CERAMICS INTERNATIONAL
·
2025
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IF 5.6
Changjian Feng,Xin Ning,Fang Liu,Lilan Huang,Hongqiang Wang,Lin Lv,Jiao Li
Flexible hydrophobic Al 2 O 3 fiber membranes doped with rare earth elements (La, Sm, Ho) were successfully fabricated via electrospinning, and the impact of rare earth doping on their mechanical and surface properties was systematically investigated. The incorporation of rare earth elements effectively suppresses Al 2 O 3 grain growth, relieves grain boundary stress, and consequently enhances the flexibility and tensile strength of the membranes. Notably, the Ho-Al 2 O 3 membrane exhibits the best flexibility and tensile strength (1.08 MPa). Furthermore, rare earth doping induces a transformation to hydrophobic surfaces for the La-Al 2 O 3 , Sm-Al 2 O 3 , and Ho-Al 2 O 3 fiber membranes, as evidenced by water contact angles of 149°, 137°, and 142°, respectively. This hydrophobicity is attributed to the formation of rare earth oxides on the fiber surface, which increases hydrocarbon affinity and lowers surface energy. The resulting doped membranes demonstrate excellent antifouling performance, achieving high permeation flux and separation efficiency in oil-water separation. The La-Al 2 O 3 membrane exhibits the highest flux (2921 L/(m 2 ·h)) and efficiency (98.4 %), owing to its superior surface hydrophobicity. These findings provide a mechanistic foundation for tailoring the microstructure and wettability of ceramic fiber membranes through rare earth doping, offering a promising strategy for advanced oil-water separation.
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高影响因子
Drug Delivery and Translational Research
·
2025
·
IF 5.5
Chen Yao,Lu Meiting,Zhang Lu,Chang Errong,Zhu Qinglan,Xu Qianlan,Gao Ziting,Pan Dongmei,Shen Chunyan,Liu Qiang,Zuo Zhong,Jiang Cuiping
Atherosclerosis (AS), a chronic inflammatory disease linked to oxidative stress and lipid imbalance, remains a major cardiovascular threat. Traditional herbs Salvia miltiorrhiza and Carthamus tinctorius exhibit multi-target anti-AS potential, yet their compositional complexity limits clinical translation. This study aimed to systematically identify core anti-AS components from these herbs and enhance their anti-AS efficacy via machine learning-aided screening and nanotechnology-driven codelivery. We initially pioneered a machine learning-aided hybrid strategy integrating network pharmacology and quantitative activity relationship (QSAR) modeling to identify four core anti-AS polyphenols (i.e., salvianic acid A, salvianolic acid B, protocatechuic acid, and hydroxysafflor yellow A). Subsequently, a quaternary metal-phenolic network (SSPH-MPN) was engineered for plaque-targeted codelivery, optimized via the median-effect principle for achieving a synergistic effect based on ROS scavenging efficacy. The optimized SSPH-MPN was characterized by a series of studies, including molecular dynamics simulations, UV, DLS, TEM, FTIR, XPS, and ICP-MS. The anti-AS effect of the optimized SSPH-MPN was evaluated by monitoring oxidative status (ROS levels, antioxidant enzymes SOD, GSH-Px, MDA, T-AOC), inflammatory markers (IL-1β, IL-6, TNF-α), lipid metabolism (DiI-oxLDL uptake, cholesterol efflux, blood lipid levels, lipid accumulation), and plaque areas. The results demonstrated that the optimized SSPH-MPN showed great efficiency in inhibiting lipid uptake and accumulation, and mediating cholesterol efflux in RAW 264.7 cells, and exhibited improved lipid metabolism, attenuated oxidative stress and inflammation, thus acquired diminished plaque area in apoE -/- mice. Furthermore, biocompatibility was assessed through hemolysis, cytotoxicity assays, and in vivo safety studies, confirming its suitability as a safe therapeutic agent. In conclusion, this work not only identified four anti-AS polyphenols from traditional herbs but also established an MPN-based co-delivery system for synergistic anti-AS therapy, providing a comprehensive paradigm from drug discovery to formulation development. Graphical
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yunjia Wang,Yunpeng Zhang,Shouping Xu,Zehao Chen,Lanfang Wen,Pihui Pi
Petroleum operations produce emulsified oil-water mixtures that pollute the environment. Efficient oil recovery and wastewater purification are crucial. Extreme-wettability single-channel separators often form barrier layers from intercepted phases, reducing efficiency and flux stability. In this study, a composited sponge (HO-HL@MS) with dual oil-water channels was constructed by stepped-interlocking of a superoleophilic/superhydrophobic torus frustum sponge and a superhydrophilic/oleophobic circular frustum sponge. During the demulsification separation of oil-in-water emulsions, the superhydrophilic/oleophobic component facilitates emulsion demulsification and allows the aqueous phase to permeate, while the superoleophilic/superhydrophobic section enables timely discharge of clogging oil phases, conversely for during water-in-oil emulsions. This synergistic “demulsification-removal” mechanism allows simultaneous oil and water discharge, fundamentally resolving the issues of clogging and flux attenuation caused by the retention of the intercepted phase in traditional single-channel systems. It demonstrates excellent demulsification efficiency for both water-in-oil and oil-in-water emulsions. For water-in-oil emulsions, a permeation flux above 3000 L·m −2 ·h −1 with a separation efficiency exceeding 97.9 % after continuously processing 800 mL was achieved. For oil-in-water emulsions, a flux over 6000 L·m −2 ·h −1 with efficiency higher than 98.9 % was obtained. When treating industrial emulsions with high water content (60 % aqueous phase), it retained 98.37 % separation efficiency and a flux of 1803 L·m −2 ·h −1 for water-in-oil systems, and 98.6 % efficiency with a flux of 7279 L·m −2 ·h −1 for oil-in-water systems, demonstrating exceptional anti-fouling capability and industrial application potential. The composited sponge achieves efficient, stable, and long-term separation of various oil-water mixtures, emulsions, and industrial-grade emulsions, thus providing a new strategy for complex emulsion separation.
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Surfaces and Interfaces
·
2025
·
IF 6.3
Shengye Chen,Kunquan Li,Yongxian Zhou,Xinyao Xie,Zeyuan Lu,Xiaojing Su,Xiaojuan Ao,Wenjian Wu
The development of super-wetting membranes has become a promising treatment material for the emulsions separation and heavy metals absorption. However, it is often limited by the slow separation flux and the non-degradable material in practical applications. Based on this, this paper proposed a superhydrophobic biodegradable zein/chitosan/polyvinyl alcohol @ carnauba wax modified titanium dioxide (ZCP@CW/TiO 2 -s) composite membrane for emulsion separation and heavy metal adsorption. The prepared ZCP@CW/TiO 2 -s membrane demonstrated outstanding superhydrophobicity, featuring a WCA of 154 o and a rolling angle as low as 3 o . Surprisingly, the composite membrane exhibited rapid emulsion separation performance under the low pressure (0.1 bar), with a flux of 23524 L·m -2 ·h -1 ·bar -1 and separation efficiency exceeding 98.2 %. The ZCP@CW/TiO 2 -s membrane achieved a high heavy metal adsorption capacity, particularly for Cu 2+ ions, with an adsorption capacity of 149.93 mg/g. The composite membrane also maintained a stable separation performance under 25 times of wear resistance test. In addition, the ZCP@CW/TiO 2 -s membrane had a great photodegradation ability, which could remove organic pollutants adsorbed on the composite membrane. Meanwhile, the composite membrane could be buried in soil after disposal, enabling rapid degradation and preventing secondary pollution. Moreover, the composite membrane is capable of effectively separating emulsions and removing heavy metal ions, thereby tackling the problem of complex oily wastewater pollution. Therefore, the biodegradable composite membrane can be used as candidate materials for future sustainable development.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
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IF 9
Jinwei Xue,Zhongning Cao,Yaohua Huang,Yu Li,Yiqian Liu,Qiang Yang
The development of efficient oil-water separation technology has gained significant importance in environmental pollution control and resource recovery. Inspired by the hydrophilic/superhydrophobic patterned surface of Namib Desert Beetles, this study designs a grid-like heterogeneous wettable microchannel device (HWMD) by fabricating heterogeneous wettable plates with tunable wettable patterns. The HWMD combines wettability gradient regulation, spatial confinement, and flow field control to enhance the coalescence-collection of oil droplets, enabling demulsification and separation of oil-in-water (O/W) emulsions. The experimental results revealed that under a flow rate of 3 mL/min and a channel height of 500 μm, the HWMD successfully separated various surfactant-stabilized O/W emulsions, reducing the oil content in the filtrate to a range of 32‐80 mg/L after recycling, though its capture efficiency was reduced for droplets smaller than 15 μm. The simple preparation process and independent operation capability of HWMD provide a practical and efficient strategy for the optimization of separators, demonstrating considerable potential for industrial applications.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Rongdi Wu,Jitong Han,Weichao Chen,Xin Yu,Ruixin Gao,Chunming Zhang
A biomimetic, fluorine-free, three-layer aqueous coating for cotton─composed of an Fe2+/Cu2+-catalyzed polydopamine (PDA) primer, a chitosan–SiO2 (CS) aerogel midlayer, and a thin polydimethylsiloxane (PDMS) overcoat─was developed to impart durable superhydrophobicity, rapid photothermal self-healing, antibacterial activity, and efficient oil–water separation. Treated cotton exhibited a static water contact angle (WCA) of 170° and retained a WCA of >155° after 2500 Martindale abrasion cycles or 30 ISO 105-C06 wash cycles; the WCA was restored to ≥160° after ambient storage or within 20 min under natural sunlight as surface temperatures approached ≈50 °C. PDA-mediated Cu2+ chelation (5 mM) produced >99% inhibition of Escherichia coli and Staphylococcus aureus; gravity-driven oil–water separation efficiencies exceeded 98% with >96% retention after 12 cycles. Preliminary scalability and environmental impact analyses, including material inventories and PDMS release estimates, support the potential for industrial translation. This fluorine-free, beetle-exoskeleton-inspired strategy offers a scalable route to multifunctional, sustainable textile finishing and environmental remediation.
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高影响因子
Food Bioscience
·
2025
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IF 5.9
Yingwei Liu,Yunpeng Sun,Ting Zhou,Xiao Huang,Guokai Wang,Lijuan Sun
Swietenia macrophylla King, a medicine food homology, has garnered attention for the hypoglycemic and hypolipidemic activities of its fruit in the improvement of metabolic dysfunction-associated steatotic liver disease (MASLD), yet the glucolipid regulating properties of its leaf remains unexplored. The study sought to examine the pharmacological mechanisms underlying the lipid-lowering effects of Swietenia macrophylla King leaf extract (SLE) and its active constituent senegalension B (one of 31 limonoids in SLE). Glucolipid regulation by SLE and active constituent was evaluated through cellular triglyceride content and peripheral glucose levels in primary mouse hepatocytes (PMHs), SLE dose-dependently reduced lipid accumulation in the range of 23.65±3.41% to 37.39±2.50%, validated by Oil Red O staining. Network pharmacology and RNA sequencing identified SREBP-1c/FASN axis as the key mechanism by which SLE improved lipid accumulation in PMHs, consistent with senegalension B. RT-qPCR and Western blot showed that SLE (40 μg/mL) decreased the lipid synthesis regulator SREBP-1c mRNA and protein levels by 60.69±1.69% and 48.07±11.83%, respectively, whereas senegalension B (40 μM) achieved 55.42 ±2.29% and 34.34±8.49% inhibition. Dual-luciferase reporter assays revealed that senegalension B suppressed SREBP-1c promoter activity in Hep G2 cells. Molecular docking suggested a potential interaction with SREBP1, consistent with molecular dynamics simulation comparing binding affinity and stability with LXRα, indicating that senegalension B may exert lipid-lowering activity by targeting key proteins involved in lipid synthesis, such as SREBP-1c. This study elucidated the mechanisms and potential of SLE and senegalension B in regulating MASLD through in vitro investigation, expanded the utilization of Swietenia macrophylla King resources, and provided a candidate plant-derived compound for dietary therapy.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
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IF 9
Lei Cao,Yu Sun,Hongpeng Liu,Huiming Lin,Lingfei Li
The efficient separation of emulsified oily wastewater was of significant practical importance. However, it was hindered by factors such as low separation flux and severe membrane fouling, making the separation process highly challenging. Inspired by the in-situ nanocomposite strategy mediated by bionic mussel adhesion, this study used oxidants to induce rapid deposition of dopamine (DA) and fulvic acid (FA) on the polyvinylidene fluoride (PVDF). Combined with in-situ growth technology, ZIF-8 nanoparticles were anchored on the coating surface to construct a PVDF-based composite membrane with heterogeneous wettability structure was constructed which were composed of lipophilic ZIF-8 protrusions, hydrophilic layer, and PVDF basement membrane. In the process of separating oil-bearing lotion, the raised ZIF-8 helps to capture and collect oil droplets, and works in synergy with the screening effect of the hydrophilic layer. The demulsification capability was enhanced by the unbalanced force derived from the wettability discrepancy between the protrusions and the substrate, thus enabling efficient separation of emulsions. The optimized composite membrane efficiently separates light/heavy emulsions, with a rejection rate exceeding 99.4 %. The n-hexane-in-water emulsion maintained a high recovery flux ( FRR ) of 92.3 % after 30 cycles. Molecular dynamics simulations confirm that the membrane's hydrophobic/hydrophilic architecture actively promotes emulsion demulsification and oil droplet separation. This study provides precious view into the design of emulsion separation membranes and advances in separation technologies.
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JOURNAL OF CONTAMINANT HYDROLOGY
·
2025
·
IF 4.4
Junjie Fu,Jiaoxia Sun,Jiang Fu,Yinghao Xie,Quancai Liang,Jianxin Fan
Oily wastewater poses a severe threat to aquatic ecosystems and public health, while the massive accumulation of waste polyester (PET) textiles exacerbates environmental pollution. To address these challenges, we developed a sustainable approach for transforming discarded PET fabrics into functional materials for efficient oil-water separation. A superhydrophilic modification layer was constructed on PET surfaces via co -deposition of polydopamine (PDA) and polyethyleneimine (PEI). Under optimized conditions (PDA/PEI mass ratio = 1:1, deposition time = 24 h), the modified PET fabric exhibited exceptional superhydrophilicity (water contact angle = 0°) and underwater superoleophobicity (oil contact angle = 161.9°). The material demonstrated robust chemical stability, maintaining >97 % separation efficiency and a stable flux of (20,570.89 ± 1213.74) L·m −2 ·h −1 across a wide pH range (2−12). It achieved high separation efficiencies (>98.3 %) for various oils (n-hexane, dichloromethane, and isooctane) and retained >98 % efficiency after 10 reuse cycles in neutral medium. This work presents a simple yet effective strategy for upcycling waste PET into high-performance oil-water separation materials, offering a sustainable solution for environmental remediation and resource recovery.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yunhao Pan,Tiancheng Zha,Yanan Zhu,Yibo Zhang,Xunming Tian,Aiwen Wang,Rui Wang,Dongmei Liu,Wei Wang,Shouzhu Li
Wastewater treatment for oil–water emulsions is a critical challenge in the environmental and energy sectors. The oil–water separation based on super-wettability membrane has received widespread attention. However, traditional membranes struggle with severe irreversible fouling due to interactions between emulsified oil and hydrophilic organic compounds in practical wastewater, problematizing continuous separation. Here, a non-synthetic polymer membrane with easy-washability after fouling is reported, which shows full recovery of original separation efficiency. The membrane is composed of cellulose blended with sepiolite, which encapsulates and infiltrates the silica nanofiber membrane through silanol condensation and capillary action, then forms a “tight top, bottom, and inside” flexible fusion structure in one step. The dynamic water absorption capability of sepiolite and cellulose can create an enhanced hydration layer on the dense membrane surface, this allows the membrane to maintain structural integrity and stable separation efficiency even in oil emulsion wastewater containing hydrophilic organic compounds. Also, the membrane may undergo assimilative healing by interacting with pollutants to form part of the membrane structure. So, it shows great performances for extended separation, withstanding oil intrusion pressures over 600 kPa, and nearly 100 % removal for oil emulsions. This promising material offers a universal modification strategy with broad wastewater treatment applications.
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高影响因子
LIVER INTERNATIONAL
·
2025
·Vol. 45
·期 4
·e70053
·
IF 5.2
Peng Ma,Hao Ou,Junze Cai,Yuanli Zhang,Yu Ou
Background & Aims G protein-coupled receptors (GPCRs) are important potential drug targets for the treatment of metabolic disorders. The D2 dopamine receptor (DRD2), a GPCR receptor, is a member of the dopamine receptor family. However, the role of DRD2 in regulating lipid metabolism, especially in hepatic steatosis, is unclear. Methods Eight-week male mice were fed HFHC/MCD to induce the MASH model. AAV2/8 containing the TBG promoter was used to knock down and overexpress DRD2 in mouse liver. Co-immunoprecipitation, Western lotting, immunofluorescence, and immunohistochemistry were used to investigate the mechanisms and screen DRD2 antagonists. Results The study found that activation of PKC leads to the elevation and internalisation of DRD2 in a high-fat environment. Knockdown of DRD2 in mouse liver can effectively interfere with the progression of MASH, while overexpression of DRD2 significantly aggravates the process of MASH. The study on the mechanism of DRD2 regulating lipid metabolism found that the internalisation of DRD2 could lead to dephosphorylation of pAKT (T308) by binding to β-arrestin2 and pAKT, thereby inducing ubiquitin-dependent degradation of AMPK and exacerbating steatosis. L-741626, a DRD2 antagonist, was found to interfere with the internalisation of DRD2 in a high-fat environment. It has been shown that L-741626 can treat MASH by regulating the AKT-AMPK signalling axis in vitro and in vivo. Conclusions In conclusion, this study demonstrated that internalisation of DRD2 in a high-fat environment aggravated MASH progression through the AKT-AMPK signalling axis. Furthermore, L-741626, as a DRD2 antagonist, has the potential to treat MASH.
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高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Jingying Xu,Xianglong Li,Wanjing Li,Mengyao Zhao,Teng Hou,Jing Zhou,Bin Yang
Complex pollutants in wastewater, such as recalcitrant oils, organic dyes, and antibiotics, have posed significant environmental challenges that adversely affect ecosystems and human health. Herein, we successfully fabricated hierarchical bioinspired polyacrylonitrile (PAN)/Zein/bismuth oxychloride (BiOCl) fibrous membranes featuring ultrafast liquid transport channels and petal-textured energy conversion layers by integrating centrifugal spinning with the in-situ growth of BiOCl nanosheets. The membranes demonstrate an exceptional capability to treat oil/water mixtures and simultaneously remove soluble dyes, thereby offering a viable solution to the issues mentioned above. The strategic construction of liquid channels, coupled with the BiOCl photocatalytic layers, optimized the water transport pathway in the oil/water mixture and facilitated the formation of an effective hydrated anti-fouling layer, achieving a separation flux as high as 6498 L·m −2 ·h −1 . Additionally, the membranes exhibited outstanding pollutant degradation performance, with removal efficiencies of 94.1 % for Rhodamine B and 64.5 % for TC-HCl. This work comes up with new insight for the rational design of multifunctional fibrous membranes, opening a window for the prospect of treating environmental wastewater.
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高影响因子
危险品化学品经营许可证（带存储）