APPLIED SURFACE SCIENCE
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2016
·
IF 3.15
Guangjian Zeng,Meiying Liu,Kexin Shi,Chunning Heng,Liucheng Mao,Qing Wan,Hongye Huang,Fengjie Deng,Xiaoyong Zhang,Yen Wei
Surface modification of nanodiamond (ND) with poly(2-methacryloyloxyethyl phosphorylcholine) [poly(MPC)] has been achieved by using metal free surface initiated atom transfer radical polymerization (SI-ATRP). The ATRP initiator was first immobilized on the surface of ND through direct esterification reaction between hydroxyl group of ND and 2-bromoisobutyryl bromide. The initiator could be employed to obtain ND-poly(MPC) nanocomposites through SI-ATRP using an organic catalyst. The final functional materials were characterized by 1 H nuclear magnetic resonance, transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and thermo gravimetric analysis in detailed. All of these characterization results demonstrated that ND-poly(MPC) have been successfully obtained via metal free photo-initiated SI-ATRP. The ND-poly(MPC) nanocomposites shown enhanced dispersibility in various solvents as well as excellent biocompatibility. As compared with traditional ATRP, the metal free ATRP is rather simple and effective. More importantly, this preparation method avoided the negative influence of metal catalysts. Therefore, the method described in this work should be a promising strategy for fabrication of polymeric nanocomposites with great potential for different applications especially in biomedical fields.
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JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
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2016
·
IF 3.958
Peng Zhou,Jing Zhang,Yongli Zhang,Juan Liang,Ya Liu,Bei Liu,Wei Zhang
Activation of hydrogen peroxide (H 2 O 2 ) and its mechanism were investigated during corrosion of nanoscale zero valent copper (nZVC) in acidic aqueous solution. As the radical probe compound, benzoic acid (BA) degradation was completely achieved after 25 min in the nZVC/H 2 O 2 system at initial pH 3.0. H 2 O 2 can accelerate the corrosion of nZVC to release Cu + resulting in the further activation of H 2 O 2 via a Fenton-like reaction in acidic aqueous solution. The released Cu + during the corrosion of nZVC is the main effective copper species to activate H 2 O 2 to produce OH in the nZVC/H 2 O 2 system. Hydroxyl radical ( OH) was verified as the primary reactive oxidant which is responsible for BA degradation in the nZVC/H 2 O 2 system owing to the intense inhibition of BA degradation with the addition of excess tert -butyl alcohol (TBA). Moreover, acidic aqueous solution facilitates the degradation of BA and optimum initial pH for BA degradation is 3.0. Higher nZVC dosage could enhance the degradation rate of BA. In addition, the present study put forward an interesting idea to make full use of intermediate Cu + to activate H 2 O 2 during corrosion of nZVC to degrade organic contaminants.
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RENEWABLE ENERGY
·
2016
·
IF 3.404
Wenlong Cui,Yanping Yuan,Liangliang Sun,Xiaoling Cao,Xiaojiao Yang
This paper reports that Nano-copper (Nano-Cu), which possesses high thermal and electrical conductivity, as an additive, can improve the supercooling properties of sodium acetate trihydrate (CH 3 COONa·3H 2 O, SAT) and enhance its thermal conductivity . To investigate the effect of Nano-Cu content on the degree of supercooling of SAT, composite phase change materials containing SAT, Nano-Cu (0.4%, 0.5%, 0.6%, 0.7% and 0.8%), CMC (thickening agent) and sodium dodecyl sulfonate (C 12 H 25 NaO 3 S, dispersant) were prepared. Melting-freezing experiments involving the composite materials indicated that the rate of heat transfer increased by nearly 20%. When an optimal amount of Nano-Cu (i.e., 0.5%) was added to SAT, the degree of supercooling was reduced to approximately 0.5 °C. Compared to the use of inorganic salt hydrates as nucleating agents , Nano-Cu is significantly advantageous in reducing the degree of supercooling of SAT. The maximum improvement in supercooling was observed when the melting-freezing experiment was conducted at an initial temperature of 70 °C. The thermal conductivity of the reported composite phasechange materialsis approximately 20% higher than that of pure SAT.
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ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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2017
·
IF 2.313
Hui Zhang,Xiaoxing Wu,Khalid Mehmood,Zhenyu Chang,Kun Li,Xiong Jiang,Fazul Nabi,Muhammad Ijaz,Mujeeb Ur Rehman,Muhammad Tariq Javed,Donghai Zhou
The nano copper has been widely used in modern clinical medicine practice. However, it has been noticed that nano copper particles induce cell injury and toxicity. The present study was designed to determine the effect of nano copper particles on cell injury of intestinal epithelial cells (IECs) in piglets. The IECs were treated with different doses of nano copper (5, 10, 20 and 40 μg/ml) for 24–48 h to observe cell injury and toxicity. Cell injury was measured based on morphological and other changes including oxidative stress and genes expression. The oxidative stress markers were assayed by differential expression levels of SOD, MDA and Metallothionein (MT) in addition to CTR1, SOD1, COX17, MT and ATOX1 genes expression. Cellular morphology showed an increasing growth of cells without nano copper treatment and nano copper showed significant damage to IECs with higher dose as compared to low dose. Higher doses of copper nanoparticles (10, 20 and 40 μg/ml) have membrane damaging effect on the intestinal epithelial cells, whereas MDA contents and MT value were significantly increased, and SOD activity was decreased with the increase in concentration of nanoparticles. Nano copper up-regulated the CTR1 and SOD1 genes and down-regulated the relative expression of COX17, MT and ATOX1 genes significantly in a dose-dependent manner. The findings of the current study provide important insights that nano copper plays an important role in intestinal epithelial cell injury and oxidative stress.
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JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
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2017
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IF 1.046
Yunhua Zhang,Jinyun Ji,Xiao Zhao,Ruoheng Jin,Jianhong Li,Hu Wan
A previous study demonstrated that a β- N -acetyl- d -hexosaminidase ( NlHex4 ) from the brown planthopper could serve as a new potential target for biopesticides due to its requirement for molting, and lethal phenotypes were observed via RNA interference . However, the enzymatic properties of NlHex4 remain unclear. In the present study, NlHex4 was expressed, purified and characterized. Recombinant NlHex4 was functionally expressed in baculovirus-infected insect cells and purified with a molecular weight of approximately 70 kDa. Recombinant NlHex4 had an optimal pH and temperature of 6.0 and 60 °C, respectively. Moreover, recombinant NlHex4 exhibited thermal stability at 50 °C for at least 1 h. Furthermore, the activity of recombinant NlHex4 was inhibited by the metal ions Fe 2 + and Fe 3 + and the serine protease inhibitor phenylmethanesulfonyl fluoride. These results reveal the enzymatic properties of NlHex4 and provide a basis for future investigation of the interaction between HEX and chitin oligosaccharide .
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Science Bulletin
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2016
·
IF 0
Miao He,Liying Lu,Jinchi Zhang,Danzhen Li
Highly stable dispersions of nanosized copper (Cu) particles with an average size of (2.6 ± 0.5) nm were synthesized by in situ reduction of Cu(II) to immobilize Cu nanoparticles on the amino-enriched surface of chitosan (CTS). The synthetic process and stability of the l -ascorbic acid-stabilized Cu-CTS nanocomposites were investigated by X-ray photoelectron spectroscopy and Fourier transform Infrared spectroscopy. The antimicrobial efficiency and potency of the Cu-CTS nanocomposites were studied. The Cu-CTS nanocomposites were found to exhibit a broad antimicrobial spectrum and high antimicrobial activity against Gram-positive bacterial pathogen Staphylococcus aureus and fungal pathogen Monilia albican . The minimum inhibitory concentration of the Cu-CTS nanocomposites toward S. aureus was found to be 6.4 μg mL −1 , much lower than those reported in the literature. Furthermore, the Cu-CTS nanocomposites were stable and maintained good disinfection potential even after 90-day shelf-time under ambient conditions.
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International Journal of Nanomedicine
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2016
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IF 4.32
Shan Jiang,Rongrong Zhu,Xiaolie He,Jiao Wang,Mei Wang,Yechang Qian,Shilong Wang
Curcumin (Cur) is a promising photosensitizer that could be used in photodynamic therapy. However, its poor solubility and hydrolytic instability limit its clinical use. The aim of the present study was to encapsulate Cur into solid lipid nanoparticles (SLNs) in order to improve its therapeutic activity. The Cur-loaded SLNs (Cur-SLNs) were prepared using an emulsification and low-temperature solidification method. The functions of Cur and Cur-SLNs were studied on the non-small cell lung cancer A549 cells for photodynamic therapy. The results revealed that Cur-SLNs induced ~2.27-fold toxicity higher than free Cur at a low concentration of 15 μM under light excitation, stocking more cell cycle at G2/M phase. Cur-SLNs could act as an efficient drug delivery system to increase the intracellular concentration of Cur and its accumulation in mitochondria; meanwhile, the hydrolytic stability of free Cur could be improved. Furthermore, Cur-SLNs exposed to 430 nm light could produce more reactive oxygen species to induce the disruption of mitochondrial membrane potential. Western blot analysis revealed that Cur-SLNs increased the expression of caspase-3, caspase-9 proteins and promoted the ratio of Bax/Bcl-2. Overall, the results from these studies demonstrated that the SLNs could enhance the phototoxic effects of Cur.
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LANGMUIR
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2016
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IF 3.993
Defeng Li,Ang Wu,Guangyin Xu,Hua Lai,Zhongjun Cheng,Yuyan Liu
In this paper, we report a simple method based on assembling n-alkanoic acids on hierarchical structured copper toward preparing surfaces with tunable oil wetting performance in water. Surface wettability from superoleophobicity to superoleophilicity in water can be regulated through tuning the chain length of n-alkanoic acids. Importantly, even in strongly acid and basic water, such phenomena can still be observed. The cooperation between the hierarchical structures and the surface chemical composition variation is responsible for the controllability. Meanwhile, the tunable ability is universal and the controllability is suitable for various oils including silicon oil, n-hexane, and chloroform. Moreover, the method was also used on copper mesh substrates, and we reported the related application of selective oil/water separation. This paper provides a flexible strategy toward preparing surfaces with tunable oil wetting performances, which can also be suitable for other materials, and offers some fresh ideas in manipulating underwater oil wetting performances on surfaces.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2015
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IF 4.152
Fanfei Meng,Sajid Asghar,Shiya Gao,Zhigui Su,Jue Song,Meirong Huo,Weidong Meng,Qineng Ping,Yanyu Xiao
In this study, a novel low density lipoprotein (LDL)-mimic nanostructured lipid carrier (NLC) modified with lactoferrin (Lf) and loaded with curcumin (Cur) was designed for brain-targeted delivery, and its effect on controlling the progression of Alzheimer's disease (AD) in rats was evaluated. NLC with the composition resembling the lipid portion of LDL was prepared by using solvent evaporation method. Lf was adsorbed onto the surface of NLC via electrostatic interaction to yield Lf modified-NLC (Lf-mNLC) as the LDL-mimic nanocarrier. In order to make sure more Lf was adsorbed on the surface of NLC, negatively charged carboxylated polyethylene glycol (100) monostearate (S100-COOH) was synthesized and anchored into NLC. Different levels of S100-COOH (0–0.02 mmol) and Lf modified NLC (0.5–2.5 mg/mL of Lf solution) were prepared and characterized. The uptake and potential cytotoxicities of different preparations were investigated in the brain capillary endothelial cells (BCECs). An AD model of rats was employed to evaluate the therapeutic effects of Lf-mNLC. The results indicate that Lf-mNLC with a high level of Lf showed the maximum uptake in BCECs (1.39 folds greater than NLC) as cellular uptake of Lf-mNLC by BCECs was found to be mediated by the Lf receptor. FRET studies showed Cur still wrapped inside NLC after uptake by BCECs, demonstrating stability of the carrier as it moved across the BBB. Ex vivo imaging studies exposed Lf-mNLC could effectively permeate BBB and preferentially accumulate in the brain (2.78 times greater than NLC). Histopathological evaluation confirmed superior efficacy of Lf-mNLC in controlling the damage associated with AD. In conclusion, Lf-mNLC is a promising drug delivery system for targeting therapy of brain disease.
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RSC Advances
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2015
·Vol. 5
·期 67
·54275-54282
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IF 3.84
Jizhen Zhang,Yuanhong Xu,Zhen Liu,Wenrong Yang,Jingquan Liu
Herein, a new graphene/Cu nanoparticle composite was prepared via the in situ reduction of GO in the presence of Cu nanoparticles which was then utilized as a sacrificing template for the formation of flexible and porous graphene capacitor electrodes by the dissolution of the intercalated Cu nanoparticle in a mixed solution of FeCl3 and HCl. The porous RGO electrode was characterized by atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). The as-prepared graphene/Cu nanoparticle composite and the pure graphene film after removal of Cu nanoparticles possessed high conductivity of 3.1 × 103 S m−1 and 436 S m−1 respectively. The porous RGO can be used as the electrode for the fabrication of supercapacitors with high gravimetric specific capacitances up to 146 F g−1, good rate capability and satisfactory electrochemical stability. This environmentally friendly and efficient approach to fabricating porous graphene nanostructures could have enormous potential applications in the field of energy storage and nanotechnology.
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ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
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2015
·Vol. 69
·期 4
·453-460
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IF 1.895
He Qun,Qin Li,Zhang Xuesheng,Wang Liansheng,Sun Ping,Wang Zunyao
Sediment and water samples collected from 8 sites of the Yangtze River in Nanjing section were characterized with 31 congeners of polychlorodibenzothiophenes (PCDTs). Concentrations and percentage compositions of these PCDTs in water and sediments were analyzed by gas chromatography–mass spectrometry. Results showed that ∑PCDT concentrations in sediments were higher (0.86–1.75 μg/kg) than those in water (0.56–1.30 μg/L). A linear relationship existed between ∑PCDT concentrations and total organic carbon content in sediments, whereas there was a poor linearity between ∑PCDTs concentrations and dissolved organic carbon content in water phase. Moreover, percentage compositions showed that penta-chlorinated DTs were the predominant congeners both in sediments and water. Differences existed in the percentage compositions between water and sediments. Highly chlorinated DTs accounted for a larger proportion in sediments than those in water. In conclusion, the present study showed the prevalent contamination by PCDTs in sediments and water from the Nanjing section of the Yangtze River.
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ACS Applied Materials & Interfaces
·
2014
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IF 5.9
Yanchun Yang,Gang Wang,Wangen Zhao,Qingwen Tian,Lijian Huang,Daocheng Pan
Solution deposition approaches play an important role in reducing the manufacturing cost of Cu2ZnSnSe4 (CZTSe) thin film solar cells. Here, we present a novel precursor-based solution approach to fabricate highly efficient CZTSe solar cells. In this approach, low-cost elemental Cu, Zn, Sn, and Se powders were simultaneously dissolved in the solution of thioglycolic acid and ethanolamine, forming a homogeneous CZTSe precursor solution to deposit CZTSe nanocrystal thin films. Based on high-quality CZTSe absorber layer, pure selenide CZTSe solar cell with a photoelectric conversion efficiency of 8.02% has been achieved without antireflection coating.
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