IONICS
·
2025
·
IF 2.6
Cai Kanghui,Hong Binsheng,Hu Xueling,Li Zhenkun,Su Jing,Lv Xiaoyan,Wen Yanxuan
MnPO 4 ∙H 2 O is an ideal precursor for the preparation of LiMnPO 4 . However, the instability of Mn 3+ in an aqueous solution necessitates the implementation of the existing preparation methods, which are carried out in ethanol and produce toxic gases such as NO and NO 2 . In this work, a radical-oxidation coupled phosphate stabilization strategy is proposed for synthesizing MnPO 4 ∙H 2 O in an aqueous solution. The strategy involves the initial oxidation of Mn 2+ to Mn 3+ by sulfate radicals, which are produced through the thermal activation of Na 2 S 2 O 8 . Subsequently, Mn 3+ is stabilized by H 3 PO 4 , leading to the formation of MnPO 4 ∙H 2 O. By implementing this strategy, the mesoporous MnPO 4 ∙H 2 O precursor can be readily obtained through a reaction at 90 °C for 5 h. Subsequently, the prepared LiMnPO 4 /C inherits the mesoporous structure of the MnPO 4 ∙H 2 O precursor, exhibiting excellent electrochemical performance. Specifically, the mesoporous LiMnPO 4 /C delivers an initial capacity of 115.8 mAh g −1 with a capacity retention of 83.1% after 100 cycles at 10 C. The enhanced performance is mainly attributed to the mesoporous structure, which facilitates electrolyte penetration, reduces interfacial charge transfer impedance, and accelerates Li + diffusion. The environmentally benign and scalable strategy presented here opens a new approach to the synthesis of high-performance LiMnPO 4 /C.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Lu Gongxun,Han Zhiyuan,Shi Lei,Wang Zhilong,Zhang Mengtian,Wu Xinru,Piao Zhihong,Xiao Xiao,Tao Shengyu,Nai Jianwei,Ju Zhijin,Zhang Xuan,Han Yanqiang,Vidaurre Karl Luigi Loza,Fu Hongyan,Li Jinjin,Tao Xinyong,Zhou Guangmin
Accurately understanding the impact of solid electrolyte interphase (SEI) on lithium deposition is critical for high-energy lithium metal batteries. Yet traditional strategies, focusing solely on isolated components, fail to capture multi-constituent synergies and underlying mechanisms. To address this challenge, we introduce the concept of SEI omics and establish a dataset of cryogenic transmission electron microscopy images combined with co-localized component information. By integrating interpretable machine learning and physics-based feature selection, we decoupled the roles of SEI constituents, revealing that higher N/S/P/F content and reduced O in the SEI improve lithium deposition. Combined density functional theory and electrochemical phase-field modeling uncovered multi-scale effects of SEI components on Li growth. Results confirm that designing an inner SEI layer with high surface energy and migration ability significantly refines deposition morphology. Guided by machine learning-optimized composition, a highly disordered SEI was engineered, achieving high average Coulombic efficiency of 99.35% over 800 cycles for Li||Cu cell at 1 mA cm −2 and 1 mAh cm −2 . This work establishes a universal framework for understanding SEI-coupled effects on lithium growth, offering transformative strategies for electrolyte and interface design.
✓ 已验证
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 11
·1-10
·
IF 5.3
Chen Zixuan,Ma Shuhui,Wang Chujun,Liu Jie,Yang Xiaoyan
Monitoring of the amyloid-beta (A β ) peptide is crucial for the diagnosis and treatment of Alzheimer’s disease. Here, a label-free, signal-on ratiometric electrochemiluminescence (ECL) aptasensor was fabricated for the detection of A β peptide. Specifically, graphite-like carbon nitride (g-C 3 N 4 ) nanosheets and luminol served as the cathodic and anodic ECL emitters, respectively. K 2 S 2 O 8 and H 2 O 2 were used as the coreactants for the two emitters. Luminol was first coated on the indium tin oxide (ITO) electrode and used as the internal standard in the ratiometric biosensor. Polyaniline was then electrodeposited on the surface of the luminol-modified electrode to improve the biocompatibility and conductivity of the sensing interfaces. Gold nanoparticles were subsequently modified on the surface of polyaniline to immobilize a DNA aptamer. g-C 3 N 4 -heme incubated with different concentrations of A β solution to form g-C 3 N 4 -heme-A β complex, in which A β could specifically bind to the DNA aptamer and thus introduce g-C 3 N 4 into the system. As a result, it was observed that the ratio value of ECL intensity ( I 1 / I 2 ) significantly increased with the increase of A β concentration. Under the optimized conditions, the biosensor has a good linear response in the range 10 fM to 10 nM with a detection limit of 4.2 fM. Consequently, the ratiometric ECL sensor, characterized by high sensitivity and favorable stability, offers a reliable method for the determination of A β . Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 4
Liu He-Chen,Zhou Xin-Xin,Zhou Song-Song,Zou Ying,Wang Yu-Li,Li Xiang-Qing
The most widely used bisphenol A-type epoxy resin (DGEBA) in electrical engineering demonstrates excellent mechanical and electrical properties. However, the insoluble and infusible characteristics of cured DGEBA make it difficult to efficiently degrade and recycle decommissioned electrical equipment. In this study, a degradable itaconic acid-based epoxy resin incorporating dynamic covalent bonds was prepared through the integration of ester bonds and disulfide bonds, with itaconic acid as the precursor. The covalent bonding effects on the mechanical, thermal, electrical, and degradation characteristics were systematically evaluated. The experimental results revealed that the introduction of dynamic ester bonds enhanced the mechanical properties and thermal stability of the resin system, achieving a flexural strength of 141.57 MPa and an initial decomposition temperature T 5% of up to 344.9 °C. The resin system containing dynamic disulfide bonds exhibited a dielectric breakdown strength of 41.11 kV/mm. Simultaneously, the incorporation of disulfide bonds endowed the epoxy resin with remarkable degradability, enabling complete dissolution within 1.5 h at 90 °C in a mixed solution of dithiothreitol (DTT) and N -methylpyrrolidone (NMP). This research provides a valuable reference for the application of itaconic acid-based vitrimer with dynamic covalent bonds in electrical materials, contributing to the development and utilization of environmentally friendly electrical equipment.
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2025
·
IF 4.8
Li Xiaoqing,Chen Ruoxin,Ren Jiahao,Duan Qingfei,Liu Fengsong
This study investigated the enhancement of carboxymethyl cellulose (CMC)-based films through the incorporation of gelatin and alkyl ketene dimer (AKD), aiming to address inherent limitations in hydrophobicity, film-forming capability, and mechanical strength. To further optimize film properties, three plasticizers, citric acid, glycerol, and isosorbide, were systematically evaluated for their effects on film morphology and flexibility. Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses revealed extensive hydrogen bonding among CMC, gelatin, and AKD, evidenced by a marked reduction in free hydroxy groups, indicative of strong intermolecular interactions. Thermal and morphological characterizations further demonstrated that isosorbide promoted homogeneous film formation, while AKD increased surface roughness and improved water resistance. Among all tested formulations, the CMC–gelatin film incorporated with isosorbide and AKD (SCGI–AKD film) exhibited the most favorable hydrophobic performance, achieving a contact angle (CA) of 105.09°, a water solubility (WS) of 28.46%, and a reduced water vapor permeability (WVP) of 0.65 g m/m 2 s Pa. This formulation also displayed superior mechanical characteristics, including a tensile strength of 13.27 MPa, a Young’s modulus of 151.24 MPa, and an elongation at break of 38.71%. Optical measurements confirmed the compatibility of composite components, as all films maintained stable visible light transmittance. Notably, the SCGI–AKD film exhibited selective light-filtering capacity, transmitting only 29.59% for UV light at 300 nm while allowing 80.25% transmittance at 600 nm in the visible range. These findings underscore the potential of CMC–gelatin–AKD composite systems as sustainable, multifunctional packaging materials with tunable barrier, mechanical, and optical properties. Graphical Synopsis: The synergistic incorporation of AKD and isosorbide into CMC films significantly enhanced hydrophobicity, film-forming capability, and mechanical performance, underscoring their potential for application in sustainable packaging systems.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2022
·Vol. 24
·期 6
·1-16
·
IF 2.533
Yang Yuhang,Zhu Zhongan,Adu-Frimpong Michael,Liu Jing,Wang Yaping,Chen Lin,Toreniyazov Elmurat,Ji Hao,Cao Xia,Shi Feng,Wang Qilong,Yu Jiangnan,Xu Ximing
Licorice chalcone A (LCA) possesses a variety of pharmacological activities amid poor solubility in water which consequently restricts its clinical application. In this study, LCA micelles (LCA-M) and LCA micelles modified with TPGS (LCA-M-T) were prepared, wherein in vitro, in vivo, and hepatoprotection potential of the formulations were evaluated. LCA-M-T and LCA-M were prepared by thin-film dispersion method and characterized by a transmission electron microscope (TEM). The encapsulation efficiency, in vitro release, and stability of LCA-M-T and LCA-M were detected by HPLC and UV, respectively. The pharmacokinetics, tissue distribution studies, and pharmacodynamics research were also carried out after oral administration. The sizes of micellar particles were 34.02 ± 0.29 nm (LCA-M) and 62.46 ± 0.51 nm (LCA-M-T) with 0.223 ± 0.021 (LCA-M) and 0.343 ± 0.006 (LCA-M-T) polydispersities, − 35.06 ± 2.27 mV (LCA-M) and − 38.58 ± 1.69 mV (LCA-M-T) zeta potentials, and 95.2 ± 0.27% (LCA-M) and 90.34 ± 0.31% (LCA-M-T) encapsulation efficiencies. The drug loadings were 8.56 ± 0.27% (LCA-M) and 8.04 ± 0.19% (LCA-M-T). The two preparations released quickly and reached over 95% in the four-dissolution media (pH = 1.2 pH = 6.8 pH = 7 pH = 7.4). The preparations of LCA showed significant elevation of cumulative release compared with the free LCA and more importantly 119% (LCA-M) and 285% (LCA-M-T) increments in the relative oral bioavailability of the drug. Preparations of LCA may act as a promising approach to improve solubility and enhance bioavailability and liver protective activity of LCA.
✓ 已验证
DOI
高影响因子
Nature Protocols
·
2021
·Vol. 16
·期 12
·5460-5483
·
IF 13.491
Yao Chi,Zhang Rui,Tang Jianpu,Yang Dayong
DNA hydrogels have unique properties, including sequence programmability, precise molecular recognition, stimuli-responsiveness, biocompatibility and biodegradability, that have enabled their use in diverse applications ranging from material science to biomedicine. Here, we describe a rolling circle amplification (RCA)-based synthesis of 3D DNA hydrogels with rationally programmed sequences and tunable physical, chemical and biological properties. RCA is a simple and highly efficient isothermal enzymatic amplification strategy to synthesize ultralong single-stranded DNA that benefits from mild reaction conditions, and stability and efficiency in complex biological environments. Other available methods for synthesis of DNA hydrogels include hybridization chain reactions, which need a large amount of hairpin strands to produce DNA chains, and PCR, which requires temperature cycling. In contrast, the RCA process is conducted at a constant temperature and requires a small amount of circular DNA template. In this protocol, the polymerase phi29 catalyzes the elongation and displacement of DNA chains to amplify DNA, which subsequently forms a 3D hydrogel network via various cross-linking strategies, including entanglement of DNA chains, multi-primed chain amplification, hybridization between DNA chains, and hybridization with functional moieties. We also describe how to use the protocol for isolation of bone marrow mesenchymal stem cells and cell delivery. The whole protocol takes ~2 d to complete, including hydrogel synthesis and applications in cell isolation and cell delivery.
✓ 已验证
DOI
PubMed
高影响因子
Acta Metallurgica Sinica-English Letters
·
2017
·Vol. 30
·期 6
·558-566
·
IF 1.292
Cao Sheng,Li He-Jun,Li Ke-Zhi,Lu Jin-Hua,Zhang Lei-Lei
Carbon/carbon (C/C) composites were deposited with graphite-like carbon (GLC) coating, and then, Arg-Gly-Asp acid (RGD) peptides were successfully immobilized onto the functionalized GLC coating. GLC coating was utilized to prevent carbon particles releasing and create a uniform surface condition for C/C composites. RGD peptides were utilized to improve biocompatibility of GLC coating. Surface chemical characterizations of functionalized GLC coating were detected by contact angle measurement, X-ray photoelectron spectroscopy and Raman spectra. Optical morphology of GLC coatings was observed by confocal laser scanning microscopy. In vitro biological performance was determined using samples seeded with MC3T3-E1 osteoblast-like cells and cultured for 1 week. Surface characterizations and morphological analysis indicated that C/C composites were covered by a dense and uniform GLC coating. Contact angle of GLC coating was reduced to 27.2° when it was functionalized by H 2 O 2 oxidation at 40 °C for 1 h. In vitro cytological test showed that the RGD peptides immobilized GLC coating had a significant improvement in biocompatibility. It was suggested that RGD peptides provided GLC coating with a bioactive surface to improve cell adhesion and proliferation on C/C composites.
✓ 已验证
DOI
高影响因子
Scientific Reports
·
2017
·Vol. 7
·期 1
·1-11
·
IF 4.259
Zhao Yating,Wang Yu,Ran Fu,Cui Yu,Liu Chang,Zhao Qinfu,Gao Yikun,Wang Da,Wang Siling
In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics and theranostics, but the effect of the shape of nanoparticles has received little attention. In the present study, we designed three different shaped fluorescent mesoporous silica nanoparticles (MSNs), long rod nanoparticles (NLR), short rod nanoparticles (NSR), and spherical nanoparticles (NS) to systematically examine their behavior in vivo after oral administration. The results of the ex vivo optical imaging study in mice indicated that rod nanoparticles had a longer residence time in the gastrointestinal compared with spherical nanoparticles. The in vivo biodistribution showed that all the orally administered MSNs were mainly taken up by the liver, and kidney. NLR had a great capacity to overcoming rapid clearance by the RES and exhibited a longer circulation in the blood than NSR and NS. During renal excretion, the spherical nanoparticles were cleared faster than rod nanoparticles. In addition, it was also found that MSNs can be degraded in vivo and NSR were degraded faster than NLR and NS probably owing to their higher specific surface area. The pharmacokinetic results demonstrated that nifedipine(NI)-loaded NLR had a higher bioavailability than NI-loaded NSR and NS.
✓ 已验证
DOI
PubMed
高影响因子
Nature Protocols
·
2026
·
IF 18.4
Guo Xuecheng,Gao Yuan,Zhang Chao,Zhang Shuai,Sang Shuaikang,Ma Jun,Murzin Dmitry Yu.,Low Jingxiang,Shao Tao,Xiong Yujie
Decentralized, sustainable ammonia production could have an immense global impact. Here we describe an electrolytic approach to synthesizing ammonia directly from air and water under ambient conditions, which could be developed and optimized toward this goal. The system integrates a gliding arc discharge plasma reactor for generating \({\rm{NO}}_{\rm{x}}\) from air with a membrane electrode assembly reactor for the electrochemical reduction of \({\rm{NO}}_{\rm{x}}^{-}\) to ammonia, enhancing both the efficiency and scalability of the process. Furthermore, the plasma-generated \({\rm{NO}}_{\rm{x}}\) feedstock can be substituted with \({\rm{NO}}_{\rm{x}}\) derived from industrial waste, further extending the potential of this system. In this Protocol, we describe the fundamental principles of this plasma-electrochemical nitrogen reduction reaction (PE-N 2 RR) system and provide advice for experimental standardization, operational mechanisms and data analysis methods. The procedure starts with the synthesis of the catalyst—a La 1.5 Sr 0.5 Ni 0.5 Fe 0.5 O 4 perovskite oxide—at either laboratory or industrial scale. This catalyst is sufficiently stable to enable the \({\rm{NO}}_{\rm{x}}^{-}\) RR to continuously work under strongly acidic conditions. We highlight the key operating parameters that are necessary for plasma-based \({\rm{NO}}_{\rm{x}}\) production and electrochemical \({\rm{NO}}_{\rm{x}}^{-}\) reduction reaction systems. This information and framework can be used to optimize and streamline the entire PE-N 2 RR system. A moderate level of expertise in electrochemistry, plasma systems and catalyst synthesis is recommended to ensure successful execution. The setup of the entire PE-N 2 RR system, from catalyst synthesis to the configuration of plasma and electrochemical, is estimated to take 72 h. The full reaction operation test requires 200 h, whereas in situ electrochemical characterizations take 3 h.
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2026
·
IF 4.9
Li Yunmei,Su Yuting,Yang Peng,Peng Chune,Cheng Xiaoyi,Zhang Xiao,Peng Lizeng,Lodi Rathna Silviya,Wang Zhixin
Trametes sanguinea belongs to the polyporaceae family and it is a white rot medicinal fungus. In the present study, pure mycelium of Trametes sanguinea ZHSJ ( T. sanguinea ZHSJ) was obtained from the fruiting body of wild basidiomycetes by tissue separation method, and its growth conditions were optimized in vitro. The results exhibited the optimal growth of T. sanguinea ZHSJ at pH 5, temperature 30 ℃ with the carbon source maltose 20 g/L and nitrogen source yeast extract 4 g/L. LC-MS based untargeted metabolomic studies revealed there are 6715 metabolites in both positive and negative ion mode detection of spores (SP), mycelium (MY) and fruiting body (MU). However, principal component analysis (PCA) represented PC1 67.10% and PC2 24.60% metabolite variance among SP, MY and MU. Further, metabolite cluster and Variable projection importance (VIP) analysis has represented differential upregulated and down regulated metabolites with p value < 0.05 and VIP ≥ 1 significance. Moreover, KEGG pathway enrichment analysis represented SP vs. MY and SP vs. MY major metabolites 23 and 31 involved in biosynthesis of co-factors and MY vs. MU major metabolites involved in diterpenoid biosynthesis. Hence, current study reveals that the morphological stages of T. sanguinea ZHSJ possess several variations in their metabolites and this is the first study to reveal the optimization of T. sanguinea spores and their metabolites comparison with mycelium and fruiting body through LC-MS based untargeted metabolomics. Further research on the biological activity of these differential metabolites of T. sanguinea spores would way a path in identification of novel medicinally important compounds.
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF MEDICAL RESEARCH
·
2026
·
IF 4.8
Xiangxi Meng,Yumo Tian,Sen Hu,Lili Wang,Yuxian Zhong,Kui Sun,Minghua Du
Introduction: Early application of sodium valproate has a certain protective effect on important organ functions. This study aimed to investigate the protective effects of sodium valproate on rats with severe thermal injury combined with seawater immersion followed by delayed intravenous infusion. Methods: Rats were divided into three groups: scald (S) group, scald with seawater immersion (SS) group, and scald with seawater immersion treated with sodium valproate (SSV) group. All rats received a 35% of total body surface area full-thickness scald and delayed rehydration 2 h after injury. SS and SSV groups were immersed in artificial seawater (23 ℃, 30 min) immediately after scalding, and the SSV group was subcutaneously injected with sodium valproate (300 mg/kg) after seawater immersion. Physiological parameters, organ functions, blood flow, and histological changes in abdominal organs were assessed. Results: The 24-h survival rate was significantly lower in the SS group (55%) compared to the S (90%) and SSV (75%) groups. Sodium valproate treatment in the SSV group significantly improved physiological indicators, organ functions, and abdominal organ blood flow compared to the SS group. Pathological damage, especially to the heart, brain, liver, kidney, and intestine, was reduced in the SSV group. Conclusion: Early administration of sodium valproate during delayed resuscitation following severe scald and seawater immersion improves the 24-h survival rate, hemodynamics, and organ function.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）