Science China-Materials
·
2023
·Vol. 66
·期 5
·1779-1792
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IF 8.1
Yang Jia,Wang Mengxiao,Chen Tao,Yu Xiang,Qin Gang,Fang Xiaohan,Su Xiaoxiang,Chen Qiang
Supercapacitors exhibiting toughness, self-healing, and high specific capacitance have practical significance for use in flexible and wearable electronic equipment. To meet these requirements, a novel multifunctional gel polymer electrolyte (GPE) consisting of polyvinyl alcohol (PVA)-sodium alginate (SA)-K 3 [Fe(CN)] 6 -Na 2 SO 4 was prepared. In this GPE, K 3 [Fe(CN)] 6 plays three crucial roles by serving as a carrier donor, ionic crosslinking agent and redox-active mediator. Consequently, the usual conflict between the conductivity and mechanical properties of GPEs is alleviated to some extent. In addition, the electrode specific capacitance and the energy density of the assembled supercapacitor are obviously improved because of the pseudocapacitance generated from the redox reaction of K 3 [Fe(CN)] 6 . Based on this GPE, the supercapacitor exhibits outstanding bending and stretching stabilities, significant self-healing, and anti-freezing properties. Therefore, the prepared GPE and supercapacitor are promising for application in flexible and wearable electronic equipment with complex service conditions.
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MOLECULAR BIOTECHNOLOGY
·
2023
·
IF 2.6
Liu Hu,Li Tao,Ma Ben,Wang Yue,Sun Jun
Osteoblast regeneration, characterized by osteoblast differentiation, is the basis of fracture healing and accelerates fracture repair. It has been reported that hyaluronan and proteoglycan link protein 1 (HAPLN1) is overexpressed during osteoblast differentiation and regulates cartilage regeneration, but its function in fracture healing remains unclear. To elucidate this issue, we collected clinical blood samples of fracture healing, established a femoral fracture rat model, and induced an osteoblast differentiation cell model. We found that HAPLN1 was overexpressed in the serum of patients with fracture healing and the bone tissues of rats with fracture healing. Furthermore, the expression of HAPLN1 was increased time dependently during the osteogenic differentiation of MC3T3-E1 cells. HAPLN1 silencing prevented osteoblast differentiation and mineralization in MC3T3-E1 cells as evidenced by decreased osteoblast differentiation-related factors, suppressed alkaline phosphatase activities, and reduced alizarin red positive staining. Mechanically, the bone morphogenic protein 4 (BMP4)/Smad1/5/8 pathway, a facilitator of osteoblastic differentiation, was found to be inhibited by HAPLN1 knockdown, and inhibition of BMP4/Smad1/5/8 signaling enhanced the effects caused by HAPLN1 silencing. These findings demonstrated that HAPLN1 might promote fracture healing by facilitating osteogenic differentiation through the BMP4/Smad1/5/8 pathway, indicating that targeting HAPLN1 may be a feasible therapeutic candidate for fracture repair. Graphical Abstract
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PubMed
高影响因子
PSYCHOPHARMACOLOGY
·
2023
·Vol. 240
·期 4
·881-897
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IF 3.4
Chen Yanming,Xiao Xinyi,Huang Chaonan,Zhu Jin,Zhou Huiling,Qin Huimin,Bao Yu,Zhuang Tao,Zhang Guisen
Rationale Drug combinations are commonly used in pain management, which can produce potent analgesic effects with reduced dosage and adverse effects. Objective This study was designed to evaluate the anti-nociceptive effects and adverse effects of new combinations of flupirtine (a Kv7 potassium channel opener) and antihistamines (promethazine, fexofenadine) on acute and chronic pain in mice, and the possible mechanisms behind the synergistic analgesic effects were preliminarily investigated. Methods In acetic acid writhing test, carrageenan-induced inflammatory pain model, and paclitaxel-induced neuropathic pain model, the interaction indexes ( γ ) between flupirtine and antihistamines were determined by isobolographic analysis. Furthermore, the Kv7 channel blocker XE991 was used to determine whether the effects of single agents and drug combinations on paclitaxel- and carrageenan-induced mechanical allodynia were mediated by Kv7 channels. Finally, hepatotoxicity markers, liver histopathology, and the rotarod test were used to investigate the adverse effects of drugs in combination doses. Results The interaction indexes of flupirtine-promethazine and flupirtine-fexofenadine in all the above three pain models were lower than 1. The analgesic effects of flupirtine (13 mg/kg), promethazine (5 mg/kg), fexofenadine (20 mg/kg), and their combinations were antagonized significantly by XE991 (3 mg/kg). And the adverse effects of flupirtine and antihistamines in combination doses were not significantly different from the vehicle group. Conclusions Flupirtine and antihistamines produced synergistic analgesic effects in all the above pain models. The analgesic effects of antihistamines were partially mediated by Kv7/M channels, and the activation of Kv7/M channels may be partly responsible for the synergistic analgesic effects between flupirtine and antihistamines.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 16
·48088-48106
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IF 5.8
Musajan Zulhumar,Xiao Pengfei
Herein, mesoporous carbon-anchored cobalt ferrite nanocomposites (nano-CoFe 2 O 4 @MC) were fabricated using a hydrothermal method for application as heterogeneous catalysts to activate peroxymonosulfate (PMS), in order to solve the problems of low activation performance and secondary pollution caused by the inter-particle agglomeration, metal ion leaching, and difficult recovery of nano metal catalysts. Analysis techniques such as SEM, TEM, XRD, BET, FTIR, VSM, TGA, and Raman spectroscopy indicated that the prepared nanocomposites have excellent surface properties, structural stability, and magnetic properties. The performance of nano-CoFe 2 O 4 @MC for Congo red (CR) degradation was evaluated by comparison with other treatment systems and study of the influence of experimental parameters, including the anchoring ratios, catalyst dosage, PMS concentration, initial pH, CR concentration, coexisting anions, and humic acid. Both radical and nonradical pathways were observed in the activation process of PMS by nano-CoFe 2 O 4 @MC. The analysis results of the element composition and ionic state of the catalyst show that the redox cycle of two ion pairs, Co 3+ /Co 2+ and Fe 2+ /Fe 3+ , could enhance the multipath electron transfer on the catalyst surface to promote the generation of reactive oxygen species. Identification of the intermediate products revealed CR was transformed into 12 intermediates through two branch pathways in the nano-CoFe 2 O 4 @MC/PMS system. After five cycles of use, the catalytic efficiency of the catalyst did not decrease significantly. Nanocomposites with high catalytic performance, stability, recyclability, and a low ion leaching rate have broad application prospects in the treatment of antibiotic wastewater.
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高影响因子
INTERNATIONAL UROLOGY AND NEPHROLOGY
·
2023
·
IF 2
Wang Hongjie,Zhang Yunxia,Liu Huan,Li Shuang
Purpose To investigate the role and underlying mechanism of GDF11 on diabetic nephropathy (DN)-related mitochondrial dysfunction and apoptosis. Methods A DN model of rats was established in this study. Human Kidney-2 (HK-2) cells were cultured under high-glucose (HG) condition with or without recombinant GDF11 (rGDF11). Mitochondrial morphology of HK-2 cells was analyzed by transmission electron microscope and MitoTracker Red CMXRos staining. Mitochondrial membrane potential (MMP) and ROS production were monitored using JC-1 assay kit and MitoSOX staining, respectively. Cell apoptosis was detected by TUNEL or flow cytometry assays. Results Herein, we observed that GDF11 was down-regulated in renal cortex and serum of DN rats, which was accompanied by renal mitochondrial morphological abnormalities. In line with the findings in vivo, HK-2 cells exposed to HG presented with mitochondrial morphological alterations and further apoptosis accompanied by GDF11 reduction. In addition, HG promoted a decrease in MMP while an increase in mitochondrial ROS production. Conversely, rGDF11 treatment significantly alleviated these HG-induced mitochondrial defects in HK-2 cells. Meanwhile, HK-2 cell apoptosis induced by HG was simultaneously suppressed by rGDF11. Mechanistically, the decreased levels of p-AKT induced by HG were attenuated after rGDF11 administration. Inhibition of the PI3K/AKT pathway resisted the effects of rGDF11 on the MMP and apoptosis of HK-2 cells. In addition, we identified that GDF11 is a target of miR-32-5p. Up-regulation of miR-32-5p could inhibit the expression of GDF11. Conclusion rGDF11 treatment rescued HG-induced HK-2 cell mitochondrial dysfunction and apoptosis, which may be dependent on the activation of the PI3K/AKT pathway.
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高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Jia Mutian,Wang Yuanyuan,Wang Jie,Qin Danhui,Wang Mengge,Chai Li,Fu Yue,Zhao Chunyuan,Gao Chengjiang,Jia Jihui,Zhao Wei
Stimulator of interferon gene (STING)-triggered autophagy is crucial for the host to eliminate invading pathogens and serves as a self-limiting mechanism of STING-induced interferon (IFN) responses. Thus, the mechanisms that ensure the beneficial effects of STING activation are of particular importance. Herein, we show that myristic acid, a type of long-chain saturated fatty acid (SFA), specifically attenuates cGAS-STING-induced IFN responses in macrophages, while enhancing STING-dependent autophagy. Myristic acid inhibits HSV-1 infection-induced innate antiviral immune responses and promotes HSV-1 replication in mice in vivo. Mechanistically, myristic acid enhances N-myristoylation of ARF1, a master regulator that controls STING membrane trafficking. Consequently, myristic acid facilitates STING activation-triggered autophagy degradation of the STING complex. Thus, our work identifies myristic acid as a metabolic checkpoint that contributes to immune homeostasis by balancing STING-dependent autophagy and IFN responses. This suggests that myristic acid and N-myristoylation are promising targets for the treatment of diseases caused by aberrant STING activation.
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高影响因子
CARDIOVASCULAR DRUGS AND THERAPY
·
2023
·
IF 3.4
Zhang Lingxi,Hu Chenghong,Jin Bo,Bai Bin,Liao Jing,Jin Leiming,Wang Minxiu,Zhu Weiwei,Wu Xuedan,Zheng Li,Xu Xuelian,Jiang Yongsheng,Wang Yi,He Ying
Purpose Diabetic cardiomyopathy (DCM) is a common and severe complication of diabetes. Inflammation and oxidative stress play important roles in DCM development. Bicyclol is a hepatoprotective drug in China that exerts anti-inflammatory effects by inhibiting the MAPK and NF-κB pathways to prevent obesity-induced cardiomyopathy. Our purpose was to explore the effect and mechanism of bicyclol on DCM. Methods A type 1 diabetes mouse model was established using C57BL/6 mice by intraperitoneal injection of STZ. The therapeutic effect of bicyclol was evaluated in both heart tissues of diabetic mice and high concentration of glucose (HG)-stimulated H9c2 cells. Results We showed that bicyclol significantly attenuated diabetes-induced cardiac hypertrophy and fibrosis, which is accompanied by the preservation of cardiac function in mice. In addition, bicyclol exhibited anti-inflammatory and anti-oxidative effects both in vitro and in vivo. Furthermore, bicyclol inhibited the hyperglycemia-induced activation of MAPKs and NF-κB pathways, while upregulating the Nrf-2/HO-1 pathway to exhibit protective effects. Conclusion Our data indicate that bicyclol could be a promising cardioprotective agent in the treatment of DCM.
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高影响因子
Food Analytical Methods
·
2023
·Vol. 16
·期 4
·689-698
·
IF 2.9
Chu Qiqi,Wu Xinze,Chen Huaixia,Dang Xueping,Liu Xiaolan
A Cu 7 Zn 2 cluster functionalized copolymer monolithic column was prepared and applied as the adsorbent of pipette tip micro-solid phase microextraction of eight phthalate esters (PAEs). The physical morphology, chemical composition, thermal stability, and specific surface area of the monolithic column were characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, thermogravimetric analysis, and N 2 adsorption and desorption experiment. Cu 7 Zn 2 cluster acted as the adsorption site effectively improved the adsorption selectivity and capacity of the copolymer monolith for PAEs. The adsorption mechanism of Cu 7 Zn 2 copolymer monolith for 8 PAEs was deduced to be mainly the H-bond interaction. And, the chemical doping and copolymerization of Cu 7 Zn 2 cluster made the composite monolithic column more stable with a long service life. Under the optimized extraction conditions, a micro-solid phase extraction-high performance liquid chromatography method with ultraviolet detector (μ-SPE-HPLC-UV) was developed for the determination of 8 PAEs in edible oil. Wide linear ranges of 0.5–1000 μg/kg with correlation coefficients ( R 2 ) above 0.996 were obtained. The limits of detection (LODs) were in the range of 0.1–0.9 μg/kg. The proposed method was applied for the detection of 8 PAEs in edible oil with satisfactory recoveries between 83.5~100.2%, and the relative standard deviations were less than 8.1%. The results indicated that the Cu 7 Zn 2 functionalized copolymerized monolithic column was an ideal enrichment medium for the detection of PAEs in complex samples.
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高影响因子
CATALYSIS LETTERS
·
2022
·Vol. 153
·期 3
·911-920
·
IF 2.936
Geng Yanyan,Lang Man,Li Guotai,Yin Wang,Yang Zhensheng,Li Hao
Developing efficient catalysts for biomass hydrodeoxygenation into high-quality biofuels and chemicals is a current topic of great interest. In this study, Ni 2 P catalysts supported on different zeolites (MCM-41, HY, Hβ) were fabricated for vanillin hydrodeoxygenation by one-pot method instead of temperature-programmed reduction (TPR). The prepared catalysts were characterized using XRD, XPS, NH 3 -TPD and N 2 physisorption. The results showed that the support has a significant influence on the reactivity of the Ni 2 P-based catalyst. The Ni 2 P/HY catalyst contains a higher acid site density, which leads to the almost complete conversion of vanillin to the quantitative yield of 2-methoxy-4-methylphenol (MMP) via direct hydrogenolysis path at 220 °C, 5 h and 2 MPa of H 2 . Graphical Abstract
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高影响因子
KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2022
·Vol. 39
·期 7
·1936-1945
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IF 3.146
Niu Hui,Feng Yuyu,Ding Jie,Zhang Wei,Hu Chenxing,Zhang Qingxiang,Zhang Chen,Li Cuiqing
This study reports reactive adsorptive dechlorination of hydrocarbon oil over TiO 2 -based metal oxides at the temperatures of 20–150 °C. TiO 2 and a series of TiO 2 -CeO 2 were prepared by precipitation method and characterized by N 2 adsorption, XRD, FT-IR, pyridine-IR, NH 3 -TPD and CO 2 -TPD. The characterization results showed that both the acidity and basicity of the adsorbent had a significant impact on its dechlorination capacity. TiO 2 -U precipitated by urea exhibited higher dechlorination capacity than TiO 2 -A precipitated by ammonia due to the higher surface area, more acid and base amounts of the former. Among various Ti (1− x ) Ce x O 2 (x=0.1, 0.3, 0.5, 0.7, 0.9, 1) oxides, Ti 0.7 Ce 0.3 O 2 and Ti 0.3 Ce 0.7 O 2 bimetallic oxides showed higher dechlorination capacity than TiO 2 -U, and the chlorine removal over Ti 0.7 Ce 0.3 O 2 reached 82.8% after adsorption at 150 °C for 3 h. Mixing 5 wt% of alkali earth metal oxide into Ti 0.7 Ce 0.3 O 2 mechanically enhanced its dechlorination capacity, and the chlorine removal over Ti 0.7 Ce 0.3 O 2 -BaO reached as high as 92.1%. The chlorine removal increased with increasing the adsorption temperature. Ion chromatography and GC-MS analysis revealed that organochlorine compound was converted into Cl − and its corresponding alcohol over the adsorbent at 150 °C. Finally, the mechanism of reactive adsorption dechlorination was proposed.
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JOURNAL OF MATERIALS RESEARCH
·
2022
·Vol. 37
·期 10
·1798-1809
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IF 2.909
Yu Qi,Liu Chaofan,Nie Weicheng,Chen Ping,Xue Yanan,Tang Yiming
A kind of reduced graphene oxide hollow microspheres loaded with FeCo alloy (AirRGO@FeCo) was synthesized by oil-in-water emulsification technology and high-temperature calcination process. By controlling the concentration of GO aqueous solution, five kinds of hollow microspheres with different RGO contents were synthesized. The diameter of the synthesized hollow microspheres was 4–6 μm, and the thickness of the spherical wall was 0.1–1 μm adjustable. As the concentration of GO aqueous solution is 6 mg/ml, the AirRGO@FeCo exhibits excellent electromagnetic wave absorption properties with an optimal reflection loss value reaching up to − 73.47 dB at 13.75 GHz and a broad effective bandwidth (lower than − 10 dB) of 7.23 GHz (10.77 to 18 GHz) at a thickness of 2.4 mm. The synergistic effects of dielectric loss and magnetic loss mechanisms as well as excellent impedance matching characteristics and strong attenuation characteristics make AirRGO@FeCo hollow microspheres obtain high efficient microwave absorption capacity. Graphical abstract
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 24
·11430-11442
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IF 4.682
Xu Jun,Zhang Zixiang,Nie YongJia,Liu Yanxia,Fan Yue,Zhao Wenpeng,Feng Xianqi
Self-healing materials can autonomously heal injury like organism, which have attracted increasing attention from academics and industry engineers. However, the mechanical property and self-healing ability of the self-healing material is hard to be reconciled. Here, we report a simple approach to fabricate fast self-healing materials with high mechanical strength and improved triple shape memory effect by incorporation of nanoclay into a polymer matrix. The nanocomposite was prepared by in situ polymerization of poly(ethylene glycol) 400 methyl ether acrylate (mPEG-acrylate) and acryloylmorpholine (ACMO) in the presence of nanoclay. The thus obtained composite exhibits remarkable mechanical properties of an optimistic maximum tensile strength of ~ 8.9 MPa, and high healing efficiency of ~ 99.6% can be achieved after healing for only 1 min at room temperature. This strategy provides insights for the preparation of high-strength, multi-shape memory and fast self-healing composites. Graphical abstract
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危险品化学品经营许可证（带存储）