ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jiajia Wang,Li Li,Ruyi Wei,Renfeng Dong
Here, we report the first PbS quantum dot (QD)-based micromotors with NIR-I light-driven photocatalytic propulsion and NIR-II fluorescence. Under the irradiation of NIR-I light (808 nm), PbS QD-doped cuprous oxide (Cu2O@PbS) micromotors can display efficient propulsion in a variety of biocompatible fuels such as malic acid, glucose, and urea. Among them, the Cu2O@PbS micromotors exhibit the best propulsion performance in a very low concentration of malic acid, with an average speed as high as 11.86 μm/s. The enhanced NIR-I photocatalytic activity of Cu2O@PbS micromotors benefits from the doping of NIR-I PbS QDs that can be excited by NIR-I light and exhibit high electron transport efficiency. The doped PbS QDs can effectively increase the absorption efficiency of the micromotors in the NIR-I region while also inhibiting the recombination of photogenerated electron–hole pairs. Interestingly, due to the presence of NIR PbS QDs, the Cu2O@PbS micromotors demonstrate prominent and stable NIR-II fluorescence (emission wavelength: 1100 nm), which offer promising potential for visualization of their position in vivo. In comparison to other photocatalytic micromotors, the simple fabrication strategy, excellent NIR-II fluorescence, together with the NIR-I light-dependent propulsion behavior of the current Cu2O@PbS micromotors, thus pave the way for further development of advanced smart “robots” for intelligent biomedical applications.
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Soft Matter
·
2024
·Vol. 20
·期 48
·9614-9621
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IF 2.9
Fengkai Liu,Xi Chen,Zhigang Suo,Jingda Tang
A composite of a knitted fabric and a soft matrix enables applications that require low stiffness and high crack resistance. Examples include heart valves and stretchable strain sensors. Here we study processes of crack growth in such a composite under monotonic and cyclic stretch. We fabricate a composite using a knitted fabric of nylon yarn and an elastomer matrix of polycarbonate urethane. We precut a sample with a crack, monotonically stretch the sample, and observe the growth of the crack. The crack grows in the matrix as the yarn slips and breaks. The stretch is converted to energy release rate G. We identify two critical energy release rates, GA and GB. When G < GA, the yarn does not slip, and the crack does not grow in the matrix. When GA < G < GB, the yarn slips but does not break, and the crack grows in the matrix stably and arrests when the stretch stops increasing. When G = GB, the yarn slips and breaks, while the crack grows unstably. When the sample is subject to cyclic stretch, we observe analogous behavior of crack growth and arrest, as well as yarn slip and yarn break. However, the two critical values, Ga and Gb, are much smaller than the corresponding values under monotonic stretch.
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Materials Today Communications
·
2025
·
IF 4.5
Wanxiao Wang,Xiaojie Liang,Jiayu Yang,Zihan Su,Yue Chen,Lijuan Chen,Yuzhu Qian,Bei Long
The development of high-performance anode materials is crucial for aqueous ammonium ion batteries. In the meanwhile, adding an additional redox pair is thought to be a good way to raise the overall electrochemical performance of the system. In this study, a hybrid battery composed of active carbon and BiOI is developed using an NH 4 AC + NH 4 I electrolyte. Electrochemical tests and ex-situ characterization validate the dual processes of NH 4 + (de)intercalation and I − /I 2 redox. Moreover, the NH 4 I additive enhances the charge transfer of the whole battery and changes the phase transition of BiOI in the charge-discharge process. Consequently, this hybrid battery exhibits a long-term cyclic stability (70 % capacity retention after 2300 cycles at 0.2 A g −1 ) and a high specific capacity (196 mA h g −1 at 0.2 A g −1 ). The cell with a high-loading BiOI electrode (12 mg cm −2 ) also exhibits satisfactory performances, reflecting its application potential. This work provides a reference for designing aqueous hybrid battery.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zhexiang Wang,Xinyi Li,Rui Lv,Ruochen Guo,Qinglei Shu,Tianjin Ge,Jun Yan,Zhihao Zhao,Guanghui Wang,Jian Liu
The click chemistry catalyzed by transition metals is the research front line for bioorthogonal therapeutics. However, it demands the use of external ligands to form transition metal–ligand complexes for the catalytic enhancement, thus leading to biosafety concerns on the undesired side effects of the complexes or the additional ligands themselves during therapies. Here we report a pH/GSH-driven inside-out nanoreactor initiating Cu(I)-precursor chelation-promoted bioorthogonal catalysis against malignant tumors. It comparts the precursors (Azide and Alkyne) and Cu(II) safely with disulfide-functionalized hyaluronic acid-polycarprolactone (abbr. PCHP1) polymersome structure. Once sensing the pH/GSH changes typically in tumor microenvironment, our nanoreactor starts with a unique programed releasing, allowing for the inside-out translocation of Azide with the highest priority. Subsequently the Cu(I)-Azide chelation can promote the catalytic reaction to generate drug molecules in a highly efficient, ligand-free manner. The PCHP1 nanoreactor can suppress malignant tumors significantly better than the other control groups in the in vitro and in vivo experiments, while inducing minimal side effects. Our strategy of ligand-free Cu(I)-precursor chelation promoted click chemistry will facilitate the development of bioorthogonal catalytic therapies for clinical translation.
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BIOCHEMICAL PHARMACOLOGY
·
2021
·
IF 5.858
Yi Wang,Zhigang Wang,Zhengping Wu,Menglin Chen,Dong Dong,Pei Yu,Danyi Lu,Baojian Wu
The molecular events underlying aristolochic acid (AA) nephropathy are poorly understood, and specific therapies for treatment of AA nephropathy are still lacking. Here we aimed to investigate a potential role of REV-ERBα and ferroptosis in renal injury induced by aristolochic acid I (AAI), a typical AA. The regulatory effects of REV-ERBα on AAI-induced renal injury were determined using kidney-specific Rev-erbα knockout mice . Ferroptosis was assessed based on measurements of iron, GSH, and GPX4 . Targeted antagonism of REV-ERBα to alleviate AAI-induced renal injury and ferroptosis was assessed using the small molecule antagonist SR8278. mRNAs and proteins were quantified by qPCR and Western blotting , respectively. We first showed that REV-ERBα was upregulated and its target BMAL1 was downregulated in the kidney of mice with AAI nephropathy. Upregulation of REV-ERBα protein was confirmed in aristolactam I (ALI, a nephrotoxic metabolite of AAI)-treated mRTECs. We also observed enhanced ferroptosis (known to be regulated by REV-ERBα) in mice with AAI nephropathy and in ALI-treated mRTECs. Kidney-specific knockout of Rev-erbα reduced the sensitivity of mice to AAI-induced ferroptosis and renal injury. Furthermore, knockdown of Rev-erbα by siRNA or SR8278 (a REV-ERBα antagonist) treatment attenuated ALI-induced ferroptosis in mRTECs. Moreover, REV-ERBα antagonism by SR8278 alleviated ferroptosis and renal injury caused by AAI in mice. In conclusion, we identify REV-ERBα as a regulator of AAI-induced renal injury via promoting ferroptosis. Targeting REV-ERBα may represent a promising approach for management of AAI nephropathy.
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Laser & Photonics Reviews
·
2025
·
IF 10
Ziyi Niu,Pengfei Zhang,Wenbo Chen,Junyang Xia,Zhili Zhang,Jinwei Liu,Yanyan Li,Bitao Liu,Lei Zhao
Near-infrared (NIR) mechanoluminescence (ML) holds significant promise for in vivo biomechanical detection and imaging due to its self-powered excitation and self-recovery capabilities. However, its broader application remains constrained by the limited availability of suitable ML materials and the narrow spectral range of NIR emission. In this study, we report the Y 3 Ga 5 O 12 (YGO): Cr 3+ , Nd 3+ , Yb 3+ /polydimethylsiloxane (PDMS) NIR-ML composite with broadband NIR emission tunable from 600 to 1100 nm, covering both the NIR-I and NIR-II windows. The ML of composite device is driven by an interfacial triboelectric effect arising from the mechanical interaction between the inorganic particles and the polymer matrix. Comparative studies on photon penetration through biological tissues reveal that co-doping with Nd 3+ and Yb 3+ markedly enhances tissue penetration depth. Specifically, the luminescence decay rate in biological tissues is reduced by 20.8% relative to Cr 3+ single doping, indicating improved optical persistence and signal transmission. These findings demonstrate the potential of full-spectrum NIR-ML devices for high-resolution, deep-tissue biomechanical sensing and imaging. This work provides a generalizable design strategy for the development of broadband NIR-ML materials tailored for in vivo mechanical diagnostics.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2022
·
IF 5.195
Xiao-guo Suo,Fang Wang,Chuan-hui Xu,Xiao-yan He,Jia-nan Wang,Yao Zhang,Wei-jian Ni,Hao Lu,Ming-lu Ji,Yuan He,Shuai-shuai Xie,Ya-ru Yang,Jia-gen Wen,Juan Jin,Qian Gong,Jun Li,Ming-ming Liu,Xiao-ming Meng
Renal fibrosis , a common feature of chronic kidney disease , causes the progressive loss of renal function, in which TGF-β 1 plays a critical role. In this study, we found that expression levels of TGF-β 1 and its receptor 1 (TGF-βR1) were both significantly increased in obstructive fibrosis kidneys. AZ12601011 is a small molecular inhibitor of TGF-βR1; however, its therapeutic potential for renal fibrosis remains unclear. During the experiments, AZ12601011 was applied to various models of renal fibrosis followed by unilateral ureteral obstruction (UUO) and ischemia/reperfusion (I/R) in vivo , in addition to renal tubular epithelial cells (TECs) challenged by hypoxia/reoxygenation (H/R) and TGF-β 1 in vitro. Our results revealed that AZ12601011 ameliorated renal injuries and fibrosis shown by PAS, HE , and Masson staining , which was consistent with the decrease in Col-1 and α-SMA expression in the kidneys from UUO and I/R mice. Similarly, in vitro data showed that AZ12601011 inhibited the induction of Col-1 and α-SMA in both TECs treated with TGF-β 1 and H/R. In addition, the results of cellular thermal shift assay (CETSA), molecular docking , and western bolt indicated that AZ12601011 could directly bind to TGF-βR1 and block activation of the downstream Smad3. Taken together, our findings suggest that AZ12601011 can attenuate renal fibrosis by blocking the TGF-β/Smad3 signaling pathway and it might serve as a promising clinical candidate in the fight against fibrotic kidney diseases.
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PubMed
高影响因子
Frontiers in Immunology
·
2022
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IF 8.786
Xin Zhao,Wenji Huang,Yanjie Shi,Jiahong Guo,Hehe Xiao,Ning Ji,Jianhua Feng,Huifeng Dang,Jun Zou
PLAAT1 is a member of the PLAAT protein family and plays important roles in tumor suppression, transglutaminase activation and peroxisomal biogenesis. Recently, PLAAT1 has been shown to promote degradation of p53 protein and cellular organelles such as mitochondria, endoplasmic reticulum and lysosome. In this study, we show that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Overexpression of Plaat1 in zebrafish cells suppresses antiviral responses and promotes virus replication. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to initiate degradation of IRF3 and IRF7, which can be attenuated by 3-methyladenine, an inhibitor of autophagosome. Our study provides novel insights into the functions of PLAAT1 in host immune response to viral infection.
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高影响因子
Journal of Radiation Research and Applied Sciences
·
2020
·
IF 1.804
Xue-Wen Liu,Ning-Yi Liu,Yuan-Qing Deng,Shan Wang,Ting Liu,Yu-Cai Tang,Yuan-Dao Chen,Ji-Lin Lu
ABSTRACT In recent years, ruthenium (II) complexes have attracted attention due to high DNA topoisomerase I inhibitory activities and good anticancer activities. Herein, an asymmetric ligand 2-(5-(1, 10-phenanthroline))-1 H-4,5-diphenyl-imidazole (pdpi) and its ruthenium complexes were synthesized. DNA-binding mode of two complexes was determined as intercalation by using UV–vis spectra, emission spectra, viscosity, and molecular docking experiments. DNA photocleavage experimental results show that two ruthenium complexes effectively cleave plasmid DNA by producing singlet oxygen. Furthermore, they both displayed good topo I inhibition activities. The cytotoxic activities results show that complex 2 displays better antitumor activities against Eca-109 cells and A549 cells (IC 50 = 25.97 ± 3.33 μM and 28.83 ± 2.49 μM, respectively) compared to complex 1 .
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2018
·Vol. 32
·期 4
·e4231
·
IF 3.581
Xue-Wen Liu,Yang Xiao,Wei-Gen Peng,Li-Jin Zhao,You-Ming Shen,Song-Bai Zhang,Ji-Lin Lu
Two ruthenium complexes containing a new ligand phipz (phipz = 2-(1,10-phenanthroline)-1H-imidazo[4,5-b]phenazine) were designed and synthesized. These complexes were found to inhibit the DNA supercoiled relaxation mediated by topoisomerase I (topo I), cleave DNA under irradiation and bind to calf thymus DNA through intercalative mode. Furthermore, complex 2 shows higher photocleavage activity, topo I inhibition activity and DNA affinity than complex 1 . Additionally, introduction of phenazine unit may be the reason that two complexes exhibit DNA ‘light switch’ behavior. The present work shows that two complexes might be potential as new DNA ‘light switches’, DNA photocleavers and topo I inhibitors.
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DRUG DELIVERY
·
2025
·
IF 8.1
Mengjie Rui,Lei Fang,Mengfei Jia,Wenyan Liang,Yinfeng Li,Yaoshun Ruan,Chunlai Feng
Apolipoprotein A-I (ApoA-I) mimetic peptides have garnered attention as potential anticancer agents owing to their role in cholesterol metabolism and ability to interact with the SR-BI receptor. However, their tendency to form lipid-bound structures in circulation limits their tumor-targeting therapeutic potential and raises the risk of off-target effects. In this study, we engineered a stimuli-responsive ApoA-I mimetic peptide by incorporating reactive oxygen species (ROS) -responsive amino acid derivatives into its sequence. Under normal physiological conditions, the peptide adopted a disordered conformation, minimizing nonspecific interactions. In contrast, the exposure to the tumor microenvironment, which is characterized by low pH and elevated ROS, could trigger a conformational transition to a structured α-helical state, thereby enhancing its membrane-disruptive and tumor-targeting capabilities. Molecular dynamics simulations predicted a rapid increase in α-helical content for the peptide candidate 5A under tumor-like conditions. These predictions were experimentally validated using circular dichroism spectroscopy, liposome leakage assays, and transmission electron microscopy, which demonstrated that peptide 5A effectively interacted with lipid membranes only upon activation in a tumor-like environment. In vitro cytotoxicity assays further confirmed the selective anticancer activity of peptide 5A under acidic conditions, while in vivo imaging and tumor inhibition studies in breast cancer models revealed significant tumor accumulation and a tumor growth inhibition rate of up to 71.43% at a 6 mg/kg dose. Our results demonstrated the potential of stimuli-responsive ApoA-I mimetic peptides for targeted cancer therapy, offering a promising strategy to enhance therapeutic efficacy while minimizing systemic toxicity.
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INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
·
2018
·
IF 3.891
Jian Xie,Jinliang Xu,Xiang Li,Huan Liu
Dropwise condensation heat transfer (DWC) on superhydrophobic nanograsses surface (NGS) was investigated for long-term operation. For DWC of pure water-vapor on fresh NGS, two heat transfer regimes are identified: higher heat transfer coefficients with droplet jumping, and constant heat transfer coefficients with droplet rolling. The one-week operation not only deteriorates heat transfer performance, but also changes jumping or rolling mode to sliding mode. The condensation heat transfer coefficients are apparently decreased from first to third day, but they approach a limit value since the third day. In order to identify if the single-molecule-layer of polymer (SML) modified on nanograsses was destroyed, DWC on a smooth single-molecule-layer of polymer surface (SSML) was tested to display stable heat transfer with drop sliding for one-week operation, concluding no failure of the polymer layer. The collapse and breakage of nanograsses were observed to explain the decayed heat transfer versus time on NGS. Compared with SSML, the NGS has smaller droplet departure size but lower heat transfer coefficients, indicating positive and negative effects after introducing nanostructures. Three nanostructure failure mechanisms are proposed. This work suggests a new research field of the nanoscale fluid-wall interaction.
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