LANGMUIR
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2026
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IF 4.4
Lu Yang,Linting Jiang,Yuxin Peng,Xianli Yi,Bin Gu,Hongru Li,Xiaozhuan Qin,Fang Gao
This study investigates the use of trace nitrogen-doped carbon dots (N-CDs) that are synthesized by low-cost natural molecules of citric acid and β-alanine as an additive in the ZnSO4 electrolyte for augmenting the zinc anode in aqueous zinc-ion batteries. A variety of experimental results demonstrate that an inclusion of N-CDs could facilitate the desolvation of zinc ions through coordination interactions, thereby regulating zinc-ion nucleation, improving uniform deposition of zinc ions, and inhibiting hydrogen precipitation on the zinc electrode surface. Various in situ and ex situ measurements of interfacial and surface engineering suggest that the N-CDs additive in the electrolyte could show intense affinity with zinc ions and form a self-assembled adsorption film on the zinc electrode film, thus inhibiting zinc anode corrosion and effectively suppressing side reactions. It is shown that zinc dendrite growth during the zinc-ion plating/stripping process during cycling of zinc-ion batteries could be prevented by the added N-CDs, thereby boosting the long reversible stability of the zinc anode. Hence, the notable improvement of the cycling performance of zinc-ion batteries could be achieved by an introduction of N-CDs in the electrolyte. This study provides deep insights into the use of low-cost and eco-friendly N-doped carbon quantum dots in aqueous zinc metal batteries, displaying great promise for practical applications.
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Research in Comparative and International Education
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2020
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IF 0
Phan Le Ha,Azmi Mohamad
This article, through autoethnographic narrative and reflection, in-depth interviews, and focus group discussions, explores how the transnational academic mobility experiences of a Muslim scholar of Islam based in Brunei may influence his identity, research, and teaching. It pinpoints how transnational academic mobilities could (re)produce, sustain and endorse East/West, local/global, and religious/secular dichotomies and binary thinking. Likewise, it shows that transnational academic mobilities often generate ambiguous and divided spaces concerning knowledge production, pedagogy, and identity formation. The article also maintains that contextualizing and engaging (with) the specificity and particularity of place and academic discipline are pivotal in studying transnational academic mobilities. Methodologically, it highlights the role of autoethnographic reflection in bringing out complex experiences and accounts that academics undergo but rarely acknowledge and conceptualize in scholarly work. Such accounts and experiences serve as reminders of the importance of humility, trust, ethics, and reflexivity in academia. Transnational academic mobilities, after all, must not be privileged.
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WATER SCIENCE AND TECHNOLOGY
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2017
·Vol. 75
·期 6
·1474-1484
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IF 1.197
Liu Jiang,Lu Jianjiang,Tong Yanbin,Li Chao
Fourteen antibiotics, including five quinolones (QNs), five sulfonamides (SAs), and four tetracyclines (TCs), were selected to investigate their occurrence and elimination in three sewage treatment plants (STPs) by employing different treatment technologies in Urumqi (two STPs) and Shihezi (one STP), China. The STP in Shihezi was chosen as representative to investigate the distribution of antibiotics in a sludge-sewage system. Results showed that the concentrations of most detected antibiotics ranged from tens to hundreds of nanograms per liter in influent samples and under 100 ng L −1 in effluent samples. QNs and TCs were dominant species with concentrations of 2.33 mg kg −1 to 3.34 mg kg −1 and 0.36 mg kg −1 to 0.47 mg kg −1 in sludge samples, respectively. The elimination rates of target antibiotics by various STPs ranged from 17% to 100%. The STP with anaerobic/anoxic/aerobic and membrane bio-reactor technology removed antibiotics more efficiently than those with anaerobic/anoxic/oxic and oxidation ditch technology. The elimination capacities of treatment units from the three STPs were also investigated. SAs were mainly degraded in biological treatment units; conversely, QNs and TCs were significantly eliminated in sedimentary treatment units. Ozonation effectively removed remaining antibiotics but not UV and chlorination disinfection in this study.
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
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2019
·Vol. 107
·期 10
·2123-2134
·
IF 3.221
Dan He,An-Sha Zhao,Hong Su,Yan Zhang,Ya-Nan Wang,Dan Luo,Yuan Gao,Jing-An Li,Ping Yang
Controlled release of functional factors contributes to target migration of therapeutic cells and plays a crucial role in the in situ vascularization of tissue repair and regeneration. A biomedical application requires the selective release of multiple factors which will guide the synergy of the cells. Here, we developed an injectable system based on a temperature-responsive hydrogel and stromal cell-derived factor-1 (SDF-1)/vascular endothelial growth factor (VEGF) loaded into two types of nanoparticles to induce migration and rapid proliferation of mesenchymal stem cells (MSCs) and endothelial cells (ECs) via selective SDF-1/VEGF release. Series of in vitro and in vivo experiments demonstrate that our composited system can accurately guide MSCs and ECs for vascularization. In addition, the properties of the nanoparticles and hydrogel, including micro/nanoscales, characteristic of charge, and biocompatibility, played crucial roles for the selective release and cells behavior (target migration and rapid proliferation).
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ENERGY
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2022
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IF 8.857
Xingxun Li,Rucheng Wei,Qingping Li,Weixin Pang,Guangjin Chen,Changyu Sun
Natural gas hydrate is a green energy with great development prospects. The exploitation of natural gas hydrate has been attracting much attention. The temperature field distribution of hydrate-bearing sediment is a crucial indication on the heat or mass transfer characteristics and thermal properties of hydrate-bearing sediment during hydrate exploitation. However, to date, the acquisition means of temperatures of hydrate-bearing sediment have been limited to the discrete temperature measurement by using the contact-type temperature sensors inserted into hydrate sediment. The continuous evolution of temperature field of hydrate-bearing sediment can be hardly achieved. Thus, in this study, a new method applying the non-contact and non-destructive infrared thermal imager was developed and applied in the in-situ measurement of the continuous evolution of temperature field of hydrate-bearing sediment. The results confirm the feasibility of application of the infrared thermal imaging technique in the hydrate-related research. The complete continuous temperature fields of hydrate-bearing sediment and non-hydrate-bearing sediment under thermal stimulation were imaged and compared. The results indicate that the temperature field distribution of hydrate sediment is predominately controlled by the effective thermal conductivity of hydrate-bearing sediment. In addition, the effects of the type of hydrate-bearing sediment, heating power and particle size of sediment were investigated.
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Scientific Reports
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2026
·
IF 4.9
Niu Jiale,Liu Guangxia,He Guangyao,Zhang Xiaomeng,Bai Huihui,Lu Yamin
To investigate the role of IL-17 in macrophage M1 polarization within a type 2 diabetic (T2DM) milieu and to evaluate the therapeutic potential of its neutralizing antibody. PMA-differentiated THP-1 macrophages were polarized to M1 state. Under high glucose, cells were treated with IL-17 and an IL-17 neutralizing antibody. Inflammatory cytokines (IL-1β, IL-6, TNF-α) were measured; mRNA levels of TNF-α, HIF-1α, and NLRP3 were assessed by qPCR; and protein expression related to the NF-κB, mTOR/HIF-1α axis and pyroptosis (NLRP3, Caspase-1, GSDMD) was analyzed by Western Blot. High glucose and IL-17 synergistically promoted M1 polarization, enhancing proinflammatory cytokine secretion. This was associated with activation of the NF-κB, mTOR/HIF-1α signaling axis and induction of pyroptosis, evidenced by NLRP3 inflammasome assembly, Caspase-1 activation, and GSDMD cleavage. The IL-17 neutralizing antibody effectively suppressed these pathological processes. IL-17 acts as a key immunological amplifier in diabetes, driving M1 polarization, oxidative stress, and pyroptosis via the NF-κB, mTOR/HIF-1α axis and NLRP3 inflammasome. Treatment with an αIL-17 effectively reversed the aberrant activation of the aforementioned cellular phenotypes and signaling pathways, partially restoring macrophage functional balance. This finding provides preliminary experimental support for further exploration of IL-17-targeted immunomodulatory strategies to ameliorate diabetes-associated metabolic inflammation.
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FOOD RESEARCH INTERNATIONAL
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2022
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IF 7.425
Qingqing Yu,Tong Shi,Zhiyu Xiong,Li Yuan,Hui Hong,Ruichang Gao,Yulong Bao
In order to study the effect of oxidation on the dye-binding behavior of myofibrillar proteins, selected dyes with different charges (positively charged Sarfarin O (SO), neutral bromophenol blue (BPB), and negatively charged Orange G (OG)) were incubated with myofibrils oxidized by the Fenton system with H 2 O 2 (10 mM). Upon oxidation, loss of free thiols, formation of carbonyls, particle size, and hydrophobicity of myofibrillar proteins (MPs) increased. The absolute value of Zeta-potential increased by 14.48 % after oxidation, the myofibrillar proteins shifted to a more acidic isoelectric point (pI) upon oxidation. Oxidation decreased net positive charges of myofibrillar protein and the binding ability of MPs towards OG in the environment with pH less than pI and the affinity of MPs towards SO in the environment with pH more than pI were thus increased. Here we propose a hypothesis that oxidation-induced change in net charges is the driving force affecting the amount of protein-bound dye. This paper aims to examine the effect of oxidation on the net charges of myofibrillar proteins and to provide insight into the mechanism of oxidation-induced changes in protein-bound dyes.
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Frontiers in Microbiology
·
2022
·
IF 6.064
Hu Xuemei,Chen Xiaoyong,Tang Yao,Xu Zhenggang,Zeng Yelin,Wang Yonghong,Zhao Yunlin,Wu Yaohui,Wang Guangjun
Photocatalysis, as a novel technique, has been widely used for antibiotic pollution remediation in wastewater. In the processes of degradation and removal of antibiotics, the impact of photocatalysts on microenvironment is very important but remains poorly understood. In the present study, the effect of typical photocatalyst g-C3N4 (Graphitic carbon nitride) on microbial community was investigated in two sediment types (riverbed sediment and pig-farm sediment) polluted by tetracycline (TC) in central southern China. The riverbed sediment and pig farm sediment samples were respectively exposed to g-C3N4 (25, 75, 125 mg⋅kg–1) and TC (60, 120, 180 mg⋅L–1) treatments alone or combination for 30 days, respectively. The bacterial community and antibiotic resistance genes (ARGs) of the treated sediments were analyzed by Illumina sequencing and metagenomic sequencing. Studies had shown that: TC, g-C3N4, and TC/g-C3N4 have significant effects on the changes of microbial communities and components in riverbed sediment, but they do not exist in pig farm sediment. The most alterations of microbial taxa were Acidobacteriota, Actinobacteriota, and Desulfobacterota in riverbed sediment, and Elusimicrobiota in the pig farm sediment under various treatments. Through network analysis, it was found that the distribution of microorganisms in the pig farm sediment is more complex and more stable. The addition of g-C3N4 reduced the absolute abundance of ARGs in the two examined sediments, but not significantly changed their relative abundance of ARGs. The g-C3N4 application was beneficial to the removal of TC residues and to the prevention of the generation and transmission of ARGs in sediments. Our results suggested that g-C3N4 was a suitable photocatalyst with excellent application prospect for the removal of TC residues and the control of ARGs in environment.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2023
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IF 6.1
Hong Lin,Jianbin Tan,Jing Wang,Chengliang Xie,Bifeng Chen,Mansi Luo,Yun Liu,Wenzhen Liao,Weiling Huang,Hongxia Wang,Ying Jiang,Kexin Wang,Ciyong Lu,Min Zhao
The widespread use of titanium dioxide nanoparticles (TiO2 NPs) in the food industry has brought about human safety risks related to nanotoxicity. In this study, food-related TiO2 NPs (anatase, 40 nm) were given to rats by oral gavage for 90 days at doses of 10, 100, and 1000 mg/kg bw. An additional two satellite groups underwent the same protocol for 45 days and for 90 days followed by a 28 day recovery. TiO2 NPs tended to agglomerate together in H2O, AGJ, and AIJ. No systemic toxicity was observed after 90 day agglomerated TiO2 NP exposure with no Ti distribution in major tissues/organs. Furthermore, TiO2 NP consumption for 90 days had no impact on microbiota diversity; the community structure of the gut microbiota is shifted to some extent at the genus level. Collectively, the NOAEL of agglomerated TiO2 NPs for 90 days of oral administration was 1000 mg/kg bw, the highest dose tested in male and female rats.
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Frontiers in Bioengineering and Biotechnology
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2023
·
IF 5.7
Xiao Fei,Shi Jingjing,Zhang Xinhai,Hu Min,Chen Kangming,Shen Chao,Chen Xiaodong,Guo Yaping,Li Yang
Reducing the incidence of bone defects caused by trauma and other primary diseases is an urgent task in modern society. In the present study, we developed a gadolinium-doped whitlockite/chitosan (Gd-WH/CS) scaffold and assessed its biocompatibility, osteoinductivity, and bone regeneration capacity for the treatment of calvarial defect in a Sprague-Dawley (SD) rat model. The Gd-WH/CS scaffolds possessed a macroporous structure, with a pore size ranging 200–300 μm, which facilitated the growth of bone precursor cells and tissues into scaffold. Results of cytological and histological biosafety experiments showed that both WH/CS and Gd-WH/CS scaffolds were non-cytotoxic to human adipose-derived stromal cells (hADSCs) and bone tissue, which demonstrated the excellent biocompatibility of Gd-WH/CS scaffolds. Results of western blotting and real-time PCR analysis provided a possible mechanism that Gd3+ ions in the Gd-WH/CS scaffolds promoted the osteogenic differentiation of hADSCs through the GSK3β/β-catenin signaling pathway and significantly upregulated the expression of osteogenic related genes (OCN, OSX and COL1A1). Finally, in animal experiments, SD rat cranial defects were effectively treated and repaired with Gd-WH/CS scaffolds due to its appropriate degradation rate and excellent osteogenic activity. This study suggests the potential utility of the Gd-WH/CS composite scaffolds in treating bone defect disease.
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Materials Today Communications
·
2023
·
IF 3.8
Shi Qiu,Fengdong Sun,Chen You,Chaokun Tang,Baoli Zhou,Shuquan Zhang,Jiangtao Feng,Aixian Tian,Minfang Chen
Through preparing the porous Zn-0.8Li scaffolds with 50–70 % porosity by using NaCl particles as pore-forming agents in the range of 150–350 µm and 350–550 µm with the infiltration casting method, the present study investigated the pore structure , mechanical properties and weight loss in simulated body fluids (SBF), and conducted the cellular activity and in vivo degradation experiments on porous Zn-0.8Li scaffolds before and after chitosan coating treatment. The results showed that the porous samples with small pore size had higher mechanical properties and lower degradation rate. However, with relatively higher average porosity and through-porosity, the porous samples with large pore size showed better pore connectivity, which provided channels for nutrient transport and promoted the lateral growth of internal tissues. In terms of cell experiments, chitosan coated Zn-0.8Li scaffolds with large pore size had better cell activity and adhesion. Since the coating of chitosan inhibited the release of Zn 2+ during the implantation of porous Zn-0.8Li scaffolds in vivo, it effectively promoted the growth of new bone tissue around the porous scaffolds, which provided an ideal microenvironment for the adhesion, proliferation and differentiation of MSCS. The results of this study demonstrated the great potential of chitosan coated porous biodegradable Zn-based scaffolds for bone tissue engineering.
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International Journal of Nanomedicine
·
2023
·
IF 8
Yanan Dong,Rongzhan Fu,Jing Yang,Pei Ma,Lihua Liang,Yu Mi,Daidi Fan
Background and purpose Ginsenoside Rg5 (Rg5), a triterpene saponin, extracted from the natural herbal plant ginseng, is one of the most potent anticancer drugs against various carcinoma cells. However, the therapeutic potential of Rg5 is limited by its low solubility in water, poor bioavailability, and nontargeted delivery. Therefore, we prepared folic acid (FA)-modified bovine serum albumin (BSA) nanoparticles (FA-Rg5-BSA NPs) to improve the therapeutic efficacy and tumor targetability of Rg5.Methods Various aspects of the FA-Rg5-BSA NPs were characterized, including size, polydispersity, zeta potential, morphology, entrapment efficiency (EE), drug loading (DL), in vitro drug release, thermal stability, in vitro cytotoxicity, cell apoptosis, cellular uptake, in vivo antitumor effects and in vivo biodistribution imaging.Results The FA-Rg5-BSA NPs showed a particle size of 201.4 nm with a polydispersity index of 0.081, uniform spherical shape, and drug loading of 12.64±4.02%. The aqueous solution of FA-Rg5-BSA NPs had favorable stability for 8 weeks at 4°C. The FA-Rg5-BSA NPs dissolved under acidic conditions. Moreover, the Rg5-BSA NPs and FA-Rg5-BSA NPs had advanced anticancer activity compared with Rg5 in MCF-7 cells, while poor cytotoxicity was observed in L929 cells. The FA-Rg5-BSA NPs facilitated cellular uptake and induced apoptosis in MCF-7 cells. In addition, in an MCF-7 xenograft mouse model, the in vivo antitumor evaluation revealed that FA-Rg5-BSA NPs were more effective in inhibiting tumor growth than Rg5 and Rg5-BSA NPs. The in vivo real-time bioimaging study showed that the FA-Rg5-BSA NPs exhibited superior tumor accumulation ability.Conclusion The results suggested that FA-Rg5-BSA NPs could serve as a promising system to improve the antitumor effect of Rg5.
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