Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 33
·6860-6868
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IF 4.543
Zhi Zeng,Zeliang Wei,Limei Ma,Yao Xu,Zhihua Xing,Hai Niu,Haibo Wang,Wen Huang
Cancer metastases represent a major determinant of mortality in patients with cancer. Cyclooxygenase-2 (COX-2) and its metabolites play important roles in tumor growth and metastasis. Overexpression of COX-2 have been found in various types of cancers including melanoma. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used to inhibit COX-2 and can be a promising additive for the management of aggressive cancers. A novel pH-sensitive drug delivery carrier based on PEG-derivatized ibuprofen, MPEG-PHEI, was synthesized for dual delivery of anticancer agents and NSAIDs. This amphiphilic and biodegradable copolymer could self-assemble into core–shell nanoparticles (NPs) and the hydrophobic doxorubicin (DOX) could be loaded into the core of the nanoparticles. DOX-loaded MPEG-PHEI nanoparticles (DOX/NPs) could release DOX in endosome microclimate via micelle collapse and ibuprofen via ester bond hydrolysis. In vitro DOX/NPs showed comparable cytotoxicity to DOX·HCl and comparable inhibition of COX-2 to ibuprofen. More importantly, DOX/NPs revealed a significant in vivo therapeutic efficacy in both experimental subcutaneous tumors and lung metastasis model while decreasing the toxicity of DOX. This study demonstrated the advantages of combining NSAIDs with chemotherapy agents and provided a novel nanoparticle system for both primary and metastatic tumor treatment.
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PROGRESS IN ORGANIC COATINGS
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2025
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IF 7.3
Chuanying Wei,Xianhui Zhang,Yajun Deng,Bo Wu,Jianhua Wu
In response to complex marine fouling issues, this study developed pH-responsive amphiphilic antifouling coatings (PDHM) synthesized via condensation reactions between protonated zwitterionic-tertiary amine polymers and polydimethylsiloxane (PDMS). These amphiphilic coatings demonstrate pH-responsive surface charge transitions governed by protonation equilibria. Under seawater conditions (pH ∼ 8.3), the PDHM surface exhibits negative charge enrichment, synergizing with a hydrated interfacial layer to impede biofouling adhesion. Subsequent surface acidification induced by colonizing organisms triggers protonation of tertiary amines, converting the surface charge to positive. This transition disrupts fouling organism viability and promotes release under hydrodynamic shear forces. Relative to PDMS, PDHM coatings achieved 99.54 % and 99.59 % reduction in bacterial adhesion ( B. subtilis and P. ruthenica , respectively), alongside a 98.23 % reduction in algal adhesion ( P. ruthenica ). Marine field evaluations in the East China Sea confirmed sustained antifouling efficacy for 180 days. Furthermore, 16S rDNA analysis revealed significantly attenuated biofilm formation and reduced abundance of mobile genetic elements (MGEs) on PDHM surfaces versus PDMS, corroborating its superior antifouling performance. This work establishes a novel methodology for designing smart-responsive marine antifouling coatings.
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Advanced Science
·
2025
·
IF 14.1
Lei Lei,Wenbin Dai,Jinchao Zhao,Angfeng Jiang,Haisheng Peng,Qiao Jin,Xiaojing Li,Zhe Tang
Photodynamic therapy (PDT) is a promising cancer therapy modality by generating reactive oxygen species (ROS) and triggering immunogenic cell death. However, the therapeutic effect of PDT is strongly limited by tumor hypoxia and immunosuppressive landscape. Herein, a pH-sensitive nanosized covalent–organic polymer (COP), composed of the photosensitizer porphyrin and pyruvate kinase inhibitor vitamin K3 (VK3), is designed to overcome these issues. The signal transducer and activator of transcription 3 (STAT3) inhibitor WP1066 is further encapsulated into COPs to form a WP1066-loaded COP (TVW). As an inhibitor of pyruvate kinase, VK3 can reduce intracellular oxygen consumption by inhibiting the glycolytic pathway, leading to the alleviation of the tumor hypoxic microenvironment. The relief of tumor hypoxia by VK3 enhances photodynamic cytotoxicity by generating more ROS. Meanwhile, STAT3 acts as a major regulator of PD-L1, a key inhibitor that promotes immune escape. WP1066 effectively inhibits the expression of STAT3 and reduces PD-L1 expression, thereby significantly inhibiting tumor immune escape and enhancing antitumor efficacy in a synergistic manner. The antitumor capacity of photodynamic immunotherapy is extensively investigated in a murine subcutaneous hepatocellular carcinoma model. This photo-immunotherapy may provide an effective combination regimen for the efficient treatment of solid tumors such as hepatocellular carcinoma.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Ahmed M. Omer,Eman M. Abd El-Monaem,Heba S. Hassan,Mahmoud A. Elmeligy,Angela Kleinová,Abdelazeem S. Eltaweil,Abolfazl Heydari
pH-sensitive carriers have emerged as an optimal choice for the oral administration of anticancer drugs, exhibiting the desired release performance. This study aims to develop biocomposite beads for the sustained release of the anticancer drug 5-fluorouracil (5-FU). Here, 5-FU was encapsulated within a ZIF-8 metal-organic framework (MOF), which was subsequently impregnated into amino-chitosan beads. The resulting Am-CS@ZIF-8 biocomposite beads were characterized for their chemical structure, surface morphology, elemental composition, crystallinity, surface charges, and mechanical properties utilizing Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), zeta potential analysis, and a texture analyzer, respectively. The developed beads exhibited a textured surface, denser composition, and a positively charged surface with a maximum zeta potential of +12.4 at pH 7.4. In comparison to Am-CS beads, the Am-CS@ZIF-8 biocomposite beads demonstrated superior mechanical properties, achieving a maximum stress value of 5.668 MPa compared to the 1.874 MPa recorded for pure Am-CS beads. pH sensitivity was assessed through the investigation of water uptake behavior at pH 1.2 and pH 7.4. The Am-CS@ZIF-8 biocomposite beads demonstrated a high encapsulation efficiency of approximately 81.6 % for 5-FU. They exhibited pH-responsive release behavior, with only 17 % of the drug released at pH 1.2 after 2 h and a sustained release of 52 % at pH 7.4 over 24 h. The release mechanism was predominantly governed by Fickian diffusion, as closely fitted by the Peppas-Sahlin kinetic model. The formulated carrier confirmed its biodegradability under enzymatic physiological conditions, suggesting its potential applicability as an effective system for the oral delivery of anticancer drugs.
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Materials Today Communications
·
2025
·
IF 4.5
Wenqiang Zhang,Hongjie Guo,Xiang Zhang,Hongliang Li
Wound infection remains a significant challenge in clinical medicine, impeding the healing process of wounds. Conventional therapeutic approaches, including antibiotics, surgical debridement, and conventional dressings, are often limited by issues such as antibiotic resistance, secondary tissue damage, and insufficient biocompatibility. Existing wound dressings exhibit poor mechanical properties and possess only single therapeutic functions, lacking the ability to effectively monitor wound healing status. To address these limitations, this study have developed a novel hydrogel dressing. This dressing utilizes microfibrillated cellulose (MFC) to stably encapsulate liquid metal (Ga) droplets, which also serve as a photothermal filler for the hydrogel. The addition of MXene stabilizes the colloidal system, and the resulting hydrogel is integrated with a pH-sensitive optical fiber to form a pH-sensitive optical fiber/ PMGa hydrogel. This composite hydrogel exhibits excellent mechanical properties (400 % elongation at break), antimicrobial activity, and pH sensitivity. Moreover, the hydrogel's tissue adhesion and stretchability enable it to conform to various skin surfaces and accommodate skin movement and stretching. The pH-sensitive optical fiber/PMGa hydrogel not only monitors the pH value of the wound through different light transmittance to judge the state of the wound environment， but also effectively inhibits bacterial growth through its photothermal effect. It provides an optimal temperature and humidity environment to promote cell proliferation and granulation tissue formation, thereby facilitating photothermal therapy. In summary, this work presents a novel hydrogel dressing that integrates monitoring and therapeutic functions. This comprehensive solution offers a new platform for the development of wound infection treatment materials.
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MATERIALS CHEMISTRY AND PHYSICS
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2025
·
IF 4.7
Muhammad Umar Farooq,Rustem R. Zairov
A smart drug delivery system (DDs) based on PEGylated (polyethylene glycol) gold/zinc oxide (PEG-Au/ZnO) loaded with doxorubicin (DOX) and chlorine-e6 (Ce6) was successfully synthesized, characterized, and evaluated against breast malignancy. With and without laser exposure, the DOX-PEG-Au/ZnO–Ce6 nanoprobe bypassed the internal barriers and exhibited much higher synergistic therapeutic activity than Ce6 and DOX alone. The controlled release kinetics of DOX in combination with Ce6 could inhibit tumor growth and remarkably enhance the sensitivity of chemotherapy. Apart from the chemotherapeutic effect, the residual PEG-Au/ZnO could amplify the reactive oxygen species (ROS) generation through cascade reactions, which will benefit the release of free zinc ions in the lysosome of inflammatory cells. Taken together, the as-prepared DOX-PEG-Au/ZnO–Ce6 nanoprobe is expected to facilitate the management of chemo-photodynamic combination therapy as Trojan horses to eliminate cancer and improve the quality of life for the patient by reducing acute toxic side effects.
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Desalination and Water Treatment
·
2024
·
IF 1
Debo Wu,Xingmin Gao,Shuiping Yang,Winston Duo Wu
Sequential removal of phenol and As(V) from co-contaminated water by ferrate (Fe(VI)) was investigated. The results showed that a neutral pH condition favored the sequential of phenol and As(V) by Fe(VI). Around 70% of phenol was removed at neutral pHs with a Fe(VI): phenol molar ratio of 10:1. While about 50% of As(V) was finally removed under similar conditions. The presence of a high concentration of Cl – (up to 0.2 M) showed 6% inhibitory effect on the final removal percentage of phenol compared to that without Cl – . Fourier transform infrared spectroscopy, X-ray powder diffraction, and X-ray photoelectron spectroscopy analyses suggested that As(V) was removed through adsorption by the precipitates (amorphous iron (oxy)hydroxide), while phenol was removed via degradation (89%) and adsorption (11%), respectively. Removal of As(V) occurred immediately when phenol degradation was initiated, indicating a rapid generation of Fe(III)- (oxy)hydroxide. Our study also revealed that an excessive amount of Fe(III) ions in the aqueous phase did not facilitate the degradation of phenol. On the other hand, improving the precipitation rate of Fe(III) could further improve the removal efficiency of phenol and As(V).
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 12
·12517-12525
·
IF 1.338
Xiao Xin,Liu Chao,Zuo Xiaoxi,Liu Jianju,Nan Junmin
Flower-like BiOCl microspheres are synthesized by a microwave route, and their pH-dependent adsorption and recovery of methylene blue (MB) are studied. The as-synthesized BiOCl exhibits hierarchical structures with dominant {001} facets, a specific surface area of 36.39 m2
g−1, and mesoporous approximately 18 nm in diameter. Compared with BiOCl nanoplates, the adsorption of MB (20 mg L−1, pH = 6.8) over the BiOCl microspheres increases from 21% to 98.2% after only 2 min using an adsorbent dosage of 1 g L−1.
The excellent adsorption capacity, i.e., a maximum capacity of 24.2 mg g−1 and 26.2 mg g−1 at pH = 6.8 and 3.5, respectively, is attributed to the negatively charged facets, high surface area, and unique defects/vacancies and micro/nanostructures of as-synthesized
material. In addition, the adsorption of MB at pH = 11.9 is only approximately 1/14 of that at pH less than 6.8, indicating the pH-dependent adsorption behavior of the BiOCl. Thus, the BiOCl microspheres are regarded as a promising green pH-dependent adsorbent, and the adsorbed MB is recovered
instead of degraded. The pH-dependent adsorption behavior for MB over the BiOCl is demonstrated to be closely related with not only the unique surface of the BiOCl microspheres but also the polarity of MB in different solution pH.
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WATER RESEARCH
·
2016
·
IF 5.991
Jingxin Yang,Ji Li,Wenyi Dong,Jun Ma,Yi Yang,Jiayin Li,Zhichao Yang,Xiaolei Zhang,Jia Gu,Wanying Xie,Yan Cang
This work investigated the fate of bromate formation during ozonation in the presence of hydroxylamine (HA). Results indicated that pH depression, as a commonly feasible control strategy for bromate formation during ozonation , unexpectedly enhanced the bromate formation during ozonation in the presence of HA. A dramatically high level of bromate was observed at acidic pH in the ozone/HA process. The scavenging experiments demonstrated the essential role of OH produced in the reaction of ozone with HA in bromate formation. In the process, OH mainly oxidizes bromide to Br , which is further oxidized by ozone and eventually converts to bromate. Further investigations suggested that the unexpected enhancement on bromate formation by pH depression can be mainly ascribed to the pH-dependent ozone decay, OH exposures and formation rate of Br . As pH decreased from 7 to 5, the reduced OH scavenging capacity of HA led to higher OH exposures, which contributed to the enhancement of bromate formation. As pH decreased from 5 to 3, the enhanced formation rate of Br largely augmented the formation of bromate. In addition, the ozone decay slowed down by pH depression provided more available ozone for the oxidation of the formed Br to bromate. The enhanced effect of pH depression on bromate formation was still observed in the real water samples in the ozone/HA process. Accordingly, pH depression might be avoided to control the bromate formation during ozonation in the presence of HA.
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ChemSusChem
·
2015
·Vol. 8
·期 11
·1850-1855
·
IF 7.657
Zhicai Xing,Qian Liu,Wei Xing,Abdullah M. Asiri,Xuping Sun
The use of electrocatalysts with low metal content (metal-deficient) or metal free for the hydrogen evolution reaction (HER) can prevent or decrease metal ion release, which reduces environmental impact; development of such catalysts with high activity and durability over the whole pH range is thus highly desired but still remains a huge challenge. Herein, we describe the direct growth of a film consisting of interconnected Co-entrapped, N-doped carbon nanotubes on carbon cloth using chemical vapor deposition from dicyanodiamine using a Co 3 O 4 nanowire array as catalyst. This integrated architecture is used as a flexible 3D electrode for the electrolytic hydrogen evolution with outstanding catalytic activity and durability in acidic media. Moreover, this electrode is also highly efficient under neutral and basic conditions. It offers us an attractive carbon-based metal-deficient HER catalyst outperforming most transition-metal and all metal-free/deficient catalysts. Graphical Ensnaring Co into catalysis : Direct growth of a film consisting of interconnected Co-entrapped, N-doped carbon nanotubes on carbon cloth (Co-NCNT/CC) leads to a high loading of catalyst and its strong coupling with CC. Co-NCNT/CC can be used as a flexible 3D carbon electrode with low metal content that has a high activity for hydrogen evolution activity and is stable over the whole pH range (0–14).
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WEAR
·
2025
·
IF 6.1
Jiajia Cen,Kai Chen,Qin Chen,Xinyue Zhang,Cunao Feng,Xiaowei Li,Dekun Zhang,Shirong Ge
The tribological performance of hip joint materials in the synovial fluid is substantially influenced by environmental factors. In this study, the tribological properties of polyether-ether-ketone (PEEK)-highly crosslinked polyethylene (XLPE) hip joint materials were investigated in composite synovial fluids with varying pH conditions, revealing the coupling mechanism between pH and composite synovial fluid components. The lubrication efficacy of the composite synovial fluid under physiological conditions was validated through a 2 million-cycle hip joint simulation test. Results indicated that the coefficient of friction (COF) decreased with the increasing pH, while the wear factor remained stable at pH = 7.5 and pH = 8.0 but decreased progressively at pH = 8.5. Notably, the Fluid C demonstrated significant pH sensitivity, reducing the wear factor by 89.12 % when pH increased from 8.0 to 8.5. Moreover, the results of the hip joint simulation tests were consistent with the sliding tribology tests. The component concentration regulated the lubrication efficiency, with amplified effects during long-term service. Hence, this study elucidated wear mechanisms in “soft-soft” hip joint materials under simulated physiological conditions and provided critical insights for predicting the lifespan of polymer-based artificial joints.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2025
·
IF 2.8
Zhikun Li,Yuanyuan Li,Yulong Ma,Wenxin Ji,Yonggang Sun
The purification of biomacromolecules, particularly proteins, plays an increasingly vital role in the fields of medicine, biopharmaceuticals, and emerging technologies. Adsorbents with excellent adsorption capacity, superior cycling performance, and environmental compatibility are crucial for protein separation and adsorption. A temperature- and pH dual-stimulus responsive hydrogel material for the adsorption and separation of protein was successfully prepared by copolymerizing sodium alginate (SA) as the matrix with N-isopropylacrylamide (NIPAM), acrylic acid (AAC), and simultaneously introducing zirconium-based metal-organic frameworks (Zr-MOF). This hydrogel material exhibits excellent adsorption and controlled release properties for protein including bovine hemoglobin (BHB) and bovine serum albumin (BSA) with maximum adsorption capacities of 617.45 mg/g and 527.06 mg/g at 45 °C, respectively. Experimental results demonstrate that the adsorption and release behavior of the hydrogel toward proteins can be effectively regulated by adjusting environmental temperature or pH value in an aqueous medium without any acidic, alkaline, high-salt, or organic solvent. Additionally, the material exhibits good cyclic stability, maintaining more than 85 % of its initial protein adsorption capacity after five adsorption-desorption cycles. This study provides new insights into the development of smart responsive biomolecular adsorption materials and has significant application potential in the fields such as drug controlled release and biological separation.
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