MACROMOLECULAR CHEMISTRY AND PHYSICS
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2016
·Vol. 217
·期 9
·1047-1056
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IF 2.495
Liang Qiu,Chao-Ran Xu,Feng Zhong,Chun-Yan Hong,Cai-Yuan Pan
Pure cross-linked spherical micelles, nanowires, and vesicles are successfully fabricated from poly(2-hydroxypropyl methacrylate- b - p -(methacryloxyethoxy)benzaldehyde)s (PHPMA– b –PMAEBAs) through reversible addition-fragmentation chain transfer dispersion polymerization of MAEBA in methanol using PHPMA as a macro-CTA and subsequent cross-linking. The cross-linking reaction is conducted by stirring a mixture of 1,4-butanediamine and the resultant nano-objects in methanol at room temperature. For all polymerizations with feed molar ratios of MAEBA/PHPMA ranging from 75/1 to 240/1, the monomer MAEBA conversions are almost complete, and block copolymers with controlled molecular weight are obtained. The transmission electron microscopy, dynamic light scattering, and gel permeation chromatography results reveal that the following three factors significantly influence the morphology of the nano-objects: the feed molar ratio of MAEBA/PHPMA, the copolymer concentration, and the degree of polymerization of PHPMA. The cross-linked nano-objects are very stable in good solvents, the spheres and nanowires slightly decrease in size after cross-linking, whereas the vesicles slightly increase in size. The cross-linked nano-objects are stable in neutral solutions, but they dissociate in weekly acidic solutions. The loading of 1-pyrenemethylamine (PMA) into the vesicles and the unloading of PMA from the vesicles are studied.
研究领域:
高分子化学
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纳米材料
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药物递送
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生物医学工程
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胶体与界面科学
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
Chunyu Qu,Yuanjin Sun,Kailei Liu,Ping Gan,Xichan Li,Yue Pan,Hui Zhang,Zhiqiang Wang,Guanghui Tan,Yingxue Jin
Immune checkpoint blockade (ICB) therapy often yields limited clinical efficacy due to immunosuppressive characteristics of the tumor microenvironment. Typical unfavorable factors include hypoxia, excessive accumulation of glutathione (GSH), and infiltration of M2-type tumor-associated macrophages. Single ICB treatment rarely achieves simultaneous in situ tumor eradication and systemic antitumor immune activation. This study develops a pH and glucose dual-responsive layered nanocarrier named BGHCCC to address the above challenges. The nanoplatform synergistically combines oxygen supplementation, starvation therapy, copper-amplified chemodynamic therapy (CDT), and calcium overload effects. Such combinatorial effects remodel the tumor microenvironment and improve tumor sensitivity to ICB therapy. Hollow calcium peroxide (HMCaO₂) serves as the core substrate for the in-situ immobilization of copper-doped resveratrol-derived carbon dots (CuRCDs). The final BGHCCC nanosystem is fabricated through noncovalent self-assembly of binary bovine serum albumin and glucose oxidase (BSA/GOx) protein complexes on the surface of HMCaO₂@CuRCDs. Comprehensive material characterizations confirm the tumor microenvironment-responsive controllable dissociation behavior of BGHCCC. Systematic assessments of in vitro catalytic performance, cellular biological functions, and in vivo antitumor efficacy are further conducted using tumor-bearing mouse models. Experimental results reveal that BGHCCC can consume intratumoral glucose, deplete intracellular GSH, and relieve hypoxic conditions through oxygen release. It also promotes the generation of hydroxyl radicals to activate cascaded biochemical reactions. These bioactive behaviors effectively induce tumor immunogenic cell death. In addition, BGHCCC can modulate the HIF-1α/PD-L1 signaling axis and regulate the phenotypic transformation of tumor-associated macrophages. This nanoplatform favors the polarization of macrophages from the immunosuppressive M2 phenotype to the antitumor M1 phenotype. In vivo experiments suggest that the combination of BGHCCC and αPD-L1 exhibits favorable biosafety and potent inhibitory effects on solid tumor growth. This combinatorial treatment increases the intratumoral infiltration of CD8 + effector T cells and triggers robust systemic antitumor immune responses. This study integrates multiple antitumor pathways into a single dual-responsive nanosystem and develops a synergistic therapeutic strategy to reverse tumor immunosuppression. It provides a feasible design reference for the development of combinatorial immunotherapeutic nanoplatforms with potential clinical translation value. Download: Download high-res image (229KB) Download: Download full-size image
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JOURNAL OF NANOPARTICLE RESEARCH
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2026
·Vol. 28
·期 8
·216
·
IF 3.5
Liu Sinan,Wang Li,Lü Fulin,Yang Shuzhen
Fusarium graminearum is a pathogenic fungus responsible for significant plant diseases. To combat infections caused by this pathogen, we designed a pH-responsive nano-pesticide thiabendazole@MIL-101(Fe). Through systematic optimization of the loading parameters, the optimal preparation conditions were determined as follows: the thiabendazole solution concentration was 3 mg/mL, the amount of carrier used was 0.0400 g, and the loading time was 6 h. Structural characterization revealed that MIL-101(Fe) possesses a uniform octahedral structure with a smooth surface. Thiabendazole was successfully loaded into its pores without damaging the crystal structure of MIL-101(Fe). Regarding release behavior, thiabendazole@MIL-101(Fe) exhibited significant pH-responsive characteristics. After 238 h, the cumulative release rate of thiabendazole reached 74.08% at pH = 5.0, while the cumulative release rates at pH = 7.0 and 9.0 were 62.17% and 57.22%, respectively. The release kinetics study showed that the release process of thiabendazole@MIL-101(Fe) followed a first-order model. Furthermore, Ritger-Peppas model fitting suggested that the release mechanism is consistent with Fickian diffusion across pH = 5.0, 7.0, and 9.0. The prepared thiabendazole@MIL-101(Fe) displayed antibacterial activity comparable to that of conventional SC Thi and exhibited no adverse effects on wheat seed germination or seedling growth. This study provides new ideas and methods for the development of efficient and environmentally friendly nano-pesticides.
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ACS Applied Materials & Interfaces
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2026
·
IF 7.8
Mengyu Li,Yan Sun,Jiamei Wang,Yuxiang Zhang,Tongzhan Dou,Chen Chen,Bo Yuan,Pengfei Cui,Yang Liu
Bacterial adhesion and biofilm formation pose significant clinical challenges in clear aligner therapy, adversely affecting both oral health and aesthetics. In this study, a machine learning-driven strategy was used to develop a novel antimicrobial peptide (AMP), IW (sequence: IDFYRKTHWWNKLLAKWWAMR), which was subsequently covalently immobilized onto the surface of clear aligners to construct a pH-responsive antibacterial coating. In response to cariogenic acidic microenvironments, the coating is specifically activated to effectively inhibit the proliferation of cariogenic bacteria and subsequent biofilm formation. Moreover, IW reduces the abundance of potential pathogens while enriching health-associated bacterial genera, exerting a beneficial modulatory effect on the oral microbiome. This dual-functional strategy, integrating antibacterial activity with microbiota homeostasis preservation, offers a promising approach to combat cariogenic bacterial infection and oral dysbiosis, presenting substantial potential for clinical translation in orthodontic applications.
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Coatings
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2026
·Vol. 16
·期 8
·967
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IF 3.4
Yuhan Liang,Lijie Chen,Mingyue Feng,Tong Zhang,Rongbang Sun,Yang Liu,Yifu Fu,Yunxiang Chen,Lan Chen
HighlightsWhat are the main findings?The Mg-Mn-Fe LDH grown in situ on the PEO coating-modified Mg alloy effectively blocks pores and introduces metal catalytic active sites.Baicalin achieves stable immobilization by forming coordination bonds with the metal ions in LDH through the oxygen-containing functional groups.The LDH/BA composite coating significantly improved corrosion resistance, along with pH-responsive drug release and near-infrared-enhanced enzyme-like catalytic performance.What are the implications of the main findings?A multi-functional modification strategy integrating “corrosion resistance, drug loading and control release” was established, which provides a novel technical solution for the long-term corrosion protection of magnesium alloys.The revealed interfacial coordination immobilization mechanism can provide theoretical references for the structural design of organic–inorganic composite protective coatings.The synergy of corrosion resistance and microenvironment stimulus-responsive functions is realized, which expands the application of LDH coatings in the modification of metal implants.Aiming at the rapid corrosion of degradable magnesium alloys in physiological environments and the insufficient long-term protection of single plasma electrolytic oxidation (PEO) coatings, Mg-Mn-Fe layered double hydroxide (LDH) and baicalin (BA)-loaded LDH/BA composite coatings were prepared in situ on PEO-pretreated ZE21C magnesium alloy substrates. BA was stably anchored on the LDH surface via coordination bonds between its oxygen-containing functional groups and laminate metal sites. Benefiting from the physical barrier of the LDH lamellar structure and the corrosion inhibition effect of baicalin, the LDH/BA coating significantly improved the corrosion resistance of the magnesium alloy matrix. The composite coating exhibited peroxidase-like catalytic activity for reactive oxygen species generation, which could be enhanced by near-infrared irradiation. It also possessed stable photothermal conversion performance and pH-responsive drug release behavior under acidic conditions. Biological characterization demonstrated that BA-loaded LDH composite coatings exert potent inhibitory effects on 143B cell proliferation. This work integrates long-term corrosion resistance, controlled drug release, and photoresponsive catalytic functions onto magnesium alloy surfaces, providing an effective strategy for developing high-performance biodegradable magnesium alloys.
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FOOD CHEMISTRY
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2026
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IF 10.4
Xiaoyu Cao,Sisheng Li,Qianqian Xu,Zilun Lei,Bo Jiao,David Julian McClements,Hai Yan
pH-responsive hydrogel microcapsules were fabricated from pea protein isolate (PPI) and low-methoxyl pectin (LMP) for the targeted intestinal delivery of Lacticaseibacillus paracasei YWC-01, a probiotic capable of biodegrading uric acid precursors in vitro . Microgels with interpenetrating networks were fabricated via emulsion-templating: probiotics, PPI, LMP, CaCl₂, and glucono-δ-lactone were emulsified in oil and crosslinked by Ca 2+ . Optimized formulation (5% w / v PPI) achieved 94.80% encapsulation efficiency. Microgel size (43–63 μm) was controlled by adjusting Span 80 surfactant concentration. FTIR confirmed probiotic encapsulation via noncovalent interactions, while TEM revealed bacterial clustering within hydrogel voids. In vitro digestion demonstrated exceptional protection: encapsulated probiotics maintained >9 log 10 CFU/g viability (<0.4 log reduction), versus 3.2 log reduction in free cells. Metabolomics indicated encapsulation preserved bioactivity and significantly upregulated functional metabolites potentially enhancing gut microbiota modulation and anti-inflammatory effects. This work establishes an effective oral delivery platform that significantly enhances probiotic gastrointestinal survival and enables targeted release.
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Foods
·
2026
·Vol. 15
·期 3
·564
·
IF 6
Zixuan Du,Zhengyang Jia,Jianyu Yang,Yue Zhao,Jiachen Zang,Guanghua Zhao
Grape pomace represents a major organic solid waste generated by the wine industry, but its application has been largely unexplored. On the other hand, so far, stable and sustainable raw materials for producing stable, edible Pickering emulsifiers suitable for the food industry have been lacking. To solve these problems, this study established a mild but effective co-extraction method to obtain protein–polysaccharide–polyphenol ternary complexes (GPTCs) from grape pomace. Subsequently, these complexes were directly developed into an edible Pickering emulsifier by a pH-controlled method. Results showed that a series of properties related to the Pickering emulsifier, such as particle size, surface charge, wettability, and interfacial adsorption behavior, could be easily controlled by adjusting the solution’s pH. Consequently, the GPTC prepared at pH 7.0 exhibited optimal emulsifying performance. The resulting particles had an average particle size of approximately 111 nm, and stabilized Pickering emulsions with a volume-weighted mean oil droplet diameter (D [4,3]) of 9.49 μm, indicating high emulsion stability. Collectively, this study provided an actionable approach for the green, high-value utilization of wine byproducts by establishing a pH-responsive design framework for edible Pickering emulsifiers.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Xinrui Yang,Xiaoling Chen,Gaohan Li,Yang Zhou,Qinhua Chen,Jinjun Hou,Changwu Zheng,Zijia Zhang,Wanying Wu
Areca nut ( Areca catechu L.) is a widely consumed food and medicinal plant with both nutritional value and documented health risks. To comprehensively characterize its chemical composition and spatial distribution, we developed an integrated analytical platform combining solid-phase extraction (SPE), offline two-dimensional liquid chromatography with high-resolution mass spectrometry (2D-LC-HRMS), and desorption electrospray ionization mass spectrometry imaging (DESI-MSI). This approach enriched trace constituents while minimizing matrix interference, enabling the identification of 323 compounds-including terpenes and triterpenoids (89), alkaloids (52), flavonoids (31), lignans (17), and steroids (12). A pH-orthogonal separation system (alkaline and acidic modes) significantly improved resolution of structurally similar, low-abundance compounds. Spatial analysis via DESI-MSI revealed three distribution patterns: seed-specific enrichment, pericarp enrichment, and uniform distribution. By integrating compositional and spatial data, this study offers new insights into the pharmacological basis, potential toxicity mechanisms, and safe applications of areca nut in food systems.
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ACS Applied Polymer Materials
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2026
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IF 5.2
Xin Luo,Xuan Ling,Xian Li,Zhao Wang,Xiaoran Hu
The rapid development of wearable electronics technology has provided considerable potential in the fields of motion monitoring and health management. However, current wearable sensors suffer from limitations of high stretchability to match the curvature deformation of human skin and function integration to realize simultaneous monitoring of multiple physiological signals. In this study, a stretchable bimodal piezoelectric/pH sensor is developed based on polylactide (PLLA)/polyester elastomer (PE)/carbon quantum dots (CQDs) composite nanofiber. The PE is synthesized to prossess an amorphous structure with a low glass transition temperature and mass of C═O dipoles, ensuring high stretchability and piezoelectricity, while the CQDs are designed with capacity to respond to pH variation by color change. The PE and CQDs were further blended with the PLLA matrix using electrostatic spinning technology to construct a nanofiber sensor with a bionic sponge structure. Ultimately, a PE–PLLA/CQDs–5% composite nanofiber film (PPC-5% film) shows a piezoelectric coefficient (d33) of 7.27 ± 0.05 pm/V, a wide range of pH responding capacity (pH = 3–7), a tensile strength of 4.40 MPa, and a recoverable elongation over 25%. This design not only enhances its stretchability but also ensures the sensor to realize simultaneous monitoring of motion and sweat by its sensitive piezoelectric and pH response. Thus, this flexible sensor with piezoelectric and pH bimodal response function, excellent biocompatibility, and wearable comfort provides an approach for the development of high-performance wearable sensors.
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INORGANIC CHEMISTRY COMMUNICATIONS
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2026
·
IF 5.9
Sahresh Majeed,Yumo Liu,Guanghui Cui,Abdul Majid Khan,Muhammad Irslan Ilyas,Xiaodong Wang,Wei Liu,Zhanpeng Wu
The persistent challenges of multidrug resistance and systemic toxicity in cancer chemotherapy necessitate the development of intelligent, tumor-targeted co-delivery systems. Herein we report a novel nickel-based metal-organic framework (CUR + PTX@Ni-MOF) engineered with a phosphazene-derived ligand for the pH-responsive co-delivery of paclitaxel (PTX) and curcumin (CUR). The framework integrates a hexachlorocyclotriphosphazene (HCCP)-based linker featuring an intrinsically acid-labile P3N3 core enabling controlled degradation within the acidic tumor microenvironment (TME). The Ni-MOF exhibits a high BET surface area (177.118 m 2 /g) and a mesoporous architecture facilitating exceptional dual-drug loading capacities of 56.15% for CUR (96.3% encapsulation efficiency, EE) and 26.18% for PTX (43.01% EE). In vitro release studies demonstrated minimal drug leakage at physiological pH (7.4), while triggered, sustained release was achieved under acidic conditions (pH 6.5 and 5.0) with maximum cumulative releases of 75.42% for CUR and 49.35% for PTX at pH 5.0. Cellular assays confirmed high biocompatibility with normal LO2 hepatocytes (>80% viability) and potent, synergistic cytotoxicity against HeLa cancer cells driven by enhanced cellular uptake and apoptosis induction. This work establishes CUR + PTX@Ni-MOF as a promising, intrinsically pH-responsive platform for targeted and synergistic combination chemotherapy.
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高影响因子
LANGMUIR
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2026
·
IF 4.4
Xiaoxia Zheng,Yong Zhang,Feng Huang,Jie Qi,Ziteng Yang,Zheng Zhang,Hongsheng Lu
The growing demand for petroleum has intensified the pressure on conventional resources, driving exploration into unconventional reservoirs. Polyacrylamide (PAM) emulsion drag reducers can suppress fracturing fluid turbulence and improve reservoir stimulation, but their poor dissolution efficiency remains a key obstacle to widespread application. Herein, a pH-responsive Gemini surfactant (PA/OA) featuring a rigid piperazine ring as the hydrophilic headgroup was synthesized using piperazine (PA) and oleic acid (HOA). The PA/OA-stabilized monomer emulsion exhibited excellent stability for over 50 days at pH 7.0, enabling the successful inverse emulsion polymerization of PAM. The introduction of the piperazine ring and double hydrophobic tails enhances the molecular rigidity to promote a tight arrangement at the oil–water interface, thereby reinforcing the interfacial film and enhancing the interfacial activity. The surface activity of PA/OA varied at different pH conditions due to the interionic proton transfer between OA and PA. The pH-responsive ionic bonds in PA/OA facilitate rapid release of emulsion drag reducers, with most released within 30 s at pH = 10.0, and achieve a drag reduction rate of 68% at a concentration of 0.05 wt %. The PA/OA-stabilized emulsion effectively reconciled the conflict between long-term storage stability and rapid release performance encountered in single-chain-responsive surfactant systems.
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CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Yuyuan Chen,Xinyu Zhu,Lisha Feng,Shuli Tian,Jianbin Ye,Yongfang Zheng,Hu Zhu
In this study, we developed an innovative stimuli-responsive oxidase-mimicking nanozyme system based on carbon dots (CDs) and ferrous ions (Fe 2+ ) for rapid detection and effective discrimination of antioxidants under neutral conditions. The uniqueness of this system lies in its exhibition of oxidase-like activity activated by Fe 2+ , which acts as both a switch and a regulator of catalytic performance. Importantly, the Fe 2+ -triggered activation shows instantaneous response and reaches steady-state within 240 s. Another key feature of this system is its exceptional oxidase-like activity at neutral pH, overcoming the limitation of most oxidase mimics that require acidic conditions. Moreover, it shows remarkable cold tolerance, retaining over 70% catalytic activity even at 0 °C. Mechanistic studies reveal that Fe 2+ coordinates with functional groups on CDs, enhancing Fe 2+ /Fe 3+ conversion efficiency and accelerating electron transfer, which greatly promotes the generation of reactive oxygen species (ROS) and subsequent TMB oxidation. Additionally, the generated Fe 3+ further catalyze TMB oxidation, synergistically enhancing the colorimetric reaction. Capitalizing on these attributes, we developed a colorimetric sensing platform for rapid and sensitive detection of antioxidants including ascorbic acid (AA), glutathione (GSH), and cysteine (Cys). Based on their differential inhibitory effects, we further constructed a sensor array that enables effective discrimination among these antioxidants. This work not only opens new avenues for designing nanozymes with stimulus-responsive properties, but also expands the toolbox for detecting and identifying antioxidants in complex samples under neutral conditions.
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