APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Kaige Li,Jianhua Qu,Zhengni Pan,Yuxin Hou,Wenzhen Li,Mingyao Ma,Jingyi Wang,Juncheng Wang,Chengjun Ge,Jiwei Luo,Ying Zhang
Near-100% selective 1 O 2 generation via Fe-pyridinic N 4 sites. • Metal-atom utilization enhanced by 10 2 -10 4 -fold in FeSA-N-C-2S. • Fe-pyridinic N 4 shifts d -band center, lowering 1 O 2 energy barrier and tuning pathway. • 1 O 2 steady-state concentration positively correlates with Fe-pyridinic N 4 proportion. • A universal strategy creates various metal-based SACs with > 90% 1 O 2 selectivity. The type and quantity of nitrogen ligands in the first-shell coordination structure (FSCS) of single-atom catalysts (SACs) govern catalytic performance. However, current research largely focuses on nitrogen atom count, overlooking its chemical structure. Herein, by reconfiguring the FSCS from Fe-pyrrolic N 4 to Fe-pyridinic N 4 (FeSA-N-C-2S), we achieve selectivity approaching 100% for singlet oxygen ( 1 O 2 ) generation. Mechanistically, Fe-pyridinic N 4 shifts the d -band center toward the Fermi level via axial d_z² orbital hybridization, reducing Fe d -orbital occupancy, which enhances electron transfer through the conjugated π-system of pyridinic N, lowering the activation barrier for 1 O 2 generation and optimizing the reaction pathway. This facilitates complete degradation of electron-rich pollutants like 2,4,6-trichlorophenol, with a 4.3-fold increase in rate constant and a 21.5-fold higher metal-atom utilization efficiency compared to the FeSA-N-C-1S. Moreover, 1 O 2 steady-state concentration exhibits a significant linear positive correlation with Fe-pyridinic N 4 proportion, which can be precisely modulated by adjusting the pyrolysis temperature and metal-to-precursor ratio. This insight extends to other transition metals (Co, Cu, Mn), affording > 90% 1 O 2 selectivity. Long-term continuous-flow experiments and life-cycle assessments highlight the potential for scalable water treatment. Our work deciphers how coordination structure governs reactive oxygen species, providing a universal design paradigm for metal-pyridinic N 4 catalysts. Download: Download high-res image (210KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
JOURNAL OF THERMAL BIOLOGY
·
2026
·
IF 3.2
Yukun Cao,Xin Li,Wangang Gong,Jia Tan,Jing Shen,Xinli Zhou
Cryoablation remodels desmoplastic TME in pancreatic cancer. • Sub-lethal freezing inhibits TGF-β/Smad signaling pathway. • Cryoablation preceding chemotherapy yields superior efficacy. • Disruption of fibrotic barriers sensitizes PDAC to chemotherapy. Cryoablation is effective for solid tumors but is often constrained by limited thermal efficiency and incomplete ablation. Conventional strategies prioritize expanding lethal isotherms to minimize the sub-lethal zone, a practice that increases the risk of collateral injury to adjacent critical structures. This study proposes a novel strategy utilizing the sub-lethal zone to remodel the tumor microenvironment for enhanced therapeutic efficacy. Using pancreatic cancer and stellate cell co-cultured spheroids and subcutaneous tumor models, we investigated fibrotic tumor microenvironment changes induced by the cryoablation sub-lethal zone combined with gemcitabine plus nab-paclitaxel. Results demonstrated that cryoablation significantly disrupted collagen structures and downregulated TGF-β1, p-Smad3, α-SMA, and Collagen I expression. This modulation is associated with the mitigation of fibrotic barriers, thereby potentially improving the accessibility of chemotherapy drugs within the sub-lethal zone. In vivo, cryoablation followed by chemotherapy yielded optimal efficacy compared to reverse sequencing or monotherapy, significantly inhibiting angiogenesis and promoting mitochondrial apoptosis via upregulated Bax and Caspase-3 levels. In conclusion, cryoablation functions as a potent tumor microenvironment remodeler. By downregulating TGF-β/Smad signaling, it sensitizes pancreatic ductal adenocarcinoma to subsequent chemotherapy, offering a superior sequential strategy to effectively inhibit the growth of residual tumor cells, offering an approach to improve local tumor control in PDAC.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Xin Wang,Jianwei Wang,Pengyang Yu,Zifei Wang,Zhijian Deng,Wulong Jiang,Lianshun Wang,Yanan Lu,Yuan Wang,Jing Gu,Li Wang,Yuting Cong,Guojun Yang,Hua Wang
A novel thermostable polygalacturonase, MlPG28A, was identified from Mucor lusitanicus and characterized for biochemical properties, structural determinants of thermostability, and potential in the enzymatic production of functional oligogalacturonides (OGs). MlPG28A exhibited exceptional heat tolerance, retaining over 70% of catalytic activity at 100 °C and maintaining stability across pH 3–11. Structural modeling and site-directed mutagenesis revealed that a unique disulfide bond (Cys275–Cys283) and hydrophobic interactions involving Tyr274 jointly stabilize the T1 loop structure, while Lys106 and Asn160 contribute to active-site stabilization via electrostatic interactions and hydrogen bonding. Under optimized hydrolysis conditions determined by response surface methodology, MlPG28A produced OGs with a maximal reducing-sugar yield of 3.233 mg·mL–1. The resulting OGs exhibited concentration-dependent antioxidant activity, demonstrating measurable DPPH and ABTS radical-scavenging effects within the tested concentration range, and displayed selective antibacterial activity. Application tests in simulated aquaculture systems confirmed that OGs effectively inhibited both Gram-negative and Gram-positive pathogens.
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2026
·
IF 17.3
Junchen Liu,Xin Shi,Yidan Liang,Liupeng Zhao,Tianshuang Wang,Fangmeng Liu,Lei Wang,Qin Li,Xu Yan,Peng Sun,Geyu Lu,Dongyuan Zhao
Wireless passive optical gas sensors reduce food waste by providing real-time freshness information through continuous biomarker analysis. However, their practical use remains limited by high cost, strict environmental requirements, poor stability, and device rigidity. Here, programmable carbon dots (CDs) were incorporated into a poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) electrospun film to monitor volatile fatty acid (VFA) levels in dairy products via fluorescence color changes. While the rational design of carboxylic and amino groups on the CD surface ensures wide-range pH sensitivity, the hydrophobic polymer matrix enables a self-cleaning mechanism for dynamic sensing. This colorimetric readout is further enhanced by a convolutional neural network model integrated into a mobile app, achieving over 98% accuracy in VFA assessment and providing a precise “best-before date.” The simplicity and integrable design of this VFA sensor make it well suited for incorporation into dairy packaging, where it can reduce food waste and uphold safety standards. Broadly, this dynamic in situ pH sensor with a regenerable surface is effective in both liquid and vapor phases, offering diverse potential practical applications.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2026
·
IF 8.4
Tianlong Huang,Zhen Mu,Yuanxiang Zhang,Xiaoxiao Wang,Maosheng Cui,Guoqiang Hu,Lingxiu Chen,Yang Zhang,Xiaolan Xue
Magnesium-metal organic batteries (MMOBs) combine high charge-storage capacity with resource abundance and favorable material economics. However, their application is limited by dissolved organic shuttle and separator issues, including thick, costly glass fiber (GF) separators and poor coating adhesion on commercial separators. Herein, we report a rationally designed ZIF-67@polypropylene (PP) separator, fabricated via a robust in situ nucleation strategy that yields a dense, binder-free, and conformal MOF layer on both faces of a commercial substrate. Compared with conventional coating, this in situ modification strategy not only suppresses shuttle and improves wettability, but also strengthens interfacial bonding, enhancing mechanical robustness and durability. Benefiting from well-defined pores, ZIF-67 acts as an ion sieve that effectively suppresses anthraquinone (AQ) dissolution/shuttle while facilitating Mg 2+ transport and accelerating redox kinetics. Consequently, symmetric Mg||Mg cells employing this modified separator deliver an extended lifespan exceeding 1300 h with a mere ∼90 mV overpotential at 0.05 mA cm −2 . More impressively, Mg||AQ full cells demonstrate exceptional durability, retaining a reversible capacity of 94.5 mAh g −1 after 250 cycles at 0.1 A g −1 . This work highlights the critical role of in-situ separator modification in unlocking the full potential of sustainable MMOBs.
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2026
·
IF 4.8
Linlin Wang,Bingjie Liu,Meng Liu,Jikun Li,Jinglei De,Yangchuan Ke
A BiOCl/ZIS heterojunction was constructed by ultrasound-assisted assembly. • Interfacial coupling induced directional redistribution of photocarriers. • 3-BZ efficiently degraded concentrated RhB, CR, and TC under visible light. • 3-BZ achieved efficient photocatalytic H₂O₂ production under visible light. • In situ XPS and DFT supported type-II electron transfer from ZIS to BiOCl. An ultrasound-assisted assembly route was used to construct a BiOCl/Zn₃In₂S₆ (ZIS) heterojunction for visible-light-driven pollutant degradation and H₂O₂ production. After 120 min of irradiation, the optimized composite degraded 99.59% of Rhodamine B (RhB, 600 mg/L), 99.82% of Congo red (CR, 200 mg/L), and 83.50% of Tetracycline (TC, 80 mg/L). In a separate O₂-saturated medium containing 10 vol% isopropanol, the H₂O₂ yield reached 5644 μmol g⁻¹ over the same period. In situ irradiated X-ray photoelectron spectroscopy showed that Bi 4 f, Cl 2p, and O 1 s shifted toward lower binding energies, whereas the ZIS-associated core levels shifted toward higher binding energies. These opposite changes indicate photoelectron enrichment in BiOCl and electron depletion in ZIS. Density functional theory calculations revealed a larger work function for BiOCl (6.72 eV) than for ZIS (5.33 eV), while the differential charge density confirmed interfacial electron redistribution. Together with the density-of-states and experimental band-edge results, these findings support a type-II pathway in which electrons migrate from the ZIS conduction band (CB) to the BiOCl CB, while holes transfer from the BiOCl valence band (VB) to the ZIS VB. The resulting carrier separation favors O₂ reduction toward H₂O₂ formation and promotes oxidative pollutant degradation. Download: Download high-res image (225KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Jiwei Xie,Zhenggang Jia,Mingfang Qian,Xuexi Zhang,Lin Geng
Aqueous zinc-ion batteries (AZIBs) suffer from interfacial instability mainly due to the inherent electrochemical incompatibility between zinc anodes and aqueous electrolytes. Herein, we report aluminum lactate (Al-Lac) as an effective electrolyte additive that stabilizes zinc anodes via comprehensive solvation structure regulation. Al-Lac competitively coordinates with water molecules via Al 3+ and lactate ions, disrupting the original [Zn(H 2 O) 6 ] 2+ solvation sheath, reducing water activity, and suppressing hydrogen evolution. Furthermore, Al 3+ preferentially adsorbs onto the Zn surface under an electric field, establishing a protective electrostatic shield that guides uniform Zn 2+ deposition. As a result, the nucleation overpotential of Zn 2+ is significantly reduced, Zn deposition is oriented preferentially along the (002) plane, and dendrite growth is effectively inhibited. Consequently, the introduction of Al-Lac effectively enhances the interfacial reaction kinetics during Zn deposition and maintains the interfacial impedance. The corresponding Zn||Zn symmetric cells achieve an ultra-long lifespan of 5000 h (2 mA cm −2 , 1 mAh cm −2 ), and full-cells with Na 2 V 6 O 16 ·2.74H 2 O cathodes exhibit negligible capacity decay after 2000 cycles at 10 A g −1 . This work provides a feasible strategy for the development of low-cost and high-stability AZIBs. Aluminum lactate regulates the competitive solvation structure and builds an electrostatic shield, enabling (002)-textured zinc deposition and long lifespan for aqueous zinc-ion batteries. Download: Download high-res image (155KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Wenjie Huang,Yuqin Zhang,Wenda Hua,Zengdong Meng,Lilin Luo
This study aimed to develop 45S5 bioglass/hydroxyapatite (BG/HA) composite scaffolds with high porosity, excellent biodegradability, and osteoblast responsiveness for bone defect repair. The scaffolds containing 0, 10, 20, 30, and 40 wt% BG were fabricated using a combination of space-holder, cold pressing and spark plasma sintering techniques. Physicochemical characterization, mechanical properties, and in vitro osteogenic and angiogenic potentials were systematically investigated. The results showed that, compared to HA scaffolds, the composite scaffolds exhibited an increase in porosity from 67% to 75% and macropore (>300 μm) content from 40% to 74%. When the scaffold containing 30 wt.% BG outperformed the others while maintaining adequate mechanical strength. And its 12-week degradation rate was 26.48% versus 5.90% for the HA scaffold. Moreover, the weight gain of the scaffold due to apatite formation increased by approximately 7.89-fold after a 7-day immersion period. In vitro, BG supplementation made cell viability exceed 83% and enhanced the adhesion of MC3T3 cells ( p<0.05 ). Additionally, BG promoted osteogenic differentiation, evidenced by higher expression of osteoblast-specific genes and proteins (Runx2, Col I, OPN and OCN), increased alkaline phosphatase activity and elevated calcium mineralization levels ( p < 0.0001). Furthermore, angiogenesis-related parameters were more desirable in the composite scaffold group. Fundamentally, these effects primarily result from BG altering the physicochemical properties, which modulates the release of bioactive ions, including silicon, calcium and phosphate, thereby driving cellular responses through cascade reactions. These findings suggest that BG/HA composite scaffolds possess consistent high porosity and superior biochemical characteristics, demonstrating significant potential for clinical development and application.
✓ 已验证
产品关联
DOI
高影响因子
DESALINATION
·
2026
·
IF 9.9
Yubin Zhang,Chen Li,Chenchang Liu,Mengmeng Lou,Shengyang Zheng,Lijun Meng,Manhong Huang
Membrane distillation (MD), a novel membrane separation technology, exhibits advantages in treating high-salinity wastewater. However, membrane wetting caused by surfactants remains a major challenge for the large-scale application of MD. Nanoplastics (NPs) commonly coexist with surfactants such as sodium dodecyl sulfate (SDS) in high-salinity industrial wastewater. Their interactions can lead to the formation of nanoplastic-surfactant complexes, thereby altering membrane wetting behavior during MD operation. Herein, we proposed an air-liquid interfacial deposition strategy to fabricate a Janus membrane with high anti-wetting performance. A dense metal-phenolic network hydrophilic layer was constructed on a hydrophobic PVDF substrate via tannic-Fe 3+ co-deposition, followed by polyethyleneimine (PEI) cross-linking. The as-prepared membrane exhibited superior anti-wetting performance in the treatment of high-salinity water containing SDS@NPs complex with stable normalized flux and ∼ 100% NPs rejection. Notably, the coexistence of NPs significantly mitigated membrane wetting, mainly attributed to the adsorption of SDS on NPs, which reduced the concentration of free SDS in feed solution. The effects of the size and surface charge of NPs were investigated. Moreover, the interactions between the membrane and SDS@NPs were calculated using the XDLVO theory to elucidate the mechanisms underlying the enhanced anti-wetting performance. This study provides a promising approach for the fabrication of high-performance Janus membranes and unveils the anti-wetting mechanism of Janus membranes induced by nanoplastic-surfactant complexes.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yichi Zhong,Jian Huang,Yuan Xiang,Kun Qian,Zhanpeng Wang,Qian Wang,Jingzhou Li,Hongxing Dong,Long Zhang
Zero-dimensional perovskite Cs 4 PbBr 6 nanocrystals have attracted considerable attention for their potential in optoelectronic and sensing applications due to their excellent optoelectronic properties and environmental stability. However, their non-emissive property has limited their development in luminescent applications. Fortunately, the reversible phase transition between Cs 4 PbBr 6 and CsPbBr 3 nanocrystals provides a promising strategy to address this limitation. This study investigates the phase transition mechanism induced by the micro-environment factors, with a particular focus on the evolution of optical properties. Small droplets of Cs 4 PbBr 6 nanocrystals were exposed to air, and real-time monitoring of their color changes and photoluminescent emission characteristics was conducted. The results reveal that the large surface area of the droplet facilitates solvent evaporation, which accelerates the phase transition of Cs 4 PbBr 6 nanocrystals, leading to a significant enhancement in photoluminescent brightness. By quantitatively correlating environmental humidity with the phase conversion rate, this work highlights the critical role of humidity in modulating the conversion kinetics. Furthermore, the study systematically explores the mechanism of tuning the photoluminescent emission peak by adjusting the surface ligands, which enables the development of an environment-responsive, color-changing optical device based on droplet dynamics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
·
2025
·
IF 14.6
Wei Xu,Minmin Shen,Junjie Ma,Chuanlin Peng,Shanshan Wu,Xinxin Yang,Jiahe Wu,Youyou Yan,Nengming Lin,Jianqing Gao,Bo Zhang
Dysregulation of cytoskeletal proteins has been found in response to DNA damage stress, yet the functional role of cytoskeletal proteins in DNA repair remained unexplored. Here, we found that DNA-damaging agents induced substantial upregulation of smooth muscle-specific cytoskeletal protein smoothelin (SMTN) in colorectal cancer (CRC) cells. Silencing SMTN abrogated G2/M arrest, exacerbated DNA damage, and markedly enhanced the chemosensitivity of CRC cells to various DNA-damaging agents. Notably, SMTN could rapidly accumulate at DNA damage sites within 1 min after laser irradiation, which was indispensable for the initiation of homologous recombination (HR) repair. Mechanistically, SMTN stabilized RAD51 by disrupting its interaction with its E3 ubiquitin ligase HUWE1, thereby maintaining the process of HR repair. To explore the therapeutic role of SMTN, customized cell membrane infused biomimetic liposomes were constructed to ensure rapid delivery of SMTN siRNA specifically into HCT-116 cells, yielding significantly enhanced anti-cancer effects of irinotecan and fuzuloparib both in vitro and in vivo . To summarize, our findings revealed a novel function of SMTN in DNA damage repair and provided a therapeutic strategy of targeting SMTN to enhance the efficacy of DNA damage agents.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Shuai Wang,Yuqi Chen,Shuyan Zheng,Yanan Yuan,Kexin Du,Min Cui,Yue Wu,Ping Li,Wei Hu,Jingui Wang,Yingshu Guo,Zexing Wu,Yanli Zhao
The incorporation of sp-hybridized nitrogen arisen from graphdiyne (GDY) into the catalyst structure significantly improves the electrocatalytic efficiency of zinc–air batteries by modulating the electronic properties of the active sites, thereby accelerating reaction kinetics and enhancing conductivity. This work highlights the efficacy of the Co–N-GDY catalyst, where sp-N moieties in GDY serving as anchoring centers for cobalt species, which demonstrates exceptional performance in the oxygen reduction reaction, achieving a half-wave potential of 0.85 V, along with high oxygen evolution reaction performance that surpasses that of commercial Pt/C + IrO2-based batteries. The Co–N-GDY catalyst also exhibits commendable cycling stability with minimal fluctuation in voltage difference, indicating its suitability for practical applications in advanced energy storage systems. These findings underscore the importance of developing cost-effective and durable M–N–C catalysts to enhance the commercial viability and sustainability of zinc–air battery technology.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）