ACS Applied Bio Materials
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2025
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IF 4.7
Jinyan Du,Jinrui Hou,Shiji Liu,Xinyue Wu,Liangde Hu,Wenjiang Xu,Shujuan Zhuo
Slow or noticeably delayed wound healing is frequently intimately linked to bacterial infection and excessive reactive oxygen species (ROS), while the inappropriate usage of antibiotics fuels the rise of bacterial resistance. The innovative materials are desperately needed to eliminate bacteria and effectively accelerate wound healing. In this work, a curcumin-loaded silver-based metal–organic framework (Cur/Ag-MOF) composite nanomaterial was developed, which exhibited good antimicrobial activity, biocompatibility, and drug resistance. Meanwhile, surface-loaded curcumin can effectively eliminate excess free radicals and promote wound healing due to its antioxidative and ROS scavenging properties. Additionally, it was discovered that the application of Cur/Ag-MOF to the site of skin trauma significantly sped up the process of wound closure in mice used as subjects. These findings highlighted its great potential for treating bacterial infection-induced skin injuries and aiding the healing and reconstruction of skin tissues.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yao Lu,Ying Sun,Yamin Dong,Zhenyong He,Yiwen Xiao,Boliang Gao,Du Zhu
Multifunctional xylanases present considerable potential across various sectors, including the food, chemical and biorefinery industries. Herein, a novel trifunctional xylanase Xyn1.28, identified from the lignocellulose-degrading endophytic fungus Chaetomium globosum DX-THS3, exhibits high xylanase activity (230.37 ± 2.69 U/mg) along with notable endo -glucanase activity and rare arabinofuranosidase activity, which accounted for 17–33 % and 43 % of the xylanase activity, respectively. When combined with commercial cellulase cocktail Celic CTec2 at a 1:10 activity ratio, a significant synergistic effect enhanced sugar release by 27.5 % during unpretreated corn straw degradation. Alkali-treated corn cob degradation efficiency was also improved, reducing the time to achieve maximum sugar yield by 12 h. The sugar release profiles during the initial degradation stages indicated that Xyn1.28 plays a crucial role in the initial stages of hydrolyzing biomass. Furthermore, molecular docking analysis indicated that the unique site GLN-74 may significantly influence the arabinofuranosidase activity of Xyn1.28 by forming a hydrogen bond with HIS-108. Experiments involving the mutated GLN-74 further confirmed the critical role of this site in the arabinofuranosidase activity of Xyn1.28. Overall, this rare multifunctional endo -xylanase is well-positioned to facilitate the development of efficient lignocellulose degradation systems and advance cost-effective biomass conversion.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Chongqing Yu,Qiqi Lu,Yichun Wang,Zujiang Liu,Sathishkumar Gnanasekar,Ugo D’Amora,En-Tang Kang,Liqun Xu,Jie Xu,Xi Rao
Methicillin-resistant Staphylococcus aureus (MRSA) wound infections remain a significant global challenge and demand new-generation biomaterials to eliminate bacterial infections and promote rapid wound healing. Although the nanozyme is a promising approach, the restricted unimodal bactericidal functionality hinders its efficacy in treating complex wound infections. In this study, copper-tannic acid (Cu-TA) nanozymes (NMs) with multifunctional properties were developed for the treatment of bacterial infections and biofilms via cuproptosis-like cell death. The as-prepared Cu-TA demonstrated peroxidase-like (POD-like) activity, generating substantial amounts of hydroxyl radicals (•OH). In vitro studies revealed that Cu-TA efficiently disrupted bacterial biofilms, while in vivo experiments demonstrated its ability to promote anti-inflammatory responses, angiogenesis, collagen synthesis, and cellular proliferation. Transcriptome sequencing revealed that bacterial reactive oxygen species (ROS) caused damage to the cell membrane and disrupted metabolic processes. Furthermore, copper overload triggered lipid peroxidation (LPO) buildup and interfered with the tricarboxylic acid (TCA) cycle, culminating in cuproptosis-like bacterial death. Overall, this study successfully developed a spindle-shaped, multifunctional nanozyme for combating bacterial infections through cuproptosis-like cell death while promoting infected wound healing. The results validate the clinical potential of Cu-TA NMs for treating MRSA-infected wounds.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
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IF 4.9
Wentao Ma,Shiwen Gong,Xianbiao He,Die Hu,Bo Cheng,Jing Yang,Binbin Li,Xinyu Wang
Thrombosis is a critical marker of cardiovascular diseases such as stroke and myocardial infarction. Timely diagnosis and dissolution of thrombi can significantly reduce patient mortality risk. Theranostic nanoparticles with targeting capabilities offer a promising solution to this issue. We developed fucoidan-modified PLGA nanoparticles loaded with indocyanine green (ICG) and lumbrokinase (LK) (FCP-ICG@LK NPs) to achieve integrated diagnosis and treatment of thrombotic diseases while minimizing hemorrhagic risks. Targeting experiments demonstrated the affinity of fucoidan for P-selectin. In a mouse model of carotid thrombosis, FCP-ICG@LK NPs demonstrated excellent diagnostic and monitoring capabilities while effectively dissolving thrombi under near-infrared light. Compared with free LK, FCP-ICG@LK NPs showed better thrombolysis effects at the same dose. Furthermore, bleeding risk assessment experiments indicated that FCP-ICG@LK NPs do not induce hemorrhagic risks. FCP-ICG@LK NPs showed no significant cytotoxicity or hemolysis. These results indicate that fucoidan-modified PLGA drug-loaded nanoparticles are a promising thrombus-targeted theranostic agent.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Shuyang Gan,Tianran Zheng,Jiayu Miao,Yunhua Bai,Xiong-Fei Zhang,Jianfeng Yao
Escalating environmental concerns over plastic packaging have prompted extensive researches into renewable bio-based alternatives. In this study, bacterial cellulose (BC) films modified with natural Sapindus saponin (SS) and gelatin were developed as multifunctional active packaging materials for fruit preservation. SS and gelatin gave the composite a denser and more stable structure via the formation of covalent crosslinking, thereby strengthening the mechanical properties of the bio-based films (BFs). The tensile stress of the designed film (BF3) was 28.21 MPa, which was 89.93% greater than that of the BC film. Compared with the control, the BFs had better thermal stability and greater barrier properties, coupled with good natural affinity. Additionally, owing to the presence of SS, the BF3 showed remarkable ultraviolet-blocking capacity (92.24% UVA and 99.71% UVB shielding rates), antioxidant activity (68.47% DPPH and 74.38% ABTS scavenging activities), and anti-bacterial property ( Escherichia coli , 6.4 mm; Staphylococcus aureus , 22.8 mm), which corresponded to the excellent freshness preservation ability. The fresh blueberries packaged with BF3 had less weight loss, reduced postharvest decay, and delayed softening, thus achieving a longer shelf life. In summary, BFs have a promising application prospect as a sustainable and effective packaging material for fruit preservation.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Tangjun Ren,Junyu Meng,Mengke Sun,Qi Zhang,Chenyang Yao,Haonan Wu,Xinting Wang,John Osilama Thomas,Liuliu yang,Enpeng Gu,Xi Wang,Jian Yang
As a physiological process maintaining skin integrity, wound healing is often disrupted by complex microenvironments, infection, and abnormal pH levels, leading to delayed healing. Additionally, irregularly shaped wounds are complex enough to cover adequately with traditional dressings. To address these issues, we developed a functional hydrogel via the Schiff base reaction between chitosan (CS) and difunctional telechelic-polyethylene glycol (DT-PEGn) of varying molecular weights, which was subsequently loaded with ciprofloxacin (CIP) to form a CS@DT-PEGn@CIP composite system. The results demonstrate that DT-PEGn of different molecular weights effectively modulate the hydrogel's swelling ratio, mechanical properties, injectability, self-healing capacity, and drug release characteristics, thereby conferring tunable functional advantages in wound repair. In vitro antibacterial assays and a rat full-thickness wound model further confirmed the outstanding efficacy of CS@DT-PEGn@CIP in significantly inhibiting bacterial growth and accelerating wound healing. Notably, the CS@DT-PEG6000 hydrogel containing only one-third of the free CIP dose exhibited superior therapeutic outcomes compared to free CIP alone, highlighting the high efficiency and safety of the composite system. In summary, this study systematically demonstrates the unique advantages of CS@DT-PEGn hydrogel in promoting wound healing, including its responsiveness to microenvironmental pH, antibacterial properties, and excellent conformability to wound surfaces. These findings provide novel strategies and potential applications for clinical wound management.
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JOURNAL OF SOLID STATE CHEMISTRY
·
2025
·
IF 3.5
Le Chen,Wen-Qing Zhang,Lin Nie,Jian-Jun Yin,Qun Chen,Pengxiang Qiu,Ming-Yang He,Zhi-Hui Zhang
Metal-organic aerogels derived from ZIF-8 frameworks were developed for xylene isomer separation, demonstrating unique structural and adsorptive properties. The incorporation of ZIF-8 transformed non-porous agar (AG) aerogel into a hierarchically porous composite, albeit with a reduced surface area compared to pure MOFs. Vapor-phase adsorption and breakthrough experiments revealed exceptional p -xylene selectivity ( p X/ o X = 19) in ZIF-8/AG composites, though with diminished adsorption capacity relative to pristine ZIF-8. While exhibiting substantial liquid-phase adsorption, the composite showed limited gas-phase selectivity, indicating hydrogen-bonding-mediated adsorption mechanisms. This work highlights the correlation between selectivity and capacity in MOF-based aerogel adsorbents for the separation of aromatics.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
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IF 5.2
Tiancheng Xiong,Yang Han,Zhiyun Qi,Sha Guo,Xueyan Hu,Cui Wang,Lingkun Li,Tianyu Ma,Jingyi Chen,Jinghui Li,Jing Han,Hao Wu
The COVID-19 pandemic has underscored the significant challenges of vaccine distribution, particularly to low- and middle-income countries. Even when vaccines are made available through purchases or donations, issues such as insufficient trained medical personnel and inadequate infrastructure impede their widespread use. To address these challenges, we propose the Microneedle & Film-Forming Gel Transdermal Delivery Strategy (MFT strategy), which combines the minimally invasive nature of microneedles with the stability of film-forming gels that can be stored at room temperature. This strategy aimed to simplify vaccine production, reduce logistical burdens, and improve the efficiency of transdermal vaccine delivery while generating strong immune responses. In this study, we used ovalbumin as a model antigen and developed microneedles from methacrylic acid-modified hyaluronic acid, polyvinylpyrrolidone, and polyvinyl alcohol, in conjunction with a polyvinyl alcohol-borax (PVA-B) film-forming gel. In vitro experiments demonstrated that the MFT strategy has achieved an efficiency improvement of 202.75 % compared to previously reported strategies. Besides, PVA-B film forming gel displayed strong antimicrobial properties and effectively stabilized proteins over 30 days at 25 °C, preserving the antigenic structure essential for vaccine efficacy. In vivo tests revealed that the MFT strategy induced humoral immune responses comparable to those achieved by intramuscular injection, with histological analysis confirming good skin tolerance and safety. Overall, the MFT strategy represents a promising vaccine delivery method with substantial clinical potential.
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WATER RESEARCH
·
2024
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IF 11.4
Yuyang Yao,Yueyue Lu,Jingwen Xu,Jiacheng Yu,Liang Guo,Heda Ding,Jian Li,Junbin Liao,Edison Huixiang Ang,Zhenlu Shen,Jiangnan Shen
Membrane-contamination during electrodialysis (ED) process is still a non-negligible challenge, while irreversible consumption and unsustainability have become the main bottlenecks limiting the improvement of anion exchange membranes (AEMs) anti-contamination activity. Here, we introduce a novel approach to design AEMs by chemically assembling 4-pyndinepropanol with bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) in an electrochromic-inspired process. Subsequently, the co-mingled TiO 2 @Ag nanosheet with the casting-solution were sprayed onto the surface of the substrate membrane to create a micrometer-thick interfacial layer. The addition of Ag nanoparticles (NPs) enhances the active sites of TiO 2 , resulting in stronger local surface plasmon resonance (LSPR) effects and reducing its energy band gap limitation (From 3.11 to 2.63 eV). Post-electrodialysis electrochromic AEMs incorporating TiO 2 @Ag exhibit synergistic enhancement of sunlight absorption, effectively suppressing photogenerated carrier binding and promoting migration. These resultant-membranes demonstrate significantly improved bacterial inhibition properties (42.0-fold increase for E. coli ) and degradation activity (7.59-fold increase for rhodamine B) compared to pure TiO 2 membranes. Importantly, they maintain photocatalytic activity without compromising salt-separation performance or stability, as the spraying process utilizes the same substrate materials. This approach to rational design and regulation of anti-contamination AEMs offers new insights into the collaborative synergy of color-changing and photocatalytic materials.
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Journal of Energy Storage
·
2024
·
IF 8.9
Yuhan Ji,Tong Wang,Xu Yao,Jingkui Gao,Yanting Chu,Jingwen Sun,Haitao Dong,Jingquan Sha
Hard carbon (HC) with larger interlayer spacing, lower operation potential and stable skeleton is a promising kind of anode materials for sodium-ion batteries (SIBs), where heteroatom doping and structural design have been proved to be effective strategies to improve its Na + storage performance. Herein, biomass agar-derived N-doped porous carbon (NPC-Ts, T = 750, 900 and 1050 °C) were successfully fabricated by modulating carbonization temperature, where interlayer spacing, specifical surface area (SSA), micro/mesopore amount and N-doping levels and configurations (pyridinic N (N-6), pyrrolic N (N-5) and graphite N (N-Q)) were explored in detail. Among the NPC-900 shows the largest interlayer spacing (0.412 nm), SSA (3991 m 2 /g) and sum percentage of N-6 and N-5 (76.7 %). When applied as anode material for SIBs, NPC-900 exhibits the highly reversible capacity (430.9 mAh/g at 100 mA/g after 100 cycles) and excellent rate capability (162 mAh/g at 5000 mA/g) and outstanding cycle life (242.6 mAh/g at 1000 mA/g after 5000 cycles). More importantly, when coupled with Na 3 V 2 (PO 4 ) 3 (NVP) cathode, the Na + full cell displays the highest practical energy density of 267 Wh/kg to date, to the best our knowledge, revealing its potential practical sodium storage applications.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
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IF 8.1
Jinyue Chai,Junlei Zheng,Haiting Yu,Fang Chai,Miaomiao Tian
Bisphenol A (BPA) has been widely detected in environmental and human products and has significant health and environmental impacts. Consequently, an innovative molecularly imprinted membrane was fabricated for the selective adsorption of BPA within water environment. Tannic acid (TA), abundant in plants, was employed to effectuate the reduction of AgNO 3 in an environmentally friendly, and gentle manner, imbuing the membrane with antibacterial properties. A functional hydrophilic layer was created utilizing TA and polyimide (PEI), and mild and efficient imprinting was accomplished through dopamine (DA) self-polymerization. Compared with the blank membrane, the contact angle of the molecularly imprinted membranes (PVDF@Ag@P@MIMs) was reduced to 67.62°, and the optimal adsorption capacity was 33.41 mg g −1 . The imprinting factor of the PVDF@Ag@P@MIMs membrane was 2.90, indicating that the membrane could effectively separate BPA. After 6 cycles of utilization, the adsorption loss was only 4.55 %. In addition, the synthesis of PVDF@Ag@P@MIMs is simple and free of pollutants. The experimental results and green synthesis process of the molecularly imprinted membranes indicate that these materials have potential applications in environmental protection, selective separation, chemical industry, and other fields.
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Plants-Basel
·
2024
·Vol. 13
·期 18
·2576
·
IF 4
Yiqun Hu,Qingqing Chen,Aifang Zhang,Liyuan Zhang,Hansong Dong
Small non-coding RNAs (sRNAs) are pivotal post-transcriptional regulatory factors influencing biological activity. Studies on the rice bacterial blight pathogenXanthomonas oryzaepathovaroryzaestrain PXO99A, previously identified a virulence-associated sRNA, trans3287. A mutant strain lacking this sRNA, named SK01, resulted in markedly diminished virulence towards rice. This study aims to further elucidate the underlying bacterial virulent function of trans3287. The expression of trans3287 was quantified in virulence-inducing and standard nutritional conditions to clarify its production mechanism. The detection of virulence-associated genes revealed that trans3287 regulated the synthesis processes of extracellular polysaccharides, lipopolysaccharides, and the type III secretion system. Moreover, bioinformatics prediction and quantitative PCR indicated a potential direct target of trans3287,PXO_03470, encoding cardiolipin synthase. A dual-plasmid system fusing with GFP tag and protein immunoblotting confirmed that sRNA trans3287 negatively regulatedPXO_03470. Bacterial biofilms demonstrated trans3287 regulated the disruption of biofilm integrity through cardiolipin synthase. This study provides preliminary insights into the mechanistic underpinnings of the role of sRNA trans3287 in mediating bacterial virulence through cardiolipin synthase.
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