JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Zhichun Si,Mengxi Pei,Yishui Liu,Bo Li,Feiyu Kang
Photocatalytic degradation is considered as the most energy-efficient, environmentally benign, and effective method for treating low fraction organic contaminants. However, the photocatalysts still suffer from low utilization efficiency of visible-light and severe carrier recombination. Heterojunctions can resolve these two main problems in some extent but still be restrained by the low quality of hetero-interface. In this study, homojunction was constructed of β-FeOOH quantum dots and nanorods with the same lattice by a two-step precipitation method, to avoid the heterointerface with too many defects and possess good charge separation as a consequence. The catalysts were characterized by activity test, electron spin resonance, Mott-Schottky plots, photocurrent density tests and open-circuit potential measurements, etc. The results revealed that a strong internal electric fields (IEFs) was created at the interface of catalyst. Beneficently, the electron rearrangement leads to a more rational distribution of oxygen vacancies in the catalyst, resulting in more efficient dissociation of oxygen molecules and formation of active radicals, thus facilitating the efficient degradation of toluene. This study proposes a novel strategy to boosting the photocatalytic activity of low dimensional semiconductors via forming homojunction interfaces to improve their charge transfer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2023
·
IF 5.4
Yiyang Du,Tingxu Yan,Bo Wu,Bosai He,Ying Jia
Ethnopharmacological relevance Increased inflammatory response and disruption of neuroplasticity are important mechanisms in the hypothesis of the pathogenesis of depression. Thus, these two aspects are conducive to the development of treatments for depression. Suanzaoren Decoction (SZRD) is a classic traditional Chinese medicine compound for the treatment of insomnia, which can clinically relieve depression symptoms, but its antidepressant pharmacological mechanism remains to be elucidated. Aim of this study Based on the hypothesis of inflammation and neuroplasticity in depression, this study aimed to investigate the antidepressant effect of SZRD and its specific molecular mechanism through chronic unpredictable mild stress (CUMS) induced SD rat model and lipopolysaccharide (LPS) induced BV2 cell neuroinflammation model. Materials and methods The body weight and behavioral indexes of CUMS model rats treated with orally or without oral SZRD for 4 weeks were detected. Hematoxylin and eosin staining was used to observe brain pathological damage. Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling (TUNEL) staining was used to observe neuronal apoptosis. Immunofluorescence, ELISA kit and Western blotting were used to detect the inflammatory index Iba-1 and inflammatory factors, as well as the important inflammatory pathway TLR4/MyD88/NF-κB. Enzyme linked immunosorbent assay (ELISA) and western blotting were used to detect neuroplasticity indexes proteins-brain-derived neurotrophic factor (BDNF), presynaptic membrane protein-synaptophysin (SYP), and postsynaptic protein- 95(PSD95), and the key pathway Wnt/β-catenin. The possible mechanism of SZRD antidepressant was further explored in LPS-induced BV2 cells. Results In vivo and in vitro experiments showed that SZRD treatment significantly reversed the depression-like behaviors in rats, decreased the levels of inflammatory factors and increased the expression levels of BDNF, SYP, PSD95 in depression model rats. Furthermore, SZRD treatment inhibited the activation of TLR4/MyD88/NF-κB and Wnt/β-catenin pathways and reduced the massive nuclear translocation of NF-κB and β-catenin. The addition of NF-κB pathway agonists could partially offset the inhibitory effect of SZRD on the Wnt pathway, and the addition of Wnt pathway agonists could also partially offset the inhibitory effect of SZRD on the TLR4 pathway. Conclusion This study suggestted that SZRD may exert its antidepressant effect by regulating TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway in combination.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Qian Tan,Chao Chen,Cuixia Lin,Jiahui Zhang,Saiwen Liu,Jin Zhang
Kaempferol (KA), which is a biologically active natural polyphenol compound with considerable medicinal value, can be used to fight various diseases. Herein, a β-cyclodextrin/fullerene-graphene oxide/Nickel-metal–organic framework (β-CD/C 60 -GO/Ni-MOF) composite-based electrochemical sensor was developed to detect KA; the composite was characterized using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and X-ray photoelectron (XPS) spectroscopy. The biocompatibility and host–guest recognition performance of β-cyclodextrin (β-CD); the porosity and the catalytic performance of the nickel-metal–organic framework (Ni-MOF); and the excellent electrical conductivity of fullerene-graphene oxide (C 60 -GO) work together to considerably improve the detection performance of the sensor for KA. The sensor has an extensive linear range (0.5–50 μM) and a low detection limit (58 nM) with an electrochemically active specific surface area of 0.0971 cm 2 ; furthermore, the redox mechanism of KA in the sensor is explained. For the detection of actual natural samples of broccoli containing KA, satisfactory recovery rates and accuracy were observed; the recovery rate was 96.4 %–101.1 %.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2021
·
IF 6.789
Ying Zhang,Yujie Luo,Shiqi Fu,Xiulong Lv,Qian He,Fangying Ji,Xuan Xu
UVC (wavelength < 280 nm) has a wide range of applications in the field of water disinfection due to its excellent bactericidal performance. In this work, we synthesized an upconversion luminescent material, β-NaYF 4 : Pr 3+ , Li + (NYF), which can generate UVC, and compounded it with a BiOCl photocatalyst to synthesize β-NaYF 4 : Pr 3+ , Li + @BiOCl (NYF-Bi) with a core-shell structure. The NYF-Bi composite material can be driven under visible light and has high photocatalytic activity . The bactericidal performance of NYF and NYF-Bi were evaluated using Escherichia coli , Staphylococcus aureus , Shigella and Salmonella . The NYF-Bi composite material killed 99.99% of E. coli under visible light (λ ≥ 420 nm) within 180 min and maintained high germicidal efficacy after 4 cycles. Finally, we deduced the sterilization mechanism of the NYF-Bi composite material through carrier dynamics studies and catching agent experiments. The death of bacteria was mainly caused by UVC light and active species , including h + , OH, and O- 2. This research provides a new material for water disinfection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Physiology
·
2021
·
IF 4.566
Wangzhou Kaixin,Lai Zhiying,Lu Zishao,Fu Wanren,Liu Cheng,Liang Zhengeng,Tan Yi,Li Conghui,Hao Chunbo
Human periodontal ligament cells (hPDLCs) play a vital role in cell regeneration and tissue repair with multi-directional differentiation potential. microRNAs (miRs) are implicated in the osteogenesis of hPDLCs. This study explored the mechanism of miR-143-3p in osteogenesis of hPDLCs. Osteogenic differentiation of isolated hPDLCs was induced. KLF5 expression during osteogenic differentiation of hPDLCs was detected and then silenced in hPDLCs. Binding relationship between KLF5 and miR-143-3p was predicted and verified. hPDLCs were treated with miR-143-3p mimic or overexpressing KLF5, and then osteogenic specific markers and mineralized nodules were measured. The key factors of the Wnt/β-catenin pathway during osteogenesis of hPDLCs were measured. KLF5 expression was upregulated during osteogenesis of hPDLCs. KLF5 silencing or miR-143-3p mimic reduced osteogenic specific markers and mineralized nodules. Overexpression of KLF5 could reverse the inhibitory effect of miR-143-3p on osteogenic differentiation. miR-143-3p mimic and KLF5 silencing inactivated the Wnt/β-catenin pathway. Activation of the Wnt/β-catenin pathway reversed the repression effect of miR-143-3p mimic on osteogenesis of hPDLCs. In conclusion, miR-143-3p inhibited osteogenic differentiation of hPDLCs by targeting KLF5 and inactivating the Wnt/β-catenin pathway.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2021
·
IF 4.464
Jing-He Yang,Xiuhong Xu,Miaomiao Chen,Duo Yang,Hongye Lu,Yazhou Sun,Can Shao,Qiangqiang Song,Jie Zhang,Li Gao,Yatao Zhang
The establishment of non-noble metal electrocatalysts with controllable morphology is crucial significance for overall water splitting. Ni-based catalyst is perceived as a promising electrocatalyst due to its excellent oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) performance. Herein, β-Ni(OH) 2 /NF is designed for OER and HER, using a facile hydrothermal etching method. The separation rate of hydroxide is controlled by the copper-ammonium complexation reaction, and the different amounts of oleic acid is added as a protective agent to regulate the surface morphology of the Ni foam. The ingenious combination of several reactants allows us to synthesize different morphology catalysts, and get the best performance from them. The catalyst exhibits superior OER and HER electrocatalytic performance, which overpotential is 329 mV during the OER and 170 mV for the HER at 50 mA cm −2 . Meanwhile, it demonstrates small Tafel slopes of 51 mV dec −1 for HER and 40 mV dec −1 for OER in 1.0 M KOH solution. Moreover, the catalyst presents a stable activity with no significant attenuation after 24 h OER and HER reaction. The hydrothermal etching method is expected to offer an adjustable synthetic strategy for the reasonable design of highly efficient, durable and non-noble-metal bifunction catalysts.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2021
·
IF 6.558
Meiyan Zhu,Xiaotong Dong,Ming Li,Liangbin Jia,Ye Ma,Minggang Zhao,Hongzhi Cui
Detection of pollutants in seawater faces a great challenge of strong interference, and the facile detection method is lacked. The CoMn 2 O 4 /β-MnO 2 p-n junction oxidase mimetics were successfully prepared for colorimetric detection of hydroquinone in seawater. The catalysis ability was enhanced significantly by the photo-induced p-n junction interface effect. It not only promoted the formation of H 2 O 2 by suppressing the recombination of photon-generated carriers, but also provided the driving force for electron transport . The colorimetric detection of hydroquinone was achieved by fading and exhibited good adaptability in seawater. The obtained good recovery rate (97.23%–101.37%) in seawater makes it an inspiring method for practical application. The photo-induced p-n junction interface effect provides an opportunity for developing the application of colorimetric sensing in seawater detection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Microbial Drug Resistance
·
2021
·Vol. 27
·期 3
·337-341
·
IF 3.431
Mingzhi Wang,Bo Ma,Yunfeng Ni,Xiaoyan Xue,Mingkai Li,Jingru Meng,Xiaoxing Luo,Chao Fang,Zheng Hou
Multidrug resistance poses a severe threat to public health and urgently requires new solutions. The natural product chelerythrine (CHE) is a benzophenanthridine alkaloid with antimicrobial potential. In this study, CHE was effective against seven gram-positive bacterial strains, and the minimum inhibitory concentrations (MICs) ranged from 2 to 4 μg/mL. By contrast, CHE showed inferior antibacterial activities against 11 gram-negative strains, and the MICs varied from 16 to 256 μg/mL. We also determined the synergistic/additive effects of combining CHE with nine currently used antibiotics. CHE restored the antibacterial efficacy of the antibiotics against methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamases producing Escherichia coli. This study suggests that the combination of CHE with conventional antibiotics may be a promising strategy to combat infections caused by multidrug-resistant organisms.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Huicui Liu,Tao Chen,Xiaoqing Xie,Xinlei Wang,Yiwen Luo,Nan Xu,Zhen Sa,Min Zhang,Zhifei Chen,Xinzhong Hu,Juxiu Li
Nonalcoholic fatty liver disease (NAFLD) is characterized by marked imbalances in lipid storage and metabolism. Because the beneficial health effects of cereal β-glucan (BG) include lowering cholesterol and regulating lipid metabolism, BG may alleviate the imbalances in lipid metabolism observed during NAFLD. The aim of our study was to investigate whether BG from highland barley has an effect on western diet-induced NAFLD in mice. Using lipidomics, we investigated the underlying mechanisms of BG intervention, and identified potential lipid biomarkers. The results reveal that BG (300 mg/kg body weight) significantly alleviated liver steatosis. Lipidomics analysis demonstrated that BG also altered lipid metabolic patterns. We were able to identify 13 differentially regulated lipid species that may be useful as lipid biomarkers. Several genes in the hepatic lipid and cholesterol metabolism pathways were also modulated. These findings provide evidence that BG ameliorates NAFLD by altering liver lipid metabolites and regulating lipid metabolism-related genes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED POWDER TECHNOLOGY
·
2021
·
IF 4.833
Li-Wang Jiang,Feng-Tao Zeng,Yi Zhang,Meng-Ya Xu,Ze-Wu Xie,Hua-Ying Wang,Ying-Xuan Wu,Fu-An He,Hong-Liu Jiang
A novel composite basing on the Fe 3 O 4 nanoparticle, the graphite oxide nanosheet (GON), and the citric acid-crosslinked β-cyclodextrin polymer (CA-CDP) was prepared for the purpose of removing the methylene blue (MB) dye from water. The structure of the resultant Fe 3 O 4 /GON/CA-CDP composite was investigated by the scanning electron microscope, the two dimensional EDS mapping, the thermal gravimetric analyzer, the Fourier transform infrared spectroscope, the wide angle X-ray diffraction, the X-ray photoelectron spectroscope, and the zeta potential measurement. The Fe 3 O 4 /GON/CA-CDP composite not only had a good MB adsorption capacity of 173 mg/g but also a high saturation magnetization of 36.4 emu/g. It was found that the MB adsorption capacity of the Fe 3 O 4 /GON/CA-CDP composite increased with the increasing initial MB solution pH value especially in the low-pH-value range. Moreover, the MB adsorption mechanism, the MB adsorption isotherm, and the MB adsorption kinetic of the Fe 3 O 4 /GON/CA-CDP composite were investigated. It was found that 1) the good adsorption ability of the Fe 3 O 4 /GON/CA-CDP composite for the MB dye originated from the electrostatic attraction, the Lewis acid-Lewis base interaction, the host-guest supramolecular interaction and the π-π interaction, and 2) the MB adsorption isotherm and the MB adsorption kinetic of the Fe 3 O 4 /GON/CA-CDP composite could be well explained by the Sips model and the intraparticle diffusion model, correspondingly.
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Weide Wang,Dongxu Yao,Hanqin Liang,Yongfeng Xia,Kaihui Zuo,Jinwei Yin,Yu-Ping Zeng
The effect of the GdH 2 on the shrinkage behavior, microstructure, thermal conductivity , and flexural strength was investigated. The pre-sintering enables the elimination of native SiO 2 and the simultaneous formation of Gd 2 O 3 . The N/O ratio in the liquid phase was increased because of the increasing Gd 2 O 3 /SiO 2 ratio, resulting in the restricted shrinkage during gas pressure sintering. The high N/O ratio in the liquid phase benefits not only the nucleation and growth of β-Si 3 N 4 but also the removal of lattice oxygen, leading to the increase of thermal conductivity . Although the replacement of Gd 2 O 3 by GdH 2 leads to enhanced flexural strength at low temperature, it tends to reduce the flexural strength at high temperature. This variation related largely to the exaggerated bimodal microstructure. This work signifies that GdH 2 is an effective sintering additive for obtaining Si 3 N 4 ceramics with both high flexural strength and high thermal conductivity.
✓ 已验证
DOI
高影响因子
Journal of Materiomics
·
2020
·
IF 5.797
Pramod K. Kalambate,Sharad S. Upadhyay,Yue Shen,Wanida Laiwattanapaisal,Yunhui Huang
A highly sensitive and selective electrochemical chiral sensor was developed based on the competitive supramolecular interaction of carbon nanofibers (CNFs) embedded sulfobutyl ether-β-cyclodextrin (SBE-β-CD) with optically active cationic drugs at glassy carbon electrode (GCE). The difference in intermolecular hydrogen bonding/stability constant/enantioselectivity coefficient and Gibbs free energy of anionic host SBE-β-CD with enantiomers of amlodipine (R-/S-AML), clenbuterol (R-/S-CBL) and metoprolol (R-/S-MET) as a guest paved the way for efficient discrimination. The proposed sensing platform (CNFs-SBE-β-CD/GCE) could recognize the aforementioned enantiomers based on the discernible difference of peak potential (S/R-AML (ΔE p = 135 mV), R/S-MET (ΔE p = 99 mV) and R/S-CBL (ΔE p = 111 mV). The binding mechanisms and thermodynamic study of the enantiospecific behavior have been investigated using the host-guest chemistry approach inside the nanocavity and results suggest that S-AML, R-MET, and R-CBL show stronger stability constants than their antipodes. Formation of the diastereomeric complex was taken as a measure of enantioselectivity and experimental results indicated that anionic SBE-β-CD is a better chiral ligand than neutral cyclodextrins. The fabricated sensor could be a useful low-cost electrochemical tool for molecular recognition of a variety of cationic species not only of drugs but also from other sources.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）