Nature Communications
·
2021
·Vol. 12
·期 1
·1-11
·
IF 14.919
Zhang Qiu-Long,Wang Liang-Liang,Liu Yan,Lin Jiao,Xu Liang
Ligand-oligonucleotide transduction provides the critical pathway to integrate non-nucleic acid molecules into nucleic acid circuits and nanomachines for a variety of strand-displacement related applications. Herein, a general platform is constructed to convert the signals of ligands into desired oligonucleotides through a precise kinetic control. In this design, the ligand-aptamer binding sequence with an engineered duplex stem is introduced between the toehold and displacement domains of the invading strand to regulate the strand-displacement reaction. Employing this platform, we achieve efficient transduction of both small molecules and proteins orthogonally, and more importantly, establish logical and cascading operations between different ligands for versatile transduction. Besides, this platform is capable of being directly coupled with the signal amplification systems to further enhance the transduction performance. This kinetically controlled platform presents unique features with designing simplicity and flexibility, expandable complexity and system compatibility, which may pave a broad road towards nucleic acid-based developments of sophisticated transduction networks.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2021
·Vol. 56
·期 28
·15653-15666
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IF 4.22
Zhang Nan,Zhang Yaoming,Duan Chunjian,Li Song,Yang Zenghui,Zhang Xinrui,Wang Tingmei,Wang Qihua
Traditional “top-down” methods for graphene preparation, like micromechanical cleavage and ultrasound methods, usually cannot preserve both efficiency and quality simultaneously. Herein, we provide an environmental-friendly graphene exfoliating method with high efficiency and high quality that combines the microfluidization process (liquid phase) and supercritical carbon dioxide process (gas phase), namely the dual-phase exfoliating (DPE) method. The combination of effective tangential force (shearing force) and normal force (push and pull), which are originally from microfluidization and supercritical carbon dioxide process, respectively, maximizes the exfoliating efficiency. The DPE method offers a high yield of up to 70.25% for graphene preparation (941.04 g per day theoretically), while the graphene sheets could remain single or a few layers (> 80%) and around micron size. By molecular dynamic simulations, it is theoretically proved that carbon dioxide can intercalate between graphite layers and expand the interlayer spacing under supercritical conditions. This DPE method, by combining the advantages of different phase processes, provides an ideal process design perspective for large-scale preparation of other 2D materials.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2021
·Vol. 328
·期 1
·397-410
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IF 1.371
Wang Yanlin,Long Jun,Xu Wenjie,Luo Huan,Liu Jun,Zhang Yaping,Li Jinchao,Luo Xuegang
The development of highly efficient adsorbent presents an enticing prospect for U(VI)-containing radioactive wastewater treatment. In this work, a novel porous cCS/PVA/UiO-66-NH 2 membrane absorbent comprising of crosslinked chitosan (cCS), polyvinyl alcohol (PVA) and UiO-66-NH 2 is designed and prepared. The adsorption capacity of porous cCS/PVA/UiO-66-NH 2 membrane achieves 316.50 mg g −1 under an optimal condition. Furthermore, the porous cCS/PVA/UiO-66-NH 2 membrane exhibits a high selectivity for U(VI) adsorption in simulated radioactive wastewater treatment. The possible mechanism of U(VI) adsorption onto porous cCS/PVA/UiO-66-NH 2 membrane mainly includes surface complexation and cation exchange processes. In addition, the porous cCS/PVA/UiO-66-NH 2 membrane also exhibits excellent cycling adsorption-desorption performance. All these results demonstrate that the porous cCS/PVA/UiO-66-NH 2 membrane is a promising candidate for application in U(VI) removal from radioactive wastewater.
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Advanced Composites and Hybrid Materials
·
2021
·Vol. 4
·期 2
·274-285
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IF 5.693
Gao Qingsen,Pan Yamin,Zheng Guoqiang,Liu Chuntai,Shen Changyu,Liu Xianhu
The prosperous development of smart wearable electronic devices has caused extensive demand for flexible composite films with integrated electromagnetic interference (EMI) shielding and thermal management performances. However, it is still a challenge to prepare flexible composite films with desirable properties. Herein, the flexible multilayered MXene/thermoplastic polyurethane films were prepared via a simple layer-by-layer spraying technique. The multilayered films with 28.6 wt% MXene and 52-µm thickness exhibit high electrical conductivity of 1600 S/m, excellent EMI shielding effectiveness of 50.7 dB in the X-band, and outstanding specific shielding effectiveness of 7276 dB.cm 2 g −1 . Meanwhile, a high in-plane thermal conductivity of 6.31 W/(m.k) and low cross-plane thermal conductivity of 0.42 W/(m.k) were obtained. Besides, the obtained films exhibit excellent Joule heating performance (113 °C) with low voltage (5 V), fast response time (< 10 s), excellent heating stability, and efficient de-icing as well as potential thermal stealth performance. Graphical abstract The multilayered MXene/TPU films were prepared by layer-by-layer spraying and exhibited excellent EMI shielding, thermal conductivity, and management performances.
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CATALYSIS LETTERS
·
2021
·Vol. 151
·期 11
·3170-3188
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IF 3.186
Zhang Qian,Zhou Yu-lian,Wang Bao-zong,Hong Jun-ming
The performance of electrocatalytic-oxidation process depends on the anode characteristics, so the preparation of active anode materials is an attractive method to enhance the efficiency of this process. However, the high catalytic properties of graphene and its derivatives have been well confirmed, an efficient method of controlling catalytic activity and stability remains to be established. In this research, the relationship between the precursor and catalytic performance was clarified by regulating the oxygen-containing groups in the precursor. Results indicated that the surface O groups on the precursor were sensitive to controlling the catalytic activity and stability of tri-doped reduced graphene oxide (RGO). With more O groups in the precursor (catalysts from graphene oxide), the doped heteroatom species is vulnerable involved into reaction, leading to the flaking of active sites, and ultimately decreasing the activity and stability performance. By contrast, the fewer O groups in the precursor (catalysts from RGO) created stable and active defects for oxidation activity. The interactions of O groups in the C precursor with those in the heteroatom precursor were further confirmed by DFT calculations. The findings of this research presented a new strategy for controlling the stability and performance of the resulting catalysts. Graphic Abstract DEME-TFSI-coated GO and GN are first formed via covalent bonds through functional groups (O groups) on the graphene surface, non-covalent ionic bonds, and π–π stacking interactions. In this step, N, S, and F groups are weakly bonded with graphene. Stable pyridine and pyrrole structures could then be generated via dehydration and decarbonylation under a controlled temperature and pressure in the hydrothermal process. Finally, cyclization rearrangement is carried out to form graphite with a tri-doped structure.
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Advanced Composites and Hybrid Materials
·
2021
·Vol. 4
·期 3
·685-695
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IF 5.693
Fu Xiaona,Su Jiling,Hou Li,Zhu Ping,Hou Ying,Zhang Kai,Li Huowang,Liu Xiangyi,Jia Chengxinzhuo,Xu Juan
Physicochemical and thermal characteristics of Moringa oleifera seed oil were studied. The refractive index of Moringa oleifera seed oil at ambient temperature was 1.46. The acid, peroxide, saponification, and iodine values content of Moringa oleifera seed oil were 2.35 g KOH/kg oil, 7.2 meq O 2 /kg oil, 189.84 g KOH/kg oil, and 66.78 g I 2 /100 g oil, respectively. Moringa oleifera seed oil contains ten fatty acids. Among 10 kinds of fatty acids in Moringa oleifera seed oil, oleic acid is the most abundant fatty acid comprising 70.85% of total oil followed by palmitic acid (8.98%). The unsaturated fatty acids represented by oleic acid are mainly distributed in the Sn-2 position, which is as high as 95.59%. It contains a high level of unsaturated fatty acids. Moringa oleifera seed oil contains 233.29 mg/kg α-tocopherol, 9.04 mg/kg β-tocopherol, and 10.13 mg δ-tocopherol, respectively. Determination of 10 elements in Moringa oleifera seed oil by ICP-MS. Among them, calcium has the highest content. Moringa oleifera seed oil remained stable up to 305 °C with a negligible degradation. Moringa oleifera seed oil has high nutritional value and broad development prospect. This research provides a prospect for the comprehensive development and utilization of Moringa oleifera seed oil. Graphical abstract
The basic physical and chemical properties and structure of Moringa oleifera seed oil was analyzed and characterized
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Science China-Technological Sciences
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2021
·Vol. 64
·期 10
·2142-2152
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IF 3.572
Song Chao,Liu XiangLei,Xuan YiMin,Zheng HangBin,Gao Ke,Teng Liang,Da Yun,Li Chuan,Li YongLiang,Ding YuLong
Calcium carbonate is promising thermochemical heat storage material for next-generation solar power systems due to its high energy storage density, low cost, and high operation temperature. Researchers have tried to improve energy storage performances of calcium carbonate recently, but most researches focus on powders, which are not suitable for scalable applications. Here, novel granular porous calcium carbonate particles with very high solar absorptance, energy storage density, abrasive resistances, and energy storage rate are proposed for direct solar thermochemical heat storage. The average solar absorptance is improved by 234% compared with ordinary particles. Both cycle stability and abrasive resistances are excellent with almost no decay of energy storage density over 25 cycles nor apparent particle weight loss over 24 h of continuous operation insides a planetary ball mill. In addition, the decomposition temperature is reduced by 2.8%–5.6% while the reaction rate of heat storage is enhanced by 80%–205% depending on the CO 2 partial pressure. The decomposition process of doped granular porous CaCO 3 particles is found to involve three overlapping processes. This work provides new routes to achieve scalable direct solar thermochemical heat storage for next-generation high-temperature solar power systems.
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Medical Molecular Morphology
·
2021
·Vol. 54
·期 4
·337-345
·
IF 2.309
Xu Sijia,Dong Wenxin,Shi Yu
The purpose of this study is to explore whether LncRNA PICSAR binds to miR-485-5p and thereby activates TGF-β1/Smad signaling pathway, influencing the abnormal proliferation of fibroblasts and excessive deposition of ECM in hypertrophic scar formation. PICSAR and miR-485-5p expressions were detected by qPCR. Cell proliferation was examined by CCK-8. Protein expressions were determined by western blot. Immunofluorescence detected the Ki-67 expression. Dual-luciferase followed by immunoprecipitation was performed to verify the interaction between PICSAR and miR-485-5p. Interference with PICSAR inhibited the abnormal proliferation of hypertrophic scar fibroblasts (HSFs) and the excessive deposition of ECM. It was also confirmed in our study that MiR-485-5p is a direct target of PICSAR in HSFs. Additionally, inhibition of miR-485-5p reversed the effect of PICSAR knockdown in HSFs. LncRNA PICSAR binds to miR-485-5p and thereby activates TGF-β1/Smad signaling pathway, promoting the abnormal proliferation of fibroblasts and excessive deposition of ECM in hypertrophic scar formation.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 29
·16290-16306
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IF 4.22
Liu Cansen,Zhuang Mingta,Huang Qishan,Mai Yongjin,Zhang Liuyan,Jie Xiaohua
Mold fouling during vulcanization is a widespread issue faced by tire industry that urgently needed to be addressed as it can degrade comprehensive performance of molded products and increase production time for cleaning mold, resulting in tremendous economic loss and resource consumption. Here, a novel and promising fouling mitigation strategy inspired by nature is presented, and its antifouling behavior in vulcanization conditions is investigated. The inspired slippery liquid-infused surfaces were successfully designed on aluminum alloy by anodic oxidation, followed by myristic acid modification and impregnation with perfluorinated oil. The prepared surfaces showed a water contact angle of 112.3° and sliding angle of 0.5°, accompanying with self-cleaning ability, stability for repelling hot water and under high-pressure condition as well as excellent corrosion resistance in 0.05 M H 2 SO 4 corrosive medium. Moreover, remarkable antifouling performance was obtained for slippery liquid-infused surfaces as no trace of fouling was observed after vulcanization test and thus a potential strategy for practical industrial applications. Graphical abstract
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2021
·Vol. 105
·期 13
·5607-5616
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IF 4.813
He Ying,Ding Haotian,Xia Xingya,Qi Wenyi,Wang Huaisong,Liu Wenyuan,Zheng Feng
Abstract Nitrosamine compounds, represented by N -nitrosodimethylamine, are regarded as potentially genotoxic impurities (PGIs) due to their hazard warning structure, which has attracted great attention of pharmaceutical companies and regulatory authorities. At present, great research gaps exist in genotoxicity assessment and carcinogenicity comparison of nitrosamine compounds. In this work, a collection of GFP-fused yeast cells representing DNA damage repair pathways were used to evaluate the genotoxicity of eight nitrosamine compounds (10 −6 –10 5 μg/mL). The high-resolution expression profiles of GFP-fused protein revealed the details of the DNA damage repair of nitrosamines. Studies have shown that nitrosamine compounds can cause extensive DNA damage and activate multiple repair pathways. The evaluation criteria based on the total expression level of protein show a good correlation with the mammalian carcinogenicity data TD 50 , and the yeast cell collection can be used as a potential reliable criterion for evaluating the carcinogenicity of compounds. The assay based on DNA damage pathway integration has high sensitivity and can be used as a supplementary method for the evaluation of trace PGIs in actual production. Key points • The genotoxicity mechanism of nitrosamines was systematically studied . • The influence of compound structure on the efficacy of genotoxicity was explored . • GFP-fused yeast cells have the potential to evaluate impurities in production . Graphical abstract
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高影响因子
CATALYSIS LETTERS
·
2021
·Vol. 152
·期 4
·1076-1085
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IF 3.186
Wang Gongshu,Chen Zhangpei,Chen Tian,Lv Kexin,Reheman Aikebaier,Hu Jianshe
A magnetic nanostructured catalyst (Fe 3 O 4 @SiO 2 -Amp-Rh) modified with 2-(aminomethyl)phenols (Amp) was designed and prepared, which is used to catalyze the reduction of aromatic nitro compounds into corresponding amines and the degradation of dyes. The 2-aminomethylphenol motif plays a vital role in the immobilization of rhodium nanoparticles to offer extraordinary stability, which has been characterized by using various techniques, including transmission electron microscopy (TEM), thermal gravimetric analyzer (TGA), X-Ray Diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). A variety of nitroaromatic derivatives have been reduced to the corresponding anilines in water with up to yields of 99% within 1 h at room temperature. In addition, the catalyst system is effective in catalyzing the reduction of toxic pollutant 4-nitrophenol and the degradation of MO, MB and RhB dyes. Importantly, this catalyst Fe 3 O 4 @SiO 2 -Amp-Rh can be easily recovered by an external magnetic field because of the presence of magnetic core of Fe 3 O 4 , and the activity of Fe 3 O 4 @SiO 2 -Amp-Rh does not decrease significantly after 7 times’ recycling, which indicates that the catalyst performed high reactivity as well as stability. Graphical abstract
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
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2021
·Vol. 23
·期 5
·1-14
·
IF 2.253
Yang Shuoye,Niu Yakun,Li Luheng,Liu Jiaxin,Ma Mengjin,Duan Xiaoyu,Zhang Lu,Wang Le,Qu Lingbo
Coenzyme Q10 (CoQ10) has a wide range of physiological functions and therapeutic value. However, its biomedical application as a health product or drug is limited by its insolubility and low bioavailability. Single-walled carbon nanotubes (SWCNTs) have attracted great interest for drug or therapeutic agent delivery due to their unique properties. In this study, the pristine SWCNTs are purified with different oxidizing acid, and the resulting shortened CNTs (CNTs-COOH) are conjugated with poly-(ethylene glycol) (PEG) groups. Afterwards, CoQ10 is loaded by CNTs carriers. CNTs carriers are systematically characterized and evaluated in terms of drug loading, in vitro release, cytotoxicity, and cellular uptake. The results reveal that the sizes (length) of CNTs-COOH and CNTs-PEG are 253.2 and 328.7 nm, respectively, and they have high loading capacity for CoQ10 and low cytotoxicity toward Caco-2 cells. In comparison with CNTs-COOH, CNTs-PEG exhibited better sustained-release property for CoQ10. Also, CNTs-PEG carriers loaded with CoQ10 can be effectively delivered into cells and have enhanced cellular uptake efficiency over time. Further study results of the uptake mechanism illustrate that CNTs-PEG can be internalized into cells through the broader and more efficient entry routes, including direct penetration, clathrin-mediated endocytosis and macropinocytosis pathway. In summary, the PEG-conjugated CNTs may be used as novel nanocarriers, and the findings will contribute to the rational design of multifunctional delivery vehicles for CoQ10. Graphical abstract
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危险品化学品经营许可证（带存储）