BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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2022
·
IF 5.011
Xijie Yu,Xiaoxiao Xu,Wei Dong,Chang Yang,Yao Luo,Ying He,Chenxi Jiang,Yanru Wu,Jiawei Wang
Endoplasmic reticulum (ER) stress is an evolutionarily conserved cellular stress response related to multiple diseases, including temporomandibular joint (TMJ) cartilage-related diseases. Recent studies have indicated that DDIT3/CHOP (a downstream transcription factor of ER stress) is an important effector in mediating ER stress to inhibit chondrogenesis . However, the underlying mechanism by which DDIT3 regulates chondrogenesis remains unclear. In this study, tunicamycin (an ER stress agonist)-induced ER stress inhibited chondrocyte differentiation and matrix synthesis in vitro and led to an osteoarthritis-like phenotype in mouse TMJ cartilage. Meanwhile, DDIT3 expression in chondrocytes was robustly upregulated. Loss-of-function experiments validated the inhibiting effect of DDIT3 on chondrocyte differentiation and matrix synthesis. Mechanistically, the inhibiting effect was attributed to the direct and indirect regulatory effect of DDIT3 on SIRT1 (sirtuin1, silent mating type information regulation protein type 1, a member of NAD+ dependent class III histone deacetylases). On one hand, DDIT3 directly promoted the transcription of SIRT1. On the other hand, DDIT3 indirectly increased the expression of SIRT1 by promoting AMPKα phosphorylation and activation. Furthermore, activation of AMPKα or SIRT1 with the corresponding agonist AICAR or resveratrol in the DDIT3-knockdown cells partially restored the inhibiting effect of DDIT3 on chondrocyte differentiation and matrix synthesis. Collectively, these novel findings indicate that DDIT3 regulates the inhibitory effect of ER stress on chondrocyte differentiation and matrix synthesis partially via the AMPKα-SIRT1 pathway. A thorough understanding of ER stress in regulating chondrocyte homeostasis and its role in the onset of osteoarthritis may be promising to develop therapeutic targets and prevent condyle cartilage destruction.
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Nanoscale Research Letters
·
2022
·Vol. 17
·期 1
·1-8
·
IF 5.418
Yuan Maohui,Yang Zining,Yang Xu,Wang Linxuan,Wang Rui,Lan Sheng,Han Kai,Wang Hongyan,Xu Xiaojun
Controlling the upconversion luminescence (UCL) intensity ratio, especially pumped at 808 nm, is of fundamental importance in biological applications due to the water molecules exhibiting low absorption at this excitation wavelength. In this work, a series of β-NaYbF 4 :Er microrods were synthesized by a simple one-pot hydrothermal method and their intense green (545 nm) and red (650 nm) UCL were experimentally investigated based on the single-particle level under the excitation of 808 nm continuous-wave (CW) laser. Interestingly, the competition between the green and red UCL can be observed in highly Yb 3+ -doped microcrystals as the excitation intensity gradually increases, which leads to the UCL color changing from green to orange. However, the microcrystals doped with low Yb 3+ concentration keep green color which is independent of the excitation power. Further investigations demonstrate that the cross-relaxation (CR) processes between Yb 3+ and Er 3+ ions result in the UCL competition. Graphical Abstract
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CATALYSIS TODAY
·
2022
·
IF 6.562
Yunfei Ma,Wenhui Yue,Zehong Xu,Ziwei Ye,Jinlong Zhang
Composite nanoparticles consisting upconversion nanoparticles (β-NaYF 4 :Yb/Er) and nitrogen doped TiO 2 nanoparticles were constructed via a chemical assembly method. Efficient energy transfer was enabled since the upconverted energy matched up with the band gap of N-TiO 2 . This enables the resulting composite nanoparticles to possess excellent Rhodamine B (RhB) degradation activity under near infrared (NIR) light irradiation.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Haoran Ning,Lihong Jing,Yi Hou,Sergii Kalytchuk,Yingying Li,Xiaodan Huang,Mingyuan Gao
Epitaxially growing a semiconductor shell on the surface of upconversion nanocrystals to form a core/shell structure is believed to be a promising strategy to improve the luminescent efficiency of lanthanide ions doped in particle cores and, meanwhile, enriches the optical properties of the resulting nanocrystals. However, liquid-phase synthesis of such core/shell-structured nanocrystals comprised of a lanthanide ion-doped core and semiconductor shell remains challenging because of the chemical incompatibilities between lanthanides and the most intermediate gap semiconductors. In this context, the successful growth of ZnS shell on a KMnF3 core codoped with Yb3+/Er3+ ions is reported to enhance the upconversion luminescence of Er3+ ions. The underlying core/shell formation mechanism is elucidated in detail combining the hard–soft acid–base theory with structural analysis of the resulting nanocrystals. Quite unexpectedly, Mn2+ diffusion across the core/shell interface occurs during ZnS shell growth, giving rise to Mn2+ emission from the ZnS shell. Thus, the resulting core/shell particles exhibited unique up/downconversion luminescence from doped lanthanide metal ions and transition-metal ions, respectively. By manipulating the ion diffusion and shell growth kinetics, the upconversion and downconversion luminescent performance of KMnF3:Yb,Er@ZnS nanocrystals are further optimized and the related mechanisms are discussed. Further, temperature-dependent upconversion and downconversion photoluminescence properties of KMnF3:Yb,Er@ZnS nanocrystals show potential for ratiometric luminescence temperature sensing.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 33
·期 31
·23880-23887
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IF 2.478
Ding Yanli,Zhang Xiaodan,Zhao Ying
The use of upconversion (UC) materials is an effective strategy for harvesting the near-infrared (NIR) solar photons in perovskite solar cells. Hexagonal β-NaLuF 4 :Yb,Er submicron prisms were synthesized by a facile solvothermal method. Gd 3+ doping is used to enhance the UC emission intensity. We investigated how the concentration of Gd 3+ ions affected the morphological evolution, microstructure, and luminescence performance of NaLuF 4 :Yb,Er and explored the mechanism for improving luminescence at 980 nm excitation. By incorporating the optimized NaLuF 4 :Yb,Er,Gd into the perovskite solar cells’ (PSCs) hole transport layer, the short-circuit density ( J sc ) of UC-PSCs can be enhanced from 19.31 to 21.77 mA cm −2 .
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JOURNAL OF CONTROLLED RELEASE
·
2019
·
IF 7.901
Hui Xiong,Cheng Wang,Zihan Wang,Zhijie Jiang,Jianping Zhou,Jing Yao
Estrogen receptor-positive (ER+) breast carcinoma therapy faces the challenges of estrogen receptors heterogeneity and endocrine therapy resistance. Selectively attacking glutathione (GSH) biosynthesis which is the metabolic vulnerability of ER+ breast carcinoma could bypass conventional treatment limitations through blocking oxidative stress disorders-driven tumor cell proliferation . Herein, we developed drug-organics-inorganics self-assembled nanosystem (DFTA) with doxorubicin (DOX) as chemotherapeutic agent, ferric chloride (FeCl 3 ) as ferroptosis inducer and tannic acid (TA) as activator of superoxide dismutase (SOD)-like reaction in intracellular cascade for the combined therapy in ER+ breast carcinoma. DFTA displayed a particle size of 106.4 ± 0.7 nm with flat irregular nanonetwork-like shape and predominant photothermal effect produced in the assembly process. The drug release from DFTA could be triggered by photothermal excitation efficiently. ELISA analysis showed that DFTA + laser group significantly reduced intracellular GSH level through reactive oxygen species (ROS)-produced intracellular oxidative stress cascade amplification and photothermal therapy (PT)-mediated ROS production. Furthermore, in vivo antitumor efficiency evaluation showed that the tumor inhibition ratio of DFTA + laser was as high as 93.38 % even though the dosage of iron and DOX reduced by about 9 times and 1.5 times respectively. In summary, our study established a high-efficiency nanosystem based on triple combination therapy of chemotherapy, ferroptosis and PT, which might be a promising nanosystem for effective ER+ breast carcinoma therapy.
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CERAMICS INTERNATIONAL
·
2019
·
IF 3.45
Wenwen Zhao,Kuibao Zhang,Weiwei Li,Baozhu Luo,Haibin Zhang,Kai Xu
In this study, transparent LaErZr 2 O 7 ceramic with high excess La and Er contents (nominally La 1.28 Er 1.28 Zr 2 O 7.84 ) was successfully prepared by vacuum sintering at 1850 °C for 6 h using nanosized powder. The XRD , SEM, EDX and TEM results reveal that the single pyrochlore phase in the powder sample transforms to the coexistence of La-rich pyrochlore phase and Er-rich defect fluorite phase after high temperature sintering . The high excess amounts of La and Er favor the formation of pyrochlore structure. Despite the coexistence of two phases, the sample with 1 mm thickness shows excellent in-line transmittance in the visible to mid-infrared region (as high as 81% at 1100 nm). The upconversion and infrared emission under 980 nm exciting were measured and discussed as well.
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Journal of Materials Chemistry C
·
2018
·Vol. 6
·期 38
·10226-10232
·
IF 5.976
M. Yuan,R. Wang,C. Zhang,Z. Yang,W. Cui,X. Yang,N. Xiao,H. Wang,X. Xu
Exploiting new transitions in the visible light range is important in the development of advanced color displays, superior laser materials, and novel optical devices. Here, for the first time, we observed several intensive upconversion (UC) emission bands at 382, 472, 506, 560, and 618 nm from a single β-NaYF4:Yb/Er microcrystal via saturated excitation. Compared to the traditional red (650 nm) and green (545 nm) UC emissions, these new emission bands intensify rapidly as the excitation intensity increases, which leads to full-color UC luminescence in the visible region. Nearly white luminescence was elicited from a single microcrystal with a relatively high excitation power. Moreover, the mechanism of these newly observed UC emissions was elucidated by examining the energy migration. It was also found that these microcrystals exhibit waveguide-transmission characteristics and are transparent to their own UC emissions. These findings provide a basis for further exploration of the silent transitions of other rare-earth-ions and demonstrate the potential for using β-NaYF4:Yb/Er microcrystals in a variety of applications in color display and waveguide-based optical devices.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 30
·期 12
·11043-11053
·
IF 2.195
Zheng Jianfeng,Deng Xueshuang,Zhou Xin,Yu Meidong,Xia Zhetao,Chen Xiaohong,Huang Sumei
We report a strategy to fabricate high quality TiO 2 nanrod array ETLs for efficient PSC devices with Cs 0.05 (MA 0.17 FA 0.83 ) 0.95 Pb(I 0.83 Br 0.17 ) 3 triple cation composition perovskite as light absorption material. Mg doped compact TiO 2 (c-TiO 2 ) was employed as seeds for hydrothermal growth of one-dimensional (1D) TiO 2 nanorod (NR) arrays. Assisted with these seed layers, Mg and Er doped TiO 2 rutile NR arrays were synthesized using tetrabutyltitanate (TBT) and Er(NO 3 ) 3 as Ti and Er precursors, respectively. It was found that uniform, straight and vertical TiO 2 NRs with a high area density were formed using Mg and Er co-modification, improving the pore-filling and crystallization of the triple cation perovskites, facilitating charge separation and suppressing recombination at the perovskite/titania NR interface of the PSC device. The shorter PL decay time with Mg/Er doping compared to the cases without Mg or Er doping is assigned to the more excellent electron extraction from the mixed cation perovskite film. The control device without modification shows an average power conversion efficiency (PCE) of 17.10%. Under the same fabrication conditions, doping of the single element Er or Mg or both Mg and Er enhances the average PCE to 17.54, 18.41 and 18.99% respectively. Our champion cell based on Mg/Er modified TiO 2 NR arrays demonstrates a PCE of 19.11%, exhibiting an enhancement of 10.33% compared with that of the PSCs based on unmodified TiO 2 NR arrays (17.32%). This work provides a simple and efficient interface engineering method to improve the efficiency of the mixed cation PSCs.
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Materials Express
·
2018
·Vol. 8
·期 2
·141-148
·
IF 1.597
Tan Haihu,Xie Shaowen,Li Na,Tong Chao,Xu Lijian,Xu Jianxiong,Zhang Changfan
Luminescent polymer composite films were prepared by aqueous solution casting method employing poly(vinyl alcohol) (PVA) as a matrix polymer and NaYF4:Yb, Er up-conversion phosphors (UCPs) as the filler. A series of luminescent UCP/PVA composite films were obtained by varying
the amount of the UCP filler. The effects of UCP incorporation on the structure, morphology, thermal stability and optical properties were also examined. The well-dispersed UCPs in the polymer matrix enhanced the thermal stability of composite films due to hydrogen bonding between the PVA
and UCPs. Besides, the incorporation of UCPs did not greatly decrease the transparency of films but imparted fluorescent properties to the polymer matrix. The fabricated UCP/PVA composite films exhibited strong up-conversion photoluminescence upon the 980 nm laser excitation. The UCP/PVA composite
fluorescent films may have promising application in anti-counterfeiting packaging and in other optics related fields.
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Nanoscale Research Letters
·
2013
·Vol. 8
·期 1
·1-8
·
IF 2.524
Zhou Na,Qiu Peiy,Wang Kan,Fu Hualin,Gao Guo,He Rong,Cui Daxiang
Water-soluble upconversion nanoparticles (UCNPs) were prepared by a one-pot procedure in a two-phase reacting system. Four kinds of surfactants were tested in the synthesis process as capping agent to tune size and morphology of nanocrystals. Nanoparticles (approximately 70 nm) and rods (400 nm and 2.5 μm) were synthesized, respectively. Then, Fourier transform infrared spectroscopy analysis confirmed the successful linking between UCNP surface and surfactant. Ionic liquids (ILs) and surfactants participated in synthesis process together, competing with each other to cap on UCNPs. ILs still led the competition of capping, while surfactants worked as cooperative assistants to develop functional surface. Further characterizations such as high-resolution transmission electron microscopy and X-ray diffraction indicated the changes in crystallization and phase transformation under the influence of surfactants. In addition, the growth mechanism of nanocrystals and upconversion fluorescence luminance was also investigated in detail. At last, the cytotoxicity of UCNPs was evaluated, which highly suggest that these surface-functionalized UCNPs are promising candidates for biomedical engineering.
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RSC Advances
·
2015
·Vol. 5
·期 115
·94980-94985
·
IF 3.84
Chuanying Wang,Xianhua Cheng
In this work, amino-functionalized NaYF4:Yb,Er upconversion nanoparticles (UCNPs) were synthesized by a hydrothermal method. Then a simple self-assembly method was carried out to prepare a NaYF4:Yb,Er upconversion (UC) film on a silicon (Si) substrate, using γ-(2,3-epoxypropoxy)propyltrimethoxysilane (KH-560) as an intermediate coupling agent. The chemical composition and surface morphology of the UC film were characterized using X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), water contact angle (WCA), and scanning electron microscopy (SEM) measurements. Furthermore, the tribological properties of the UC film were investigated by a UMT tester. The results indicate that the UC film has been successfully prepared on the Si substrate by the formation of chemical bonds and its lifetime is about five times longer than that of the NaYF4:Yb,Er UCNPs on a bare Si substrate. This work provides a facile way to synthesize a NaYF4:Yb,Er UC film with robust adhesion to the substrate, which can be applicable for other UC films.
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