PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2011
·Vol. 13
·期 32
·14542-14549
·
IF 3.454
Kelei Zhuo,Yujuan Chen,Jing Chen,Guangyue Bai,Jianji Wang
Extensive applications of ionic liquids (ILs) may result in their accumulation in the ecological environment and organisms. Although ILs are popularly called “green solvents”, their toxicity, in fact, has been exhibited. Therefore the interaction of ILs with biomolecules is a cutting-edge research subject. Herein, the interactions of 1-butyl-3-methylimidazolium carboxylate ionic liquids ([C4mim][HCOO], [C4mim][CH3COO] and [C4mim][CH3CH2COO]) with glucose in water were studied for their volumetric properties, viscosity, conductivity and NMR spectra. Limiting apparent molar volumes (V0Φ,IL), viscosity B-coefficients, limiting molar conductivities (Λ0) and Walden products (Λ0η0) were evaluated for the ILs in glucose + water solutions. Volumetric interaction parameters were also obtained from the transfer volumes of the ionic liquids. The contributions of the solvent properties (B1) and the ionic liquid–solvent interactions (B2) to the B-coefficient were extracted, together with molar activation energies (Δμ0≠IL) of the ionic liquids for viscous flow of the aqueous glucose + IL solution. In addition, the 13C and 1H NMR spectra of methyl β-D-glucopyranoside and ILs in β-D-glucopyranoside + IL + D2O were studied. The NMR results show that no special and strong interactions were observed between glucopyranoside and the ILs. However, it was confirmed that the H2 on the imidazolium ring has more activity (acidity) than atoms H4 and H5. The macro-properties and their changes were also discussed in terms of the size, structure and solvation of the ILs and glucose.
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CELL BIOLOGY AND TOXICOLOGY
·
2024
·Vol. 40
·期 1
·1-28
·
IF 5.3
Liu Yuhan,Qin Yanling,Zhang Yanning
Uremic encephalopathy (UE) poses a significant challenge in neurology, leading to the need to investigate the involvement of non-coding RNA (ncRNA) in its development. This study employed ncRNA-seq and RNA-seq approaches to identify fundamental ncRNAs, specifically circRNA and miRNA, in the pathogenesis of UE using a mouse model. In vitro and in vivo experiments were conducted to explore the circRNA-PTPN4/miR-301a-3p/FOXO3 axis and its effects on blood–brain barrier (BBB) function and cognitive abilities. The research revealed that circRNA-PTPN4 binds to and inhibits miR-301a-3p, leading to an increase in FOXO3 expression. This upregulation results in alterations in the transcriptional regulation of ZO-1, affecting the permeability of human brain microvascular endothelial cells (HBMECs). The axis also influences the growth, proliferation, and migration of HBMECs. Mice with UE exhibited cognitive deficits, which were reversed by overexpression of circRNA-PTPN4, whereas silencing FOXO3 exacerbated these deficits. Furthermore, the uremic mice showed neuronal loss, inflammation, and dysfunction in the BBB, with the expression of circRNA-PTPN4 demonstrating therapeutic effects. In conclusion, circRNA-PTPN4 plays a role in promoting FOXO3 expression by sequestering miR-301a-3p, ultimately leading to the upregulation of ZO-1 expression and restoration of BBB function in mice with UE. This process contributes to the restoration of cognitive abilities. Graphical Abstract 1. The circRNA-PTPN4/miR-301a-3p/FOXO3 axis is identified as a key regulator of blood–brain barrier integrity and cognitive function in uremic encephalopathy. 2. circRNA-PTPN4 sequestration of miR-301a-3p enhances FOXO3 expression, leading to upregulation of ZO-1 and improved endothelial permeability. 3. Overexpression of circRNA-PTPN4 in uremic mice restores cognitive abilities and reduces neuronal loss and inflammatory infiltration.
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JOURNAL OF COORDINATION CHEMISTRY
·
2015
·
IF 2.012
Yan Xie,Junjie He,Tingting Wang,Heping Zeng
Reactions of Zn(II) salts, 5-(4-(1H-imidazol-1-yl)phenyl)-1H-tetrazolate (HIPT) and 2-mercaptobenzoic acid or 2-propyl-1H-imidazole-4,5-dicarboxylic acid (H3PrIDC), result in two mixed-ligand coordination polymers (CPs), [Zn2(IPT)(DSDB)(OH)]n (H2DSDB = 2,2′-disulfanediyldibenzoic acid, 1) and [Zn2(IPT)(PrIDC)(H2O)]n (H3PrIDC = 2-propyl-1H-imidazole-4,5-dicarboxylic acid, 2). Compound 1 possesses a 2-D structure built by 1-D [Zn(IPT)]n chains and DSDB2− connectors, in which the DSDB2− is generated via in situ reaction from 2-mercaptobenzoic acid. It displays a new intricate 4-nodal {3·4·6·7·8·9}{3·6·7·8·9·10}{3·8·9}{4·6·8} topology. Compound 2 displays a 3-D framework with new 3-connected topology with Schläfli symbol of (4·8·10) (8·122), in which the 1-D Zn-carboxylate chains were bridged by 3-connected IPT− ligands. The thermal stabilities and luminescence properties of 1 and 2 have also been studied. The compounds exhibit intense solid-state fluorescent emissions at room temperature.
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JOURNAL OF SEPARATION SCIENCE
·
2016
·Vol. 39
·期 23
·4585-4591
·
IF 2.741
Xinpei Li,Shigang Wei,Ying Sun,Qun Sun,Li Liang,Bo Zhang,Huilan Piao,Daqian Song,Xinghua Wang
A novel and simple supported ionic-liquid-based solid-phase extraction method for the determination of triazine herbicides in rice was developed. Glass slides were functionalized by an ionic liquid, 1-carboxyethyl-3-methylimidazolium chloride, and were used for the simultaneous extraction of seven triazine herbicides in rice samples. The effects of the type of extraction solvent, the extraction time, the type and volume of loading solvent, and the type of eluting solvent on the extraction efficiency were investigated and optimized. Under the optimum operation conditions, the limits of detection for seven triazine herbicides in rice samples obtained by high-performance liquid chromatography were 3.16–5.42 ng/g, which were lower than the maximum residue levels established by various organizations. The linear correlation coefficients were higher than 0.9975 in the concentration range of 0.015–1.08 μg/g for the seven triazine herbicides. The recoveries of the seven triazine herbicides at the two concentration levels of 0.15 and 0.45 μg/g are between 82.47 and 104.21%, with relative standard deviations of 0.69–9.19%. The intra- and inter-day ( n = 5) precisions for all triazine herbicides at the spiked level of 0.30 μg/g were 1.72–11.71%.
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JOURNAL OF SURFACTANTS AND DETERGENTS
·
2017
·Vol. 20
·期 5
·1121-1127
·
IF 1.45
Chen Xuewei,Xin Yujuan,Yu Fangcai,Lan Zhili
A series of carboxylic ester-containing imidazolium-based zwitterionic surfactants, namely, monoalkyl 2-(3-methylimidazolium-1-yl) succinate inner salts (C n MimSU, n = 8, 10, 12 and 14), have been synthesized. Their structures were confirmed by 1 H NMR, 13 C NMR and FTIR. The typical physicochemical properties parameters such as isoelectric point, critical micelle concentration (CMC), surface tension at CMC ( γ
CMC ), surface pressure at CMC (Π CMC ), adsorption efficiency (p C
20 ), the maximum surface excess ( Γ
m ), the minimum molecular cross-sectional area ( A
min ) and the value of CMC/ C
20 were determined. The effect of the long-chain length on the important physicochemical properties of C n MimSU was studied. It is found that the surface activity of C n MimSU is enhanced with the long-chain length increases.
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MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 10
·3721-3728
·
IF 4.58
Yin Dan,Tao Yiyi,Tang Lan,Li Wei,Zhang Zhang,Li Junlong,Xie Guoming
The authors describe a dual-signal electrochemical biosensor for highly sensitive determination of the HIV-1 related gene. This method is based on the application of cascaded toehold-mediated strand displacement reactions (TMSDRs) in combination with non-enzymatic target recycling amplification (TRA). A DNA machine with two TMSDRs was designed, and this resulted in reusable target and an output of two oligonucleotides, referred to as strand A (AS) labeled with the redox tag methylene blue (MB) and as untagged strand B (BS). A ferrocene (Fc)-modified signal probe (Fc-P 1 ) is immobilized on the gold electrode surface by hybridizing with a thiolated probe (P 2 ). The labeled AS causes the dissociation of Fc molecules and the gathering of MB molecules via strand displacement reaction. The target gene triggers TMSDRs and TRA. This leads to an increase in the distance changes between the redox tags and the gold electrode. The assay works in the 1 pM to 10 nM concentration range. On account of target recycling and dual recognition, the limit of detection is as low as 0.88 pM (at an S/N ratio of 3). The assay also has a remarkable selectivity which is ascribed to the use of both cascaded TMSDRs and dual recognition. In our perception, this assay represents a robust means of wide scope in that it may be applied to the detection of various kinds of nucleic acid even in complex samples.
Schematic of a dual-signal electrochemical biosensor based on cascaded toehold-mediated strand displacement and non-enzymatic target recycling amplification strategy for the HIV-1 related gene detection. Two electroactive molecules are used to produce electrochemical signals in this “signal-on/off” sensing system.
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ELECTROCHIMICA ACTA
·
2013
·
IF 3.777
Rui Li,Changxian Liu,Ming Ma,Zhengguo Wang,Guoqing Zhan,Buhai Li,Xian Wang,Huaifang Fang,Huijuan Zhang,Chunya Li
1,3-Di(4-amino-1-pyridinium)propane tetrafluoroborate (DAPPT) ionic liquid was successfully synthesized, and was used as a modifier to functionalize graphene nanosheets through covalent binding of amino groups and epoxy groups in an alkaline solution. The as-prepared graphene-DAPPT nanosheets (Gr-DAPPT) were confirmed with transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), UV/vis and FTIR spectroscopy. A biocompatible platform based on Gr-DAPPT was constructed for the immobilization of hemoglobin (Hb) through a cross-linking step with chitosan and glutaraldehyde. The direct electron transfer and bioelectrocatalytic reaction of Hb immobilized on Gr-DAPPT surface were achieved. A pair of reversible redox peaks of hemoglobin was observed, and bioelectrocatalytic activity toward the reduction of H 2 O 2 was also demonstrated, displaying a potential application for the fabrication of novel biosensors to sense H 2 O 2 . Such results indicated that Gr-DAPPT based interface would be a promising platform for biomacromolecular immobilization and biosensor preparation.
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RSC Advances
·
2014
·Vol. 5
·期 7
·5164-5172
·
IF 3.708
Yuhao Xiong,Fanggui Ye,Cong Zhang,Shufen Shen,Linjing Su,Shulin Zhao
A novel and inexpensive approach was adopted to develop magnetic porous γ-Fe2O3/C@HKUST-1 composites for the adsorption of dyes and heavy metal ions from aqueous solution. The γ-Fe2O3/C with unique functional groups present such as –OH and –NH2 was used as the support to directly grow HKUST-1 by a stepwise liquid-phase epitaxy process. The crystallographic, morphology, and magnetic properties as well as porosity of the as-synthesized γ-Fe2O3/C @HKUST-1 composites were carefully studied by XRD, SEM, TEM, XPS, TGA, and BET. The results indicated that the BET surface area, micropore volume, and saturation magnetization of the γ-Fe2O3/C @HKUST-1 are 993.4 m2 g−1, 0.69 cm3 g−1, and 12.6 emu g−1, respectively. In addition, a uniform distribution of ultrafine γ-Fe2O3 nanoparticles with an average diameter of 2–3 nm was observed in the γ-Fe2O3/C@HKUST-1 composites. Our results showed that methylene blue (MB) and Cr(VI) (used as a model for typical dye pollutants and heavy metal ions) are effectively removed from aqueous solutions by γ-Fe2O3/C@HKUST-1. The maximum adsorption capacities were 370.2 and 101.4 mg g−1 of adsorbent for MB and Cr(VI), respectively. Moreover, a removal efficiency of about 90% was retained after five cycles of consecutive adsorption–desorption. The adsorption kinetics data were well described by a pseudo-second-order model (R2 > 0.99), and equilibrium data were well fitted to the Langmuir isotherm model (R2 > 0.99). Finally, our results suggested that the γ-Fe2O3/C@HKUST-1 composites have a great potential to be employed for treatment of wastewater containing MB and Cr(VI).
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2014
·Vol. 117
·期 2
·603-610
·
IF 2.206
Liu Jialin,Li Jingrui,Fan Mengjin,Zhang Junying,Cheng Jue
Aromatic amine curing agent with flexible unit in backbone, 1,4-bis (4-diaminobenzene-1-oxygen) n -butane (DDBE), was synthesized, and the structure was confirmed by FT-IR and 1 H NMR. The curing kinetics of tetraglycidyl methylene dianiline (TGDDM, or AG80) using DDBE and 4,4′-bis-(diaminodiphenyl) methane (DDM) as curing agents, respectively, were comparatively studied by non-isothermal DSC with a model-fitting Málek approach and a model-free advanced isoconversional method of Vyazovkin. The dynamic mechanical properties and thermal stabilities of the cured materials were investigated by DMTA and TG, respectively. The results showed that the activation energy of AG80/DDBE system was slightly higher than that of AG80/DDM system. Šesták-Berggren model can generally simulate well the reaction rates of these two systems. DMTA measurements showed that the storage modulus of cured AG80/DDBE is similar to that of cured AG80/DDM at the temperature below glass transition temperature ( T
g ) and lower than that of cured AG80/DDM at the temperature above glass transition temperature, while T
g of cured AG80/DDBE is lower than that of cured AG80/DDM. TG showed that the thermal stabilities of these two cured systems are similar.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2014
·
IF 3.552
Jian-Wen Shi,Hui-Ying Ai,Jian-Wei Chen,Hao-Jie Cui,Ming-Lai Fu
Composite photocatalysts composed of nitrogen-doped anatase TiO 2 plates with exposed {0 0 1} facets (NTS) and graphene nanosheets (G) were firstly synthesized by a facile one-pot hydrothermal process. The morphologies, structural properties, and photocatalytic activities of the resultant NTS/G composites were investigated in detail. Graphene nanosheets were demonstrated play three important roles in the NTS/G composites, as transporter of photo-excited electrons, extender of light absorption range and enhancer of adsorptive capacity, respectively. Due to the effective charge anti-recombination, the efficient utilization of the visible light and the high adsorptive capacity to target pollutants, the composites exhibited significant improvement in photocatalytic degradation of methylene blue under visible light irradiation. Based on the results, the mechanism of enhanced visible-light photocatalytic activity on NTS/G composites was proposed.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2015
·
IF 2.037
Rongrong Li,Jian Wan,Yingjie Zhang,Danxia Liang,Bin Zhang,Chenghong Li
The equilibrium solubility of sodium 1-naphthalenesulfonate in binary NaCl + water, Na2SO4 + water, and C2H5OH + water solvent mixtures was measured by a steady-state method at elevated temperatures from (278.15 to 323.15) K. The results of these data were correlated by a modified Apelblat equation. The dissolution enthalpy (ΔHd) and entropy (ΔSd) of sodium 1-naphthalenesulfonate in solutions of different mole fraction were obtained.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zhenrui Li,Haifeng Zuo,Minglei Su,Zhenbing Sun,Jianfeng Ma,Xing’e Liu,Pengyi Zhang
Continuous adsorption removal of trace VOCs under humid conditions, especially when the relative humidity (RH) is ≥50 %, faces great challenges in indoor air purification. Herein, we synthesized super-activated carbons (LSACs) using alkali lignin extracted from black liquor via potassium hydroxide (KOH)-assisted chemical activation. The LSAC-3 with ultra-high specific surface area ( S BET : 2535 m 2 /g) and microporosity (92.4 %) was then covalently grafted with the CF 2 groups onto its surface through a [2 + 1] cycloaddition reaction to significantly enhance humidity resistance. After modification, the LSAC-3-CF 2 preserved adsorption sites to the greatest extent, with a minimal loss of S BET , at only 4.9 %. Moreover, LSAC-3-CF 2 , which contained a trace fluorine element (0.55 %), exhibited excellent hydrophobic performance, with a water contact angle (WCA) of 153.7°. The dynamic adsorption experiments further demonstrated that LSAC-3-CF 2 exhibited superior trace toluene adsorption capacity, with 145.9 mg/g at 50 RH% and 46.0 mg/g at 80 RH%, respectively, superior to many reported adsorbents. In addition, LSAC-3-CF 2 displayed excellent regeneration performance after three dynamic adsorption cycles. The adsorption mechanism of toluene on LSAC-3-CF 2 could be attributed to (1) the improved π-π stacking interaction between toluene molecules and the adsorbent surface, and (2) the reduced hydrogen bond interaction between water molecules and oxygen-containing groups onto the adsorbent surface due to the covalent grafting of CF 2 group. This study provides valuable insights and design references for developing adsorbents that can effectively adsorb trace VOCs under high humidity conditions, offering potential solutions for improving indoor air quality.
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