INORGANIC CHEMISTRY COMMUNICATIONS
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2023
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IF 3.8
Dan Tang,Qin Wang,Shaojing Zhao,Jianing Yi,Minhuan Lan,Jie Zeng,Lei Huang
Herein, carbon dots (CDs) with bright yellow fluorescence were synthesized by using kaempferol as a carbon source, through a hydrothermal method in NaOH solution. The as-prepared CDs were highly soluble and spherical with uniform size and mean particle diameter of 3.2 nm. The CDs have unique high selectivity, sensitivity and anti-interference ability to mercury (Hg 2+ ). Under different pH conditions, Hg 2+ ions can still quench the fluorescence of CDs effectively and stably. On the other hand, cysteine can re-ignite the fluorescence of CDs as a result of strong chelation interaction that exists between -SH and Hg 2+ . There are good linear relationships between the concentration of Hg 2+ and (F 0 -F)/F 0 , the concentration of cysteine and (F-F 0 )/F 0 , and the detection limits are 1.6 μM and 0.8 μM, respectively. In addition, CDs can effectively detect Hg 2+ in tap water and lake water and detect cysteine in serum.
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MATERIALS & DESIGN
·
2023
·
IF 8.4
Chenchen Zhao,Dongbo Wang,Zhi Zeng,Bingke Zhang,Jingwen Pan,Donghao Liu,Sihang Liu,Shujie Jiao,Gang Liu,Zhikun Xu,Liancheng Zhao,Jinzhong Wang
Over-consumption of limited fossil fuels has caused serious environmental pollution and a global energy crisis, threatening human life and biodiversity. As an ideal, environmentally friendly renewable energy, hydrogen can satisfy human clean energy requirements. Therefore, whether hydrogen can be catalytically generated in the wastewater treatment process is a highly meaningful investigation. Herein, Bi 2 Te 3 /Te/C heterojunction nanowires with high specific surface area and rich pore structure were successfully synthesized. The efficient catalytic degradation process is accompanied by the generation of hydrogen. The catalytic degradation of methylene blue and methyl orange was achieved in less than 20 s and 150 s, respectively. Meanwhile, in scaled-up degradation/hydrogen production experiments, fast and efficient H 2 production from NaBH 4 can be realized in the presence of Bi 2 Te 3 /Te/C nanowires. The mechanism of efficient synergistic organic dye degradation and hydrogen production is due to the efficient carrier transfers and accumulation at the hetero-interface. In contrast to previous work, rapid degradation of organic dyes and hydrogen production by decomposition of NaBH 4 were achieved without the help of high-cost catalysts such as precious metals. This work could provide an alternative pathway for the future degradation of organic matter in synergistic heterogeneous catalytic wastewater and recovery of by-products including hydrogen.
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ACS Nano
·
2023
·
IF 17.1
Qiang Chu,Congkun Xie,Guodong Cao,Zefeng Hu,Feiyu Li,Yike Fu,Gaorong Han,Xiang Li
A hybrid platform, constructed via the surface “armoring” of living yeasts by a manganese silicate compound (MS@Yeast), is investigated for combinational cancer treatment. The intrinsic characteristics of living yeasts, in both acidophilic and anaerobic conditions, empower the hybrid platform with activated selected colonization in tumors. While silicate particles are delivered in a targeting manner, yeast fermentation occurs at the cancerous region, inducing both alcohol and CO2. The excessive content of alcohol causes the hemangiectasis of tumor tissue, facilitating the penetration of therapeutics into central tumors and subsequent endocytosis. The catalytic Mn2+ ions, released from silicate particles, react with CO2 to induce forceful oxidative stress in tumor cells, ablating the primary tumors. More interestingly, the debris of sacrificed tumor cells and yeasts triggers considerable antitumor immune responses, rejecting both rechallenged and metastatic tumors. The integration of biologically active microorganisms and functional materials, illustrated in this study, provides distinctive perspectives in the exploration of potential therapeutics for tackling cancer.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Jinxin Li,Dan Zhong,Zhaoyu Wu,Yiru Chen,Kefei Li,Qinghui Du,Wencheng Ma,Zhaopeng Li,Jingna Zhang,Jun Ma
Double oxygen vacancies (V O ) tuned core–shell La V CuO δ @CeO x (V O -LCO@CeO x ) nanoreactors with direct electron transfer (DET) structure was synthesized as an effective heterogeneous Fenton-like catalyst for the quinoline removal. The DET structure was constructed by electron-rich ≡Cu center of V O -LCO core and electron-capture center of CeO x shell for electrons supplying and consuming. This structure elevated total V O levels of catalyst through the removal of oxygen atoms in CeO 2 from attice to interface sites. Meanwhile, the ≡Ce(III) acted as reactive sites for the adsorption of hydrogen peroxide (H 2 O 2 ) to form surface peroxide species, and then the electron-rich ≡Cu center was further provided electrons to surface peroxide species by DET to produce hydroxyl radical. Moreover, the newly formed surface V O would also be further promote hydroxyl radical production through self-activation of H 2 O 2 . This catalyst displayed excellent catalytic activity and stability. The density functional theory (DFT) results further pointed out that this structure had excellent adsorption energy, and generable electron transfer from V O -LCO to CeO x . This work provided a novel approach for the development of heterogeneous Fenton-like catalysts to degrade quinoline wastewater.
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CELL RESEARCH
·
2023
·
IF 44.1
Ai Yuan-li,Wang Wei-jia,Liu Fan-jian,Fang Wei,Chen Hang-zi,Wu Liu-zheng,Hong Xuehui,Zhu Yuekun,Zhang Ci-xiong,Liu Long-yu,Hong Wen-bin,Zhou Bo,Chen Qi-tao,Wu Qiao
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear. Here, we demonstrate that mannose, a hexose, inhibits GSDME-mediated pyroptosis by activating AMP-activated protein kinase (AMPK). Mechanistically, mannose metabolism in the hexosamine biosynthetic pathway increases levels of the metabolite N -acetylglucosamine-6-phosphate (GlcNAc-6P), which binds AMPK to facilitate AMPK phosphorylation by LKB1. Activated AMPK then phosphorylates GSDME at Thr6, which leads to blockade of caspase-3-induced GSDME cleavage, thereby repressing pyroptosis. The regulatory role of AMPK-mediated GSDME phosphorylation was further confirmed in AMPK knockout and GSDME T6E or GSDME T6A knock-in mice. In mouse primary cancer models, mannose administration suppressed pyroptosis in small intestine and kidney to alleviate cisplatin- or oxaliplatin-induced tissue toxicity without impairing antitumor effects. The protective effect of mannose was also verified in a small group of patients with gastrointestinal cancer who received normal chemotherapy. Our study reveals a novel mechanism whereby mannose antagonizes GSDME-mediated pyroptosis through GlcNAc-6P-mediated activation of AMPK, and suggests the utility of mannose supplementation in alleviating chemotherapy-induced side effects in clinic applications.
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Food Bioscience
·
2023
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IF 5.2
Shijin Xiong,Dandan Qiu,Xiaoyan Xu,Tonghao Du,Zhen Peng,Muyan Xiao,Tao Huang,Jinqing Huang,Hongbing Ren,Mingyong Xie,Tao Xiong
Laotan Suancai is a well-known Chinese traditional fermented vegetable with a unique flavor. However, there are significant differences in the quality of Laotan Suancai pickled by jars (LTSC-J) and pools (LTSC-P) on an industrial scale. To reveal the effect of fermentation craft on Laotan Suancai quality, the microbial community, flavor metabolites, and physicochemical properties of the two types of Laotan Suancai, as well as their interrelationship were investigated. LTSC-P had higher salinity, glucose content, and histidine content, while LTSC-J had higher TA, lactic acid content, and isobutyric acid content. Nine differential aroma-active compounds were found between the two types of Laotan Suancai: anethole , eucalyptol, diallyl sulfide, estragole, diallyl disulfide , eugenol, linalool, nonanal , and ethyl butyrate. LTSC-P showed a higher relative abundance of Weissella , Acinetobacter , Pseudomonas , Allorhizobium-Neorhizobium-Pararhizobium-Rhizobium , Inhella , and Leuconostoc compared to LTSC-J. Co-occurrence analysis indicated the distinct differences in the co-occurrence patterns of the microbial network across the two types of Laotan Suancai. RDA analysis indicated that glucose, salinity, TA, maltose , and nitrite were the main drivers for the differences in bacterial communities between the two types of Laotan Suancai. Spearman correlation analysis revealed strong correlations between 18 bacteria and 61 flavor compounds. Finally, bacterial metabolic function prediction indicated that sulfide and aromatic ester may be biosynthesized by sulfur metabolism , cysteine and methionine metabolism, pyruvate metabolism, and butanoate metabolism. Overall, these findings provide important guidance for improving the manufacturing and quality of Laotan Suancai.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 7
·1-8
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IF 5.7
Huang Yan,Sun Xuyuan,Yang Jing,Cao Zhiyuan,Wang Rujie,Li Li,Ding Yaping
A molecularly imprinted electrochemical sensor was designed for the selective determination of gatifloxacin (GTX) based on dual functional monomers. Multi-walled carbon nanotube (MWCNT) enhanced the current intensity and zeolitic imidazolate framework 8 (ZIF8) provided a large surface area to produce more imprinted cavities. In the electropolymerization of molecularly imprinted polymer (MIP), p-aminobenzoic acid (p-ABA) and nicotinamide (NA) were used as dual functional monomers, and GTX was the template molecule. Taking [Fe(CN) 6 ] 3−/4− as an electrochemical probe, an oxidation peak on the glassy carbon electrode was located at about 0.16 V (vs. saturated calomel electrode). Due to the diverse interactions among p-ABA, NA, and GTX, the MIP-dual sensor exhibited higher specificity towards GTX than MIP-p-ABA and MIP-NA sensors. The sensor had a wide linear range from 1.00 × 10 −14 to 1.00 × 10 −7 M with a low detection limit of 2.61 × 10 −15 M. Satisfactory recovery between 96.5 and 105% with relative standard deviation from 2.4 to 3.7% in real water samples evidenced the potential of the method in antibiotic contaminant determination. Graphical abstract
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Di Zhang,Guoyu Cao,Nitong Bu,Liying Huang,Huanglong Lin,Ruojun Mu,Jie Pang,Lin Wang
In this work, a multifunctional bilayer film was prepared by solvent casting method. Elderberry anthocyanins (EA) were incorporated into konjac glucomannan (KGM) film as the inner indicator layer (KEA). β-cyclodextrin (β-CD) loaded with oregano essential oil (OEO) inclusion complexes (β [email protected] ) was prepared and incorporated into chitosan (CS) film as the outer hydrophobic and antibacterial layer (CS-β [email protected] ). The impacts of β [email protected] on the morphological, mechanical, thermal, water vapor permeability and water resistance properties, pH sensitivity, antioxidant, and antibacterial activities of bilayer films were thoroughly evaluated. The incorporation of β [email protected] into bilayer films can significantly improve the mechanical properties (tensile strength (TS): 65.71 MPa and elongation at break (EB): 16.81 %), thermal stability, and water resistance (Water contact angle (WCA): 88.15°, water vapor permeability (WVP): 3.53 g mm/m 2 day kPa). In addition, the KEA/CS-β [email protected] bilayer films showed color variations in acid-base environments, which could be used as pH-responsive indicators. The KEA/CS-β [email protected] bilayer films also presented controlled release of OEO, good antioxidant, and antimicrobial activity, which exhibited good potential for the preservation of cheese. To sum up, KEA/CS-β [email protected] bilayer films have potential applications in the field of food packaging industry.
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CARCINOGENESIS
·
2023
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IF 4.7
Han Sijia,Jin Xueying,Hu Tianyu,Chi Feng
Downregulation of ARHGAP25 was found in the tumor samples from breast cancer patients and five breast cancer cell lines. However, its precise role and molecular mechanisms in breast cancer remain completely unknown. Herein, we found that knockdown of ARHGAP25 in breast cancer cells promoted proliferation, migration and invasion of breast cancer cells. Mechanistically, ARHGAP25 silence facilitated the activation of the Wnt/β-catenin pathway and the upregulation of its downstream molecules (including c-Myc, Cyclin D1, PCNA, MMP2, MMP9, Snail, and ASCL2) by directly regulating Rac1/PAK1 in breast cancer cells. In vivo xenograft experiments indicated ARHGAP25 silence promoted tumor growth and activated the Wnt/β-catenin pathway. In contrast, overexpression of ARHGAP25 in vitro and in vivo impeded all of the above cancer properties. Intriguingly, ASCL2, a downstream target of the Wnt/β-catenin pathway, transcriptionally repressed the expression of ARHGAP25 and therefore constituted a negative feedback loop. Moreover, bioinformatics analysis indicated that ARHGAP25 is significantly correlated with tumor immune cell infiltration and the survival of patients with different immune cell subgroups in breast cancer. Collectively, our work revealed that ARHGAP25 suppressed tumor progression of breast cancer. It provides a novel insight for the treatment of breast cancer.
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Particuology
·
2023
·
IF 3.5
Zhuoran Deng,Liqiang Zhao,Daojian Cheng
Pt catalysts are commonly used for chemical reaction processes due to its high catalytic activity and selectivity. Notably, the size of metal particles often has a significant impact on the performance of the metal-loaded catalysts. Therefore, developing highly efficiently synthesis method for the size control of Pt catalysts has great development prospects and research value. In this study, high-throughput size tuning of Pt-based catalysts was achieved by carbonizing the carriers. The experimental and characterization results showed that the size of the loaded Pt nanoparticles varied with different concentrations of glucose solution during carriers carbonization process. The reduction of 4-nitrophenol as a template reaction indicated that the reaction rate constant of the catalyst is approximately linear with the size of Pt particles. Importantly, a laboratory-built high-throughput synthesis system was applied for the catalyst synthesis, which enhances the automation of the laboratory exploratory experiments and makes it possible to synthesize catalysts with controllable size in batches.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2023
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IF 6.1
Tong Sun,Yan Liu,Ke Wang,Feiyu Duan,Lili Lu
Herein, tyrosol [2-(4-hydroxyphenyl) ethanol], which is rich in olive oil and red wine, was converted to a novel bioactive galactoside by enzymic glycosylation. The gene of α-galactosidase from Geobacillus stearothermophilus 23 was cloned and expressed in Escherichia coli as catalytically active inclusion bodies. The catalytically active inclusion bodies efficiently catalyzed the galactosylation of tyrosol using either melibiose or raffinose family oligosaccharides as glycosyl donors, resulting in a glycoside with 42.2 or 14.2% yields. The glycoside product was purified and identified as p-hydroxyphenethyl α-d-galactopyranoside by mass spectrometry and NMR analyses. The inclusion bodies can be recycled and reused for at least 10 batch reactions of galactoside synthesis. Moreover, the galactoside showed 11-fold increased water solubility and reduced cytotoxicity as compared to tyrosol. Also, it exhibited higher antioxidative and anti-inflammatory activities than tyrosol based on lipopolysaccharide-induced activated BV2 cells. These results provided important insights into the application of tyrosol derivatives in functional foods.
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ACS Applied Polymer Materials
·
2023
·
IF 5
Jinjin Li,Ruyue Liu,Bingyan Zhang,Feifei Bai,Ling Zhao,Zhenhao Xi
In this work, a multimodal (chemotherapeutic/photodynamic/photothermal) theranostic nanodrug delivery platform was developed based on the synergetic action of self-framed polyphosphazene prodrug and heptamethine cyanine dye IR-780. First, an electronegative glutathione (GSH)-responsive polyphosphazene prodrug abbreviated as HGEH was prepared via multicomponent condensation reaction of genistein (GEN), bis-(4-hydroxyphenyl)-disulfide, and hexachlorocyclotriphosphazene. The particle size of drug (GEN)-containing HGEH nanoparticles is adjustable. Subsequently, cationic near-infrared photosensitizer IR-780 was adsorbed onto the electron-rich HGEH to obtain the multimodal theranostic nanodrug delivery platform HGEH-IR780. The platform was demonstrated to retain high stability in avoiding drug leakage and enable controlled drug release in response to the tumor microenvironment, in which a higher GSH concentration exists. The in vitro experiments show that HGEH-IR780 undergoes photothermal and photodynamic processes to concurrently generate heat and reactive oxygen species for efficiently killing mouse breast cancer cells (4T1) upon exposure to a single-bandwidth near-infrared laser (808 nm). Specifically, HGEH-IR780 inhibits 4T1 cells by up to 80% at a concentration of 100 μg/mL. The as-developed HGEH-IR780 exhibits promising results in GSH-responsive anticancer activity and photodynamic/photothermal therapy, which provides a reference for the construction of the polyphenol flavonoid multimodal therapeutic nanoplatform.
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