ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2023
·
IF 5.8
Yu Changhao,Xu Yawen,Wei Yiping,Guo Yuxue,Wang Yi,Song Ping,Yu Jing
Microplastics (MPs) are known to cause liver toxicity as they can spread through the food chain. Most researches on their toxicity have focused on individual organs, neglecting the crucial “gut-liver axis”—a bidirectional communication pathway between the gut and liver. Probiotics have shown promise in modulating the effects of environmental pollutants. In this study, we exposed mice to Lactobacillus rhamnosus GG (LGG, 100 mg/kg b.w./d) and/or polystyrene microplastics (PS-MPs, 5 mg/kg b.w./d) for 28 d via gavage to investigate how probiotics influence live toxicity through the gut-liver axis. Our results demonstrated that PS-MPs induced liver inflammation (increased IL-6 and TNF-α ) and disrupted lipid metabolism. However, when combined with LGG, these effects were alleviated. LGG also improved colon health, rectifying ciliary defects and abnormal mucus secretion caused by PS-MPs. Furthermore, LGG improved gut microbiota dysbiosis induced by PS-MPs. Metabolomics and gene expression analysis ( Cyp7a1 and Cyp7b1 ) indicated that LGG modulated bile acid metabolism. In summary, LGG appears to protect the liver by maintaining gut homeostasis, enhancing gut barrier integrity, and reducing the liver inflammation. These findings confirm the potential of LGG to modulate liver toxicity caused by PS-MPs through the gut-liver axis, offering insights into probiotics' application for environmental pollutant detoxification.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2018
·Vol. 410
·期 14
·3325-3335
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IF 3.307
Liu Yue,Lu Shan,Zhao Liang,Dong Xin,Zhu Zhenyu,Jin Yongsheng,Chen Haisheng,Lu Feng,Hong Zhanying,Chai Yifeng
Studies have documented the potential antitumor activities of glaucocalyxin A (GLA), an ent-kaurene diterpenoid isolated from Rabdosia japonica . However, the metabolic mechanism underlying the antitumor activity of GLA remains largely unknown. The effects of GLA on the metabolome of human liver cancer cells using GC/MS- and LC/MS-based metabolic profiling have been investigated. An untargeted metabolomics approach in conjunction with orthogonal projection to latent structures–discriminant analysis (OPLS-DA) has been developed to characterize the metabolic modifications induced by GLA treatment in human hepatoma cell line SMMC7721. Results demonstrated that cells cultured in the presence or absence of GLA displayed different metabolic profiles: the treatment induced an increased purine metabolism, pyrimidine metabolism, and sphingolipid metabolism and a decreased amino acid metabolism. At the same time, GLA treatment induced cell apoptosis and cell cycle arrested at G2/M phase in a dose-dependent manner. In addition, two representative apoptosis-inducing cytotoxic agents were selected as positive control drugs to validate the reasonableness and accuracy of our metabolomic investigation on GLA. The study displayed a systemic metabolic alteration induced by GLA treatment, showing the impaired physiological activity of SMMC7721 cells, which also indicated anti-proliferative and apoptotic effects of GLA. In the meantime, GC/MS- and LC/MS-based metabolomics applied to cell culture enhanced our current understanding of the metabolic response to GLA treatment and its mechanism; such an approach could be transferred to study the mechanism of other anticancer drugs.
A systemic metabolic alteration induced by glaucocalyxin A (GLA) treatment of SMMC-7721 cells
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 7
·1-10
·
IF 5.7
Chen Tingting,Qin Yingfeng,Wang Beibei,Lai Rongji,Tan Guohe,Liu Jin-Wen
A novel fluorescent strategy has been developed by using an enzymatic reaction modulated DNA assembly on graphitic carbon nitride nanosheets (CNNS) for the detection of acetylcholinesterase (AChE) activity and its inhibitors. The two-dimensional and ultrathin-layer CNNS-material was successfully synthesized through a chemical oxidation and ultrasound exfoliation method. Because of its excellent adsorption selectivity to ssDNA over dsDNA and superior quenching ability toward the fluorophore labels, CNNS were employed to construct a sensitive fluorescence sensing platform for the detection of AChE activity and inhibition. The detection was based on enzymatic reaction modulated DNA assembly on CNNS, which involved the specific AChE-catalyzed reaction-mediated DNA/Hg 2+ conformational change and subsequent signal transduction and amplification via hybridization chain reaction (HCR). Under the excitation at 485 nm, the fluorescence signal from 500 to 650 nm ( λ max = 518 nm) of the developed sensing system was gradually increased with increasing concentration of AChE. The quantitative determination range of AChE is from 0.02 to 1 mU/mL and the detection limit was 0.006 mU/mL. The developed strategy was successfully applied to the assay of AChE in human serum samples, and can also be used to effectively screen AChE inhibitors, showing great promise providing a robust and effective platform for AChE-related diagnosis, drug screening, and therapy. Graphical Abstract
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RESEARCH ON CHEMICAL INTERMEDIATES
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2023
·
IF 3.3
Sun Bingnan,Wang Yajie,Yu Haoran,Zhang Lei,Zhang Weibing
In this work, dextranase was immobilized on the surface of hydroxyapatite nanowires (HAPNWs) through covalent cross-linking method. The prepared HAPNWs-NH 2 -dextranase was characterized by FE-SEM, XRD, TGA and FT-IR spectroscopy. The results show that the dextranase was successfully immobilized on HAPNWs by covalent cross-linking method. The properties of HAPNWs-NH 2 -dextranase were studied and compared with free dextranase, such as catalytic activity, kinetic constants, thermal stability and pH stability. The loading capacity, storage stability and reusability of the immobilized enzymes were investigated. HAPNWs-NH 2 -dextranase demonstrated better enzyme activity at higher temperatures (92.28% vs 33.08% at 70 °C) and higher pH stability (93.17% vs 57.78% at pH 7.0) than free dextranase. The loading capacity of dextranase on HAPNWs-NH 2 -dextranase can reach up to 868.2 mg g −1 . HAPNWs-NH 2 -dextranase retained 83.38% of its initial activity after 12 cycles, indicating that the HAPNWs-NH 2 -dextranase could have great performance in industry fields.
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FOOD SCIENCE AND BIOTECHNOLOGY
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2023
·
IF 2.9
Hou Tianmeng,Wang Feijie,Wang Liqiang
Intelligent controlled release technologies that rely on environmental changes to control the release rate of antimicrobial agents have attracted attention in the field of food preservation. In this paper, cinnamaldehyde (CN) was grafted onto chitosan (CS) to form a pH-responsive controlled-release complex, CS–CN, via the Schiff base reaction. Then, tempo oxidized cellulose nanofibers (CNF) and PVA were prepared as aerogels loaded with CS–CN with different pore parameters (PCNF@CN). Release experiments showed that acid triggered the release of CN and increased the release from 10.3 to 68.4% with increasing pH. In addition, PCNF@CN showed significant pH-responsive antimicrobial properties against Escherichia coli and Staphylococcus aureus . Utilizing the water absorption of the aerogel and triggering the release of CN, the shelf life of fresh meat could be delayed for 4 days. This study demonstrated the potential application of PCNF@CN aerogel in functional food preservation packaging.
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Nano Research
·
2023
·
IF 9.9
Huang Tao,Li Ke,Lei Jinyu,Niu Quan,Peng Hui,Zou Bingsuo
Sb-based organic–inorganic hybrid metal halides (OIHMHs) with [SbCl 5 ] 2− units have been widely reported due to high photoluminescence quantum yield (PLQY) and occasional multiple self-trapped exciton (STE) emission bands mainly out of singlet and triplet states, and their multi-band emission is important in white light-emitting diode (WLED). However, not all these OIHMH compounds can produce both emissions out of singlet STE and triplet STE at room temperature simultaneously. It is crucial to consider how the singlet STE generates and retains to emit light at room temperature for this material’s design and application. Herein, a strategy is proposed that can significantly lift Sb halide PLQY by synthesizing two Sb-based OIHMHs using organic amine cations of different-sized and -quantity, which modulate the distance of neighboring emission centers. Therein, the occurrence of singlet STE emission is found to be closely related to the distance of [SbCl 5 ] 2− units and local unit distortion in the lattice. The larger distance can produce smaller local distortions, favoring the formation of the singlet STE emission band at higher energy. This is the first work to reveal the relationship between the local structure and the origin of the singlet STE emission band, providing new insights into the modulation of the Sb-based OIHMH’s emission.
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Scientific Reports
·
2023
·Vol. 13
·期 1
·1-14
·
IF 4.6
Jiang Linlin,Niu Hui,Chen Yuan,Li Xing,Zhao Yulian,Zhang Chunhong,Li Minhui
Platycodon grandiflorum (Jacq.) A. DC. has been proposed as a medicine and food homology, thus playing an important role in disease prevention and health promotion, with great potential for research and value in clinical application. We aimed to analyze stakeholders' production behavior and financial performance from a value chain (VC) perspective and provide a basis for improving the quality of P. grandiflorum and the interests of stakeholders. P. grandiflorum collected from different producing areas were chemically analyzed, and the quality of platycodin D was evaluated. Rstudio3.6.0 was used to analyze the correlation between total platycodins (as platycodin D, platycoside E, and platycodin D 3 ) and platycodin D in P. grandiflorum , providing the basis for quality control of P. grandiflorum . In addition, we studied the anti-inflammatory and anti-cancer activities of P. grandiflorum extract under different links. Based on the food chain energy pyramid, the transfer efficiency of active components of P. grandiflorum in different links was studied. Accordingly, 10 different types of VCs were determined in producing P. grandiflorum . Our results show that vertical coordination has led to a more consistent traceability system and strict regulation of supply chains.
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npj Quantum Materials
·
2023
·Vol. 8
·期 1
·1-7
·
IF 5.7
Xu R. Z.,Du X.,Zhou J. S.,Gu X.,Zhang Q. Q.,Li Y. D.,Zhao W. X.,Zheng F. W.,Arita M.,Shimada K.,Kim T. K.,Cacho C.,Guo Y. F.,Liu Z. K.,Chen Y. L.,Yang L. X.
TaTe 4 , a metallic charge-density wave (CDW) material discovered decades ago, has attracted renewed attention due to its rich interesting properties, such as pressure-induced superconductivity and candidate nontrivial topological phase. Here, using high-resolution angle-resolved photoemission spectroscopy and ab initio calculation, we systematically investigate the electronic structure of TaTe 4 . At 26 K, we observe a CDW gap as large as 290 meV, which persists up to 500 K. The CDW-modulated band structure shows a complex reconstruction that closely correlates with the lattice distortion. Inside the CDW gap, there exist highly dispersive energy bands contributing to the remnant Fermi surface and metallic behavior in the CDW state. Interestingly, our ab initio calculation reveals that the large CDW gap mainly opens in the electronic states with out-of-plane orbital components, while the in-gap metallic states originate from in-plane orbitals, suggesting an orbital texture that couples with the CDW order. Our results shed light on the interplay between electron, lattice, and orbital in quasi-one-dimensional CDW materials.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-10
·
IF 16.6
Wang Xiaoyue,Xu Jing,Zhang Yaoming,Wang Tingmei,Wang Qihua,Li Song,Yang Zenghui,Zhang Xinrui
Self-healing and recyclable polymer materials are being developed through extensive investigations on noncovalent bond interactions. However, they typically exhibit inferior mechanical properties. Therefore, the present study is aimed at synthesizing a polyurethane–urea elastomer with excellent mechanical properties and shape-memory-assisted self-healing behavior. In particular, the introduction of coordination and hydrogen bonds into elastomer leads to the optimal elastomer exhibiting good mechanical properties (strength, 76.37 MPa; elongation at break, 839.10%; toughness, 308.63 MJ m −3 ) owing to the phased energy dissipation mechanism involving various supramolecular interactions. The elastomer also demonstrates shape-memory properties, whereby the shape recovery force that brings damaged surfaces closer and facilitates self-healing. Surprisingly, all specimens exhibite clustering-triggered emission, with cyan fluorescence is observed under ultraviolet light. The strategy reported herein for developing multifunctional materials with good mechanical properties can be leveraged to yield stimulus-responsive polymers and smart seals.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 9
·1-10
·
IF 5.7
Xu Li,Hu Wei,Luo Xiaogang,Zhang Juan
A novel MIL-88-NH 2 @COF composite was produced by in situ growth of covalent organic framework (COF) on the metal–organic framework (MOF) surface. To obtain a coating fiber for solid-phase microextraction (SPME), the MIL-88-NH 2 @COF composite physically adhered to the stainless steel wire. Combined with gas chromatography-flame ionization detection (GC-FID), various analytes such as chlorophenols (CPs), phthalates (PAEs), and polycyclic aromatic hydrocarbons (PAHs) were extracted and determined to evaluate the extraction performance of MIL-88-NH 2 @COF coated fibers and explore their extraction mechanism. This composite exhibit excellent extraction performance and adsorption capacity for various analytes, especially for PAHs with enrichment factor up to 9858. The SPME-GC-FID method based on MIL-88-NH 2 @COF fiber was established for the determination of five PAHs after the main extraction conditions were optimized. Under optimal conditions, the proposed technique showed a wide linear range (1–150 ng mL −1 ) with a low limit of detection (0.019 ng mL −1 ) and a high coefficient of determination ( R 2 > 0.99). The developed SPME-GC-FID method was used to determine PAHs in green tea and black tea samples, with good recoveries of 51.70–103.64% and 68.56–103.64%, respectively. It is worth mentioning that this is the first time MIL-88-NH 2 @COF composites have been prepared and applied to SPME. The preparation method of the composite provides a new idea in adsorbent preparation, which will contribute to the field of SPME. Graphical abstract
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Scientific Reports
·
2023
·Vol. 13
·期 1
·1-12
·
IF 4.6
Liu Yanhua,Liu Xingfei,Chen Juanning,Zhang Zhuanli,Feng Libang
Laserjet printing is a kind of facile and digital do-it-yourself strategies, which is of importance to fabricate inexpensive paper-based microfluidic devices. However, the printed hydrophobic barrier is not hydrophobic enough due to the weak hydrophobicity and requires subsequent heating, which can lead to the pyrolysis of cellulose in the paper and influence the detection results. Here, for the first time, we report a kind of functional toner including toner and polydopamine (PDA) nanocapsules which contains oleic acid modified ferric tetroxide (OA-Fe 3 O 4 ) and octadecylamine (ODA), which is suitable for printing with desired shapes and sizes to lead to formation of superhydrophobic barriers. Moreover, patterns printed with functional toner have good stability, including resistance to moisture, ultraviolet (UV) and bending. Finally, a proof-of-concept of metal and nitrite ions testing is demonstrated using colorimetric analysis, and the results show that the printed devices successfully perform instant detection of ions. The developed functional toner offers easy fabrication, cost-effectiveness and mass production of paper-based devices. In general, this strategy provides a new idea and technical support for the rapid prototyping of microfluidic paper-based analytical devices (μPADs) using laserjet printing.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Zhu Guo-Rui,Zhang Qin,Liu Qing-Song,Bai Qi-Yao,Quan Yi-Zhou,Gao You,Wu Gang,Wang Yu-Zhong
As a replacement for highly flammable and volatile organic liquid electrolyte, solid polymer electrolyte shows attractive practical prospect in high-energy lithium metal batteries. However, unsatisfied interface performance and ionic conductivities are two critical challenges. A common strategy involves introducing organic solvents or plasticizers, but this violates the original intention of security design. Here, an electrolyte concept called liquid polymer electrolyte without any small molecular solvents is proposed for safe and high-performance batteries, based on the design of a room-temperature liquid-state brush-like polymer as the sole solvent of lithium salts. This liquid polymer electrolyte is non-flammable and exhibits high ionic conductivity (1.09 \(\times\) 10 −4 S cm −1 at 25 °C), significant lithium dendrite suppression, and stable long-term cycling over a wide operating temperature range ( ≥ 1000 cycles at 60 °C and 90 °C). Moreover, the pouch cell can resist thermal abuse, vacuum environment, and mechanical abuse. This electrolyte and design strategy are expected to provide enlightening ideas for the development of safe and high-performance polymer electrolytes.
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