MICROCHIMICA ACTA
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2021
·Vol. 188
·期 12
·1-11
·
IF 5.833
Fan Fangbin,Lu Xiaofeng,Wang Shuai,Wang Licheng,Liang Xiaojing,Guo Yong
By introducing functional groups such as quaternary amine groups, sulfonic acid groups, triazine groups, and other mespore nanomaterials into the hydrogel, better separation effect of some organic framework materials has been obtained. Due to a reasonable design and preparation strategy, the hydrogel composite-modified silica can be used in the selective separation of various analytes such as pesticides, alkylbenzenes, polycyclic aromatic hydrocarbons, nucleosides/bases, benzoic acids, antibiotics, and carbohydrates. Through the exploration of chromatographic retention behavior, it is proved that the column can be used in mixed-mode liquid chromatography. The intra-day relative standard deviation for retention time of this new stationary phase is 0.12–0.16% ( n = 10), and the inter-day relative standard deviation is less than 0.39% ( n = 5). This new stationary phase can also be used for separation in complex samples. The limit of detection (LOD) for chlorotoluron in farm irrigation water is 0.21 µg/L and the linear range is 2–250 µg/L. After optimizing the chromatographic conditions, the highest efficiency of the hydrogel column in RPLC and HILIC modes has reached 32,400 plates/m (chlorobenzuron) and 41,300 plates/m (galactose). This new type of hydrogel composite is a porous network material with flexible functional design and simple preparation method and its application has been expanded in liquid chromatography separation successfully. Graphical abstract The hydrogel composed of triallyl cyanate cross-linking agent and 3-(2-(methacryloyloxy) ethyl) dimethylamine) propane-1-sulfonate (SBMA) monomer which were co-modified on the surface of mesoporous silica with MOF-919 for separation in mixed-mode liquid chromatography.
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高影响因子
Nature Communications
·
2021
·Vol. 12
·期 1
·1-15
·
IF 14.919
Chen Junjie,Chen Longqi,Wu Yinglong,Fang Yichang,Zeng Fang,Wu Shuizhu,Zhao Yanli
Developing high-quality NIR-II fluorophores (emission in 1000–1700 nm) for in vivo imaging is of great significance. Benzothiadiazole-core fluorophores are an important class of NIR-II dyes, yet ongoing limitations such as aggregation-caused quenching in aqueous milieu and non-activatable response are still major obstacles for their biological applications. Here, we devise an activatable nanoprobe to address these limitations. A molecular probe named BTPE-NO 2 is synthesized by linking a benzothiadiazole core with two tetraphenylene groups serving as hydrophobic molecular rotors, followed by incorporating two nitrophenyloxoacetamide units at both ends of the core as recognition moieties and fluorescence quenchers. An FDA-approved amphiphilic polymer Pluronic F127 is then employed to encapsulate the molecular BTPE-NO 2 to render the nanoprobe BTPE-NO 2 @F127. The pathological levels of H 2 O 2 in the disease sites cleave the nitrophenyloxoacetamide groups and activate the probe, thereby generating strong fluorescent emission (950~1200 nm) and ultrasound signal for multi-mode imaging of inflammatory diseases. The nanoprobe can therefore function as a robust tool for detecting and imaging the disease sites with NIR-II fluorescent and multispectral optoacoustic tomography (MSOT) imaging. Moreover, the three-dimensional MSOT images can be obtained for visualizing and locating the disease foci.
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RARE METALS
·
2021
·Vol. 41
·期 3
·931-941
·
IF 4.003
Guo Jun,Wang Zi-Yuan,Zhu Yu-Ke,Chen Lin,Feng Jing,Ge Zhen-Hua
Bi 2 S 3 is composed of inexpensive and environmental friendliness elements, which has received extensive interests and been investigated as a promising mid-temperature thermoelectric material for years. Even pure Bi 2 S 3 possesses a high Seebeck coefficient and low thermal conductivity, its low electrical conductivity leads to a low figure of merit (ZT) value. In this work, Bi 2 S 3 fabricated by solid-state melting combined with spark plasma sintering can significantly enhance the thermoelectric performance via introducing small amounts of Cu and BiCl 3 . Cu interstitial doping and Cl substitution on S site result in a large increase in electrical conductivity. Additionally, the enhanced phonon scattering is derived from the point defects caused by element doping, the grain boundaries, and the small amount of secondary phase, which leads to the low thermal conductivity. Finally, a high ZT value of 0.7 is obtained at 773 K and reaches a large average ZT of 0.36 in the temperature range from room temperature (RT) to 773 K for the Cu-interstitial-doped and BiCl 3 -alloyed (Cu 0.01 Bi 2 S 3 + 0.175 mol% BiCl 3 ) sample. Furthermore, the mechanical properties of the Cu 0.01 Bi 2 S 3 + 0.175 mol% BiCl 3 sample are lower than those of other Bi 2 S 3 samples, which stem from the weak chemical bonding strength. Graphic abstract
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Scientific Reports
·
2021
·Vol. 11
·期 1
·1-9
·
IF 4.38
Yang Xin,Yu Qiuxia,Xu Hao,Zhou Jianfeng
Treatment failure or relapse due to tumor escape caused by reduction in target antigen expression has become a challenge in the field of CART therapy. Target antigen density is closely related to the effectiveness of CART therapy, and reduced or lost target antigen expression limits the efficacy of CART therapy and hinders the durability of CAR T cells. Epigenetic drugs can regulate histones for molecular modifications to regulate the transcriptional, translational and post-translational modification processes of target agents, and we demonstrated for the first time the role in regulating CD22 expression and its effect on the efficacy of CD22 CART. In this paper, we found that Chidamide promoted the expression of CD22 on the surface of B-cell tumor cells in vitro and in vivo, and enhanced the function of CD22 CART. As for mechanisms, we demonstrated that Chidamide did not affect CD22 mRNA transcription, but significantly increased the expression of total CD22 protein, indicating that Chidamide may upregulate cell surface CD22 expression by affecting the distribution of CD22 protein. In summary, our results suggest that Chidamide may enhance the efficacy of CD22 CART by inhibiting histone deacetylases to regulate post-transcriptional modifications that affect protein distribution to increase the expression of CD22 on the cell surface.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2021
·Vol. 29
·期 20
·29613-29623
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IF 4.223
Zhao Dianjia,Ye Wenkang,Cui Wenxuan
As eco-friendly adsorption material, hydroxyapatite (Ca 5 (PO 4 ) 3 OH, HA) has been extensively applied to the removal of heavy metal ions. However, separating and recovering of HA powder after the adsorption process limits their application. Alginate-based composite beads (HCA) encapsulated with HA and cellulose were designed to remove Cu(II) from aqueous solution. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) were used for characteristic analysis. An extensive discussion in terms of HCA adsorption capacity, effect of various Cu(II) concentration, and analysis of the involved mechanisms of Cu(II) removal on the biosorption. HCA beads showed that the maximum adsorption capacity for Cu(II) of 64.14 mg/g at pH = 5 with 8 h contact time. The Langmuir adsorption isotherm and second-order kinetic model gave the closest fit. HCA beads display good regeneration ability after four cycles and offer potentiality for practical application.
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Nano-Micro Letters
·
2021
·Vol. 14
·期 1
·1-13
·
IF 16.419
Xie Shiyin,Li Yang,Li Xu,Zhou Yujun,Dang Ziqi,Rong Jianhua,Dong Liubing
Zn-based electrochemical energy storage (EES) systems have received tremendous attention in recent years, but their zinc anodes are seriously plagued by the issues of zinc dendrite and side reactions (e.g., corrosion and hydrogen evolution). Herein, we report a novel strategy of employing zincophilic Cu nanowire networks to stabilize zinc anodes from multiple aspects. According to experimental results, COMSOL simulation and density functional theory calculations, the Cu nanowire networks covering on zinc anode surface not only homogenize the surface electric field and Zn 2+ concentration field, but also inhibit side reactions through their hydrophobic feature. Meanwhile, facets and edge sites of the Cu nanowires, especially the latter ones, are revealed to be highly zincophilic to induce uniform zinc nucleation/deposition. Consequently, the Cu nanowire networks-protected zinc anodes exhibit an ultralong cycle life of over 2800 h and also can continuously operate for hundreds of hours even at very large charge/discharge currents and areal capacities (e.g., 10 mA cm −2 and 5 mAh cm −2 ), remarkably superior to bare zinc anodes and most of currently reported zinc anodes, thereby enabling Zn-based EES devices to possess high capacity, 16,000-cycle lifespan and rapid charge/discharge ability. This work provides new thoughts to realize long-life and high-rate zinc anodes.
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高影响因子
Journal of Analysis and Testing
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2021
·Vol. 6
·期 2
·77-88
·
IF 0
Peng Ya-Ping,He Ya-Wen,Shen Ya-Fang,Liang Ao-Ming,Zhang Xi-Bin,Liu Yuan-Jie,Lin Jian-Han,Wang Jian-Ping,Li Yan-Bin,Fu Ying-Chun
Some veterinary drug residues in food products and environment have been widely regarded as severe threats to human health. Rapid and simultaneous detection methods are crucial to monitor and control veterinary drug usage. Here, we propose a fluorescence biosensor utilizing immunomagnetic beads (IMBs) and quantum dots (QDs) for the rapid and simultaneous detection of 1-adamantylamine (ADA), enrofloxacin (ENR) and tilmicosin (TIL) in raw chicken meat. A pretreatment method using sodium phosphotungstate–magnesium as extraction reagent was developed to simultaneously extract ADA, ENR and TIL from chicken meat with minor interference in background or response. By adding the IMBs modified with three types of antibodies and the QD-antigens modified with three types of BSA-antigens to sample, IMBs competitively conjugated to target antigens in a sample or QD-antigens. After magnetic separation, the residual QD-antigens were adopted to collect signals using fluorescence spectroscopy. Using QDs with well separated emission peaks, the detection of one type of targets was minorly interfered by the others. Under the optimum conditions, the biosensor exhibited the limit of detection of 0.96, 3.32, and 3.17 ng/mL for ADA, ENR and TIL in chicken samples, respectively, as well as good specificity. Due to the way of direct collection of signals in extracts, the tedious and complicated multiple magnetic separation and signal amplification procedures in conventional methods were avoided, thus the procedures were significantly simplified, and the reduction of the operation time of 30 min for sample pretreatment and 40 min for detection part was achieved. The biosensor might be promising in the rapid, in-field and sensitive screening of multiple veterinary drugs to ensure agriculture and food safety.
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MACROMOLECULAR RESEARCH
·
2021
·Vol. 30
·期 1
·36-42
·
IF 2.227
Zhang Hongzhen,Xu Ronghua,Yin Zuowen,Yu Jun,Liang Ning,Geng Qian
Wound treatment is an important issue and poses a critical challenge for healthcare systems. It is of great significance to develop materials for wound repair and regeneration. Herein, we presented a kind of novel drug-loaded methacryloyl chondroitin sulfate (CSMA) microspheres for promoting the wound healing process. The CSMA droplets were generated from microfluidic electrospray and polymerized with ultraviolet light. With further freeze-drying and drug uploading, the drug-loaded CSMA microspheres were achieved. The prepared microspheres exhibited excellent biocompatibility, and the following animal experiments indicated they could promote wound healing significantly. This study opens the door to drug-loaded CSMA microspheres for wound healing applications.
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JOURNAL OF NANOBIOTECHNOLOGY
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2021
·Vol. 19
·期 1
·1-14
·
IF 10.435
Qin Bing,Jiang Mengshi,Li Xiang,Shi Yingying,Zhang Junlei,Luo Zhenyu,Luo Lihua,Lu Yichao,Liu Xu,Wang Sijie,Du Yongzhong,Qiu Yunqing,Lou Yan,You Jian
Background Gene therapy shows great promise for a broad array of diseases. However, we found that hypoxic tumor microenvironment (TME) exerted significant inhibitory effects on transfection efficiency of a variety of gene vectors (such as Lipo 2000 and PEI) in an oxygen-dependent manner. Solid tumors inevitably resulted in acute hypoxic areas due to the rapid proliferation of tumor cells and the aberrant structure of blood vessels. Thus, the hypoxic TME severely limited the efficiency and application of gene therapy.Methods In our previous study, we constructed endoplasmic reticulum-targeted cationic liposomes, PAR-Lipo, which could effectively deliver genes and ensure high transfection efficiency under normoxia. Unsatisfactorily, the transfection efficiency of PAR-Lipo was rather poor under hypoxia. We believed that reoxygenation was the most direct and effective means to rescue the low transfection under hypoxia. Hence, we fabricated liposomes modified with perfluorooctyl bromide (PFOB@Lipo) to load oxygen and deliver it to tumor sites, which effectively alleviated the hypoxic nature of tumor. Then PAR-Lipo were applied to mediate high-efficiency delivery of tumor suppressor gene pTP53 to inhibit tumor progression.Results The results showed that such staged strategy augmented the expression of P53 protein in tumors and extremely suppressed tumor growth.Conclusion This work was the first attempt to utilize an oxygen nanocarrier to assist the therapeutic effect of gene therapy under hypoxia, providing a new reference for gene therapy in malignant tumors.Graphical Abstarct
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2021
·Vol. 38
·期 1
·200-208
·
IF 1.307
Wang Yue,Wang Xiaoxue,She Ping,Guan Dehui,Song Lina,Xu Jijing
D esign and fabrication of functional porous air cathode materials with superior catalytic activity is still the key point for non-aqueous lithium-oxygen(Li-O 2 ) batteries. Herein, inspired by the self-standing three-dimensional(3D) structure of the natural spinach leaves, a unique binder-free and self-standing porous Au/spinach cathode for high-performance Li-O 2 batteries has been developed. The carbonized spinach leaves serve as a superconductive current collector and an ideal porous host for accommodating catalysts. The Au/spinach cathode could offer enough spaces for accommodating the discharge products, shorten the distance of the oxygen and electrolyte diffusion, and promote the oxygen reduction reaction(ORR) and oxygen evolution reaction (OER) processes. This optimized Au/spinach cathode achieved a high specific area capacity of 7.23 mA·h/cm 2 at a current density of 0.05 mA/cm 2 and exhibited excellent stability(280 cycles at 0.05 mA/cm 2 with a fixed capacity of 0.2 mA·h/cm 2 ). The superior performance encourages the construction of more advanced cathode architectures by the use of bio-composites for Li-O 2 batteries.
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Nano Research
·
2021
·Vol. 15
·期 2
·1409-1414
·
IF 8.897
Liu Jinze,Li Yuhang,Wang Yating,Xiao Chuqian,Liu Miaomiao,Zhou Xiaodong,Jiang Hao,Li Chunzhong
Electrochemical reduction of CO 2 to valuable formate as liquid fuel is a promising way to alleviate the greenhouse effect. The edge active sites in bismuth (Bi) nanosheets play a critical role in the electrochemical reduction of CO 2 into formate, which enable the operation of CO 2 reduction with high cathodic energy efficiency, especially under large current densities of ≥ 200 mA/cm 2 . However, the undesirable reconstruction of small Bi nanosheets into large nanosheets leads to the decreasing of edge active sites during electrocatalysis. Here we report stable isolated ultrasmall bismuth nanosheets-synthesized by in-situ electrochemical transformation of ligands covered bismuth vanadate-on silver nanowires as an efficient electrocatalyst for CO 2 -to-formate reduction. The cooperative electrocatalyst achieves a formate current density of 186 mA/cm 2 and a cathodic energy efficiency of 75% for formate, which is the only best compared to the literature results. Operando Raman and morphologic measurements demonstrate that the excellent energy utilization of the electrocatalyst is originated from the rich edge active sites with Bi-O species of the ultrasmall Bi nanosheets.
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Nano Research
·
2021
·Vol. 15
·期 2
·1366-1374
·
IF 8.897
Chen Yongdong,Li Yue,Chen Wei,Xu Wen Wu,Han Zhong-kang,Waheed Ammara,Ye Zhongbin,Li Gao,Baiker Alfons
We evaluated bismuth doped cerium oxide catalysts for the continuous synthesis of dimethyl carbonate (DMC) from methanol and carbon dioxide in the absence of a dehydrating agent. Bi x Ce 1− x O δ nanocomposites of various compositions ( x = 0.06–0.24) were coated on a ceramic honeycomb and their structural and catalytic properties were examined. The incorporation of Bi species into the CeO 2 lattice facilitated controlling of the surface population of oxygen vacancies, which is shown to play a crucial role in the mechanism of this reaction and is an important parameter for the design of ceria-based catalysts. The DMC production rate of the Bi x Ce 1− x O δ catalysts was found to be strongly enhanced with increasing O v concentration. The concentration of oxygen vacancies exhibited a maximum for Bi 0.12 Ce 0.88 O δ , which afforded the highest DMC production rate. Long-term tests showed stable activity and selectivity of this catalyst over 45 h on-stream at 140 °C and a gas-hourly space velocity of 2,880 mL·g cat −1 ·h −1 . In-situ modulation excitation diffuse reflection Fourier transform infrared spectroscopy and first-principle calculations indicate that the DMC synthesis occurs through reaction of a bidentate carbonate intermediate with the activated methoxy (−OCH 3 ) species. The activation of CO 2 to form the bidentate carbonate intermediate on the oxygen vacancy sites is identified as highest energy barrier in the reaction pathway and thus is likely the rate-determining step.
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