FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Qi An,Jingnan Ren,Xiao Jia,Jiaxin Lu,Gang Fan,Siyi Pan,Zhifeng Zhang,Xiwen Hu,Wenxuan Chen
Fabricate wood-inspired anisotropic cellulose hydrogel via directional freeze casting. • Achieve 91.03% probiotic survival rate via pH-responsive alginate coating in SGF. • Enable 9-h zero-order probiotic release via unfolding cellulose rolls in SIF. • Establish structure-function relationships between anisotropy and release kinetics. Probiotics offer diverse health benefits, but their efficacy is compromised by gastrointestinal stress and burst release in conventional encapsulation systems, limiting the efficacy of probiotics in functional foods. Herein, an alginate-coated cellulose roll capsule with anisotropic porous structures and sustained release property was developed via a combined strategy of directional freeze casting and ethanol coagulation bath, which avoids the need for energy-intensive freeze-drying. The pH-responsive alginate shell and layered cellulose roll core synergistically blocked acidic penetration and enhanced probiotic survival in the gastric environment, while the gradual dissolution of alginate shell and unfolding of cellulose roll led to controlled release of probiotics from the aligned microchannels in the intestinal environment. The design endowed the capsule with excellent survival rate (91.03%), high release count (1.82 × 10 8 CFU), prolonged release duration (9 h) and zero-order release kinetics. This study is based on in vitro simulated digestion using a single probiotic strain, and future work will address in vivo validation with additional probiotic species. This bioinspired system provides a strategy for functional food delivery by addressing the burst release challenge of probiotic encapsulation. Download: Download high-res image (151KB) Download: Download full-size image
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DYES AND PIGMENTS
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2026
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IF 3.9
Xiaoli Wang,Tong Zhao,Xingwei Wang,Zhiyuan Tang,Weichao Chen,Chenchen Li,Yawei Song,Yueyao Liang,Kun Zhang
A thermo-responsive pH buffer system enables pretreatment-free reactive dye inkjet printing. • HPMC suppresses ink penetration and NaAc/HAc provides alkaline fixation during steaming. • Ink stays weakly acidic for storage yet turns alkaline upon steaming for dye fixation. • The novel ink achieves color yield and fastness comparable to conventional pretreated processes. • This strategy simplifies processing, cuts energy and chemicals, and reduces environmental pollution. Conventional reactive dye inkjet printing relies on fabric pretreatment to suppress ink penetration and provide alkaline fixation conditions, which leads to long production cycles, high energy and chemical consumption, and environmental pollution. Herein, a novel pretreatment-free reactive dye ink with a temperature-sensitive pH buffer was developed for cotton fabric. The ink employs hydroxypropyl methyl cellulose (HPMC) to control ink spreading and sodium acetate/acetic acid (NaAc/HAc) as a thermo-responsive pH regulator. The ink remains weakly acidic at room temperature to ensure stable storage and jetting, and turns alkaline during steaming to satisfy the requirements of dye fixation. Four colored novel inks (cyan, magenta, yellow, black) were prepared and compared with commercial inks. Results show that NaAc barely affects the visible absorption, surface tension, viscosity, or droplet formation of the dye inks, ensuring excellent printability. With increasing NaAc content, the K/S values of all four colors are significantly enhanced without any hue shift. When applied to untreated cotton fabric, the novel ink achieves color performance, image clarity, and rubbing fastness (≥ grade 4) equivalent to those of commercial inks on pretreated fabric, while completely eliminating the pretreatment process. This work provides a green, efficient, and biocompatible strategy for cleaner textile inkjet printing with reduced cost and pollution.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Wenjia Liu,Ying Wang,Xiangyu Hao,Yangxun Wang,Xiaofan Zhang,Jinchao Zhang,Kun Ge,Guoqiang Zhou
Triple-negative breast cancer (TNBC) is associated with rapid progression and poor sensitivity to monotherapies, necessitating combination strategies to enhance tumor immunogenicity, reprogram the tumor microenvironment (TME), and convert immunologically "cold" tumors into "hot" ones. In this study, we develop a pH-responsive, pyroptosis-inducing nanoreactor, ZnS/ZIF-90:Fe/Vk3 (ZZFV), designed to elicit potent antitumor immunity. Under acidic conditions, ZZFV rapidly degrades, releasing Zn 2+ , Fe 2+ , H 2 S, and Vk3. H 2 S promotes glucose uptake and consumption while downregulating cytochrome c oxidase subunit IV (COX IV) expression, whereas Zn 2+ suppresses lactate dehydrogenase (LDH) activity, collectively disrupting glucose metabolism and exacerbating intracellular acidification. Meanwhile, NAD(P)H quinone oxidoreductase 1 (NQO1), highly expressed in tumor cells, catalyzes the conversion of Vk3 to H 2 O 2 , which is subsequently converted to highly toxic •OH through Fe 2+ -mediated Fenton reactions. Additionally, Zn 2+ and H 2 S synergistically disrupt mitochondrial function, thereby amplifying reactive oxygen species (ROS) production. Excessive ROS triggers Caspase-1-dependent pyroptosis, leading to the liberation of damage-associated molecular patterns. These events promote dendritic cell (DC) maturation, robust T-cell activation, M1 macrophage polarization, and expansion of central memory T-cell populations, thereby conferring durable immune protection. Consequently, ZZFV demonstrates potent antitumor efficacy, effectively overcoming immune tolerance in TNBC and achieving robust, sustained antitumor immunity.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
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IF 5.4
Shousen Zhao,Zhaolin Liu,Wenxiu Yang,Yujuan Wei
Effective management of wound exudate is critical for promoting wound healing. However, conventional dressings often struggle to balance exudate regulation with bioactive functionality. In this study, a trilayered hierarchical nanofibrous dressing was developed via layer-by-layer electrospinning, featuring unidirectional water transport, bead-embedded drug delivery and pH-responsive chromatic transition for exudate management and wound monitoring. The trilayered composite dressing integrated a hydrophobic polyvinylidene fluoride/curcumin (PVDF/CUR) bottom layer providing controlled antioxidant release through distinct bead morphology and exudate drainage; anintermediate layer of polyvinylidene fluoride/polyacrylonitrile (PVDF/PAN) enabling directional water transfer; and a hydrophilic top layer composed of polyacrylonitrile/sodium polyacrylate/anthocyanin (PAN/SPA/An) for visual monitoring of wound pH and rapid exudate absorption. The mechanisms for unidirectional water transport and pH-responsive chromatic change were systematically elucidated. Results indicated that the trilayered hierarchical nanofibrous dressing with a layer mass ratio of 1:4:4 (bottom: intermediate: top) exhibited optimal unidirectional water transport performance, achieving a unidirectional transport index of 1325%. It also showed a sustained CUR release profile, with a cumulative release of 66.35% over 60 h, and retained excellent antioxidant activity with a DPPH radical scavenging efficiency of 98.9%. Furthermore, the dressing displayed pronounced color transitions across a broad pH range of 1–12. This work presents a multifunctional wound dressing with promising potential for postoperative care and wound therapy. Download: Download high-res image (278KB) Download: Download full-size image
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NEW JOURNAL OF CHEMISTRY
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2025
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IF 2.5
Qianyu Cai,Yucheng Chen,Ting Wang,Qiongmei Mai,Jianglong Hu,Yunyou Lv,Yanhui Zhou,Jie Liu
The advancement of stimulus-responsive pesticide delivery systems offers a pivotal strategy for reconciling agricultural productivity with ecological sustainability. This study engineers a cellulose-functionalized vaterite calcium carbonate (CaCO3) nanoplatform (Pro@CaCO3@HPC, PCH) endowed with pH/cellulase dual-responsive intelligence for targeted prochloraz delivery. The hierarchically porous vaterite architecture facilitates superior drug loading (12.4%, w/w), while demonstrating environmentally triggered release kinetics. Controlled liberation studies reveal 2.37-fold and 2.13-fold cumulative release enhancements under acidic conditions and cellulase exposure, respectively, compared to neutral environments—a response mechanism strategically aligned with the pathophysiological microenvironment of Sclerotinia sclerotiorum infection. The multifunctional nanoformulation exhibits threefold advantages: (1) enhanced antifungal performance, achieving 96.1% mycelial inhibition at 1 µg mL−1 compared to conventional formulations (72.7%); (2) reduced environmental footprint through 27.7% decreased soil mobility relative to free prochloraz; (3) improved biosafety profiles, maintaining crop germination rates 13.3% higher than commercial formulations while demonstrating attenuated cytotoxicity. This phytopathology-activated delivery system establishes a technological paradigm that synchronizes three critical agricultural requirements: pathogen-responsive precision, environmental persistence mitigation, and non-target organism protection. Therefore, this study provides an environmentally friendly, intelligent and efficient strategy, which shows great potential in the field of Sclerotinia sclerotiorum control.
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WEAR
·
2025
·
IF 6.1
Jiajia Cen,Kai Chen,Qin Chen,Xinyue Zhang,Cunao Feng,Xiaowei Li,Dekun Zhang,Shirong Ge
The tribological performance of hip joint materials in the synovial fluid is substantially influenced by environmental factors. In this study, the tribological properties of polyether-ether-ketone (PEEK)-highly crosslinked polyethylene (XLPE) hip joint materials were investigated in composite synovial fluids with varying pH conditions, revealing the coupling mechanism between pH and composite synovial fluid components. The lubrication efficacy of the composite synovial fluid under physiological conditions was validated through a 2 million-cycle hip joint simulation test. Results indicated that the coefficient of friction (COF) decreased with the increasing pH, while the wear factor remained stable at pH = 7.5 and pH = 8.0 but decreased progressively at pH = 8.5. Notably, the Fluid C demonstrated significant pH sensitivity, reducing the wear factor by 89.12 % when pH increased from 8.0 to 8.5. Moreover, the results of the hip joint simulation tests were consistent with the sliding tribology tests. The component concentration regulated the lubrication efficiency, with amplified effects during long-term service. Hence, this study elucidated wear mechanisms in “soft-soft” hip joint materials under simulated physiological conditions and provided critical insights for predicting the lifespan of polymer-based artificial joints.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2025
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IF 2.8
Zhikun Li,Yuanyuan Li,Yulong Ma,Wenxin Ji,Yonggang Sun
The purification of biomacromolecules, particularly proteins, plays an increasingly vital role in the fields of medicine, biopharmaceuticals, and emerging technologies. Adsorbents with excellent adsorption capacity, superior cycling performance, and environmental compatibility are crucial for protein separation and adsorption. A temperature- and pH dual-stimulus responsive hydrogel material for the adsorption and separation of protein was successfully prepared by copolymerizing sodium alginate (SA) as the matrix with N-isopropylacrylamide (NIPAM), acrylic acid (AAC), and simultaneously introducing zirconium-based metal-organic frameworks (Zr-MOF). This hydrogel material exhibits excellent adsorption and controlled release properties for protein including bovine hemoglobin (BHB) and bovine serum albumin (BSA) with maximum adsorption capacities of 617.45 mg/g and 527.06 mg/g at 45 °C, respectively. Experimental results demonstrate that the adsorption and release behavior of the hydrogel toward proteins can be effectively regulated by adjusting environmental temperature or pH value in an aqueous medium without any acidic, alkaline, high-salt, or organic solvent. Additionally, the material exhibits good cyclic stability, maintaining more than 85 % of its initial protein adsorption capacity after five adsorption-desorption cycles. This study provides new insights into the development of smart responsive biomolecular adsorption materials and has significant application potential in the fields such as drug controlled release and biological separation.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Pami Yang,Yuancheng Liu,Qin Zeng,Shuang Zhao,Yi Zhang,Junhong Yang,Ke Yin,Wuming Wu,Chunyan Deng
Bacterial-infected wounds pose a clinical challenge requiring innovative strategies integrating precise antibacterial action and microenvironment reprogramming. To address this, a multifunctional H-CuS NPs@epigallocatechin gallate (EGCG)/chitosan (CS)/3-formylphenylboronic acid (3-FPBA) hydrogel (H-CuS@EGCG HY) was engineered. This hydrogel exhibits injectability, self-healing, tissue adhesion, and pH-responsive behavior. During the initial phase of wound infection (weakly acidic microenvironment), this network undergoes controlled dissociation, enabling on-demand localized release of EGCG and Cu 1+/2+ . Under near-infrared (NIR) irradiation, the photothermal effect of H-CuS NPs promotes mild heating, which enhances EGCG/Cu 1+/2+ release and penetration. The released Cu 1+/2+ further catalyzes •OH generation from H 2 O 2 via Fenton reaction, synergizing with EGCG and photothermal therapy to improve antibacterial efficacy. Additionally, EGCG scavenges excess radicals, reducing oxidative stress and inflammation, while Cu 1+/2+ supports angiogenesis via VEGF regulation-collectively reprogramming the wound microenvironment. In vitro tests showed broad-spectrum antimicrobial activity with a 99 % eradication rate. In S. aureus -infected mouse models, compared to the control group, the H-CuS@EGCG HY + NIR group significantly reduced the levels of inflammatory cytokines (TNF-α), promoted the expression of CD31 and CD206, and effectively modulated the wound microenvironment, ultimately resulting in complete wound closure (100 %) by day 13, accompanied by full epidermal regeneration and minimal scarring. This study provides a promising strategy for the treatment of clinical wounds.
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Materials
·
2025
·Vol. 18
·期 19
·4632
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IF 3.2
Fan Zhang,Haotian Yu,Qiongyue Zhang,Yahao Wang,Haodong Ren,Huirong Liang,Jinrui Li,Yuanyuan Feng,Bin Zhao,Xiaogang Han
Aqueous zinc-ion batteries (ZIBs) have emerged as a promising candidate for large-scale energy storage due to their inherent safety, low cost, and environmental friendliness. However, manganese dioxide (MnO2)-based cathodes, which are widely studied for ZIBs owing to their high theoretical capacity and low cost, face severe capacity fading issues that hinder the commercialization of ZIBs. This performance degradation mainly stems from the weak van der Waals forces between MnO2layers leading to structural collapse during repeated Zn2+insertion and extraction; it is also exacerbated by irreversible Mn dissolution via Mn3+disproportionation that depletes active materials, and further aggravated by dynamic electrolyte pH fluctuations promoting insulating zinc hydroxide sulfate (ZHS) formation to block ion diffusion channels. To address these interconnected challenges, in this study, a synergistic strategy was developed combining crystal engineering and pH buffer regulation. We synthesized three MnO2polymorphs (α-, δ-, γ-MnO2), identified δ-MnO2with flower-like microspheres as optimal, and introduced sodium dihydrogen phosphate (NaH2PO4) as a pH buffer (stabilizing pH at 2.8 ± 0.2). The modified electrolyte improved δ-MnO2wettability (contact angle of 17.8° in NaH2PO4-modified electrolyte vs. 26.1° in base electrolyte) and reduced charge transfer resistance (Rct = 78.17 Ω), enabling the optimized cathode to retain 117.25 mAh g−1(82.16% retention) after 2500 cycles at 1 A g−1. This work provides an effective strategy for stable MnO2-based ZIBs, promoting their application in renewable energy storage.
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SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Mingyue Luo,Min Gao,Honghong Rao,Xin Xue,Zhentong Zhu,Zhengang Han,Baodui Wang,Zhonghua Xue
The pH-dependent activity of nanozymes, optimal in acidic conditions but inert at neutral pH, significantly limits their practical applications. Herein, we demonstrate a dual-ion (Pb 2+ /Cl − ) modulation strategy that activates nanozymes at neutral pH through the spatially controlled generation of dual reactive oxygen species (ROS). Using Au@Pt core-shell nanoparticles (with negligible peroxidase (POD)-like activity at pH 7.0) as a model, we elucidate two synergistic pathways: (i) Pb 2+ -driven structural reconstruction to form catalytically active Pb-Au@Pt species, and (ii) Cl − -mediated electronic modulation for dual-ROS (ClO − and 1 O 2 ) generation. This system circumvents proton dependence through an optimized electron transfer in a nanozyme catalysis system. A photothermal biosensing platform leveraging this mechanism demonstrates sensitive Pb 2+ detection (limit of detection: 1.36 nM, S/N = 3) with >100-fold selectivity against interferents. Unlike conventional single-ROS or surface-engineering methods, our ionic strategy introduces three paradigm-shifting advantages: (i) complete decoupling of catalysis from intrinsic material properties, (ii) elimination of the need for nanostructure redesign, and (iii) establishment of a dual-ROS generation framework. This work redefines nanozyme activation mechanisms while providing actionable principles for next-generation biosensor designs, particularly in physiological environments.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Yaning Li,Yue Wang,Hongchao Ma
The tumor microenvironment (TME), characterized by hypoxia, limited H 2 O 2 availability, and elevated glutathione (GSH) concentrations, challenges reactive oxygen species (ROS)-based therapies. To address these, we developed a GOx@Cu-ZIF-8/DOX (GCZD) nanoplatform combining chemotherapy (CT), chemodynamic therapy (CDT), and starvation therapy (ST). This system utilizes Cu-incorporated ZIF-8 (Cu-ZIF-8) as a versatile carrier to load glucose oxidase (GOx) and doxorubicin (DOX). Under acidic TME conditions, GCZD disintegrates, releasing GOx, Cu 2+ , and DOX. GOx catalyzes intratumoral glucose oxidation, producing gluconic acid and H 2 O 2 to achieve a triple-therapeutic effect. Gluconic acid maintains a weakly acidic environment for continuous GCZD degradation. Glucose depletion induces metabolic starvation. Generated H₂O₂ serves as substrate for Cu 2+ -mediated Fenton-like reactions, boosting ROS production. Cu 2+ exhibits catalytic activity, efficiently converting TME and GOx-generated H 2 O 2 into cytotoxic ·OH. Increased ROS concentration enhances biological macromolecule oxidation damage, intensifying CDT. Additionally, Cu 2+ oxidizes GSH to form GSSH and Cu + . This inhibits GSH-mediated ROS degradation and leverages excellent Fenton-like activity of Cu + to further enhance CDT. Simultaneously, DOX exerts chemotherapeutic effects by intercalating into DNA and inhibiting topoisomerase II, blocking tumor cell proliferation. This integrated approach, combining enhanced ROS generation, tumor cell metabolic intervention, and DNA damage, demonstrates enhanced antitumor efficacy by simultaneously targeting multiple cancer cell vulnerabilities.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Jinyuan Geng,Guowei Zhou,Song Guo,Gaoyuan Wang,Jiangfeng Ma,Chaoqun Ma
Chronic non-healing wounds requires dressings that combine flexibility, infection control, and responsive environments, a need unmet by current options. In this study, we developed a dual-dynamic-network hydrogel using covalent Schiff base bonds and non-covalent Al 3+ -carboxyl coordination with oxidized dextran (ODex), polyethyleneimine-modified gelatin (PEI-Gel), polyacrylic acid (PAA), and aluminum ions (Al 3+ ), achieving three synergistic functions critical for clinical application. The DPA (ODex/PEI-Gel/PAA) hydrogel exhibits tissue-like deformability, with an elongation capacity of 920.9 ± 1.2 % and a tensile strength of 0.54 ± 0.3 MPa, while preserving structural integrity under cyclic stress conditions. In vitro tests demonstrated the hydrogel's antibacterial efficacy, with MIC 90 values of 25, 20, and 6 mg/mL against Escherichia coli , Staphylococcus epidermidis , and S. saprophyticus , respectively. The hydrogel's pH-responsive drug release mechanism facilitates intelligent therapeutic delivery, achieving over 90 % cumulative release of emodin at pH 3.0 within 168 h. Overall, this work highlights the promising potential of the antibacterial hydrogel drug delivery platform with superior mechanical characteristics for the treatment of chronic cutaneous wounds.
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