POLYMER BULLETIN
·
2026
·Vol. 83
·期 9
·495
·
IF 4.2
Wu Yan,Wang Chanjuan,Wang Jie,Chen Jinghong,Yin Xiaoshuang,Yang Wenzhong,Xu Hui
Antimony contamination from industrial activities poses severe threats to aquatic ecosystems. To address this challenge, we engineered a breakthrough electrospun nanofibrous membrane through functional graphene-polymer synergy, specifically polyacrylonitrile (PAN) nanofibers doped with quaternary ammonium-grafted graphene oxide (GO). This innovation begins with molecular precision functionalization, where poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) is covalently grafted onto GO via surface-initiated atom transfer radical polymerization (SI-ATRP), followed by quaternization, yielding GO- g - q PDMAEMA with ultra-high positive charge density (ζ-potential: +31.21 mV), optimized for electrostatic capture of Sb(OH)₆ ⁻ anions. Moreover, incorporation of GO- g - q PDMAEMA into PAN induced nodular protrusions during electrospinning, creating hierarchical pores that boosted specific surface area by 14.3 times (157.7 m²/g vs. 11.0 m²/g for PAN). This morphology-driven enhancement significantly contributes to the membrane’s exceptional performance. Additionally, the membrane achieves a high Sb(V) adsorption capacity of 180.02 mg/g, while maintaining relatively stable adsorption performance across pH 3–7, validated by removing 87.8% Sb from real mining effluent. Consequently, this electrostatic-porosity coupled design establishes a new paradigm for heavy metal remediation membranes, combining scalable fabrication with operational robustness.
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JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 7
·281
·
IF 3.5
Liu Lunyuan,Hu Shuheng,Qin Peng,Xu Zimu,Qi Xianbin,Li Helong,Ding Lijian
Phase-change energy storage materials are of great significance for the efficient utilization of solar energy. However, conventional calcium carbonate-based phase-change microcapsules usually suffer from weak light absorption and relatively low photothermal conversion efficiency. In this study, an electrostatic self-assembly strategy was employed to load carboxylated carbon nanotubes onto the surface of calcium carbonate-based phase-change microcapsules through surface potential regulation, thereby constructing CNTs@CaCO 3 -MEPCM composite microcapsules. The effect of CNTs loading on the photothermal energy-storage performance of the microcapsules was systematically investigated. The results show that, at a CNTs loading of 4 wt%, the composite microcapsules maintained a phase-change enthalpy of approximately 104 J/g, while achieving a latent-heat-based photothermal storage efficiency of 88.46% and a thermal conductivity of 0.9267 W·m − 1 ·K − 1 . After 500 thermal cycles, the sample still retained stable phase-change behavior, indicating good thermal reliability. Compared with representative reported photothermally functionalized MEPCM systems, the present material exhibits a relatively balanced performance among photothermal energy storage, heat transfer, and latent-heat storage capabilities. This study provides a feasible strategy for designing composite phase-change microcapsules with integrated photothermal conversion and energy-storage capabilities, offering useful guidance for solar thermal utilization and building energy-efficiency applications.
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Cell Death Discovery
·
2026
·
IF 10.4
Yin Shilin,Yang Fang,Zhang Zhiwei,Liu Mingyuan,Tang Hong,Yang Kai
Dysregulation of cholesterol homeostasis is closely associated with the development of various cancers, but the underlying mechanisms remain unclear. This study found that the circadian clock gene Period 2 (PER2) is downregulated in oral squamous cell carcinoma (OSCC), promoting intracellular cholesterol synthesis and cell proliferation. Conversely, PER2 overexpression inhibits cell proliferation by suppressing intracellular cholesterol synthesis. Mechanistically, PER2 binds to Myosin Heavy Chain 9 (MYH9) and recruits Tripartite Motif Containing-21 (TRIM21) to promote ubiquitin-dependent degradation of MYH9, thereby inhibiting the cholesterol synthesis rate-limiting enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), reducing intracellular cholesterol synthesis, and suppressing OSCC proliferation. In OSCC xenograft models, overexpression of PER2 or treatment with the HMGCR inhibitor simvastatin significantly inhibited OSCC growth, with the combination showing markedly enhanced anti-OSCC efficacy compared to either approach alone. To explore the circadian regulatory role of PER2, overexpression or silencing experiments in OSCC demonstrated that PER2 modulates the circadian rhythms of HMGCR expression, intracellular cholesterol, and cell proliferation. Further investigations in subcutaneous OSCC mouse models revealed sex-specific circadian rhythms in PER2 and HMGCR expression, intracellular cholesterol, cell proliferation, and tumor growth in OSCC cells. Specifically, the acrophases of these indicators in OSCC of male mice were delayed relative to females, and the mesors of HMGCR expression, intracellular cholesterol, and cell proliferation were significantly higher than in females. The anticancer efficacy of simvastatin against OSCC in mice varied up to 2.5-fold across six different time points within 24 h, with broader time windows for optimal therapeutic efficacy and adverse effects in female mice than in males. This study identified a novel mechanism by which PER2 reprograms intracellular cholesterol, demonstrating that PER2 upregulation combined with simvastatin represents a potential novel strategy to improve the prognosis of OSCC patients, and clarifies that the anti-OSCC effect of simvastatin exhibits time-dependent and sex differences.
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Nature Communications
·
2026
·Vol. 17
·期 1
·2565
·
IF 18.1
He Mingbin,Wang Weiwei,Zhou Haiwu,Liu Cong,Zhao Chunbei,Li Jian,Han Yuewen,Qin Yali,Chen Mingzhou
Pyroptosis plays a crucial role in immune defense against infections and endogenous threats by eliminating harmful cells and modulating the immune response through inflammation. However, the natural activation of pyroptosis involves intricate signaling pathways, posing significant challenges for its artificial manipulation in research and therapies. Here, we present DAMAGE ( D e a th Ma nipulation Ge ne), an innovative system that integrates gasdermins within the type III-E CRISPR framework, enabling the specific recognition of target RNA (tgRNA) and triggering pyroptosis. This mechanism allows DAMAGE to selectively identify and eliminate virus-infected, cancerous, and senescent cells, all of which exhibit altered RNA transcriptomes. Additionally, DAMAGE exhibits considerable promise as a platform for mRNA-LNP therapy. Our study highlights the potential of this CRISPR-based system in the controllable induction of pyroptosis, offering an innovative therapeutic strategy for treating RNA-heterogeneous diseases.
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Silicon
·
2025
·
IF 3.3
Yang Ke,Zhou Chuncai,Wang Zixuan,Wang Feng,Liu Guijian
The extraction of critical elements from coal gangue has resulted in rapid accumulation of silica-rich byproducts, imposing a significant burden on the environment. In this study, a novel and environmentally sustainable approach was proposed for synthesizing high-purity white carbon black from coal gangue acid leaching residue via ammonium fluoride (NH 4 F)-assisted activation. The F/Si molar ratio, roasting temperature, and roasting time were investigated in detail to elucidate their impacts on fluorination roasting process. Systematic characterization mechanistically revealed that siloxane (Si-O-Si) bonds in amorphous silica were cleaved through F⁻ ions nucleophilic attack. This selective bond cleavage fragments the tetrahedral framework into discrete [SiO 4 ] units, which subsequently react with NH 4 F to form water-soluble (NH 4 ) 2 SiF 6 intermediates. Through the integrated process of fluorination roasting, water leaching, and ammonia precipitation, the leaching efficiency of (NH 4 ) 2 SiF 6 reached 99.76%, while the white carbon black product with purity and recovery rate of 98.16% and 95.20%, respectively. The closed-loop design achieved 81.45% recovery of high-purity NH₄F (99.57%) from fluoride-rich filtrate via evaporative crystallization, coupled with capture of 74.34% roasting-derived ammonia gas as 0.2313 mol/L aqueous ammonia (200 mL DI water) for precipitation reuse, thereby largely eliminating fluoride and ammonia discharge as environmental pollutants. This work offers a unique approach for the further study on the facile synthesis of white carbon black with similar mineral composition. Graphical
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Surface Science and Technology
·
2026
·Vol. 4
·期 1
·29
·
IF 7
Huang Shuang,Yu Zhiyun,Mao Ronghui,Huang Du,Wei Xuanchen,Liang Tianquan
This work investigates the growing behavior of reaction layers on TiO 2 -doped Al 2 O 3 ceramics in molten CMAS at 1250 °C. Initial reactions rapidly form Ca 2 MgSi 2 O 7 and CaAl 2 Si 2 O 8 phases. A thin-dense CaAl 2 Si 2 O 8 reaction layer (DRL) forms within 15 min, evolving into a double-layered structure (outer CaAl 2 Si 2 O 8 / inner MgAl 2 O 4 ) after 4 h. The reaction layer thickening follows the parabolic law, with a rate that decreases significantly after 4 h as the DRL plays a positive role in inhibiting the diffusion of Si 4+ , Al 3+ , and less effect on the, Mg 2+ and Ca 2+ . Crucially, the study elucidates the mechanism by which TiO 2 modulates the growing kinetics: TiO 2 enhances the chemical driving force for Ca 2+ infiltration through the DRL. This accelerated diffusion leads to the precipitation of a CaTiO 3 zone beneath the DRL, which alters the local compositional gradients and sustains the reaction layer growth. Kinetic models describing the layer thickness over time were established, and the underlying corrosion mechanisms were analyzed.
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FIBERS AND POLYMERS
·
2026
·
IF 3.1
Feng Yulei,Ji Shurui,Li Nian,Chen Xin,Guan Fanglan,Bao Lihong
Indigo-dyed denim is widely used in clothing because of its fashionable appeal and durability. However, this fabric exhibits poor color fastness, especially wet rubbing and washing fastness. Post-treatment of indigo-dyed denim with high molecular weight fixing agents is an effective method to enhance its color fastness. In this study, a series of quaternized epoxidezed glycidyl ether-modified polyurethane fixing agents with quaternary ammonium cation and multiple hydroxyl groups were synthesized by adjusting the molar ratio of glycidyl ether (AGE) to polyurethane terminal agent hydroxyethyl acrylate (HEA). The molecular weight, structure, and thermal stability of the obtained products were investigated using GPC, FTIR, H 1 NMR, and TGA. These fixing agents were then applied to indigo-dyed denim, and the finished fabric was characterized using XPS, SEM, and zeta potential analysis. The results showed that the molecular weight of the fixing agent gradually increased as the n (AGE)/ n (HEA) ratio decreased, with a number-average molecular weight ranging from approximately 10,000–20,000. IR spectra indicated the presence of C–N + stretching vibration absorption peaks near 930–960 cm −1 . The color shade of the indigo-dyed denim remained unchanged after finishing with the fixing agent. Furthermore, its dry and wet rubbing fastness improved from rating 2 and 1 to rating 4 and 2–3, respectively. The washing fastness also increased to rating 4 to 4–5. The whole fastness performances are comparable to or 0.5 ~ 1 ratings surpasses that of the commercial fixing agents CPFA-1 and CPFA-2. XPS and SEM analyses of the treated indigo-dyed denim revealed that the fixing agent adhered to the fiber surface and formed a robust bond with the fiber. This phenomenon is likely attributed to the formation of a hydrogen-bonded cross-link network among the fixing agent, indigo dye molecules and denim fibers. Consequently, this interaction significantly enhanced the binding of the indigo dye to the fiber.
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Nature Communications
·
2026
·
IF 18.1
Wu Bingfeng,Liu Liu,Zhu Junheng,Song Dongzhe,Wang Zhenming,Huang Dingming,Ye Ling
Periodontitis is an inflammatory disease driven by bacterial infection and immune dysfunction. Immune-subversive bacteria in the periodontitis microenvironment, such as Porphyromonas gingivalis , can evade conventional therapies by invading cells and inducing lysosomal dysfunction. Here we develop an injectable supramolecular hydrogel through the co-assembly of recombinant human type I collagen (COL), poly-ε-lysine (PL), and puerarin (PUE). Supramolecular amorphization improves PUE’s solubility and permeability, enabling a dual-compartment antibacterial strategy via effective trans-barrier delivery. Extracellularly, PL and PUE synergistically disrupt bacterial membranes and metabolism, while concurrently mitigating bacterial toxin induced pro-inflammatory macrophage polarization. Intracellularly, the supramolecular complexes facilitate PUE accumulation in phagolysosomes. By counteracting local oxidative stress, the internalized PUE restores lysosomal acidification and alleviates bacteria-induced immuno-metabolic dysregulation. In vivo, the hydrogel manipulates the local inflammatory microenvironment and facilitates periodontal tissue repair. This study provides a clinically translatable supramolecular strategy for treating intracellular infections and restoring tissue homeostasis.
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PubMed
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IONICS
·
2026
·
IF 3.4
Jie Yuxin,Wang Wenhai,He Maowei,Yang Can,Wang Linyu
Hexavalent chromium (Cr(VI)) poses serious risks to human health and ecological environment due to its high toxicity and non-biodegradability. Therefore, developing highly sensitive detection methods for Cr(VI) is of significant importance. Here, a colorimetric sensing platform based on hollow cobalt and nitrogen co-doped porous carbon (H-Co, NPC) was proposed for the sensitive detection of Cr(VI). H-Co, NPC was synthesized by high-temperature calcination of a ZIF-8@ZIF-67 precursor, and it exhibited excellent peroxidase-like and oxidase-like activities. The hollow structure significantly enhances the accessibility of active sites and facilitates mass transport, while the co-doping of Co and N effectively improves electron transfer capability and substrate affinity. These synergistic effects make H-Co, NPC a promising candidate for colorimetric sensing applications. The sensing platform demonstrated excellent detection capabilities toward Cr(VI), including low detection limit (5 nM), wide linear range (0.015-1.5 µM), outstanding reproducibility and anti-interference ability. Moreover, it exhibited satisfactory detection performance of Cr(VI) in real samples. This work would provide new insights into the development of highly sensitive colorimetric sensing platforms.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Wang Chaohui,Wang Xiaoyan,Zhang Xinting,Liu Ke,Yang Jingfeng
This study developed an intelligent pH-responsive film (PRF) using holocellulose and anthocyanins for real-time monitoring of food freshness. The holocellulose film, prepared via dissolution in N-methylmorpholine-N-oxide and solidified in 30% glycerol and 3% potassium sorbate, showed excellent barrier properties (74.2° water contact angle, 3.25 g h −1 m −2 water vapor permeability, 0.982 × 10 −3 g m −2 s −1 oxygen permeability). The surface self-assembly of anthocyanins on the film markedly improved antioxidant performance, with 2.76- and 3.59-fold enhancements in DPPH and ABTS radical-scavenging capacities, respectively. The film demonstrated significantly improved antimicrobial activity, exhibiting 1.34-fold and 1.41-fold larger inhibition zones against E. coli and S. aureus , respectively. The PRF exhibited distinct color transitions from pink to yellow across the pH range of 2–10. Practical application tests using sea cucumbers and strawberries revealed clear, visually observable color changes that correlated precisely with standard freshness indicators. These results confirm the PRF’s excellent potential for real-time, non-destructive freshness monitoring across diverse food products. Graphical abstract
The alternative text for this image may have been generated using AI.
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Communications Biology
·
2026
·
IF 5.8
Huang Xinyun,Shi Huan,Shan Weiyan,Zhang Jingxia,Xu Qiaoping,Shang Hongkai
Epithelial ovarian cancer (EOC) is characterized by late diagnosis and high recurrence, with dysregulated lipid metabolism emerging as a hallmark of progression. Here, we identify pyruvate carboxylase (PC) as a key metabolic driver that promotes lipid synthesis in EOC. PC is upregulated in EOC tissues and correlates with poor prognosis and triglyceride accumulation. Mechanistically, PC enhances acetyl-CoA production, promoting sterol regulatory element-binding protein 1a (SREBP1a) acetylation and stability, and increases α-ketoglutarate levels to facilitate ten-eleven translocation 1 (TET1)-mediated DNA hydroxymethylation at lipid synthetase gene promoters. These dual effects augment SREBP1a recruitment and transcriptional activation of lipid synthesis genes. Pharmacological or genetic inhibition of PC, TET1, and SREBP1a, either individually or in combination, effectively suppresses lipid synthesis and tumor growth in vitro and Balb/c nude mouse xenografts. Our findings uncover a PC–TET1–SREBP1a metabolic-epigenetic axis for EOC lipid reprogramming and tumor progression, offering a potential therapeutic target to suppress ovarian cancer aggressiveness. The alternative text for this image may have been generated using AI.
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JOURNAL OF FLUORESCENCE
·
2026
·
IF 3.4
Huang Haiyin,Zhou Shuping,Yang Mei,Xie Shenghui,Jiang Xiaohua,Yue Jiahui,Yang Haipeng
A near-infrared (NIR) fluorescence sensing platform based on NIR carbon dots (CDs), gold nanoparticles (AuNPs) and sarcosine-specific aptamers (SA-Apt) was developed for the sensitive and selective detection of sarcosine (SA), a potential biomarker associated with prostate cancer. Nitrogen- and sulfur-co-doped NIR-CDs were synthesized via a solvothermal method using L-glutathione and formamide, while AuNPs were prepared through a classical citrate-reduction approach. The sensing mechanism is based on an aptamer-regulated inner filter effect (IFE) between NIR-CDs and aggregated AuNPs. In the absence of SA, SA-Apt adsorbs onto the AuNP surface, stabilizing the nanoparticles against salt-induced aggregation and preserving the fluorescence of the NIR-CDs. Upon target recognition, SA-Apt preferentially binds to sarcosine and detaches from the AuNP surface, triggering salt-induced aggregation of AuNPs. This aggregation produces significant spectral overlap with the NIR-CD emission band, resulting in efficient fluorescence quenching via the inner filter effect. The incorporation of NIR-CDs enhances detection sensitivity by providing strong fluorescence emission, minimal background interference, and improved photostability. Under optimized conditions, the NIR-CDs/AuNPs/SA-Apt platform exhibited a linear response to sarcosine over the range of 1–15 µM, with a correlation coefficient (R 2 ) of 0.996 and a limit of detection of 0.32 µM (S/ N = 3). The sensing system demonstrates high selectivity, good reproducibility, and stable NIR fluorescence performance. By integrating NIR-emissive carbon dots with plasmonic aggregation and aptamer-mediated regulation, this work provides a robust non-enzymatic strategy for sarcosine detection.
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