ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Hanyu Hu,Zeyu Lyu,Dashuai Sun,Shuai Wei,Jia Liu,Xin Wang,Luhui Zhou,Hongpeng You
Although there have been numerous reports on broadband near-infrared (NIR) emitting phosphors, their emissions are mainly concentrated in the range of 700–1000 nm (NIR-I). Herein, we successfully synthesized a broadband near-infrared phosphor CaMgGeO4:Cr4+(CMG:Cr4+) with an emission in the range of 1000–1600 nm (NIR-II). The introduction of Er3+ ions into CMG:Cr4+ resulted in a wider near-infrared emission phosphor CaMgGeO4:Cr4+,Er3+ (fwhm = 361 nm), compensating for the luminescence of 1500–1600 nm. More importantly, an energy transfer from Cr4+ to Er3+ ions has been discovered. Furthermore, a NIR pc-LED was fabricated by combining the CMG:Cr4+,Er3+ phosphor with a 590 nm chip. The changes in intensity and profile of the transmission spectra of light passing through different liquids reveal its potential application in organic compound recognition. This work opens a direction for the development of NIR-II phosphors.
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BIOMATERIALS
·
2019
·
IF 10.273
Zheng Liu,Feng Ren,Hao Zhang,Qiang Yuan,Zhilin Jiang,Hanghang Liu,Qiao Sun,Zhen Li
Rare-earth nanoparticles (RE NPs) with narrow long wavelength emissions have been recently investigated for their potential application for fluorescence imaging in the second near-infrared window (NIR-II). Previously these RE NPs have a very limited application in the diagnosis and treatment of deep-seated tumors such as brain tumors, due to their weak fluorescence in the range of 1300–1700 nm. Herein, we report a significant enhancement of more than 10 times regular emission of NaNdF 4 nanoparticles at 1340 nm wavelength by coating them with an inert layer of NaLuF 4 , followed by sensitizing with a near-infrared dye (IR-808). We deliver these highly bright nanoparticles into the brain by using focused ultrasound to temporarily open the blood-brain barrier (BBB), and then detect the orthotopic glioblastoma by fluorescence imaging at 1340 nm. The images obtained from long wavelength fluorescence ( i.e. 1340 nm) exhibited better resolution and contrast compared to the short wavelength fluorescence ( i.e. 1060 nm). Our study not only provides insights for enhancing often overlooked emissions of rare-earth nanoparticles for NIR-II fluorescence imaging of deep-seated tumors, but also demonstrates great potential of focused ultrasound based technology in delivering nanotheranostic agents.
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Laser & Photonics Reviews
·
2022
·Vol. 16
·期 11
·2200318
·
IF 10.947
Xin Xu,Peigeng Han,Daoyuan Zheng,Kaimin Du,Chunxia Li,Feng Liu,Ruiling Zhang,Keli Han
Recently, lanthanide-doped halide perovskites have attracted increasing attention due to their unique optical properties, such as upconversion (UC) and near-infrared (NIR) emission. However, these emitters suffer from low efficiency, limiting further practical applications. Herein, a Bi 3+ -alloyed double perovskite, Cs 2 NaEr 0.5 Bi 0.5 Cl 6 , with strong NIR-triggered UC and NIR-II (1000–1700 nm) emission is reported. Cs 2 NaEr 0.5 Bi 0.5 Cl 6 exhibits efficient green UC emission with a high quantum yield up to 2.1% and NIR-II emission peaking at 1541 nm with a quantum yield of 37.9% under 980 nm excitation. The strong UC emission is related with the efficient energy transfer between Er 3+ and self-trapped exciton states induced by corporation of Bi 3+ ions. In addition, Bi 3+ ions can act as diluters, suppressing the energy loss caused by undesirable successive energy transfer among Er 3+ ions, enhancing the UC and NIR-II emission. Furthermore, a water-resistant Cs 2 NaEr 0.5 Bi 0.5 Cl 6 /polydimethylsiloxane film is prepared. Excitingly, Cs 2 NaEr 0.5 Bi 0.5 Cl 6 not only shows the potential as a UC thermometry with high sensitivity but also exhibits a high signal to noise ratio in NIR imaging.
研究领域:
材料科学
·
光学
·
纳米技术
·
光子学
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Science China-Chemistry
·
2021
·Vol. 64
·期 12
·2218-2229
·
IF 9.445
Ye Jiamin,Fu Qinrui,Liu Luntao,Chen Lanlan,Zhang Xuan,Li Qingqing,Li Zhi,Su Lichao,Zhu Rong,Song Jibin,Yang Huanghao
Varieties of contrast agents have been developed for photoacoustic (PA) and ultrasound (US) imaging of cancers in vivo . However, access of traditional contrast agents into the sites of tumors has been principally through passive infiltration without any external force, preventing their deep penetration into the tissues of the tumors, and hindering the use of PA and US for deep tumor imaging. The concept of micro/nanomotors has been the focus of increasing attention as active theranostic agents due to their active movement in particular fluids, thereby conducting assigned tasks. Herein, US-propelled Janus mesoporous SiO 2 partially coated gold nanorods (Au NR-mSiO 2 ) were fabricated for deep tumor NIR-II PA imaging and synergistic sonodynamic-gas therapy. Following US irradiation, 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) loaded in mSiO 2 (Au NR-mSiO 2 /AIPH) generated N 2 microbubbles with high efficiency to achieve nanomotor drive. Due to the deep penetration of US, the nanomotors exhibited a capability to travel deep within sites of tumors, providing enhanced PA/US imaging inside the tumors. Furthermore, the nanomotor based cancer therapy was demonstrated through synergistic N 2 gas and sonodynamic therapy. The US-propelled nanomotors demonstrated a novel strategy for the simultaneous PA/US dual imaging deep within tumor tissues and precise therapy of large tumors.
研究领域:
生物医学工程
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治疗诊断学
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成像科学
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癌症研究
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Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 23
·7611-7618
·
IF 6.4
Xiaoxuan Guo,Bomei Liu,Rongyi Kuang,Weijiang Gan,Lin Huang,Jing Wang
Cr-activated phosphor-converted light sources have attracted widespread attention in various applications based on near-infrared (NIR) spectroscopy. Unfortunately, Cr ions usually face the issue of multivalence and typically exist in the valence of +3, which gives the emission mainly at NIR-I (700–1000 nm) and greatly limits its potential application. In this study, we propose the control strategies of site occupancy confinement and sintering atmosphere to synthesize Cr4+-activated Li2SrGeO4 (LSGO:Cr4+) phosphors. Interestingly, the as-optimized LSGO:Cr4+ achieves a NIR broadband emission peak at 1170 nm with an FWHM of 208 nm upon excitation at 680 nm and exhibits excellent thermal stability and high efficiency with the external quantum efficiency of 30.0%. Furthermore, the as-fabricated LSGO:Cr NIR phosphor-converted light emitting diode (NIR pc-LED) device shows a high power of up to 69.1 mW at 550 mA. Furthermore, as NIR-II (1000–1700 nm) light source, the phosphor successfully distinguishes deuterium and non-deuterium reagents. For example, the quantitative detection of H2O in heavy water (D2O) is demonstrated by NIR spectroscopy with a limit of detection (LOD) of 0.47 vol%. Our findings will open up a new avenue to develop novel Cr4+-activated NIR-II phosphors and NIR-II light sources.
研究领域:
材料科学
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光学工程
·
分析化学
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Journal of Materials Chemistry B
·
2021
·Vol. 10
·期 4
·506-517
·
IF 6.331
Nuernisha Alifu,Rong Ma,Lijun Zhu,Zhong Du,Shuang Chen,Ting Yan,Gulinigaer Alimu,Linxue Zhang,Xueliang Zhang
Near-infrared II (NIR-II, 900–1700 nm) fluorescence bioimaging with advantages of good biosafety, excellent spatial resolution, high sensitivity, and contrast has attracted great attention in biomedical research fields. However, most of the nanoprobes used for NIR-II fluorescence imaging have poor tumor-targeting ability and therapeutic efficiency. To overcome these limitations, a novel NIR-II-emissive theranostic nanoplatform for fluorescence imaging and treatment of cervical cancer was designed and prepared. The NIR-II-emissive dye IR-783 and chemotherapy drug doxorubicin (DOX) were encapsulated into liposomes, and the tumor-targeting peptide TMTP1 (a polypeptide with a sequence of cyclic ASN Val Val Arg Gln Cys) was conjugated to the surface of the liposomes to form IR-783-DOX-TMTP1 nanoparticles (NPs) via self-assembly methods. The IR-783-DOX-TMTP1 NPs showed strong NIR-II emission, excellent biocompatibility and a long lifetime in vivo. Furthermore, high-definition NIR-II fluorescence microscopy images of ear blood vessels and intratumoral blood vessels were obtained from IR-783-DOX-TMTP1 NP-stained mice with high spatial resolution under 808 nm laser excitation. Moreover, IR-783-DOX-TMTP1 NPs showed strong tumor-targeting ability and highly efficient chemotherapeutic characteristics towards cervical tumors. The novel targeting and NIR-II-emissive IR-783-DOX-TMTP1 NPs have great potential in diagnosis and therapy for cervical cancer.
研究领域:
生物医学工程
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癌症研究
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诊疗一体化
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纳米技术
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生物医学成像
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高影响因子
Materials Today Advances
·
2026
·
IF 8
Jiabao Xiong,Yuan Wang,Lijun Zhu,Zhong Du,Le Guo,Jiayi Ding,Chi Zhang,Siyiti Amuti,Junhua Hu,Chao Wang,Biao Dong,Nuernisha Alifu
Overcoming thermoresistance and achieving precise, efficient tumor therapy remain major challenges. Heat shock protein 70 (HSP70) expression and autophagy activation are two major cellular defense mechanisms associated with thermal resistance. However, strategies that target both mechanisms to improve tumor treatment efficacy remain limited. Herein, this study presents a novel type of near-infrared II (NIR-II)-responsive theranostic nanoplatform (IR-820@γ-PGA/Arg NPs, PIRA NPs) that integrates photothermal therapy (PTT), photodynamic therapy (PDT), nitric oxide (NO)-mediated gas therapy (GT), and dual-pathway inhibition mechanisms to overcome thermal resistance. The theranostic nanoplatform utilizes a γ-polyglutamic acid (γ-PGA) to encapsulate the NIR-II dye IR-820, which forms stable J-aggregates to improve NIR-II fluorescence emission and photothermal conversion efficiency. The nanoplatform adsorbs L-arginine (Arg) and releases NO under 808 nm laser excitation, exhibiting excellent photothermal properties and NIR-II fluorescence emission for precise tumor treatment. PIRA NPs overcome photothermal resistance via two pathways: suppressing HSP70-mediated thermoresistance and disrupting the autophagy-lysosomal degradation pathway (LC3B/p62 axis) through Arg-derived NO generation. This dual-pathway blockade effectively neutralizes tumor defenses, achieving a 92.7% tumor inhibition rate with minimal systemic toxicity. The γ-PGA framework enhances the stability of J-aggregates and their biocompatibility, further improving therapeutic efficacy. This work provides a versatile nanotherapeutic platform based on a promising strategy for reversing thermoresistance and achieving highly efficient cancer therapy.
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Advanced Optical Materials
·
2026
·
IF 7.2
Qian Zhu,Huilin Chen,Ruichan Lv,Yuzhen Wang,Zhiguo Xia
Near-infrared II (NIR-II) emissions are unique and selective for non-destructive detection owing to their specific response to temperature changes and the ability to cover the characteristic overtone absorption bands of molecular functional groups. However, cross-interference in the spectral responses occurs for simultaneous temperature sensing and chemical reagent identification, therefore it is necessary to realize reliable decoding. Herein, the Nd 3+ / Er 3+ co-doped Y 2 MgTiO 6 phosphors with NIR-II emissions under 808 nm excitation have been designed and prepared, and the temperature sensing properties have been evaluated, in which the distinctive thermally enhanced luminescence is attributed to the efficient energy transfer process from Nd 3+ to Er 3+ ions. Besides, NIR-II-emitting composite film based on the rationally designed phosphors has been fabricated as the sensing platform, and the concentration recognition of water and methanol is enabled by the overtone absorption of C─H and O─H bonds. Finally, a Large Scale Convolutional Neural Network model is constructed to synchronously decouple, which can accurately extract temperature and chemical concentration from complex spectral data. This work paves the way for constructing a feasible and compact platform for dual-function intelligent sensors.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Xinru Chen,Xiaoyan Wang,Jin Li
Raman spectroscopy in the second near-infrared (NIR-II, 1000–1700 nm) window has received ever-increasing attention in intraoperative tumor imaging due to its high specificity and penetration depth. However, the overwhelming majority of existing NIR-II Raman probes are fabricated by SERS with substrate enhancement, which raises serious biosafety concerns. Herein, we present van der Waals (vdW) enhanced Raman scattering (vdW-ERS) effect based on intermolecular charge transfer of dithiolene to develop ultrabright metal-free NIR-II Raman probes. The intermolecular charge transfer within dithiolene through vdW stacking is well illustrated by independent gradient model and ultrafast spectroscopy, which significantly boosts the intrinsic Raman properties with ultrahigh scattering cross-section (1.59 × 10 −19 cm 2 ) as well as the photothermal conversion efficacy (60.4%) through an additional femtosecond-scale non-radiative decay channel. Moreover, the fluorescence-free property of dithiolene greatly inhibits the spectral backgrounds and improves the photostability. In the tumor models of triple-negative breast cancer, vdW-ERS probes enable intraoperative CXCR4-targeted Raman-guided surgical resection and postoperative hyperthermia ablation of the residual microscopic tumors, resulting in approximately 100% survival rate. Importantly, vdW-ERS probes are hepatically excreted (ca. 92% excretion within two months), in stark contrast to accumulation in the liver for typical gold substrate-enhanced counterparts. Free from fluorescence background and photobleaching, intermolecular vdW-ERS effect presents a new mechanism for fabricating charge transfer Raman probes with the potential for clinical translation.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·Vol. 24
·期 1
·150
·
IF 12.6
Li Bei,Chen Zhengqiang,Sun Yong,Gou Maling,Luo Yuting,Zhang Wenli,Ye Xiwen,Zhao Yaqin,Feng Lei,You Zhen
The deep-seated locations and hypoxic microenvironments of tumors critically hinder conventional phototherapies. To overcome these limitations, we engineered a novel Au@Cu 2 − x Se nanoprobe via precise aspect ratio control of gold nanorods for NIR-II plasmonic resonance and site-specific growth of Cu 2 − x Se domains, resulting in the formation of a unique “lollipop” nanostructure. This design enables single-wavelength NIR-II laser-activated photothermal therapy and dynamic dual-modal therapy with intrinsic hypoxia tolerance: the nanoprobes achieve exceptional photothermal stability while simultaneously driving photothermally enhanced chemodynamic activity through accelerated Fenton-like catalytic cycles. Crucially, this strategy not only eradicates deep tumors but also activates systemic antitumor immunity. Combined with real-time photoacoustic imaging guidance, the platform establishes an oxygen-independent paradigm for treating hypoxic solid tumors. Graphical
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Polymers
·
2026
·Vol. 18
·期 3
·378
·
IF 4.9
Lin Sun,Zihao Zhang,Bingxin Sun,Zhiheng Yu,Guoyong Wang
Vanadium carbide (V 2 C) MXene shows great potential for addressing challenging implant-associated infections in bone regeneration due to its strong photothermal conversion efficiency. However, its photothermal efficacy is restricted to the near-infrared I (NIR-I) region due to a limited absorption range. To address this, we designed platinum nanoparticle-decorated V 2 C heterostructures (Pt@V 2 C) via an in situ growth method, leveraging Pt’s plasmonic and catalytic properties to extend the photoresponse to the NIR-II window. Subsequently, Pt@V 2 C was integrated into poly-L-lactic acid (PLLA) to fabricate PLLA-Pt@V 2 C scaffolds with photothermal antibacterial function by selective laser sintering. The optimized PLLA-Pt@V 2 C scaffold achieves a record photothermal conversion efficiency (56.03% at 1064 nm), triggering simultaneous hyperthermia (>52 °C) and catalytic ·OH radical generation. In vitro studies demonstrate exceptional antibacterial efficacy against Staphylococcus aureus and Escherichia coli, achieving over 99% killing rates upon 1064 nm near-infrared irradiation. Furthermore, the scaffold demonstrated significant inhibition of biofilm formation, achieving over 90% reduction in biofilm biomass. Moreover, the scaffold demonstrated high cell viability, confirming its dual functionality of potent bactericidal activity and biocompatibility that supports tissue regeneration. This work provides a feasible strategy for combating implant-associated infections.
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Communications Chemistry
·
2026
·
IF 6.9
Yuan Yuan,Liu Yongze,He Lei,Ma Xiaofeng,Wang Heyan,Li Yuanchao,Zhang Zhaoxiang,Zhang Jun,Wu Yongjun,Gao Xia
Acute sinusitis, common across populations, worsens seasonally due to pollution and improper medication, increasing the risk of chronic disease and impairing quality of life. To improve treatment and limit antimicrobial resistance in acute sinusitis, we developed a natural injectable QACS/SA@Py@Ta 4 C 3 hydrogel. It integrates the traditional Chinese medicine phillyrin with Ta 4 C 3 quantum dots and natural polymers—quaternary chitosan and sodium alginate. The hydrogel is designed for NIR II–mediated treatment of acute sinusitis via combined photothermal and photodynamic therapy. It exhibited a photothermal conversion efficiency of 22.6% and generated transient ROS, as demonstrated in vitro. Bacteriostatic experiments revealed that the hydrogel inhibited S. aureus with an efficiency of 99.7%. Furthermore, cell studies showed that the hydrogel was minimally cytotoxic, modulated macrophage cytokine expression, and displayed anti-inflammatory and antioxidant activities. Finally, in a rabbit sinusitis model, hydrogel implantation at the treatment site significantly reduced bacterial burden and decreased inflammation after NIR II laser treatment, demonstrating promising therapeutic potential.
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