JOURNAL OF NANOBIOTECHNOLOGY
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2023
·Vol. 21
·期 1
·1-17
·
IF 10.2
He Yiman,Chen Huawan,Li Wenbo,Xu Lu,Yao Huan,Cao Yang,Wang Zhigang,Zhang Liang,Wang Dong,Zhou Di
Background Radiotherapy (RT) is one of the most mainstream cancer therapeutic modalities. However, due to the lack of specificity of the radiation adopted, both normal and cancerous cells are destroyed indiscriminately. This highlights the crucial need to improve radiosensitization. This study aims to address this issue by constructing a multifunctional nanospheres that can sensitize multiple aspects of radiotherapy.Results Nanospheres containing high atomic element Bi can effectively absorb ionizing radiation and can be used as radiosensitizers. Cell viability after Bi2S3 + X-ray treatment was half that of X-ray treatment alone. On the other hand, exposed 3-bromopyruvate (3BP) could reduce the overactive oxygen (O2) metabolism of tumor cells and alleviate tumor hypoxia, thereby promoting radiation-induced DNA damage. The combination index (CI) of 3BP and Bi2S3-based RT in Bi2S3-3BP + X-ray was determined to be 0.46 with the fraction affected (fa) was 0.5 via Chou-Talalay’s isobolographic method, which indicated synergistic effect of 3BP and Bi2S3-based RT after integration into Bi2S3-3BP + X-ray. Under the combined effect of 3BP and RT, autophagy was over-activated through starvation-induced and redox homeostasis dysregulation pathways, which in turn exhibited pro-death effects. In addition, the prepared nanospheres possess strong X-ray attenuation and high near-infrared (NIR) optical absorption, thus eliminating the need for additional functional components and could serve as bimodal contrast agents for computed tomography/photoacoustic (CT/PA) imaging.Conclusion sThe rational design of multifunctional nanospheres with the unique properties provided a novel strategy to achieving high therapeutic efficacy in RT. This was accomplished through simultaneous activation of multiple sensitization pathways by increasing ionizing radiation, reducing tumor oxygen consumption, inducing pro-death autophagy, and providing multiple-imaging guidance/monitoring.
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Cell Communication and Signaling
·
2023
·Vol. 21
·期 1
·1-18
·
IF 8.4
Liao Zhaohong,Lan Haiqiang,Jian Xiaoting,Huang Jingwen,Wang Han,Hu Jijie,Liao Hua
Background To explore the role of skeletal muscle specific TGF-β signaling on macrophages efferocytosis in inflamed muscle caused by Cardiotoxin (CTX) injection. Methods CTX myoinjury was manipulated in TGF-βr2 flox/flox (control) mice or transgenic mice with TGF-β receptor 2 (TGF-βr2) being specifically deleted in skeletal muscle (SM TGF-βr2 −/− ). Gene levels of TGF-β signal molecules, special inflammatory mediators in damaged muscle or in cultured and differentiated myogenic precursor cells (MPC-myotubes) were monitored by transcriptome microarray or qRT-PCR. TGF-β pathway molecules, myokines and embryonic myosin heavy chain in regenerating myofibers, the phenotype and efferocytosis of macrophages were evaluated by immunofluorescence, immunoblotting, Luminex, or FACS analysis. In vitro apoptotic cells were prepared by UV-irradiation. Results In control mice, TGF-β-Smad2/3 signaling were significantly up-regulated in regenerating centronuclear myofibers after CTX-myoinjury. More severe muscle inflammation was caused by the deficiency of muscle TGF-β signaling, with the increased number of M1, but the decreased number of M2 macrophages. Notably, the deficiency of TGF-β signaling in myofibers dramatically affected on the ability of macrophages to conduct efferocytosis, marked by the decreased number of Annexin-V − F4/80 + Tunel + macrophages in inflamed muscle, and the impaired uptake of macrophages to PKH67 + apoptotic cells transferred into damaged muscle. Further, our study suggested that, the intrinsic TGF-β signaling directed IL-10-Vav1-Rac1 efferocytosis signaling in muscle macrophages. Conclusions Our data demonstrate that muscle inflammation can be suppressed potentially by activating the intrinsic TGF-β signaling in myofibers to promote IL-10 dependent-macrophages efferocytosis.
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Journal of Central South University
·
2023
·Vol. 30
·期 5
·1523-1538
·
IF 4.4
Xu Jia-qi,Liu Wei,Jiao Fen,Han Jun-wei,Qin Wen-qing,Cai Can
Pyrolysis is a promising technology to treat waste printed circuit boards (WPCBs) with significant advantages of full source utilization, high separation efficiency and scarce pollutant emissions. In this work, TG and DTG analyses were performed to determine pyrolysis characteristics. The kinetic analysis adopting the Starink Kissinger-Akahira-Sunose (SKAS) model was conducted to confirm the apparent activation energy ( E α ). Pyrolysis products were collected using a lab-scale pyrolyzer. GC-MS analysis coupled with MS-DIAL data processing was applied to clarify the distribution pattern of valuable liquid products. The results indicated that the main thermal decomposition of WPCBs occurred within the temperature range of 157–664 °C, with E α ranging from 80.70 to 279.46 kJ/mol. During pyrolysis, the WPCBs were converted into three kinds of products, in which solid and gas products could be applied in the field of materials and energy. The composition of WPCBs oil products was complicated and sensitive to the pyrolysis temperature. The largest proportion of valuable liquid products (82.94%) was obtained at 600 °C, containing 52.87% monocyclic aromatic phenols, 4.39% polycyclic aromatic phenols, 3.07% brominated phenols, and 22.61% hydrocarbons, respectively. These valuable liquid products would be an attractive alternative as raw materials for the synthesis of phenolic resins and the production of petrochemicals.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-10
·
IF 16.6
Wang Yanbo,Li Qing,Hong Hu,Yang Shuo,Zhang Rong,Wang Xiaoqi,Jin Xu,Xiong Bo,Bai Shengchi,Zhi Chunyi
Solid polymer electrolytes (SPEs) and hydrogel electrolytes were developed as electrolytes for zinc ion batteries (ZIBs). Hydrogels can retain water molecules and provide high ionic conductivities; however, they contain many free water molecules, inevitably causing side reactions on the zinc anode. SPEs can enhance the stability of anodes, but they typically possess low ionic conductivities and result in high impedance. Here, we develop a lean water hydrogel electrolyte, aiming to balance ion transfer, anode stability, electrochemical stability window and resistance. This hydrogel is equipped with a molecular lubrication mechanism to ensure fast ion transportation. Additionally, this design leads to a widened electrochemical stability window and highly reversible zinc plating/ stripping. The full cell shows excellent cycling stability and capacity retentions at high and low current rates, respectively. Moreover, superior adhesion ability can be achieved, meeting the needs of flexible devices.
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Science China-Chemistry
·
2023
·
IF 9.6
Tang Xianqing,Chen Jinghuang,Zhang Mengqian,Sun Jian,Yang Xiurong
Alkaline phosphatase (ALP) activity and pyrophosphate ion (PPi) levels are remarkable for the human body functions such as signal transduction pathways and metabolism. Current quantitative methods mainly focus on developing complicated organic substrates or employing unstable metal ions as signal-regulated medium. Herein, we have developed a facile hydrothermal method for preparing FeWO 4 nanomaterials with intrinsic peroxidase-like activity and further confirmed that such a catalytic activity could be significantly enhanced by adjusting the size and oxygen vacancy content. More encouragingly, PPi can easily inhibit the catalytic activity of FeWO 4 , whereas orthophosphate ions (Pi) cannot. Therefore, we constructed an FeWO 4 -based colorimetric assay for sensing PPi by means of the classical 3,3′,5,5′-tetramethylbenzidine-peroxidase chromogenic reaction. A facile and reliable ALP activity assay was also designed and developed because of the logical regulation of the peroxidase-like activity of FeWO 4 through the ALP-catalyzed hydrolysis of PPi into Pi. Based on the clear mechanism and mimetic-enzyme FeWO 4 -catalyzed amplification, the sensing system exhibited excellent performance and was able to evaluate ALP activity in real serum samples and screen for potential ALP inhibitors. The proposed mimetic enzyme-involved colorimetric assay provides an alternative pathway, and FeWO 4 nanomaterials with excellent performance have great potential for further biosensing and biomedical applications.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 27
·70506-70518
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IF 5.8
Gao Ziqiang,Dai Zhineng,Wang Rui,Li Yang
Atrazine has been widely used as an herbicide, and its harm has attracted more and more attention. In this study, magnetic algal residue biochar (MARB) was prepared from algae residue, a by-product of aquaculture, by ball milling it with ferric oxide to study the adsorption and removal of the triazine herbicide atrazine in a soil medium. The adsorption kinetics and isotherm results showed that atrazine removal by MARB reached 95.5% within 8 h at a concentration of 10 mg·L −1 , but the removal rate dropped to 78.4% in the soil medium. The pseudo-first- and pseudo-second-order kinetics and Langmuir isotherms best described atrazine adsorption on MARB. It is estimated that the maximum adsorption capacity of MARB can reach 10.63 mg·g −1 . The effects of pH, humic acids, and cations on the adsorption performance of MARB for atrazine were also studied. When pH was 3, the adsorption capacity of MARB was twice that of other pHs. Only in the presence of 50 mg·L −1 HA and 0.1 mol·L −1 NH 4 + , Na, and K, the adsorption capacity of MARB to AT decreased by 8% and 13%, respectively. The results showed that MARB had a stable removal profile over a wide range of conditions. The adsorption mechanisms involved multiple interaction forms, among which the introduction of iron oxide promoted hydrogen bonding formation and π-π interactions by enriching –OH and –COO on the surface of MARB. Overall, the magnetic biochar prepared in this study can be used as an effective adsorbent to remove atrazine in complex environments and is ideal for algal biomass waste treatment and environmental governance. + +
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 24
·66303-66313
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IF 5.8
Xu Zhimin,Ju Shaohua,Gao Peng,Lin Junjian,Niu Yifan,Meng Fei,Li Shunling,Li Fangfang,Du Jiahao,Xu Li,Peng Hongbo,Pan Bo
In this study, ferrous composites (Fe x O 4 ) were prepared by microreactor to activate peroxydisulfate (PDS) for the degradation of bisphenol A (BPA) with visible (Vis) light irradiation. X-ray diffraction (XRD), energy-dispersive spectrometry (EDS), X-ray photoelectron spectroscopy (XPS), and scanning electron microscope (SEM) were used to characterize the morphology and crystal phase of Fe X O 4 . Photoluminescence (PL) spectroscopy combined with amperometric tests were used to determine the role of PDS on the performance of photocatalytic reaction. The main reactive species and intermediates for BPA removal were determined by electron paramagnetic resonance (EPR) measurement and quenching experiments. The result indicated that singlet state oxygen ( 1 O 2 ) contributed more to the BPA degradation than that of other reactive radicals (·OH, SO 4 ·− and ·O 2 − ); these reactive radicals and 1 O 2 formed by the reaction between photo-generated electrons (e − ) and holes (h + ) of Fe x O 4 and PDS. During this process, the consumption of e − and h + also improved their separation efficiency and thus enhanced the degradation of BPA. In addition, the photocatalytic activity of Fe x O 4 in Vis/Fe x O 4 /PDS system was 3.2-fold and 6.6-fold higher than that of single Fe x O 4 and PDS under Vis light, respectively. The Fe 2+ /Fe 3+ cycle could effectively drive the photocatalytic activation of PDS through indirect electron transfer and the formation of reactive radicals. This work illustrated that the degradation of BPA was rapidly in Vis/Fe x O 4 /PDS system mainly through 1 O 2 , which further improve our understanding on the efficient removal of organic contaminants in the environment.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2023
·Vol. 415
·期 22
·5353-5363
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IF 4.3
Yu Yang,Pai Nanya,Chen Xiaoya,Wang Baoling,Gao Shulin,Ge Dandan
A new type of hexafluorobutanol (HFB) primary alcohol ethoxylate (AEO)-based supramolecular solvent (SUPRAS) with density higher than water was prepared for the first time. HFB acted as AEO micelle-forming agent and density-regulating agent for SUPRAS formation. The prepared SUPARS was applied as extraction solvent for vortex-assisted direct microextraction of malachite green (MG) and crystal violet (CV) from lake sediment followed by high-performance liquid chromatographic determination. In the present work, SUPRASs prepared from AEO with different carbon chains as the amphiphiles and various coacervation agents were investigated. SUPARS formed from MOA-3 and HFB provided better extraction efficiency in comparison with other SUPRASs. Parameters influencing the extraction recovery of target analytes including the type and volume of AEO, volume of HFB, and vortex time were investigated and optimized. Under optimized conditions, linearity in the range of 2.0–400 μg g −1 for MG and 2.0–500 μg g −1 for CV with a correlation coefficient higher than 0.9947 was obtained. Limits of detection of 0.5 μg g −1 and relative standard deviations in the range of 0.9–5.8% were obtained. Compared to conventional extraction techniques for analysis of analytes in solid samples, the proposed method reduced sample usage and eliminated a primary extraction process by using a toxic organic solvent. The proposed method is simple, fast, and green and can be used for the analysis of target analytes in solid samples. Graphical Abstract
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Science China-Technological Sciences
·
2023
·Vol. 66
·期 7
·2059-2068
·
IF 4.6
Gao Ling,Xie YuLin,Tong Yan,Xu Miao,You JiaLe,Wei HuiPing,Yu XiangXiang,Xu SiQi,Zhang Yi,Che Yong,Tang Ya,Suzuki Kota,Kanno Ryoji,Zhao GuoWei
Argyrodites, Li 6 PS 5 X ( X =Cl, Br, I), have piqued the interest of researchers by offering promising lithium ionic conductivity for their application in all-solid-state batteries (ASSBs). However, other than Li 6 PS 5 Cl (651Cl) and Li 6 PS 5 Br (651Br), Li 6 PS 5 I (651I) shows poor ionic conductivity (10 −7 S cm −1 at 298 K). Herein, we present Al-doped 651I with I − /S 2− site disordering to lower activation energy ( E a ) and improve ionic conductivity. They formed argyrodite-type solid solutions with a composition of (Li 6−3 x Al x )PS 5 I in 0⩽ x ⩽0.10, and structural analysis revealed that Al 3+ is located at Li sites. Also, the Al-doped samples contained anion I − /S 2− site disorders in the crystal structures and smaller lattice parameters than the non-doped samples. Impedance spectroscopy measurements indicated that Al-doping reduced the ionic diffusion barrier, E a , and increased the ionic conductivity to 10 −5 S cm −1 ; the (Li 5.7 Al 0.1 )PS 5 I had the highest ionic conductivity in the studied system, at 2.6×10 −5 S cm −1 . In a lab-scale ASSB, with (Li 5.7 Al 0.1 )PS 5 I functioned as a solid electrolyte, demonstrating the characteristics of a pure ionic conductor with negligible electronic conductivity. The evaluated ionic conduction is due to decreased Li + content and I − /S 2− disorder formation. Li-site cation doping enables an in-depth understanding of the structure and provides an additional approach to designing better-performing SEs in the argyrodite system.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2023
·Vol. 27
·期 9
·2499-2507
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IF 2.5
Wu Jiani,Lu Yan,Wu Huacheng,Luo Qian,Bai Zhe,Li Jun
All solid-state lithium batteries have been widely used in mobile communications and electric vehicles due to their high energy density, wide operating voltage, and long cycle life. However, solid-state electrolytes have shortcomings such as insufficient stability and low conductivity. In this study, the sol–gel method prepared the solid electrolyte Li 6.25 Al 0.25 La 3 Zr 2 Ti 0.25 O 12 co-doped with Al and Ti. The influence of Al and Ti on the structure and conductivity of Li 7 La 3 Zr 2 O 12 was investigated by X-ray diffraction, impedance spectroscopy, scanning electron microscopy, and inductively coupled plasma spectrometer (ICP). With optimal additions of Al and optimal additions of Ti, Li 6.25 Al 0.25 La 3 Zr 1.75 Ti 0.25 O 12 electrolyte calcined at 900 °C for only 6 h showed an ionic conductivity of 1.51 × 10 −4 S/cm at room temperature. Li/Li 6.25 Al 0.25 La 3 Zr 1.75 Ti 0.25 O 12 /LiFePO 4 all solid-state battery was assembled. The initial charge and discharge capacity of the lithium-ion phosphate positive electrode at 10 μA/cm 2 was 165.1 mAh/g and 130.1 mAh/g at room temperature. The initial coulomb efficiency was 78.9%. After 100 cycles, the discharge capacity was 149.1 mAh/g, and the capacity retention rate was 99.8% at room temperature.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 30
·75681-75693
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IF 5.8
Kang Fei,Lv Qilin,Fan Jingbiao,Zhang Yun,Song Yuling,Ren Xueqin,Hu Shuwen
Soil acidification is a worldwide eco-environmental problem detrimental to plant growth and threatening food security. In this study, calcium poly(aspartic acid) (PASP-Ca) and calcium poly-γ-glutamic acid (γ-PGA-Ca) were obtained through cation exchange and used to mitigate soil acidity owing to high solubility and complexing capability. Three rates at 6.7, 13.4, and 20.1 g kg −1 , denoted as PASP-Ca1, PASP-Ca2, and PASP-Ca3, and γ-PGA-Ca (7.4 g kg −1 ) were surface-applied and compared with conventional lime (CaCO 3 , 2.5 g kg −1 ) along with control in two soil layers (top soil 0–10 cm, subsoil 10–20 cm). After leaching, various soil properties and aluminum fractions were measured to assess their ameliorative performance and mechanisms. Although lime achieved the highest soil pH (6.91) in the topsoil followed by PASP-Ca and γ-PGA-Ca (pH: 5.57–6.33), it had less effect on subsoil increase (5.3) vs. PASP-Ca and γ-PGA-Ca (pH: 5.44–5.74). Surface-applied PASP-Ca demonstrated efficiency in elevating soil pH and reducing exchangeable acidity, mainly as exchangeable Al 3+ , whereas γ-PGA-Ca addition superiorly improved soil pH buffering capacity (pHBC). Moreover, PASP-Ca and γ-PGA-Ca addition improved organic carbon by 34.4–44.9%, available P by 4.80–20.71%, and cation exchange capacity (CEC) by 6.19–29.2%, thus greatly enhanced soil fertility. Ca 2+ from polyAA-Ca promoted the displacement of exchangeable Al 3+ or H + from soil colloid, which were subsequently complexed or protonated and facilitated leaching. Additionally, the transformation into stable organo-aluminum fractions via complexation inhibited further hydrolysis. Under PASP-Ca or γ-PGA-Ca addition, the saturation of aluminum in cation exchange complex was reduced 2.91–7.81% compared to the control without addition amendments. Thus, PASP-Ca and γ-PGA-Ca can serve as potent ameliorants to alleviate soil acidity and aluminum toxicity for sustainable agricultural development.
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Advanced Composites and Hybrid Materials
·
2023
·Vol. 6
·期 3
·1-9
·
IF 20.1
Xu Ting,Wang Yaxuan,Liu Kun,Zhao Qingshuang,Liang Qidi,Zhang Meng,Si Chuanling
With the depletion of fossil resources and the gradual intensification of environmental pollution, green and sustainable electrochemical devices have aroused intensive attraction. The supercapacitor, demonstrating fast charging rate, high power densities, and long cycling life, has great application prospects in high power output and backup power supply. Herein, an ultralight and robust MXene/carbon nanotube aerogel is constructed by facile directional freezing and subsequent freeze-drying. Benefiting from the strongly π-π interactions between MXene nanosheets and carbon nanotube, the assembled MXene/carbon nanotube composite aerogel exhibits abundant pore structures, superior conductivity, and good mechanical properties. The electrical conductivity of MXene/carbon nanotube aerogel is up to 1600 S m −1 . The MXene/carbon nanotube aerogel can be subjected to 70% compressive strain and retain 85% initial strain over 1000 compress-release cycles. The as-prepared all-solid-state supercapacitor with MXene/carbon nanotube aerogel shows outstanding electrochemical performance (410.7 mF cm −2 at the current density of 0.8 mA cm −2 ). The supercapacitor is flexible and can be bent from 0 to 90° as the cyclic voltammetry curves are almost consistent. Furthermore, the LED can be lighted by four devices in series.
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危险品化学品经营许可证（带存储）