Biomedical Materials
·
2021
·Vol. 16
·期 3
·035006
·
IF 3.715
Yuecheng Cui,Ronghua Jin,Yang Zhou,Meirong Yu,Yun Ling,Li-Qun Wang
Temperature-sensitive hydrogels with mild gel-forming process, good biocompatibility and biodegradability have been widely studied as bioinks and biomaterial inks for 3D bioprinting. However, the hydrogels synthesized via copolymerization of aliphatic polyesters and polyethylene glycols have low mechanical strength and cannot meet the needs of 3D printing. In this paper, we propose a strategy of enhancing the strength of hydrogels by introducing crystallization between blocks to meet the requirements of 3D bioprinting inks. A series of polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) triblock polymers were prepared by ring-opening polymerization, of which the strong crystallinity of polycaprolactone blocks improved the printability and enhanced the mechanical properties of the ink. It was found that the resulted hydrogels were temperature-responsive, and the PCL blocks could form a crystalline phase in the state of the hydrogel, thereby significantly increasing the modulus of the hydrogel. Moreover, the mechanical strength of the hydrogel could be adjusted by changing the composition ratio of each block of the copolymer. The 3D printing results showed that the PCL-PEG-PCL hydrogel with crystallinity can not only be extruded and printed via temperature adjustment, but also the three-dimensional structure can be effectively maintained after 3D printing. The gels demonstrated good cell compatibility, and the cell survival rate was maintained at a high level.
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PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Yunran Zhang,Haiping Zhou,Zhe Zhang,Yijun Zhu,Tao Wang,Liguo Yu,Hongrui Song
Betulinic acid (BA) is a new class of anticancer drug , but its relatively short half-life and poor water solubility limit its therapeutic effect and clinical application. Herein, to tackle the dilemma, BA prodrugs were prepared by conjugating BA onto the polyethylene glycol (PEG) polymer via cleavable disulfide bonds. The prodrugs exhibited high water solubility (270-fold of free BA) and a relatively high drug-loading efficiency of 14.2 %. To further endow the BA prodrugs with a photothermal therapeutic effect, the near-infrared (NIR) agent Cypate was grafted on the Pluronic triblock copolymer . The different PEG polymers and different Pluronic polymers were chosen to obtain the optimal drug loading efficiency and the photothermal generation effect. The P-SS-BA/F68-Cy prodrug micelles integrate the redox-responsive BA prodrugs and the NIR-responsive amphiphilic triblock polymer into one single nanocomposite . The release of BA was less than 20 % in pH 7.4 PBS in the absence of glutathione (GSH), whereas the release of BA was obviously accelerated in pH 5.0 PBS with 10 mM GSH. In addition, the release of BA was further accelerated under the NIR irradiation. The P-SS-BA/F68-Cy micelles showed an excellent photothermal heating effect under NIR irradiation. The prepared P-SS-BA/F68-Cy micelles showed the synergistic thermochemotherapeutic effect on tumors both in vitro and in vivo . Therefore, the present study shows the great potential of dual-triggered drug delivery and thermochemotherapy for combination therapy.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Yuhui Xie,Weijie Li,Haowei Huang,Dexuan Dong,Xinya Zhang,Li Zhang,Ying Chen,Xinxin Sheng,Xiang Lu
Phase change materials with desirable light-thermal conversion ability are particularly attractive for solar energy harvesting and storage. Herein, we demonstrate that the combination of efficient light-thermal conversion, excellent thermal property, and reliability can be achieved via the construction of a novel form-stable phase change composite material, that is, Radish@PDA/PEG with a sandwich structure. A 3D porous structure derived from radish via freeze-drying is adopted as the substrate; then, self-polymerization of dopamine is initiated in the surface of Radish to produce a layer of polydopamine (PDA). Finally, polyethylene glycol (PEG) impregnation via vacuum infusion is applied to form the Radish@PDA/PEG composite. These results prove that the incorporation of interlayer PDA can not only improve the strength of the porous structure to protect the PEG from leakage, but also enhance the encapsulation capacity of PEG and light absorption ability of the composite. The preparation method is based on common biomass with green chemicals and thus provides a general way to prepare eco-friendly and biodegradable composite with promising applications in light thermal energy management.
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高影响因子
FIBERS AND POLYMERS
·
2017
·Vol. 18
·期 5
·817-824
·
IF 1.113
Ma Xuebin,Xu Tingting,Chen Wei,Wang Rui,Xu Zheng,Ye Zhiwen,Chi Bo
New applications call for many new requirements. In order to improve the toughness of aldehyde hyaluronic acid (A-HA) and adipic acid dihydrazide (ADH) hydrogel, the poly(ethylene glycol) (PEG) was added. PEG content and molecular weight have little effect on the gelation time, and the composite hydrogels can form in situ within 20 seconds at room temperature. The press test showed that the hydrogels containing PEG possessed a better compression resistance, after pressed more than five times, the composite hydrogels could restore. Rheological properties were measured to evaluate the working ability and the effect of PEG on hydrogels. By analyzing the shear viscosity ( η
γ=0.01 ), yield stress ( σ
0 ) and threshold shear stress ( σ
c
), the addition of PEG can make the structure of composite hydrogels get loose and improve the shear resistance. Especially, PEG800 can enhance the antishear ability obviously. The amplitude sweep tests showed a broad linear viscoelastic region, indicating a wide processing range. In the meanwhile, we also found that PEG can improve the optical transmittance of xerogel evidently.
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高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Jianbing Wu,Xusheng Xie,Zhaozhu Zheng,Gang Li,Xiaoqin Wang,Yansong Wang
The effects of changing solution pH in the range of 3.6–10.0 during a one-step silk microsphere preparation process, by mixing silk and polyethylene glycol (PEG), was assessed. The microspheres prepared at low pH (3.6) showed a more homogeneous size (1–3 μm) and less porous texture than those prepared at neutral pH. High pH (10.0) inhibited microsphere formation, yielding small and inhomogeneous microspheres. Compared to neutral pH, low pH also increased the content of silk crystalline β-sheet structure from approx. 30% to above 40%. As a result, the microspheres produced at low pH were more thermally stable as well as resistant to chemical (8 M urea) and enzymatic (protease XIV) degradation when compared to microspheres prepared at neutral pH. Doxorubicin hydrochloride (DOX) and curcumin (CUR) were successfully loaded in silk microspheres via control of solution pH. The loading efficiency of DOX was approx. 95% at pH 7.0 and approx. 60% for CUR at pH 3.6, attributed to charge-charge interactions and hydrophobic interactions between the silk and drug molecules, respectively. When PBS, pH 7.4, was used as a medium for release studies, the pH 3.6 microspheres released both drugs more slowly than the pH 7.0 microspheres, likely due to the high content of crystalline β-sheet structure that enhanced drug-silk interactions as well as restricted drug molecule diffusion.
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PubMed
高影响因子
Bioactive Materials
·
2017
·
IF 0
Tianmu Hu,Anwar Saeed Ahmed Qahtan,Lei Lei,Zhixin Lei,Dapeng Zhao,Hemin Nie
In order to improve the release pattern of chemotherapy drug and reduce the possibility of drug resistance, poly(ethylene glycol amine) (PEG)-modified alginate microparticles (ALG-PEG MPs) were developed then two different mechanisms were employed to load doxorubicin (Dox): 1) forming Dox/ALG-PEG complex by electrostatic attractions between unsaturated functional groups in Dox and ALG-PEG; 2) forming Dox-ALG-PEG complex through EDC-reaction between the amino and carboxyl groups in Dox and ALG, respectively. Additionally, tuftsin (TFT), a natural immunomodulation peptide, was conjugated to MPs in order to enhance the efficiency of cellular uptake. It was found that the Dox-ALG-PEG-TFT MPs exhibited a significantly slower release of Dox than Dox/ALG-PEG-TFT MPs in neutral medium, suggesting the role of covalent bonding in prolonging Dox retention. Besides, the release of Dox from these MPs was pH-sensitive, and the release rate was observably increased at pH 6.5 compared to the case at pH 7.4. Compared with Dox/ALG-PEG MPs and Dox-ALG-PEG MPs, their counterparts further conjugated with TFT more efficiently inhibited the growth of HeLa cells over a period of 48 h, implying the effectiveness of TFT in enhancing cellular uptake of MPs. Over a period of 48 h, Dox-ALG-PEG-TFT MPs inhibited the growth of HeLa cells less efficiently than Dox/ALG-PEG-TFT MPs but the difference was not significant ( p > 0.05). In consideration of the prolonged and sustained release of Dox, Dox-ALG-PEG-TFT MPs possess the advantages for long-term treatment.
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PubMed
Polymers
·
2019
·Vol. 11
·期 6
·965
·
IF 3.164
Yanxiang Wang,Haiwa Wu,Zihao Wang,Jingjing Zhang,Jing Zhu,Yifan Ma,Zhaogang Yang,Yuan Yuan
Poly(glycerol sebacate) (PGS), a biodegradable elastomer, has been extensively explored in biomedical applications for its favorable mechanical properties and biocompatibility. Efforts have been made to fabricate multifunctional PGS copolymer in recent years, in particular PGS-co-PEG (poly(glycerol sebacate)-co-polyethylene glycol) polymers. However, rare research has been systematically conducted on the effect of reactant ratios on physicochemical properties and biocompatibility of PGS copolymer till now. In this study, a serial of PEGylated PGS (PEGS) with PEG content from 20% to 40% and carboxyl to hydroxyl from 0.67 to 2 were synthesized by thermal curing process. The effects of various PEGS on the mechanical strength and biological activity were further compared and optimized. The results showed that the PEGS elastomers around 20PEGS-1.0C/H and 40PEGS-1.5C/H exhibited the desirable hydrophilicity, degradation behaviors, mechanical properties and cell viability. Subsequently, the potential applications of the 20PEGS-1.0C/H and 40PEGS-1.5C/H in bone repair scaffold and vascular reconstruction were investigated and the results showed that 20PEGS-1.0C/H and 40PEGS-1.5C/H could significantly improve the mechanical strength for the calcium phosphate scaffolds and exhibited preferable molding capability for fabrication of the vascular substitute. These results confirmed that the optimized PEGS elastomers should be promising multifunctional substrates in biomedical applications.Keywords:poly(glycerol sebacate) (PGS);polyethylene glycol (PEG);biomedical application;biodegradable elastomer
研究领域:
材料科学
·
生物医学工程
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PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2020
·
IF 2.734
Ning Ding,Yaxi Wang,Xiaolin Wang,Wei Chu,Tian Yin,Jingxin Gou,Haibing He,Yu Zhang,Yanjiao Wang,Xing Tang
Gemcitabine , as a nucleoside analog , has been used as first-line chemotherapy drug for many years. However, the treatment dose of gemcitabine in the clinic has been usually extremely high due to its rapid metabolism. The aim of this study was to achieve successful chemotherapy at low doses by a PEGylated liposomal delivery system. The liposomes were prepared with Lipoid S-100, Cholesterol and DSPE-PEG2000 (at a molar ratio of 9:2:0.07) by the film dispersion-extrusion-ammonium sulfate gradient method. The entrapment efficiency (EE, %) and drug loading (DL, %) of the liposomes (117.8 ± 16.85 nm) were 68.83% and 2.52%, respectively. The in vitro release study and plasma stability experiments showed the gemcitabine liposomes (GEM-Lip) was more stable than gemcitabine solutions (GEM-Sol) at pH 7.4 and in the plasma. AUC and C max of GEM-Lip were shown to be 6.20 and 16.44-fold higher than that of the solutions. The pharmacodynamics (PD) experiment in Kunming mice bearing a H22 cancer cell model showed that the tumor inhibition rate (TIR) of GEM-Lip was 6.25-fold as that of GEM-Sol when administrated intravenously. Our findings demonstrated that the preparation of GEM-Lip could effectively enhance the pharmacokinetic properties , the plasma stability and antitumor effect of gemcitabine.
研究领域:
药学
·
肿瘤学
·
生物医学工程
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高影响因子
Polymer Chemistry
·
2013
·Vol. 5
·期 6
·2018-2026
·
IF 5.231
Weipu Zhu,Lilong Gao,Qiaojie Luo,Chen Gao,Guangyu Zha,Zhiquan Shen,Xiaodong Li
This study presented a facile method to prepare two PEG derivatives with multi-thiols or multi-enes by polycondensation on a large scale using scandium trifluoromethanesulfonate (Sc(OTf)3) as highly efficient and chemoselective catalyst. A novel type of biodegradable and biocompatible PEG hydrogel was easily obtained through the thiol–ene “click” reaction under physiological conditions. 1H NMR spectra and GPC were used to characterize the chemical compositions and molecular weights of the two PEG derivatives. FT-IR and rheological experiments were used to investigate the gelation behavior of the PEG hydrogel. Degradation studies revealed a precursor concentration-dependent degradation behavior of the resultant PEG hydrogel. In vitro cell viability assay showed the excellent biocompatibility of the two precursors and also the resultant hydrogel. Furthermore, the rat model of abdominal sidewall defect-cecum abrasion suggested that the PEG hydrogel developed in the present study is a promising physical barrier for the prevention of post-operative peritoneal adhesion.
研究领域:
生物材料学
·
医学
·
化学工程
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高影响因子
Journal of Materials Chemistry A
·
2014
·Vol. 2
·期 45
·19315-19323
·
IF 0
Chunli Gong,Fangli Deng,Chi-Pong Tsui,Zhigang Xue,Yun Sheng Ye,Chak-Yin Tang,Xingping Zhou,Xiaolin Xie
The poor electronic conductivity and low lithium ion diffusion rate of a LiFePO4 cathode material are the two major obstacles for its commercial applications in the power lithium ion batteries. This article utilized an electroactive and ion conductive copolymer, polyaniline–poly(ethylene glycol) (PANI–PEG), to modify carbon-LiFePO4 (cLFP) by a facile in situ chemical copolymerization method. The structure and morphology of the cLFP/PANI–PEG composite were confirmed by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compared with a cLFP/PANI composite, the cLFP/PANI–PEG composite exhibited a more uniform and full polymer coating layer. Furthermore, this cLFP/PANI–PEG cathode material exhibits excellent cyclic stability (95.7% capacity retention after 100 cycles at 0.1 C) and high rate capability (125.3 mA h g−1 at 5 C) as the PANI–PEG copolymer coating layer facilitated electron and ion transport within the electrode. Electrochemical impedance spectroscopy (EIS) proved that the lithium ion diffusion in the cLFP/PANI–PEG composite was increased significantly by one order of magnitude compared with cLFP, indicating its possibility to be served as a cathode material for high-performance lithium ion batteries.
研究领域:
材料科学
·
电化学
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DOI
CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Defu Li,Youxin Ye,Derong Li,Xinying Li,Changdao Mu
Gelatin-based composite hydrogel fibers were prepared by gel-spinning with PEG6000 as the modifier. Dialdehyde carboxymethyl cellulose (DCMC), as an ideal crosslinking reagent for protein, was used to fix the composite hydrogel fibers. Then the biological properties of the hydrogel fibers for wound dressings were evaluated. The results indicate that the hydrogen bond interactions and C N linkages between gelatin and DCMC can be formed. The addition of DCMC can efficiently improve the mechanical properties, enzymatic stability and blood compatibility of the hydrogel fibers. Crosslinking with DCMC can reduce the degree of swelling of the hydrogel fibers, which is beneficial for hydrogel fibers to avoid undesired reduction in mechanical properties. Moreover, the composite hydrogel fibers present three-dimensional structure, porous networks and low cytotoxicity. The study suggests that DCMC is an effective crosslinking reagent for biomaterials fixation. The developed composite hydrogel fibers can be well-suited for biomedical applications such as wound dressings.
研究领域:
生物材料学
·
医学工程
·
组织工程
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 22
·18318-18327
·
IF 3.201
Na An,Ying Wang,Meng Li,Huiming Lin,Fengyu Qu
Recently, with strong NIR absorption, CuSx nanomaterials have been considered as potential photothermal and photodynamic anticancer agents. Herein, Cu9S5 nanoparticles were synthesized as the core and coated with mesoporous silica to construct the core–shell nanostructure (Cu9S5@mSiO2). The as-synthesized Cu9S5@mSiO2 nanomaterial possesses uniform sphere morphology, about 50 nm in size. Considering its ample porous structure, Cu9S5@mSiO2–NH2 was used as a nanocarrier to demonstrate the high loading efficiency of the photosensitizer indocyanine green (ICG). Under 808 nm NIR light illumination, the temperature rises to 55.8 °C (3 W cm−2), and the high photo-thermal converter is ascribed the combined action of Cu9S5 and ICG. Moreover, Cu9S5@mSiO2–ICG also reveals the illumination-dependent ROS generation. In addition, polyethylene glycol (PEG) and lactose acid (PEG–LA) was prepared and grafted outside Cu9S5@mSiO2–ICG to further guarantee the targeting and cell uptake performance. Under the synergistic effect of PTT and PDT, the Cu9S5@mSiO2–ICG@PEG–LA nanocomposite shows enhanced cytotoxicity to human hepatoma cells (HepG2), making it a promising candidate in nanomedicine as an antitumor agent.
研究领域:
肿瘤学
·
材料科学
·
纳米医学
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高影响因子
危险品化学品经营许可证（带存储）