo studies confirmed that the system achieved > 99.9% biofilm eradication efficiency and accelerated wound healing by 25.6% compared to the model group. Conclusion: This nanoplatform offers a clinically translatable therapeutic strategy for biofilm-associated diabetic wounds by synergistically combining gas therapy and immune reprogramming.
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高影响因子
Journal of Water Process Engineering
·
2026
·
IF 6.6
Chunke Zhao,Yueying Gao,Jiaye Duan,Shiting Li,Bo Zhang,Ke Ma,Longtao Dang,Gen Wang
Polymeric removal of various FPs with concurrent defluorination is achieved in a CuO/PMS system. • FPs are efficiently converted into solid PPO-like polymers with minimal PMS consumption. • 1 O 2 and O 2 •− synergistically drive the polymerization and defluorination of FPs. • Continuous-flow operation over 120 h sustains ∼95% 4-FP removal, confirming practical applicability. Fluorophenols (FPs) are persistent organic pollutants of high concern owing to the extreme stability of their C F bonds. Here we report an oxidative polymerization strategy that enables simultaneous pollutant removal and defluorination by transforming FPs into solid polymers. In a CuO-activated peroxymonosulfate (PMS) system, a superoxide radical (O 2 •− ) and singlet oxygen ( 1 O 2 ) co-mediated oxidation process was established. The system achieved near-complete removal of a series of FPs with different fluorine substitution patterns (2-FP, 4-FP, 2,4-DFP, and 2,3,5,6-TeFP) using minimal oxidant consumption. Polymerization efficiencies ranged from ∼26% to ∼72%, accompanied by significant defluorination (up to ∼74%). Mechanistic studies reveal that FPs are converted into solid poly(phenylene oxide)-like polymers via a nucleophilic aromatic substitution route. Beyond batch performance, the system demonstrated excellent practical viability, with ∼95% removal of 4-FP sustained in a continuous-flow reactor and defluorination remaining as high as ∼47% after prolonged operation. The process also maintained high efficiency under hypersaline and complex water matrices. This integrated defluorination-polymerization approach offers a cost-effective, environmentally benign and operationally stable solution for treating FPs-contaminated wastewaters, shifting the paradigm from conventional mineralization toward sustainable resource recovery. Download: Download high-res image (163KB) Download: Download full-size image
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Jing Lan,Yuran Yu,Luyao Xing,Fujun Miao,Guosheng Shao,Peng Zhang
Self-supporting Cu/TiN nano-furry serves as a superior bifunctional catalyst for ORR/OER. • DFT reveals Cu/TiN heterojunctions facilitate uniform Li 2 O 2 film growth via enhanced LiO 2 affinity. • Carbon-free catalytic system effectively suppresses Li 2 CO 3 byproduct formation, reducing overpotential. • Delivers ultralow overpotential, high areal capacity and superior stability, outperforming Au-based counterparts. The major hindrance against developing high-performance lithium oxygen batteries (LOBs) lies in their infamously sluggish redox kinetic processes involving undesirable parasitic reactions, which results in large overpotential, low capacity and inferior cycling stability. The rational catalyst design is proposed as an efficient strategy to address the above issue. Herein, we have developed a self-supporting nano-furry cathode based on a Cu foam-supported hierarchical nanotube array architecture decorated with Cu/TiN nanojunctions, which contributes to a fresh bifunctional catalytic mechanism for enhancing ORR/OER catalytic kinetics. Such an integrated cathode with Cu/TiN nanojunctions catalyst enables resilient LOBs through minimizing the energy barriers and excessive input energy to form/decompose Li 2 O 2 , outperforming similar Au-based system. DFT simulation elaborates that the Cu-based heterojunctions with favorable LiO 2 -affinity tend to promote surface deposition of uniform Li 2 O 2 film, alleviating disproportionated reaction and achieving remarkably enhanced capacity. Consequently, this rationally designed cathode for LOBs achieved high area capacity up to 25.6 mAh cm −2 with a small overpotential of 0.37 V at 0.1 mA cm −2 , and exceptional cycle stability with over 350 cycles at 0.2 mA cm −2 under a fixed capacity of 0.25 mAh cm −2 . This work provides an insightful approach towards designing efficient, clean and cheap cathode with abundant metal-based catalysts for LOBs. Download: Download high-res image (278KB) Download: Download full-size image
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Sipeng Tian,Baobing Tang,Mingzi Sun,Zhangpeng Xu,Tongtong Zhai,Huanhuan Xing,Bolong Huang,Yunling Liu,Jing Li,Erkang Wang
Classic luminol-H2O2 chemiluminescence (CL) systems are plagued by inherent self-decomposition, which compromises detection reliability. Although luminol-dissolved oxygen systems circumvent this issue, their ultralow reactivity necessitates innovative catalytic microreactor design. Herein, we pioneer a hydrogen-bonded organic framework (HOF) constructed from metal–organic square units and 1,2-propanediamine ligands as terminal hydrogen-bonding sites, achieving an unprecedented 4284-fold CL enhancement in luminol-O2 systems. HOF with porous zeolite-like supramolecular assemblies (ZSA) serves as the coreaction accelerator with strong O2 adsorption at tetrahedral Co–N/O sites that activates O2 to generate reactive oxygen species (ROS). And the kinetic confinement effect provided by the ZSA host with suitable channel and hydrogen-bonding contributions efficiently captured the luminol emitter in the nanocages, shortening electron-transfer pathways and reducing nonradiative energy loss. And the synergistic confinement catalysis enhanced CL performance is linearly related to the O2 adsorption capacity of the ZSA series (ZSA-1, ZSA-3, and ZSA-4). Theoretical calculations further confirmed that the adsorption of O2 and luminol in ZSA-1 optimizes the electron-transfer pathways to promote CL emission performances compared with those of zeolitic imidazolate framework-67 (ZIF-67). This work not only expands the application of HOF in the field of CL but also provides new insights for engineering materials to boost the CL photon emission efficiency of weak luminol-O2 systems.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Shanjian Liu,Jia Liu,Wenjing Zhao,Wei Chen,Chengxizi Zhang,Weiming Yi
To synergistically achieve industrial flue gas resourcing and high-value biomass conversion, a novel process of cellulose-catalyzed nitrogen-rich pyrolysis mediated by oxygen-poor flue gas was proposed in this paper. A systematic investigation of the influences of O 2 concentration (1–7 vol%), temperature (450–600 °C), and the presence of Al-MCM-41 on the cellulose-urea co-pyrolysis for preparing nitrogen-containing compounds (NCCs) was conducted. Under optimal conditions (550 °C, 5 vol% O 2 ), the synergistic effect of mesoporous structure and acid sites of Al-MCM-41 transformed the product distribution from levoglucosan-dominated oxygenated compounds to high-value NCCs mainly comprising nitriles (25.3 %) and pyrazines (25.2 %). The relative content of NCCs reached 92.1 %, showing a 46.1 % increase compared to non-catalytic conditions. The process opens up a green and efficient synergistic path for the co-conversion of industrial waste gas and biomass, demonstrating significant industrial application value.
研究领域:
能源与环境科学
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催化化学
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高影响因子
ADVANCED MATERIALS
·
2024
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IF 27.4
Shuyu Wang,Miaomiao Cheng,Shenghui Wang,Wei Jiang,Feifei Yang,Xiaomei Shen,Lirong Zhang,Xiyun Yan,Bing Jiang,Kelong Fan
Radiotherapy (RT), essential for treating various cancers, faces challenges from tumor hypoxia, which induces radioresistance. A tumor-targeted “prosthetic-Arginine” coassembled nanozyme system, engineered to catalytically generate nitric oxide (NO) and oxygen (O 2 ) in the tumor microenvironment (TME), overcoming hypoxia and enhancing radiosensitivity is presented. This system integrates the prosthetic heme of nitric oxide synthase (NOS) and catalase (CAT) with NO-donating Fmoc-protected Arginine and Ru 3+ ions, creating HRRu nanozymes that merge NOS and CAT functionalities. Surface modification with human heavy chain ferritin (HFn) improves the targeting ability of nanozymes (HRRu-HFn) to tumor tissues. In the TME, strategic arginine incorporation within the nanozyme allows autonomous O 2 and NO release, triggered by endogenous hydrogen peroxide, elevating NO and O 2 levels to normalize vasculature and improve blood perfusion, thus mitigating hypoxia. Employing the intrinsic O 2 -transporting ability of heme, HRRu-HFn nanozymes also deliver O 2 directly to the tumor site. Utilizing esophageal squamous cell carcinoma as a tumor model, the studies reveal that the synergistic functions of NO and O 2 production, alongside targeted delivery, enable the HRRu-HFn nanozymes to combat tumor hypoxia and potentiate radiotherapy. This HRRu-HFn nanozyme based approach holds the potential to reduce the radiation dose required and minimize side effects associated with conventional radiotherapy.
研究领域:
肿瘤学
·
纳米技术
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生物化学
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治疗学
·
放射肿瘤学
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高影响因子
ADVANCED MATERIALS
·
2022
·Vol. 34
·期 40
·2201838
·
IF 32.086
Guiru Sun,Rui Gao,Hailiang Jiao,Dan Luo,Yan Wang,Zexu Zhang,Wei Lu,Ming Feng,Zhongwei Chen
The major challenges for Li-O 2 batteries are sluggish reaction kinetics and large overpotentials due to the cathode passivation resulting from insulative and insoluble Li 2 O 2 . Here, a novel nanodot (ND)-modified electrolyte is designed by employing cobalt bis(trifluoromethylsulfonyl)imide (Co(TFSI) 2 ) as an electrolyte additive. The Co(TFSI) 2 additive can react with discharge intermediate LiO 2 and product Li 2 O 2 to form CoO NDs. The generated CoO NDs are well dispersed in electrolyte, which integrates both the high catalytic activity of solid catalyst and the good wettability of soluble catalyst. Under the catalytis of CoO NDs, Li 2 O 2 is produced and deposits on the cathode together with them. At the recharge process, these well dispersed CoO NDs help to decompose solid Li 2 O 2 at a lower overpotential. The Li-O 2 cells with Co(TFSI) 2 exhibit a long cycle life of 200 cycles at a current density of 200 mA g −1 under a cutoff capacity of 1000 mAh g −1 , as well as a superior reversibility associated with the Li 2 O 2 formation and decomposition. The study is expected to broaden the range of electrolyte additives and provide a new view to developing highly dispersed NDs-based catalysts for Li-O 2 batteries.
研究领域:
材料科学
·
电化学
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高影响因子
Energy Storage Materials
·
2022
·
IF 20.831
Yiqiao Wang,Siyuan Pan,Yong Guo,Shichao Wu,Quan-Hong Yang
Li-O 2 batteries require catalysts to solve the problem of sluggish oxygen-related reaction kinetics. However, the solid catalysts and redox mediators are intrinsically deficient due to poor solid contacts and shuttle problems, respectively. Here, we report lithium phthalimide-N-oxyl (LiPINO) as a phase transfer catalyst (PTC) for promoting Li 2 O 2 formation and its reversible decomposition through the solution-phase reactions. The interaction between LiPINO and oxygen species in the electrolyte enables the high dissolution and stability of oxygen species, the fast charge transfer at liquid-solid interfaces and superior kinetics, and the suppressed side reactions. The efficient bidirectional catalytic activity and high stability of LiPINO capacitate batteries with a highly improved discharge capacity (11400 mAh g −1 ), a largely lowered charge potential (3.14 V) and an extended cycle life (more than 200 cycles) both in O 2 and air. Our understanding of the phase-transfer catalysis towards the Li-O 2 electrochemistry and the discovery of the PTC with superior activity and stability provide deep insights into the design of the most reliable catalysts for Li-O 2 batteries.
研究领域:
电化学
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能源材料
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物理化学
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电池技术
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催化化学
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高影响因子
Surfaces and Interfaces
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2024
·
IF 5.7
Xinru Wang,Qiuxu Chen,Daming Yang,Ying Li,Dongxu Yin,Baoxin Ni,Wei Lu,Guiru Sun,Ming Feng
Photo-assisted electrochemical strategy has garnered interest for its ability to diminish the large overpotential of lithium-oxygen batteries (LOBs). Nonetheless, creating a sophisticated photocatalyst capable of absorbing a wide spectrum of light and dramatically lowering the recombination rate for electron-hole pairs presents a significant challenge. Herein, we design an Ag-doped ZnO (Ag@ZnO) hollow nanosphere as photocatalysts to boost the reaction dynamics of photo-assisted LOBs. The Ag@ZnO hollow nanospheres, featuring a mesoporous structure, are beneficial for improving O 2 transport and enabling the retention of discharge products. Additionally, the ability to absorb light and the efficiencies of electron-hole separation are enhanced for Ag@ZnO as a result of Ag doping. The electrons generated by photoexcitation facilitate the conversion of O 2 to produce Li 2 O 2 during discharge, whereas during charging, the presence of holes causes the decomposition of Li 2 O 2 . Consequently, a significantly low overpotential of 0.22 V, ultrahigh cycling efficiency of 93.73%, and good reversibility was achieved for the photo-assisted LOBs using Ag@ZnO. We consider that this work can offer a reliable strategy to improve electrochemical kinetics and contribute to the development of efficient photocatalysts for photo-assisted LOBs.
研究领域:
材料科学
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能源存储与转换
·
光电化学
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Bingbing He,Qinyuan Wang,Ying Chen,Weifeng Yao
The development of a cost-effective method for synthesizing hydrogen peroxide (H2O2) holds significant importance. Here, we introduce a novel catalyst, a nitrogen-doped carbon-loaded nickel nanoparticle catalyst (Nix NPs@N–C), tailored for efficient H2O2 production via the two-electron oxygen reduction reaction. Benefiting from the synergistic interplay between highly active nickel nanoparticles and nitrogen-doped carbon, the optimal Nix NPs@N–C catalyst demonstrates an outstanding 78% selectivity for H2O2 at 0.5 V vs a reversible hydrogen electrode (RHE), yielding approximately 387 mmol g–1 h–1 in a 0.1 M KOH alkaline solution at 0.3 V vs RHE. With its utilization of cost-effective raw materials, streamlined synthesis method, and exceptional catalytic performance, the Nix NPs@N–C catalyst emerges as a promising candidate for electrocatalytic H2O2 synthesis in practical applications.
研究领域:
化学
·
材料科学
·
环境科学
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Yu-Zhen Xu,Yu-Le Wang,Yu-Dong Shan,Song-Hai Wu,Yong Liu,Xu Han
Selective oxidation of cyclohexene (Cy) to cyclohexene oxide (Cy-ep) by O2 under solvent- and initiator-free conditions is a challenge in chemical processes, which is still constrained by its low selectivity (theoretical selectivity of 50.0%). Given the low epoxide selectivity (<20.0%) of single metal catalysts, we propose a relay catalysis strategy on the oxidation of Cy to Cy-ep with high selectivity by the spherical Mg–Mo bimetallic oxide (MMO). Such a relay catalyst exhibits a desirable Cy conversion of 31.0% and a high selectivity of 49.3% toward Cy-ep. Meanwhile, the high stability and reusability of MMO also indicate its potential to be used for industrial scale-ups. A series of characterizations and DFT calculations reveal that the negatively charged lattice oxygen in [MgII–O–II] adsorbs allylic H of Cy to weaken the bond energy of the allylic C–H bond and form Cy•, and then Cy• rapidly traps O2 to give CyOO•, which subsequently abstracts H from allylic C–H of another Cy to form 2-cyclohexene-1-hydroperoxide (Cy-OOH) and Cy•, achieving the propagation cycle. On the other hand, the Mo(VI) site in MMO catalyzes the produced Cy-OOH peroxo, which then oxidizes Cy to Cy-ep and 2-cyclohexene-1-ol. This work provides insight into the relay catalyst for the epoxidation of olefin with O2 with high selectivity under solvent- and initiator-free conditions.
研究领域:
化学工程
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材料科学
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催化化学
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高影响因子
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2025
·
IF 2
Zhang Dongbo,Tang Xinyue,Wang Ning,Xiao Mingwei,Yan Jiangrong,Zhang Yongsheng
High-entropy oxides used as thermal barrier coating materials have attracted considerable attention from scientific communities owing to their unique properties, such as low thermal conductivity and good stability at high temperatures. In this study, a new (La 0.2 Gd 0.2 Zr 0.2 Ce 0.2 Ho 0.2 )O 2-δ ((LGZCH)O) fluorite-structured high-entropy oxide was successfully synthesized through a solid-state reaction at 1400 °C. The resulting material demonstrated good phase stability after sintering at high temperatures. The microstructure, microscopic morphology, ionic valence, compositional distribution, optical properties, thermal conductivity, thermal expansion properties, and mechanical properties of (LGZCH)O were investigated. X-ray diffraction results showed that the (LGZCH)O fluorite-structured high-entropy oxide exhibited good stability during sintering at different temperatures with an optimum sintering temperature of 1580 °C. Ce 4+ converted to Ce 3+ at high temperatures. Scanning electron microscopy results showed that the material had a high porosity of approximately 28.9% after sintering at 1580 °C. (LGZCH)O had a higher infrared radiation emissivity of 82.2%-87.6% in the range of 2.5-6.0 μm indicating that it had better thermal radiation shielding performance. After porosity modification, the thermal conductivity ranged from 1.27 to 1.00 W m −1 K −1 from room temperature to 1000 °C, which is considerably lower than that of yttria-stabilized zirconia. Additionally, (LGZCH)O exhibited low coefficients of thermal expansion measuring 9.65 × 10 −6 K −1 and 10.13 × 10 −6 K −1 at 1000 and 1200 °C, respectively. The hardness and Young’s modulus of the bulk (LGZCH)O measured via nanoindentation tests were 8.86 GPa and 153.98 GPa, respectively, which are marginally inferior to those of YSZ. Therefore, (LGZCH)O can be considered a promising candidate material for thermal barrier coatings.
研究领域:
材料科学
·
能源工程
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高影响因子
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