MOLECULAR BIOLOGY REPORTS
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2026
·Vol. 53
·期 1
·1271
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IF 3.2
Luan Haiyan,Li Jingyuan,Gao Lili,Li Mengyu,Liu Ying,Liu Xingyuan
Background Cardiac remodeling induced by continuous pressure overload exacerbates heart failure (HF), yet effective treatments remain limited. This study investigates the therapeutic efficacy and underlying mechanisms of paeoniflorin (Pae) in the treatment of HF. Methods A transverse aortic constriction (TAC)-induced HF model in male Sprague-Dawley (SD) rats was used to evaluate four groups: Sham, TAC, TAC + Pae (10 mg/kg/day, i.p.), and TAC + fosinopril (5 mg/kg/day, p.o.). Cardiac function, morphology, and biomarker expression were assessed via echocardiography, hemodynamics, histology, ELISA, Western blot, and qPCR. Therapeutic targets were identified using network pharmacology, molecular docking, pull-down, and cellular thermal shift assays. Additionally, in vitro rescue assays were performed using Ang II-treated H9c2 cells and the AKT1 agonist SC79. Results Pae improved cardiac function, characterized by enhanced myocardial contractility and decreased serum NT-proBNP levels. Pae treatment decreased cardiomyocyte cross-sectional area (CSA), collagen deposition, and the expression of ANP , BNP , and β-MHC . Mechanistic studies identified AKT1 as a key binding partner of Pae. Pae binding to AKT1 inhibited its phosphorylation, thereby suppressing the downstream NF-κB inflammatory pathway and reducing the expression of pro-inflammatory cytokines ( IL-1β , IL-6 , and TNF-α ). Pae reversed Ang II-induced hypertrophy, fibrosis, and NF-κB nuclear translocation in H9c2 cells. Furthermore, the protective effects of Pae against hypertrophy, fibrosis, and inflammation were abolished by SC79. Pae demonstrated an excellent safety profile. Conclusion Pae alleviates HF by targeting the AKT1/NF-κB signaling axis to mitigate pathological remodeling and inflammation, presenting a safe and promising therapeutic candidate for heart failure management.
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HEREDITAS
·
2026
·Vol. 163
·期 1
·24
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IF 2.6
Wu Lizheng,Su Rui,Jia Jinjin,Kuang Zijun,Zeng Cheng,Pei Fangli
Background Luoshi Neiyi prescription (LSNYP) is a traditional Chinese medicine that has a clinical effect on endometriosis (EMs). This study combined network pharmacology with experimental validation to explore its potential molecular mechanisms. Methods The primary components of LSNYP were identified based on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and a Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). The possible target proteins were predicted using the SwissTargetPrediction online tool. The GeneCards and DisGeNET databases were used to identify targets associated with EMs. The protein-protein interaction (PPI) network, herb-component-target network, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Molecular docking, molecular dynamics (MD) simulation and experimental verification were carried out. Results 217 potential therapeutic targets were identified. Enrichment analyses revealed involvement in key biological processes and pathways, including cell migration, inflammatory response, focal adhesion, and the VEGF signaling pathway, which are closely related to the adhesion-invasion-angiogenesis progression in EMs pathogenesis. Molecular docking and MD simulation results showed stable binding between corresponding components and typical targets (ICAM1, MMP9 and VEGFA) involved in the progression. Experimental results demonstrated that LSNYP could decrease typical targets of the progression in rats and inhibit the invasion, migration and adhesion capabilities of human endometriotic stromal cells (ESCs). Conclusion These findings suggest LSNYP may be a promising candidate for EMs, potentially through inhibiting the adhesion-invasion-angiogenesis progression.
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JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 2
·42
·
IF 3.5
Wang Haiyan,Qiu Jiahua,Wang Xiwen,Yang Jin
This paper breaks through the traditional hydrophobic design concept of antifouling coatings by combining aggregated state structure, interface structure, and coating micro-nano surface structure to prepare an organic-inorganic hybrid epoxy resin with a mesogenic structure, addressing the defects of poor coating toughness and insufficient antifouling performance in complex marine environments. Firstly, a liquid crystalline epoxy curing agent and Ag@SiO 2 antifouling particles with both reactivity and hydrophobicity were designed and prepared. By blending the self-made curing agent, modified nano-Ag, and E-44, an organic-inorganic hybrid epoxy resin integrating microbial attachment inhibition, hydrophobicity, liquid crystallinity, and micro-nano surface structure was successfully prepared. Results showed that the adhesion of the composite coatings reached grade B or above, and the hardness reached grade H or above. Due to the increase in the number of flexible C atoms in the side chain of the curing agent molecule, ordered liquid crystal microdomains are induced during the curing process. The synergistic effect of the rigid liquid crystal mesogenic units and the flexible side chains effectively promotes stress dispersion and increases the mobility of molecular segments, thereby increasing the elongation at break from 0.51% to 5.3%, achieving a transition from brittle fracture to ductile fracture. The composite coating (TC-20) surface possessed a complex micro-nano rough structure, with a contact angle of 127° and a surface energy of 8.9 mJ/m 2 , exhibiting significant self-cleaning performance. After continuous abrasion and acid-base corrosion, the surface structure of the composite coating remained intact, demonstrating persistent hydrophobic and barrier properties. When the addition amount of SG-1 was only 1.5%, the antibacterial rates of the composite coating against E. coli and S. aureus reached 99% and 99.4%, respectively; when the addition amount of SG-1 was 2%, the anti-protein adsorption efficiency reached 82.5%, indicating high-efficiency antifouling performance.
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Nature Water
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2026
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IF 30.7
Liu Tanghao,Dong Tao,Zhang Ting,Bai Xiaohui
The mineral content in drinking water is an emerging regulator of intestinal health. While certain mineral waters are generally considered beneficial, their health effects under enteric infection conditions remain unclear. Here we show that Mg 2+ in drinking water exacerbates inflammation caused by enteric pathogen Salmonella Typhimurium via two interlinked mechanisms: direct activation of its key bacterial competition machinery type VI secretion system (T6SS) and indirect amplification through inflammation-driven dysbiosis. Mg 2+ depletes beneficial Akkermansia and enriches Bacteroides , elevating pro-inflammatory bile acids and arginine that enhance T6SS-mediated competitive fitness. These effects vary with host health and water sources. Our findings support the use of low-mineral water for vulnerable groups during infection risk periods, establishing Mg 2+ in drinking water as a modifiable risk factor for infectious enteritis.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 20
·1600
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IF 3.2
Geng Zhihao,Yang Yujie,Ding Hongyu,Hu Tan,Ge Shaofan,Wang Xiyan,Tang Ying
To improve the inherently poor impedance matching of spinel ferrites, a synergistic strategy combining Cr 3+ doping, in-situ reduction to metallic Ni, and amorphous carbon modification via a ternary carbon source is proposed. A porous Cr 3+ -doped Ni-Zn ferrite composite co-modified with in-situ-generated metallic Ni and amorphous carbon was fabricated by pyrolysis of sucrose/citric acid/polyethylene glycol under N 2 atmosphere. The composites feature a hierarchical porous structure, with Ni nanoparticles and carbon uniformly decorating the ferrite surface. Saturation magnetization increases progressively with carbon content owing to the formation of ferromagnetic Ni 0 , while coercivity rises to 20 Oe. The complex permittivity is substantially enhanced: the real part ( ε ′) increases from 3.8 to 11.0 and the imaginary part ( ε ″) from 0.1 to 3.8 (at 10 GHz). At a thickness of 2.6 mm, the composite with 10 wt % carbon source achieves an effective absorption bandwidth of 5.44 GHz, while the 20 wt % sample delivers a minimum reflection loss of − 44.1 dB at a thickness of only 2.4 mm. This strategy offers an effective pathway for designing broadband, low-thickness ferrite-based microwave absorbers.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 19
·1518
·
IF 3.2
Zhu Tao,Wang Juanjuan,Ma Pengkang,Chen Mingyang,Zhao Zhongliang,Peng Zhanhui,Chao Xiaolian
The combination of high power density, fast charging–discharging speeds, and environmental friendliness positions lead-free ceramic-based dielectric capacitors as a leading candidate material for next-generation pulsed power devices. However, to achieve a high recoverable energy density, a relatively large external electric field needs to be applied, which compromises the electrical insulation integrity and stymies the future development of ceramic capacitors. Under the guidance of various cooperative strategies, this study successfully prepared (1 − x )[0.94(Bi 0.5 Na 0.5 )TiO 3 – 0.06BaTiO 3 ]– x Ca 0.5 TaO 3 ceramics, discussing the influence of the linear dielectric Ca 0.5 TiO 3 in BNBT ceramics. The paper has found that increasing the content of CTa can enhance the density of BNBT ceramics and reduce the grain size. When x = 0.12, a grain size of 0.70 μm is obtained, and the breakdown electric field increases from 250 kV/cm at x = 0.01 to 454 kV/cm at x = 0.12. Meanwhile, a likewise considerable recoverable energy storage density is achieved, exceeding 7.19 J/cm 3 under moderate electric fields and achieving an outstanding energy storage efficiency ( η ) of 78%, which can be suitable for advanced energy storage capacitors that operate under medium electric fields.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
·
IF 4.6
Wang Meng-Ting,Wang Yi-Ming,Cai Fu-Gui,Zhang Yi-Mei,Chen Hong-Zheng,Zuo Li-Jian
Simultaneously optimizing the optoelectronic properties and the morphology of active layer is the key to high-performance polymer solar cells. Here, we present a novel materials-processing paradigm that incorporates a thermally activated delayed fluorescence (TADF) additive into the layer-by-layer (LBL) fabrication process to concurrently optimize nanoscale morphology and mitigate non-radiative recombination. We demonstrate that the TADF additive facilitates the formation of an ideal interpenetrating network during LBL film deposition, while its intrinsic TADF properties effectively reduce non-radiative voltage loss, enhance exciton lifetimes, and facilitate charge generation and transport. Devices fabricated with this synergistic strategy achieve both high short-circuit current density and open-circuit voltage, culminating in a remarkable power conversion efficiency exceeding 20%. This work not only provides an efficient and reproducible processing route for high-performance polymer solar cells (PSCs) but also opens a new avenue for addressing fundamental optoelectronic limitations through coordinated material design and processing innovation.
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Nature Communications
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2026
·
IF 18.1
Ma Chao,Li Ning,Xu Lin,Wang Sa,Du Juan,Pang Jiandong,Chen Aibing,Qiao Zhihua,Hou Jingwei
Metal-organic frameworks (MOFs) are promising membrane materials for molecular separations because of their well-defined porosity and tunable chemistry. However, their separation performance is often limited by grain boundaries and interfacial defects that introduce non-selective transport pathways. Here, we proposed an in-situ interfacial polyesterification-assisted bonding strategy for constructing MOF-rich self-standing membranes using triethanolamine (TEOA) in the UiO-66 system. Under thermal treatment, TEOA is proposed to induce localized interfacial reactions that generate anchored polyester species at MOF-MOF contacts, thereby enhancing particle bonding and suppressing non-selective interface defects. The resulting UiO-66 polyester membrane exhibits 92.7 wt% UiO-66 loading, a CO 2 permeance of 1310 GPU, and a CO 2 /N 2 selectivity of 38, surpassing the upper bound for this gas pair, with the selectivity arising primarily from solubility-selective transport. In addition, the UiO-66 polyester membrane shows good moisture tolerance and performance regenerability, further suggesting that the polyesterified interface helped mitigate humidity-induced interfacial deterioration and suppress particle-interface defects. A similar strategy is also demonstrated in the MOF-808, UiO-67, and MIL-101 systems, indicating representative applicability within a subset of carboxylate-based MOFs. These results highlight the importance of interfacial chemical engineering in constructing defect-suppressed, highly MOF-rich separation membranes.
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Nature Communications
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2026
·
IF 18.1
Zhao Wenguang,Li Zijian,Li Mingyang,Ren Hengyu,Lin Cong,Yi Haocong,Wu Shengyu,Wang Xiaohu,Wang Jun,Fei Bin,Zhang Muyu,Wang Mingwei,Sun Ye,Chen Guojie,Chen Zhefeng,Chen Weixin,Zhao Xiaoxu,Li Shunning,Zhou Dong,Zhao Qinghe,Pan Feng
Although the anionic activity in layered oxide positive electrodes is partially understood, the mechanism by which it induces internal crack propagation under high-voltage conditions remains unclear, severely limiting stable cycle life and available capacity. In this study, the mechanism underlying internal crack propagation is elucidated in LiCoO 2 under harsh float-charge conditions at 60 °C and a potential of 4.6 V vs. Li + /Li. We reveal that sequential phase transitions from O3 to O1 and then to a cation-mixed phase during deep Li + extraction generate significant lattice-mismatch stresses that initiate internal cracks. Crucially, the accompanying anionic activity drives the migration of the oxidized lattice O n− (0 < n < 2) towards these cracks, where it even accumulates as molecular O 2 that can be released upon crack propagation to the surface. It is identified that the sustained O1tocation-mixed phase transition and the bulk lattice O n− migration synergistically drive the interior crack propagation, ultimately leading to LiCoO 2 disintegration and electrochemical degradation. This work not only deepens our understanding of the anionic activity in layered positive electrodes but also provides mechanistic insights for the future design of stable LiCoO 2 positive electrodes.
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Nature Communications
·
2026
·
IF 18.1
Xiaoyong Zhang,Hang Yu,Kai Zhu,Yao Xiao,Yuxuan Gong,Dandan Che,Wanyi Chen,Guoxing You,Xiyun Yan,Quan Wang,Kelong Fan,Hong Zhou,Gan Chen
Drug-resistant bacterium-infected wounds pose a serious clinical challenge, underscoring the need for therapeutic materials that respond to dynamic healing stages. Herein, we report a sequential multimodal platform embedding a self-adaptive IrPtCu nanozyme into a madecassoside-enriched hyaluronic acid hydrogel (HIPCM) for rapid bacterial eradication and accelerated wound healing. Leveraging trimetallic synergy and pH-adaptive reactive oxygen species (ROS) regulation, IrPtCu nanozyme exhibits strong oxidase, peroxidase, glutathione oxidase, and glutathione peroxidase-like activities, enabling efficient ROS generation and potent antibacterial performance. After disinfection, it switches to ROS scavenging through superoxide dismutase and catalase-like cascades, alleviating oxidative stress and cooperating with madecassoside to promote tissue repair. In a methicillin-resistant Staphylococcus aureus ( MRSA )-infected mouse model, HIPCM demonstrates strong antibacterial efficacy, promotes M2 macrophage polarization and angiogenesis, and accelerates high-quality repair. Preclinical studies in Bama mini-pigs further confirm improved collagen deposition, hair follicle regeneration, and functional restoration. This work offers a comprehensive strategy integrating adaptive nanozymes and natural herbal medicines for treating drug-resistant wounds. Drug-resistant wound treatment requires adaptive response to the microenvironment. Here, authors develop a pH-responsive hydrogel therapy incorporating an IrPtCu nanozyme to sequentially eliminate pathogens and promote tissue regeneration.
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Applied Biological Chemistry
·
2026
·Vol. 69
·期 1
·42
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IF 4.2
Gao Xinyue,You Long,Qi Luyao,Jin Lei,Zhang Jianmei,Liu Yanan,Niu Zhiqiang
As a disease of high mortality rate, acute lung injury (ALI) has been getting increased attention. Heme oxygenase-1 (HO-1), which plays an essential role in alleviating the pathological symptoms of ALI. There have few studies noted that the improvement effect of HO-1 on ALI may associated to NOD-like receptor protein 3 (NLRP3) inflammasome. However, the roles of HO-1 in the process of NLRP3 inflammasome activation is remains unknown. This study investigated the mechanism that HO-1 blocking NLRP3 inflammasome in ALI. The sepsis model induced by LPS was used in C57BL6 mice, LPS triggered obviously pulmonary damage and edema formation, increased the expression of NLRP3 inflammasome component proteins and IL-1β, but those negative effects were reversed by the pretreatment of hemin. NOD-like receptor signaling pathway was down-regulated after hemin treatment through RNA-Seq. Meanwhile, hemin pretreatment exerted significantly inhibit effect on the activation of NLRP3 inflammasome, and the component proteins of NLRP3 inflammasome were not influenced in immortalization of bone marrow-derived macrophages (iBMDMs). Moreover, the immunoprecipitation and immunofluorescence experiments were indicated that HO-1 could bind to NLRP3, silencing HO-1 prevented the block effect of hemin on NLRP3 inflammasome activation. Our study suggested that hemin-inhibited NLRP3 inflammasome activation involved HO-1 bind to NLRP3 and alleviated ALI mice induced by LPS.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
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IF 4.1
Wang Ying,Yan Yiting,Zhang Jun,Yang Lin,Liu Fanghua,Tan Chao,Jiang Xue
p-Benzoquinone (PBQ), as a key toxic derivative of benzene, is widely present in industrial wastewater and the production and manufacturing of daily chemicals. Long-term exposure poses a serious health threat, making the development of rapid and sensitive on-site detection technologies highly significant. Electrochemical methods, due to their simple operation, high sensitivity, and ease of miniaturization, are an ideal approach for detecting PBQ. Co-MOF-74 is extensively used in the electrochemical field because of its structural stability, tunable metal nodes, and large surface area, but its low conductivity limits further applications. In this study, Co-MOF-74 was rapidly synthesized using dielectric barrier discharge (DBD) microplasma technology, and then the large π-conjugated organic ligand HATP was introduced for ligand engineering to successfully prepare Co-MOF-74-HATP. This synthesis strategy is not only efficient, but also the introduction of HATP effectively regulates the material’s electronic structure, significantly enhancing its conductivity and electrocatalytic activity. The electrochemical sensor employs chronoamperometric detection at −0.15 V (vs. Ag/AgCl) and exhibits excellent performance for PBQ, featuring two wide linear ranges (17–1602 µM and 1602–5602 µM) with corresponding sensitivities of 1440 µA·mM −1 ·cm −2 and 497.8 µA·mM −1 ·cm −2 , a low limit of detection (LOD) of 3.43 µM ( S / N = 3), and good reproducibility (RSD < 3.0%). It was successfully applied to the detection of PBQ in actual water samples with recoveries ranging from 90.5% to 102.32%. This work expands the synthesis of ligand-functionalized MOFs through DBD microplasma technology and applies them to the electrochemical detection of PBQ in water samples. Graphical abstract
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危险品化学品经营许可证（带存储）