Current Stem Cell Research & Therapy
·
2024
·Vol. 20
·期 7
·795-809
·
IF 2.1
Wenpo Feng,Chenxi Feng,Binbin Wang,Mengqi Lv,Xicong Li,Aihua Jing,Yuanhao Qiu,Huashan Gao,Gaofeng Liang
BackgroundWith the passage of time, the incidence rate of diabetes continues to rise. As a common and serious complication of diabetes, the economic burden of diabetes ulcers is also increasing. However, there is currently no unified clinical treatment strategy for its repair and research, and the treatment effect is not satisfactory. Exosomes derived from MSCs play a crucial role in improving diseases.MethodsThis study used the explant culture method to isolate human umbilical cord mesenchymal stem cells (hucMSCs) from Wharton’s jelly, which were identified by flow cytometry and differentiation potential and evaluated tumorigenic potential. The supernatant of P3-P5 cell culture medium was collected and high-concentration human umbilical cord mesenchymal stem cell exosomes (hucMSCs-Exos) were isolated through ultracentrifugation. Qualitatively identified were finished by transmission electron microscopy (TEM), nanosight tracking analysis (NTA) and Western blot (WB). CCK-8 assay and cell scratch experiment were used to evaluate the effects of hucMSCs-Exos on proliferation and migration ability of cells; chicken embryo chorioallantoic membrane experiment (CAM) was used to evaluate the angiogenic effect of hucMSCs-Exos. In order to study the effect of hucMSCs-Exos on diabetes wound healing, type 2 diabetes mellitus (T2DM) mouse model was constructed by a high-fat feeding and a low-dose streptozotocin (STZ) injection. Fasting blood glucose and blood lipids were measured and oral glucose tolerance test (OGTT) was conducted; HucMSCs-Exos were subcutaneously injected into the T2DM wound model mice which were established by a high-fat diet and by a low-dose STZ, and the wound healing was evaluations.ResultsCells were isolated by explant culture method, and flow cytometry analyses showed that these isolated cells were positive for cells markers CD29, CD90, and CD105, while negative for CD34 and CD45; moreover, these cells could be induced to osteoblasts, adipocytes, and islet-like cells. The tumorigenic experiments showed that these cells have no tumorigenicity. HucMSCs-Exos, separated by ultracentrifugation, displayed spherical or ellipsoidal vesicles with a diameter of around 120 nm, positive for CD9, CD63, and CD81. And they could promote cell proliferation and migration, as well as promote vascular growth (p < 0.01). In vivo experiments showed that hucMSCs-Exos had a promoting effect on wound repair in T2DM mice (p < 0.01).ConclusionThis study provides a new scheme for the treatment of T2DM ulcer.
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2017
·Vol. 17
·期 3
·2201-2205
·
IF 1.483
Yuan Lin,Li Zhong Yan,Zhang Min,Yuan Xian You,Zhu Xiao Qing
A series of novel sodium 2-alkyl-5-(ethoxycarbonyl)-1,3-dioxane-5-carboxylate surfactants were synthesized in high yield using nanosolid superacid sulfonated carbon as a catalyst and characterized by 1H NMR, IR and elemental analysis. Critical micelle concentration (CMC)
of the surfactants was determined and the results showed that the CMC values were less than 1.0 × 10–3 mol/L. Other relevant surface properties were also evaluated, such as emulsion stability, foam ability and degradability. In relation to emulsion formation, foam stability
and the range of application of temperature, the new surfactants showed better properties than traditional surfactants when used as an emulsifier in emulsion polymerization. Moreover, the surfactants were stable under alkaline and neutral conditions, and degraded into raw materials under acid
condition. Convenient synthesis process with high yield and superior properties promisingly make the title compounds to be a type of ‘environmentally friendly’ surfactants.
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2020
·Vol. 2020
·期 42
·4007-4014
·
IF 2.529
Lu Qi,Zhaohui Chen,Lu Li,Qun Jing,Na Li,Zhongqi Jiang,Xiaoyu Dong,Ming-Hsien Lee
Two homologous new mixed-metal phosphates K 2 PbBi 2 (PO 4 ) 2 (P 2 O 7 ) ( I ) and Rb 2 CdBi 2 (PO 4 ) 2 (P 2 O 7 ) ( II ) were successfully synthesized in A 2 BBi 2 (PO 4 ) 2 (P 2 O 7 ) (A = K, Rb, B = Pb, Cd) system through the traditional high-temperature solid-phase method. The single crystal structures of the two compounds are shown to be the unique three-dimensional (3D) framework composed of different types of layers, but not isomorphic. We compared series compounds A 2 PbBi 2 (PO 4 ) 2 (P 2 O 7 ) (A = K, Rb, Cs), which are isomorphic and crystallize in the same space group Pnma . It is noteworthy that they are distinct different in degree of structural disorder, which is tuned by A-site cations. The effect of A-site cations is recognized by analyzing the disorder degree in three related structures and other available 182 mixed-metal phosphates. To the best of our knowledge, such structural analysis is rarely reported in inorganic phosphates and the cation modulation strategy can be used to guide structural disorder according to the difference-value (D-value) of cation radii. Furthermore, the syntheses, thermal analysis, relevant spectroscopic measurements and theoretical calculations for I and II compounds were also discussed. Graphical Two new mixed-metal phosphates K 2 PbBi 2 (PO 4 ) 2 (P 2 O 7 ) and Rb 2 CdBi 2 (PO 4 ) 2 (P 2 O 7 ) were firstly reported and the cation size effect has substantial influence on the crystal structural disorder combining with the title compounds and 182 phosphates.
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 1
·1085-1089
·
IF 1.338
Yuan Lin,Jia Guo Kai,Li Zhong Yan,Zhang Min,Yuan Xian You
A series of novel sodium (5-methyl-2-alkyl-1,3-dioxane-5-yl) carboxylate surfactants were synthesized using nanosolid superacid SO4
2−/Fe2O3 as a catalyst and characterized by 1H NMR, IR and elemental analysis. The critical
micelle concentration (CMC) of surfactants was determined and the results showed that the CMC values were less than 2.0 × 10−3 mol/L. Other relevant surface properties (Krafft point, emulsion stability, foam ability, degradability) were also evaluated. It was suggested
that with respect to emulsion formation, foam stability and the range of application temperature, compared with traditional surfactants, the new surfactants could give better results and showed better properties when used as an emulsifier in emulsion polymerization. In addition, the surfactants
were stable under neutral and alkaline conditions, and could form solid under acid condition. The solid will generate the original surfactants for reuse with alkali. Sodium (5-methyl-2-alkyl-1,3-dioxane-5-yl) carboxylate is likely to be a new type of ‘environmentally friendly’
surfactant.
✓ 已验证
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2018
·
IF 4.92
Nadia Taloub,Abdelkhalek Henniche,Li Liu,Jun Li,Nahla Rahoui,Mohammad Hegazy,Yudong Huang
The pursuit of improving the performance of rigid-rod polymeric fibers using a new inorganic nano-materials and efficient methods is very attractive topic. The combination of the unusual properties of both materials could definitely produce an outstanding final product. Herein, we proposed a simple grafting method of a graphene-like titanium carbides Ti 3 C 2 (OH) 2 nanosheets (MXene) onto PIPD surface via covalent bond by using (3-Aminopropyl) triethoxysilane (APTES) as a bridging agent. The surface morphology and element compositions of PIPD fiber before and after grafting were characterized, and the effect of such treatment on the mechanical properties was also evaluated. The IFSS of the PIPD-Ti 3 C 2 (OH) 2 was highly increased by 61.54% because of the significant improvement the fiber/epoxy interaction and surface wettability . Though the tensile strength (TS) was slightly decreased by only 5%. Furthermore, the experiment results showed a great enhancement of UV and hydrothermal aging resistance of the grafted fibers comparing with untreated ones by 33% and 25% respectively.
✓ 已验证
DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Hui Sun,Baoyang Lu,Xuemin Duan,Jingkun Xu,Liqi Dong,Xiaofei Zhu,Kaixin Zhang,Dufen Hu,Shouli Ming
The copolymerization of 2’-aminomethyl-3, 4-ethylenedioxythiophene (EDOT-MeNH 2 ) and 3, 4-ethylenedioxythiophene (EDOT) was successfully performed electrochemically in acetonitrile (CH 3 CN) containing tetrabutylammonium hexafluorophosphate (Bu 4 NPF 6 ) as the supporting electrolyte by direct anodic oxidation of the monomer mixtures. A series of experiments with different monomer feed ratios were carried out to investigate the influence of monomer feed ratio on the electrochemical copolymerization and the overall properties of the copolymer films. As-formed novel copolymers owned both the advantages of poly(2’-aminomethyl-3, 4-ethylenedioxythiophene) (PEDOT-MeNH 2 ) and poly(3, 4-ethylenedioxythiophene) (PEDOT), i.e ., good electrochemical behavior, excellent electrochemical stability, and good thermal stability. Spectroelectrochemistry analysis of copolymer with the feed ratio of 1:1 reflected λ max due to the π–π* transition and polaron band formation was found to be 620 nm and the band gap ( E g ) was calculated as 1.67 eV. The structure, thermogravimetry and morphology of the copolymers were investigated by infrared spectroscopy, thermal analysis, and scanning electron microscopy, respectively.
✓ 已验证
DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2017
·
IF 2.446
Changlin Liao,Renping Cao,Wudi Wang,Wen Hu,Guotai Zheng,Zhiyang Luo,Pan Liu
NaY(MoO 4 ) 2 :R (R = Sm 3+ /Bi 3+ , Tb 3+ /Bi 3+ , Sm 3+ /Tb 3+ ) phosphors are synthesized by solid-state reaction method in air. The crystal structures, excitation and emission spectra, luminescence properties, the lifetimes, and the dopant concentration influences are investigated. The emission intensity of activators Sm 3+ and Tb 3+ can be enhanced ∼3.04 and 1.64 times due to energy transfer (ET) from Bi 3+ to Sm 3+ /Tb 3+ . NaY(MoO 4 ) 2 :Sm 3+ , Tb 3+ phosphor with excitation 300 nm shows a tunable emission from red to yellow with change Sm 3+ or Tb 3+ ion concentration. Emission intensity of NaY(MoO 4 ) 2 :Sm 3+ phosphor can be enhanced ∼2.24 times via co-doping Tb 3+ ion owing to ET from Tb 3+ to Sm 3+ ions. The results indicate that ET between sensitizer and activator (Bi 3+ → Tb 3+ , Bi 3+ → Sm 3+ , and Tb 3+ → Sm 3+ ) is beneficial to improve the luminescence properties of activator (Sm 3+ and Tb 3+ ). ET and luminous meachanisms are explained by energy level diagrams of Bi 3+ , Tb 3+ , and Sm 3+ ions.
✓ 已验证
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Wanli Li,Zhaoyang Chen,Bo Zhang,Pengjun Zhao,Yanwei Fan
Highly thermally stable BaZn 2 (PO 4 ) 2 : Dy 3+ /Eu 3+ glass-ceramic (GC) phosphors were synthesized using a high-temperature solid-state reaction and controlled-temperature pre-crystallization method. It is found that Dy 3+ -doped BaZn 2 (PO 4 ) 2 GC phosphors produce cold white light emission at 484 nm and 575 nm under 350 nm excitation with the optimal Dy 3+ doping concentration of 0.25 mol%. The theoretical analysis indicates that the dipole-dipole interaction might be the origin of the concentration quenching mechanism of phosphor. The Eu 3+ -doped BaZn 2 (PO 4 ) 2 GC phosphors produce orange-red emission at 592, 616, 654 and 700 nm under 395 nm excitation. More than that, tunable white light emission can be achieved by optimize the co-doped concentration of Eu 3+ on BaZn 2 (PO 4 ) 2 : 0.25Dy 3+ GC phosphor. The emission spectral intensity and luminescence decay curves from BaZn 2 (PO 4 ) 2 : 0.25Dy 3+ /yEu 3+ (range of y) GC phosphors show the energy transfer from Dy 3+ to Eu 3+ and the emission color can be tuned from cool white to warm white region with the color correlated temperatures (CCTs) reduction from 7299 K to 2520 K. The typical BaZn 2 (PO 4 ) 2 : 0.25Dy 3+ /1Eu 3+ GC phosphors have a high thermal stability with an activation energy of 0.30641 eV. Finally, the white LED devices were fabricated by coupling a 363 nm UV light-emitting diode chip with the BaZn 2 (PO 4 ) 2 : 0.25Dy 3+ /yEu 3+ GC phosphors. These results suggest that BaZn 2 (PO 4 ) 2 : Dy 3+ /Eu 3+ GC phosphors may be suitable candidates for single-component white light-emitting phosphors for application in UV-WLEDs.
✓ 已验证
DOI
高影响因子
Journal of Physical Chemistry C
·
2024
·
IF 3.3
Tianyao Pei,Zheng Tang,Dequan Jiang,Chen Li,Yingying Ma,En Chen,Binbin Yue,Yonggang Wang
Sr8(Al12O24)(CrO4)2 (SACR) is a kind of aluminate sodalite, which has been found to have a ferroelectric phase transition near room temperature. The main reason for a phase transition is the freezing of anionic group orientation caused by temperature reduction. The β-cage based on the AlO4 framework with abundant vacancies also brings new possibilities for introducing functional ions. For effectively optimizing its properties, chemical doping is a common modification method. In this study, we reported the (Sr1–xCdx)8(Al12O24)(CrO4)2 series doped at the central cationic site of β-cage and the Sr8(Al12O24)(Cr1–xRexO4)2 series doped at the central anionic site of the molecular cage and compared the effect of doping at different point sites on the phase transformation properties of SACR. Among them, the cationic site doping is not complete and does not affect the phase transition temperature, and the phase transitions are still first-order phase transitions with thermal effect. For the doping of the anionic site, a complete doping series is achieved, and the new end compound Sr8(Al12O24)(ReO4)2 is synthesized. Compared with Sr8(Al12O24)(CrO4)2, the phase transition behavior of Sr8(Al12O24)(ReO4)2 is obviously different, and there is no orthorhombic–tetragonal phase transition between 103 and 450 K.
✓ 已验证
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Wu Yanqiu,Yang Shuzhang,Li Enlong,Liu Yu,Yuan Feng,Wen Jincheng,Hua Lina,Wang Wunan,Yang Yingguo,Lei Yusheng,Chu Junhao,Li Wenwu
Quasi-2D tin-based perovskites are promising p-type semiconductors due to their thermodynamic stability and suppressed ion migration tendencies. However, the competitive growth of low- and high-dimensional phases leads to pronounced structural disorder, increased defect density, and poor crystallographic orientation, thereby restricting charge transport. Here, phenethylammonium thiocyanate (PEASCN) is incorporated into the precursor to promote the preferential formation of PEA 2 FA n -1 Sn n I 3 n -1 SCN 2 ( n = 2) templates. Substituting formamidinium iodide (FAI) with formamidinium formate (FAHCOO) and ammonium iodide (NH 4 I) suppresses the uncontrollable growth of 3D FASnI 3 at room temperature, enabling precise crystallization control. These low-dimensional templates guide the growth of high-dimensional phases upon annealing, yielding vertically oriented films with reduced defects. The fabricated field-effect transistors exhibit mobility up to 43 cm 2 V −1 s −1 and an on/off ratio exceeding 10 8 , alongside nearly negligible hysteresis and enhanced stability. These results demonstrate a viable approach for regulating crystallization kinetics and realizing high-performance, stable tin-based perovskite devices.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOM
·
2025
·
IF 2.3
Zhang Kaifei,Sun Youping,He Jiangmei,Li Wangzhen,Liu Chenglong,Li Qian
This study investigated the effects of different homogenization treatments on the microstructure, mechanical properties, and in vitro degradation behavior of an Mg-2Zn-0.1Ca alloy. The results indicated that homogenization significantly increased the alloy's grain size, reaching 1327.5 μm after 400°C/12-h treatment, an approximately 38.8% increase compared to 956.27 μm for the as-cast alloy. Regarding mechanical properties, homogenization markedly improved the tensile elongation, with the highest value of 20.8% achieved after 400/12-h treatment, representing an approximately 95% increase from the as-cast alloy's 10.66%. Conversely, the ultimate tensile strength (UTS) peaked at 138.53 MPa under the 350°C/12-h condition, an approximately 13% improvement over the as-cast state. In terms of in vitro degradation, homogenized alloys exhibited higher degradation rates than as-cast samples. Notably, the 400°C/12-h homogenization treatment resulted in the fastest corrosion rate, approximately 1.68 times higher than that of the as-cast alloy.
✓ 已验证
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-18
·
IF 15.7
Cao Hui,Meng Xin,Ma Yuan,Li Zhe,Xu Xinyu,Fu Jiaqi,Zhang Qingpeng,Wei Hanlin,Liang Peng,Lu Dingyou,Li Jinyu,Yin Baoli,Huan Shuangyan,Zhang Xiao-Bing,Song Guosheng
Atherosclerosis is a leading cause of cardiovascular diseases worldwide. Neutrophil elastase, a key protease secreted by neutrophils, contributes significantly to atherosclerosis by degrading the extracellular matrix and destabilizing the fibrous cap of plaques. However, current detection methods for neutrophil elastase lack the ability to monitor its dynamic changes within plaques in a non-invasive and real-time manner. To overcome this limitation, we develop a neutrophil elastase-activated semiconductor polymer nanoprobe with high selectivity, sensitivity, and resistance to interference. We successfully establish a calibration curve correlating the in vivo photoacoustic signal ratio with neutrophil elastase concentration, enabling quantification of intraplaque neutrophil elastase levels. Importantly, we introduce a vulnerability index to assess plaque instability, allowing the nanoprobe to predict the adverse effects of inflammatory responses on the risk of plaque rupture in ApoE -/- male mice. Additionally, the nanoprobe can visualize dynamic changes in neutrophil elastase during intimal hyperplasia under inflammatory conditions. In conclusion, this nanoprobe provides a tool for elucidating the role of neutrophil elastase in cardiovascular disease progression.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）