JOURNAL OF LIPOSOME RESEARCH
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2026
·
IF 4.7
Li Zhang,Yize Lv,Xuedi Weng,Yan Gao,Jie Gao,Xia Cao,Michael Adu-Frimpong,Qilong Wang
Chitosan-polyethylene glycol (CS-PEG)-modified long-circulating liposomes were developed and loaded with tanshinone I (TaI@CS-PEG-L) to overcome its poor solubility and low bioavailability, as well as enhance the lipid-lowering efficacy of atorvastatin (At) and mitigate its tissues toxicity. After synthesis of CS-PEG copolymer, it was characterized with infrared and proton nuclear magnetic resonance. Thin-film hydration was used to prepare TaI@CS-PEG-L before optimization was performed using Box-Behnken design. Optimal liposomal formulation was obtained when mass ratio of lecithin:cholesterol:TaI mass ratio was 12:1:1 along with 0.2% CS-PEG, which displayed appropriate particle size (117.41 nm), polydispersity index (0.182), zeta potential (+17.31 mV), encapsulation efficiency (93.15%), and drug loading (5.19%). Besides, the liposomal preparation exhibited good long-term storage stability (over 30 days at 4 °C and 25 °C) and satisfactory gastrointestinal stability in simulated gastric (pH 1.2) and intestinal (pH 6.8) fluids for 4 h. TaI@CS-PEG-L displayed increased cellular uptake and in vitro release compared with free TaI and unmodified liposomes. Regarding pharmacokinetic studies, TaI@CS-PEG-L increased AUC0-ₜ, t1/2, and Cmax in rats by 7.26-fold, 2.43-fold, and 3.12-fold, respectively, which indicates significantly enhanced oral bioavailability. TaI@CS-PEG-L monotherapy markedly lowered serum lipid levels in hyperlipidemic mice, thereby improving liver function indices, and alleviating pathological liver injury. TaI@CS-PEG-L demonstrated synergistic lipid-lowering effects and efficiently reversed At-induced hepatic and pancreatic injuries after combination with At, thus outperforming free TaI and TaI@L. Therefore, CS-PEG-modified long-circulating liposomes could efficiently address delivery challenges of TaI, thereby yielding a formulation that could potently lower serum lipid levels and protect liver against injury. The findings of this study offer a promising ‘efficacy-enhancing and toxicity-reducing’ strategy for potential treatment of hyperlipidemia in the clinics.
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高影响因子
Processes
·
2026
·Vol. 14
·期 12
·1998
·
IF 3.4
Zhuangzhuang Zhang,Lingling Ma,Yang Shao,Diandou Xu,Min Luo
To tackle the environmental challenges associated with industrial oily wastewater discharges and recurrent marine oil spill incidents, developing high-efficiency oil–water separation technologies represents a pressing environmental challenge. This research presents a novel design approach comprising the deposition of a stable SiO2anchoring layer followed by the fabrication of a PDA/CS crosslinked coating, thereby achieving successful construction of a superhydrophilic/underwater superoleophobic (SH/UWSO) coating on stainless steel meshes (SSM). In the first step, SiO2microspheres were deposited via vapor deposition to create a micro-rough surface architecture. Subsequently, a dopamine/chitosan (DA/CS) reaction solution was introduced to form a Polydopamine/chitosan (PDA/CS) coating, yielding a SiO2@PDA/CS-SSM separation membrane. The resulting membrane exhibited separation efficiencies surpassing 99% for various oil–water mixtures, achieving a flux of 1.24 × 105L·m−2·h−1in petroleum ether systems. Notably, the membrane maintained high efficiency and structural stability even after 25 separation cycles, immersion in strong acid and base solutions for 72 h, and 100 abrasion tests. The rational design of the anchoring and crosslinking layers endows SiO2@PDA/CS-SSM with high efficiency and stability, making it an effective oil–water separation material.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Xiaoye Wen,Chenjie Pang,Chenxi Dai,Zhefeng,Fan
As novel energy level-tunable photocatalysts, copper nanoclusters (CuNCs) have been used for combining with conventional catalysts to synergize enhanced the catalytic capabilities. However, conventional photocatalysts have their own drawbacks. In particular, their fixed energy levels are unfavorable for regulating the energy level structure of composite catalysts. In this study, a novel nanoplatform (CuNCs@CS/MOF) was constructed for the detection and photocatalytic degradation of MBT. The chitosan-modified CuNCs were encapsulated within the MOF matrix. The CuNCs maintained an aggregated state and the rotation of their ligands was restricted, thereby further enhancing the photoluminescence intensity and photostability of CuNCs. When exposed to light irradiation, CuNCs@CS/MOF showed remarkable photocatalytic activity, and the underlying mechanism governing the photocatalytic degradation process was elaborated in detail. Specifically, CuNCs@CS/MOF generated photogenerated electrons and holes, the photogenerated electrons reacted with H 2 O 2 to produce ·OH, while the remaining holes accepted electrons donated by MBT. The generated ROS oxidized TMB to oxidized TMB (oxTMB) under light irradiation, which was thereafter diminished by MBT. On this basis, the quantitative detection of MBT was established. Furthermore, ROS could oxidize and decompose MBT into small-molecule fragments, thus achieving the efficient elimination of MBT. This work provides an attractive strategy for designing multifunctional novel nanoplatform, which can be applied for the accurate detection and further harmless treatment of pollutants.
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高影响因子
Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 30
·9203-9210
·
IF 6.641
Y. Y. Zhou,E. H. Song,M. G. Brik,Y. J. Wang,T. Hu,Z. G. Xia,Q. Y. Zhang
Mn4+-doped fluoride red-emitting phosphors have been developed for backlighting white light-emitting diodes (WLEDs). However, the long fluorescence lifetime (τ > 5 ms) leads to the image-retention phenomenon for the human eye when Mn4+ is doped into equivalent X sites in A2XF6 (A = Na, K, Rb, Cs; X = Si, Ge, Ti, Zr). Herein, we report on novel red-emitting A2NaScF6:Mn4+ (A = K, Rb, Cs) (ANSF) phosphors with short fluorescence lifetimes (τ < 4 ms) and characteristic zero phonon line (ZPL) emission, which can be realized via non-equivalent doping of Mn4+ into Sc3+ sites. Density functional theory (DFT) calculations verified the formation of a slightly distorted environment of Mn4+ and an Na+ vacancy to balance the charge with Mn4+ non-equivalent doping. The WLED backlight using ANSF as a red-light component can reach a wide color gamut above 105% of the National Television Standards Committee (NTSC) standard, and the image-retention on the backlighted screen can be effectively avoided compared to the backlight obtained using commercial K2SiF6:Mn4+. Such a Mn4+ non-equivalent doping strategy opens a new perspective for the modification of local symmetry and enhancement of the luminescence properties of Mn4+-doped red-emitting fluoride phosphors.
研究领域:
材料科学
·
光学工程
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高影响因子
PROGRESS IN ORGANIC COATINGS
·
2020
·
IF 4.469
Nan Zheng,Jie Liu,Yuhang Wang,Chunmei Li,Qiuyu Zhang
Self-healing coatings healed by the synergistic action of ultraviolet light and moisture are developed. Firstly, a polysiloxane-based healing agent, containing acryloyloxy (CH 2 =C(CH 3 )COO-)and methoxy silane(-SiOCH 3 )groups, is synthesized and encapsulated in chitosan-reduced graphene oxide (CS-RGO) microcapsules with compact CS-RGO shell structures. The CS-RGO microcapsules containing the polysiloxane core are then embedded in epoxy-modified silicone resin to achieve efficient self-healing coatings. Herein, an assembly time of 2.5 h results in a complete stacking of GO sheets on the emulsion droplets. As the CS/GO ratio increase, the reduction degree of GO, the sphericity of the CS-RGO microcapsules, and the average diameter all increase. Moreover, the compact CS-RGO shell formed by the assembly and stacking GO sheets as well as the interactions between CS and GO helps to maintain effectiveness of the core and stability of the microcapsules. The result shows that embedding of the CS-RGO microcapsules in the resin matrix improves the mechanical properties and anti-corrosion properties of the matrix. What’s more, the self-healing coatings with the UV/moisture dual healing mode is beneficial for achieving superior self-healing effects, which is promising for various industries, especially the over-water construction of ships, bridges, pipelines, etc.
研究领域:
材料科学
·
化学工程
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高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Chili Zhao,Xun Liu,Xia Zhang,Hong Yan,Zhilei Qian,Xinghui Li,Zhenye Ma,Qiaorong Han,Chonghua Pei
In this paper, Fe 3 O 4 /chitosan/isoniazid magnetic nanoparticles (Fe 3 O 4 /CS/INH-MNPs) were prepared as an environmental stimuli-responsive drug-delivery system by automated in situ click technology, in which Fe 3 O 4 magnetic nanoparticles, chitosan and isoniazid were simultaneously in situ crystallized by one-step method. The Fe 3 O 4 magnetic nanoparticles and tripolyphosphate act as stable crosslinkers to produce numerous intermolecular crosslinkages for the mobility of the chitosan chains. Characterization results indicated that the multifunctional drug delivery system with optimized size, excellent loading capacity, well magnetic properties, nontoxicity and pH triggered drug release property is expected to be applied in tuberculosis treatment with excellent magnetic sensitivity and sustained release.
研究领域:
药学
·
生物医学工程
·
纳米医学
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高影响因子
LANGMUIR
·
2026
·
IF 4.4
Zhihai Wu,Gongxuan Lu
The highly efficient enrichment of Li+ and Cs+ from their low-concentration aqueous solutions is a crucial step for Lithium and Cesium clean production, as well as radioactive Cs+ safety remediation from water. The current adsorption and precipitation routes are high energy cost and environmental unfriendly. Electrochemical ion exchange route may serve as a promising alternative route. This study presents results of high efficient, multicycle Li+ and Cs+ enrichment from their low concentration solutions via intercalation and deintercalation in WO3/GaAs composite electrode with Faraday efficiency above 99% and high intercalation capacities 7.25 mg/g for Li+ and 38.89 mg/g for Cs+, respectively. After six cycles, 95 and 90% capacities for Li+ and Cs+ still remained. Both enrichment efficiency and stability are higher than those of LiFePO4 (LFP) and LiMn2O4 (LMO) under the same conditions. This route might provide a way for low-energy cost and highly efficient Li+ and Cs+ recovery from contaminated water.
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高影响因子
Frontiers of Chemical Science and Engineering
·
2025
·Vol. 19
·期 4
·1-11
·
IF 4.5
Shao Siqing,Jin Liping,He Siyuan,Feng Yijing,Guo Wenwen
To achieve fire-resistant epoxy resin (EP), a UiO-66-based novel flame retardant coating (CS@APP@UiO-66) was prepared by modifying UiO-66 with chitosan (CS) and ammonium polyphosphate (APP) through a layer-by-layer (LbL) self-assembly method, which was then introduced into an EP system to improve its fire safety. The results of scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy show that the unsaturated Zr atoms in the UiO-66 framework provide many active sites conducive to modification, so that the UiO-66 particles, which originally had a regular octahedral structure, are more dispersed by LbL modification without causing doping or distortion issues. The thermogravimetric analysis results indicate that the char residue of EP/2% UiO-66 is increased by 2.52% compared with that of pure EP, indicating that the thermal properties of the EP composite are improved after modification. In addition, the cone test results indicate that EP/2%UiO-66-5L has good flame retardancy and smoke suppression properties, and the peak heat release rate, total smoke production and rate of CO generation values are 25.2%, 5.7% and 38.5% lower than those of the unmodified EP. Moreover, it can be concluded from the Raman test that the graphitization degree of the modified EP composite is strengthened. The above results indicated that after the incorporation of CS@APP@UiO-66 into the EP composites, more char layers formed as physical barriers to prevent the transfer of mass and heat, thus reducing the speed of flame propagation. Therefore, the flame resistance and smoke suppression of the EP composites improved. These favorable characteristics, including high flame retardant efficiency and good smoke suppression, make LbL-functionalized UiO-66 promising for flame retardant polymer applications.
研究领域:
材料科学
·
化学工程
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高影响因子
Biochar
·
2023
·Vol. 5
·期 1
·1-16
·
IF 12.7
Liu Fenglei,Wang Shanshan,Zhao Chaofeng,Hu Baowei
Herein, a biochar-based composite (Ti 3 C 2 T x @biochar-PDA/PEI) was constructed by decorating Ti 3 C 2 T x and polydopamine on coconut shell biochar via electrostatic self-assembly method. Different characterization techniques were applied to explore the structure, morphology and composition of the sorbents. It was found that the higher porosity and diverse functional groups were conducive for Ti 3 C 2 T x @biochar-PDA/PEI to capture radionuclides, and the water environmental conditions made a great contribution to the adsorption process. The process of removing U(VI)/Cs(I) well complied with the Langmuir isotherm and Pseudo-second-order equations, which indicated that the single layer chemical adsorption occurred on the solid liquid interface. Meanwhile, this produced composite exhibited superior removal performance under complex co-existing ion environment, and the maximum adsorption amounts of U(VI) and Cs(I) reached up to 239.7 and 40.3 mg g −1 . Impressively, this adsorbent still exhibited good adsorption performance after three cycles of regeneration. The spectral analysis and DFT calculation demonstrated that adsorption of U(VI) might be a chemical process, while the adsorption of Cs(I) should be ion exchange or electrostatic attraction. This study demonstrated the potential application of Ti 3 C 2 T x @biochar-PDA/PEI as an effective remediation strategy for radioactive wastewater cleanup. Graphical Abstract
研究领域:
环境科学
·
材料科学
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高影响因子
CHEMISTRY OF MATERIALS
·
2020
·
IF 9.567
Lu Qi,Zhaohui Chen,Xuerui Shi,Xiaodong Zhang,Qun Jing,Na Li,Zhongqi Jiang,Bingbing Zhang,Ming-Hsien Lee
Exploring novel photoelectric functional materials via chemical substitution-oriented design is an effective strategy, which can be expanded to the discovery of high-performance UV nonlinear optical (NLO) materials. Two new NLO pyrophosphates, Rb3BaBi(P2O7)2 (I) and Cs3BaBi(P2O7)2 (II), are rationally developed by a cation substitution technique based on A3PbBi(P2O7)2 (A = Rb and Cs), of which I inherits the large second-harmonic generation (SHG) response (exptl 2.5 × KDP; calcd 2.9 × KDP) and moderate birefringence (0.025@1064 nm) accompanied by a broadened UV transparent region. Compounds I and II are isomeric and exhibit different Ba–P–O frameworks. Especially, I possesses a large SHG effect benefiting from the favorable pentagonal-net topological structure. Detailed theory calculations elucidate the origin of the linear and nonlinear optical properties of the compounds. The insights obtained from the atomic-level module adjustment involving lone-pair-active optical anisotropy are useful for designing more efficient UV NLO materials.
研究领域:
材料科学
·
非线性光学
·
无机化学
·
晶体工程
·
计算材料科学
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高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Jing Duan,Huiping Shao,Jialei Wu,Hongyuan Liu,Siqi Wang,Tao Lin
The design of magnetic composite scaffolds with superior properties has the potential to construct a targeted delivery platform with hyperthermia. In this study, strontium hexaferrite (SrFe 12 O 19 , SrM) magnetic nanoparticles (MNPs) were obtained by the chemical precipitation method. Non-toxic cross-linked biogels were prepared for adhesive ceramic scaffolds, and chitosan/polyvinylalcohol (CS/PVA)-bonded SrM magnetic nanoscaffolds were successfully prepared by 3D gel printing (3DGP) method. The effects of PVA physical cross-linking and in situ formed SiO 2 on the properties of CS-bonded scaffolds were evaluated, and the compressive strengths were increased from 6.13 ± 2.45 MPa to 8.80 ± 2.02 MPa and 17.18 ± 2.15 MPa, respectively. The results showed that the saturation magnetization of SiO 2 /CS/PVA/SrM composite scaffolds was 59.96 emu/g. In vitro immersion experiments showed that the degradation rates of SiO 2 /CS/PVA/SrM scaffolds were 4.90% after 28 days, and the in situ SiO 2 improved the deposition of calcium salts on the scaffolds. The experiments showed that the SrM magnetic scaffolds could not only concentrate magnetic fields to improve the efficiency of targeting deposition but also achieve a weak targeting process without external magnetic field assistance. In vitro cell proliferation test showed that MC3T3-E1 cells had good adhesion and proliferation on the surface of SiO 2 /CS/PVA/SrM scaffolds, which indicated that the scaffolds may be used for bone repairing.
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高影响因子
MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 9
·1-13
·
IF 6.408
Chen Jing,Li Shuying,Chen Ying,Yang Jiao,Dong Jianbin
Adenine (A) and guanine (G) are mainly found in deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) and play a crucial role in genetic information transfer and protein synthesis. In this study, NH 2 -MIL-53(Fe)/CS/MXene nanocomposites were prepared for detecting guanine and adenine. With high specific surface area, excellent water dispersion, and numerous active sites, MXene (transition metal carbides, nitrides, and carbonitrides) provides a good platform for loading primitive metal-organic frameworks (MOFs). At the same time, the problem of poor conductivity and dispersion of MOFs is solved. The electrochemical catalytic oxidation of adenine and guanine of NH 2 -MIL-53 (Fe)/CS/MXene nanocomposites was carried out by differential pulse voltammetry (DPV). Operating voltage of DPV: 0.7–0.9 V (vs. Ag/AgCl) for G, 1.0–1.2 V (vs. Ag/AgCl) for A, 0.8 V (vs. Ag/AgCl), and 1.1 V (vs. Ag/AgCl) for G and A. The concentration ranges for detecting A and G were 3–118 μM and 2–120 μM with detection limits of 0.57 μM and 0.17 μM (S/N = 3), respectively. The nanocomposite was used for detecting G and A in herring sperm DNA, and the content of G and A was found to be about 9 and 11 μM; the RSD values were 3.4 and 1.3%, respectively. Graphical abstract
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高影响因子
危险品化学品经营许可证（带存储）