Nano Research
·
2021
·Vol. 14
·期 11
·4264-4273
·
IF 8.897
Chen Zhongyin,Liao Tao,Wan Lihui,Kuang Ying,Liu Chang,Duan Junlin,Xu Xiangyu,Xu Ziqiang,Jiang Bingbing,Li Cao
Due to better penetrating abilities of near-infrared (NIR) light and lower autofluorescence of biological tissue at NIR region, the combination of NIR fluorescent imaging with therapeutic abilities has gradually emerged as a promising strategy for cancer therapy. Herein, tumor microenvironment (TME) sensitive nanocarriers based on doxorubicin hydrochloride (DOX), NIR emitting carbon dots (C-dots), hollow mesoporous silica nanoparticles (HMSN) and anionic polymer citraconic anhydride-modified polylysine (PLL(cit)) are fabricated for imaging guided drug delivery. The NIR emitting C-dots were conjugated onto the surface of HMSN via disulfide bonds which can be reduced by intracellular glutathione (GSH) and result in the release of DOX into cells. And then the PLL(cit) was grafted on the surface of the nanocarriers to endow the nanocarriers with charge convertible property in mildly acidic TME (pH = 6.50) which results in prolonged blood circulation time and enhanced cellular internalization. The in vitro and in vivo experiments confirmed that the dual pH/GSH responsive features of nanocarriers can eliminate the tumor tissues effectively and elicit much slighter side effects. Moreover, since the fluorescence of C-dots can be recovered after the reduction of disulfide bonds and selectively accumulation of nanocarriers around tumor tissue, the DOX@HMSN-SS-C-dots-PLL(cit) can be served as a promising NIR fluorescence probe for targeted imaging of tumor tissue. As a kind of multifunctional nanocarrier with NIR fluorescent imaging and therapeutic functions, the theranostic nanocarriers hold great potential for tumor therapy and in vivo imaging of tumor tissue.
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IRANIAN POLYMER JOURNAL
·
2021
·Vol. 30
·期 10
·1041-1052
·
IF 1.899
Cheng Zenghui,Wang Chunpeng,Yu Juan,Liu Meihong,Wang Jifu,Zhang Daihui,Chu Fuxiang
Abstract The utilization of rosin to fabricate functional polymers has attracted great attention due to its unique structure and property. Herein, we prepared a new type of carboxyl-containing cross-linked rosin microspheres (CCRMs) using a renewable-resource rosin as the raw material through the suspension polymerization. For comparative purpose, vanillin methacrylate (VMA), styrene (St) and isobornyl methacrylate (IBOMA) were separately used to replace DAGMA as monomer for the preparation of microspheres. Our results indicated that the obtained porous CCRMs showed a broad size distribution ranging from mesopores (3–50 nm) to macropores (> 50 nm), whereas the counterparts derived from VMA, St or IBOMA showed a powder state. Moreover, the CCRMs exhibited moderately high thermal stability. The integration of DAGMA into polymer microspheres provided CCRMs with excellent adsorption ability, which exhibited robust selective cationic dye (e.g., methylene blue (MB) and crystal violet (CV)) adsorption from waste aqueous solution. The adsorption process was fitted well with the Langmuir isotherm and the pseudo-second-order kinetic model. The maximum adsorption capacity was observed to be 602.4 mg/g for CV at 40 °C, and 512.8 mg/g for MB at 20 °C. In general, the high dye adsorption properties suggest that CCRMs may be highly efficient in adsorption selectivity for some cationic dyes. Graphic abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 28
·期 47
·67310-67320
·
IF 4.223
Liu Yanan,Zhou Quan,Li Zhenyu,Zhang Ai,Zhan Jiaxun,Miruka Andere Clement,Gao Xiaoting,Wang Jie
Glucocorticoids (GCs) have drawn great concern due to widespread contamination in the environment and application in treating COVID-19. Most studies on GC removal mainly focused on aquatic environment, while GC behaviors in soil were less mentioned. In this study, degradation of three selected GCs in soil has been investigated using citric acid (CA)–modified Fenton-like processes (H 2 O 2 /Fe(III)/CA and CaO 2 /Fe(III)/CA treatments). The results showed that GCs in soil can be removed by modified Fenton-like processes (removal efficiency gt; 70% for 24 h). CaO 2 /Fe(III)/CA was more efficient than H 2 O 2 /Fe(III)/CA at low oxidant dosage (< 0.28–0.69 mmol/g) for long treatment time (> 4 h). Besides the chemical assessment with GC removal, effects of Fenton-like processes were also evaluated by biological assessments with bacteria and plants. CaO 2 /Fe(III)/CA was less harmful to the richness and diversity of microorganisms in soil compared to H 2 O 2 /Fe(III)/CA. Weaker phytotoxic effects were observed on GC-contaminated soil treated by CaO 2 /Fe(III)/CA than H 2 O 2 /Fe(III)/CA. This study, therefore, recommends CaO 2 -based treatments to remediate GC-contaminated soils. Graphical abstract
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2021
·Vol. 39
·期 11
·1403-1411
·
IF 3.603
Cao Bo-Han,Chen Wu,Wei Wan-Yuan,Chen Yu-Lan,Yuan Yuan
1,2-Dioxetane is a well-known chemiluminescent mechanophore allowing real-time monitoring of polymer chain scission, but usually suffers from fluorescence quenching in polar environments. Herein, a series of mechanochemiluminescent waterborne polyurethanes/carbon dots composites ( WPU-CDs ) have been synthesized by incorporating fluorescent CD s to promote the energy transfer process in different environments. The resulting bulk WPU s, and in particular, their swollen films filled with a large amount of polar solvents (water and ionic liquid) emit intense mechanochemiluminescence. Thus force-induced covalent bond scission and stress distribution within these different WPU-CDs films can be sensitively visualized. Furthermore, the ionic liquid containing films exhibited both electrical and luminescent signal changes under stretching, which offer a new kind of force sensor responsive at a broad detecting strain range and for multi-mode strain analysis. This study is expected to stimulate new research endeavors in mechanistic insight on waterborne polyurethanes and the corresponding stretchable sensing devices.
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Scientific Reports
·
2021
·Vol. 11
·期 1
·1-10
·
IF 4.38
Gong Dian,Zeng Gaofeng
Transition metal oxides are the potential catalysts to replace noble-metal based catalyst for the catalytic combustion of methane due to the tolerable reactivity and low cost. However, these catalysts are challenged by the low temperature reactivity. Herein, the surface defective Co 3 O 4 nanoplates are realized through a facile co-precipitation and thermal reduction method with the association of GO. The resultant catalysts (CoGO50) demonstrate a superior low-temperature reactivity for the methane oxidation to CO 2 and H 2 O in comparison with the common Co 3 O 4 catalyst. The reliable stability of CoGO50 catalyst was proved by 80 h testing with intermittent feeding of water vapor. The experimental analysis demonstrates that the presence of a small amount of GO significantly affects the catalysts in surface valence state, active oxygen species and surface oxygen vacancies through reacting with the cobalt oxide as a reductant. Moreover, GO plays as 2D confine template to form smaller and thinner nanoplates. This work provides a facile method to control the surface properties of catalyst not only for Co 3 O 4 based catalysts but also for wider solid catalysts.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2021
·Vol. 39
·期 8
·966-974
·
IF 3.603
Feng Li-Dong,Bian Xin-Chao,Li Gao,Chen Xue-Si
The effect of exogenous hydroxyl, carboxyl groups and/or Sn 2+ on pyrolysis reactions of poly(L-lactide) (PLLA) was investigated by thermogravimetric analysis (TGA). The activation energy ( E a ) of pyrolysis reactions was estimated by the Kissinger-Akahira-Sunose method. The kinetic models were also explored by the Malek method, and the random degradation behavior was determined by comparing the plots of In{-In[1 - (1 - w ) 0.5 ]} versus 1/ T for experimental data from TGA with model reactions. The pyrolysis reaction rate of PLLA was affected slightly by exogenous hydroxyl and carboxyl groups at lower levels of Sn with 65–70 mg·kg -1 but increased appreciably in the presence of extraneous Sn 2+ , -COOH/Sn 2+ , or -OH/Sn 2+ . The E a values for the pyrolysis reactions of the PLLAs that provided lactide were different under the catalysis of Sn 2+ in different chemical environments because Sn 2+ can form the new Sn-carboxylate and Sn-alkoxide with exogenous carboxyl and hydroxyl groups, which were different in steric hindrance for the formation of activated complex between Sn 2+ and PLLA. Under the catalysis of Sn 2+ , a lactide molecule can be directly eliminated selectively at a random position of PLLA molecular chains, and the molecular chain of PLLA cannot change two PLLA fragments at the elimination site of lactide. However, it was regenerated into a new PLLA molecule with the molecular weight reduced by 144 g·mol -1 .
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Nature Communications
·
2021
·Vol. 12
·期 1
·1-10
·
IF 14.919
Liu Chang,Kang Jincan,Huang Zheng-Qing,Song Yong-Hong,Xiao Yong-Shan,Song Jian,He Jia-Xin,Chang Chun-Ran,Ge Han-Qing,Wang Ye,Liu Zhao-Tie,Liu Zhong-Wen
The selective hydrogenation of CO 2 to value-added chemicals is attractive but still challenged by the high-performance catalyst. In this work, we report that gallium nitride (GaN) catalyzes the direct hydrogenation of CO 2 to dimethyl ether (DME) with a CO-free selectivity of about 80%. The activity of GaN for the hydrogenation of CO 2 is much higher than that for the hydrogenation of CO although the product distribution is very similar. The steady-state and transient experimental results, spectroscopic studies, and density functional theory calculations rigorously reveal that DME is produced as the primary product via the methyl and formate intermediates, which are formed over different planes of GaN with similar activation energies. This essentially differs from the traditional DME synthesis via the methanol intermediate over a hybrid catalyst. The present work offers a different catalyst capable of the direct hydrogenation of CO 2 to DME and thus enriches the chemistry for CO 2 transformations.
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Nano-Micro Letters
·
2021
·Vol. 13
·期 1
·1-14
·
IF 16.419
Su Die,Pei Yi,Liu Li,Liu Zhixiao,Liu Junfang,Yang Min,Wen Jiaxing,Dai Jing,Deng Huiqiu,Cao Guozhong
The unique wire-in-wire structure endows TiO 2 /C nanofibers film with superior mechanical flexibility.
The wire-in-wire TiO 2 /C nanofibers (TiO 2 ww/CN) film shows outstanding electrochemical performances as free-standing anodes for Li/K-ion batteries and full cells.
The TiO 2 ww/CN film shows an extremely high pseudocapacitance contribution ratio in K-ion batteries.
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BIOPROCESS AND BIOSYSTEMS ENGINEERING
·
2021
·Vol. 44
·期 8
·1781-1792
·
IF 3.21
Jin Li-Qun,Chen Xian-Xiao,Jin Yi-Ting,Shentu Jun-Kang,Liu Zhi-Qiang,Zheng Yu-Guo
To improve the operational stability of glucose isomerase in E. coli TEGI-W139F/V186T, the immobilized cells were prepared with modified diatomite as a carrier and 74.1% activity of free cells was recovered after immobilization. Results showed that the immobilized cells still retained 86.2% of the initial transformational activity after intermittent reused 40 cycles and the yield of D-fructose reached above 42% yield at 60 °C. Moreover, the immobilized cells were employed in the continuous production of High Fructose Corn Syrup (HFCS) in a recirculating packed bed reactor for 603 h at a constant flow rate. It showed that the immobilized cells exhibited good operational stability and the yield of D-fructose retained above 42% within 603 h. The space–time yield of high fructose corn syrup reached 3.84 kg L −1 day −1 . The investigation provided an efficient immobilization method for recombinant cells expressing glucose isomerase with higher stability, and the immobilized cells are a promising biocatalyst for HFCS production.
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CELLULOSE
·
2021
·Vol. 28
·期 8
·5123-5134
·
IF 5.044
Shen Yanqin,Yao Yijun,Wang Zhongliang,Wu Hailiang
A series of hydroxypropylated starch (HPS) that can be dissolved in water at 60–65 °C was obtained via two-step method in water system from corn starch. The structure and property of the HPS and its gelatinization temperature were characterized by Fourier transform infrared spectrometer, nuclear magnetic resonance spectroscopy ( 1 H NMR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and transmission electron microscope (TEM). It was concluded that hydroxypropyl mainly bonded on the hydroxyl group at C 2 position from glucose residue of starch in the form of C–O–C, and the substitution level at C 6 position was slightly higher than that at C 3 position, as well as the crystallinity of starch decreased from 52.41% to 29.4% due to the introduction of hydroxypropyl and was confirmed by XRD. At the same time, the grooves on the surface of starch granules were observed by SEM. The above-mentioned two synergies promoted the permeation and transmission of water molecules in the starch microstructure. Moreover, the gelatinization temperatures and enthalpy of synthetic HPS were lower than those of raw corn starch, as further confirmed by DSC. This caused the HPS with a molar substitution greater than 0.1 to be soluble in water at 65 °C, and its dissolution state was similar to that of HPS at 95 °C (transmittance above 55%), as well as exhibited high slurry stability. Interestingly, compared with the raw starch, the HPS film showed excellent tensile strength and elongation at the relative humidity of 65%, which could be attributed to the hydrophilic ether bond and the flexible alkyl chain bonded on the structure of starch. This study will provide a new way for the preparation of high performance starch size for sizing yarn at medium–low temperature. Graphic abstract
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 5
·1-10
·
IF 5.833
He Hang,Meng Song,Li Haimin,Yang Qingyuan,Xu Ziqiang,Chen Xueqin,Sun Zhengguang,Jiang Bingbing,Li Cao
Mitochondria, as the energy factory of most cells, are not only responsible for the generation of adenosine triphosphoric acid (ATP) but also essential targets for therapy and diagnosis of various diseases, especially cancer. The safe and potential nanoplatform which can deliver various therapeutic agents to cancer cells and mitochondrial targeted imaging is urgently required. Herein, Au nanoparticles (AuNPs), mesoporous silica nanoparticles (MSN), cationic ligand (triphenylphosphine (TPP)), doxorubicin (DOX), and carbon nanodots (CDs) were utilized to fabricate mitochondrial targeting drug delivery system (denoted as CDs(DOX)@MSN-TPP@AuNPs). Since AuNPs, as the gatekeepers, can be etched by intracellular glutathione (GSH) via ligand exchange induced etching process, DOX can be released into cells in a GSH-dependent manner which results in the superior GSH-modulated tumor inhibition activity. Moreover, after etching by GSH, the CDs(DOX)@MSN-TPP@AuNPs can serve as promising fluorescent probe ( λ ex = 633 nm, λ em = 650 nm) for targeted imaging of mitochondria in living cells with near-infrared fluorescence. The induction of apoptosis derived from the membrane depolarization of mitochondria is the primary anti-tumor route of CDs(DOX)@MSN-TPP@AuNPs. As a kind of GSH-responsive mitochondrial targeting nanoplatform, it holds great promising for effective cancer therapy and mitochondrial targeted imaging. Graphical abstract
The mitochondrial targeting drug delivery system was fabricated by AuNPs, MSN, TPP, and CDs. The nanoplatform can realize redox-responsive drug delivery and targeted imaging of mitochondria in living cells to improve the therapeutic efficiency and security.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2021
·Vol. 39
·期 7
·896-905
·
IF 3.603
Feng Pei-Feng,Song Guo-Jun,Zhang Wen-Jian,Zheng Hao,Li Bo-Wen,Zhou Shao-Feng,Liu Ya-Qing,Wu Guang-Shun,Ma Li-Chun
In order to enhance the interfacial adhesion of carbon fiber (CF) and polymer matrix, a multiscale gradient modulus intermediate layer with rigid-flexible (GO-PA) hierarchical structure was designed and fabricated between CFs and matrix by a facile and businesslike strategy. The polarity, roughness and wettability of CFs surface as well as the thickness of intermediate layer in composite have been significantly increased after rigid-flexible hierarchical structure was constructed. The IFSS, ILSS, compression and impact toughness manifested that the hierarchical structure could bring about a fantastic improvement (76.8%, 46.4%, 40.7% and 37.8%) for the interfacial and mechanical properties than other previous reports. Consequently, the establishment of CF surface with gradient modulus rigid-flexible hierarchical structure via regulation of nanoparticles and polymer array would open a new, viable and promising route to obtaining high-performance composites.
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