INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Shaopei Jia,Yanfeng Gao,Xiaofei Ma,Yunfei Cao,Quan Huang,Qian Zhang,Zhixin Wang,Yanjie Wang,Yuanyuan Li,Dan Li,Renkai Chang,Yunchao Mu
Designing and synthesizing highly efficient and stable electrocatalysts of seawater electrolysis for the hydrogen evolution reaction is important for realizing green hydrogen production. Herein, a heterostructured V-doped Co2P anchored on N–P-doped three-dimensional covalently cross-linked graphene (V–Co2P@NPPC/3DG) electrocatalysts was synthesized with the help of V-doped ZIF-67 as an intermediate and a controlled phosphidation process. The as-prepared V–Co2P@NPPC/3DG-1:5 had low overpotentials of 98.3 and 88.3 mV (at 10 mA cm–2) in alkaline water and artificial seawater, respectively, and the corresponding Tafel slopes were 56.4 and 51.0 mV dec–1. The electrolyzer with a flowing alkaline artificial seawater assembled from V–Co2P@NPPC/3DG-1:5 with a commercial RuO2 catalyst exhibited a cell voltage of 1.54 V at 10 mA cm–2, which is close to that of Pt/C||RuO2 (1.52 V). Notably, the cell voltage of V–Co2P@NPPC/3DG-1:5||RuO2 was lower than that of Pt/C||RuO2 at a high current density (>58 mA cm–2), which exhibited superior stability. V doping effectively enhanced the intrinsic activity of Co2P, and the complexation with NPPC/3DG achieved full exposure of the active sites while enhancing the charge transfer rate during HER. This work will attract attention to the role of metal compound-carbon support interactions in enhancing the intrinsic activity, conductivity, and stability of electrocatalysts.
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PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2025
·
IF 4.1
Sumin Xu,Wenjing Liu,Jiajia Zhang,Jianying Qu
In this work, a MOF-on-MOF synthesis strategy was employed to successfully prepare (ZIF-8)-on-(CoCu-MOF) composites, which were further pyrolyzed at high temperature to obtain CoCu-CN nanomaterials. The morphological and structural properties of the materials were systematically investigated using SEM, FTIR, XRD and XPS. A novel sensor of CoCu-CN/GCE was constructed at a glassy carbon (GC) substrate, which exhibited excellent electrocatalytic activity to redox reactions of acetaminophen (PA) and p-aminophenol (4-AP). Under optimal conditions, the CoCu-CN/GCE sensor can be employed to detect simultaneously PA and 4-AP in the wider linear ranges of 0.05–270.00 μM and 0.05–170.00 μM, respectively with the lower detection limits of 0.020 μM and 0.019 μM respectively. Practical sample analysis for pharmaceutical and lake water gave satisfactory results. The proposed sensor displays excellent selectivity and stability with potential analytical applications
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高影响因子
TOXICOLOGY
·
2017
·
IF 3.582
Juanli Fu,Xiaomin Xia,Zixuan Liu,Yawen Wang,Yuxin Wang,Qiong Shi,Xiufang Song,Erqun Song,Yang Song
This study is aimed to investigate the inflammation and neurological dysfunction induced by tetrachloro- p -benzoquinone (TCBQ) through Toll-like receptor 4 (TLR4) signaling. We also investigated the protective role of melatonin as an antioxidant and anti-inflammatory agent. In vitro model was established by rat pheochromocytoma PC12 cells, meanwhile, TLR4 wild-type (C57BL/6) and knockout mice (C57BL/10ScNJ TLR4 −/− ) were used as in vivo model. In vitro study showed TCBQ exposure enhanced the expression of TLR4, myeloid differentiation factor 88 (MyD88) at both transcriptional and post-transcriptional levels. By contrast, melatonin decreased TLR4 and MyD88 expressions. Moreover, our result indicated that melatonin disrupted the formation of TLR4/MyD88/MD2/CD14 complex. In addition, melatonin terminated TCBQ-mediated phosphorylation of c-Jun N-terminal kinase (JNK), p38, and extracellular regulated protein kinase (ERK) signaling and hampered its downstream pro-inflammatory cytokine releases. In vivo result also indicated TLR4 deficiency partially protected against TCBQ-induced morphological and neuropathological changes in mice brain, suggested the role of TLR4. In conclusion, melatonin modulates TCBQ-mediated inflammatory genes through TLR4/MyD88-dependent signaling pathway. Our current study, to the best of our knowledge, is the first time show melatonin not only disrupt the binding of TLR4 and MyD88, but also restricted the formation of TLR4/MD2/CD14 complex, suggesting that melatonin supplementary may represent a valuable therapeutic strategy for inflammatory neurological dysfunction.
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PubMed
高影响因子
Journal of Proteomics
·
2014
·
IF 3.929
Feifei Xu,Ting Yang,Danjun Fang,Qingqing Xu,Yun Chen
One missing puzzle piece to study heat shock protein 27 (HSP27) in P-glycoprotein (P-gp) mediated multi-drug resistance (MDR) was the amount of HSP27 and the extent of its phosphorylation in the biological context. Liquid chromatography–tandem mass spectrometry (LC/MS/MS)-based targeted proteomics allows researchers to monitor associated proteins and their modification simultaneously and quantitatively. In this study, a targeted proteomics assay was first developed and validated for the quantification of HSP27 and its phosphorylated forms. Using this assay, the level of HSP27 was determined in non-tumoral cells MCF-10A, parental drug-sensitive cancer cells MCF-7/WT and drug-resistant cancer cells MCF-7/ADR. A decrease of HSP27 expression was observed in P-gp overexpressed MCF-7/ADR cells. A quantitative time-course analysis of both HSP27 and P-gp in doxorubicin (DOX)-treated MCF-7/WT cells also implied that HSP27 may participate in the P-gp modulation. Furthermore, stoichiometry of site-specific HSP27 phosphorylation indicated that DOX treatment rapidly induced the HSP27 phosphorylation at Ser82. Moreover, conventional analytical methods were also performed for a comparison. Biological significance LC/MS/MS-based targeted proteomics turns out to be a promising quantification approach for the study of proteins in the preclinical and clinical environment. Unfortunately, rare studies applied this technology to detect multiple associated proteins or protein modification in one experiment. This study demonstrated the potential of LC/MS/MS-based targeted proteomics to understand the cell events in a more accurate context of biological system. By the quantitative time-course analysis of HSP27 and its phosphorylated forms at sites of Ser15 and Ser82, the possible role of HSP27 in P-gp mediated MDR was suggested. Further development of targeted proteomics in future may provide more insight into signal transduction pathways upon perturbation of a protein network or changes to a panel of proposed biomarkers in a given disease state.
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PubMed
高影响因子
Catalysts
·
2025
·Vol. 15
·期 11
·1077
·
IF 4
Yin Wang,Siqi Xu,Yixin Yang,Yule Gao,Linlang Lu,Hu Jiang,Xiaodong Zhang
In this work, two novel nanoscale zero-valent iron (nZVI) composites (nanoscale zero-valent iron and copper-intercalated montmorillonite (MMT-nFe0/Cu0) and carbon microsphere-supported sulfurized nanoscale zero-valent iron (CMS@S-nFe0)) were used to treat soil contaminated with both Cr(VI) and p-nitrophenol (PNP), and added persulfate (PMS). Experiments found that the pollutant removal effect has a great relationship with the ratio of water to soil, the amount of catalyst, the amount of PMS, and the pH value. When the conditions are adjusted to the best (water–soil = 2:1, catalyst 30 g/kg, PMS 15 g/kg, pH 7–9), both materials fix Cr(VI) well and decompose PNP. The removal rates of Cr(VI) and PNP by the MMT-nFe0/Cu0system are 90.4% and 72.6%, respectively, while the CMS@ S-nFe0system is even more severe, reaching 94.8% and 81.3%. Soil column leaching experiments also proved that the fixation effect of Cr can last for a long time and PNP can be effectively decomposed. Through detection methods such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS), we found that Cr(VI) was effectively reduced to Cr(III) by Fe0and Fe2+ions and subsequently transformed into stable FeCr2O4spinel oxides, and the groups produced after the decomposition of PNP could also help fix the metal. This work provides a way to simultaneously treat Cr(VI) and PNP pollution, and also allows the use of multifunctional nZVI composites in complex soil environments.
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高影响因子
POLYMER
·
2023
·
IF 4.6
Jinrong Liu,Jiangang Zhang,Yuesheng Zhang,Wen Cao,Xiong Liu,Jianna Bao,Xianming Zhang,Wenxing Chen
As a biodegradable material , polylactic acid (PLA) has very bright application prospects, but its high flammability and poor crystallinity limit its use in electronics, automotive components, and other applications. In this paper, a macromolecular P–S synergistic multifunctional flame retardant (PTP) was obtained by an easy one-pot approach using polyethyleneimine , thiophene-2-formaldehyde and phytic acid. The addition of PTP to PLA improved the combustion resistance, anti-melt dripping and crystallization performance. The PLA compounds attained UL-94 V-0 grade at an ultra-low load (3 wt%) of the PTP, and the limiting oxygen index improved to 28.3 % when added at 9 wt%. The effective heat combustion and the total heat release value of PLA/9PTP composite were reduced from 24.4 and 93.1 to 18.9 MJ/kg and 86.0 MJ/m 2 , respectively. PLA/PTP composites provided a denser and more stable char layer during combustion than PLA and emitted significantly less-flammable gaseous volatiles. Meanwhile, PTP significantly facilitated the nucleation and crystallization of PLA, and the crystallinity elevated from 2.9 % to 35.5 % while the crystallization half-time reduced to 3.3 min about 10 % of pure PLA at 110 °C when added at 3 wt%. Besides, as PTP was a macromolecular flame retardant, PLA/PTP composites still maintained superior mechanical properties with the addition of PTP. This article gave an easy and effective way to fabricate PLA compounds with excellent flammability resistance, anti-dripping, crystallization and mechanical performance, which may be helpful for extending practical applications of PLA materials.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 30
·30160-30169
·
IF 2.8
Ding Jiafeng,Long Gaoyuan,Luo Yang,Sun Runze,Chen Mengxia,Li Yajun,Zhou Yanfang,Xu Xinhua,Zhao Weirong
Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are ubiquitous and highly toxic emerging endocrine disruptors found in surface and subsurface soils and clay deposits. Seriously, they could be easily transformed to the more toxic dioxins (PBDD/Fs) in photochemical processes and incineration, but the spontaneous formation of PBDD/Fs has rarely been reported. This study focused on the formation of 1,3,8-tribromodibenzo- p -dioxin (1,3,8-TrBDD) and 2,4,6,8-tetrabromodibenzofuran (2,4,6,8-TeBDF) from 2′-OH-BDE-68 and 2,2′-diOH-BB-80 under the oxidization of iron and manganese oxides (goethite and MnO x ). Approximately 0.09 μmol/kg (2.33%) and 0.17 μmol/kg (4.15%) were transformed to 1,3,8-TrBDD and 2,4,6,8-TeBDF by goethite in 8 days and a higher conversion 0.15 μmol/kg (3.77%) and 0.23 μmol/kg (5.74%) were observed for MnO x in 4 days. However, the formation of PBDD/Fs, probably proceeding via Smiles rearrangements and bromine elimination processes, was greatly inhibited by the presence of water. Transformation of OH-PBDEs by goethite and MnO x was accompanied by release of Fe and Mn ions and the possible pathways for the formation of reaction products were proposed. In view of the ubiquity of OH-PBDEs and metal oxides in the environment, oxidation of OH-PBDEs mediated by goethite and MnO x is likely an abiotic route for the formation of PBDD/Fs.
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高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Fangzheng Liu,Yunfei Ouyang,Xinyao Xie,Junwei Ke,Lu Qiu,Zhaoyang Zhang,Shiyi Huang,Xiangxiang Chen
To effectively detect the volatile terpineol and butyl xanthate gases produced during the flotation process in mineral processing plants, Co 3 O 4 nanosheets, Co 3 O 4 nanoparticles, and Co 3 O 4 nanoflowers were synthesized via one-pot hydrothermal method as sensing materials. The crystal structure and microscopic morphology of the synthesized materials were characterized using XRD, SEM and TEM, respectively. The specific surface area and pore-size distribution were recorded using BET. The elemental distribution and valence states were analyzed using XPS, and the chemical bonds and functional groups were analyzed using FTIR. The gas sensing properties demonstrated that Co 3 O 4 nanosheets exhibited superior sensing performance over Co 3 O 4 nanoparticles and Co 3 O 4 nanoflowers. The Co 3 O 4 nanosheets showed maximum responses of 8.06 and 9.17 to 50 ppm volatile terpineol and 200 ppm volatile butyl xanthate gases at the optimal operating temperature of 200 °C, respectively, as well as favorable gas sensing response-recovery characteristics and reproducibility. The superior performance is attributed to the abundant oxygen vacancies and the distinctive porous structure of Co 3 O 4 nanosheets. This work significantly contributes to the development of high-performance gas sensors for the mining industry.
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高影响因子
RSC Advances
·
2014
·Vol. 4
·期 76
·40241-40250
·
IF 3.708
Yuan-Yuan Zhu,Ting-Ting Yin,Ji Yin,Na Liu,Zhi-Peng Yu,Yan-Wu Zhu,Yun-Sheng Ding,Jun Yin,Zong-Quan Wu
A family of well-defined poly(3-hexylthiophene)-b-poly(5,8-di-p-tolylquinoxaline-2,3-diyl) rod–rod block copolymers was designed and synthesized in one pot via mechanistically distinct, sequential living polymerization using Ni(dppp)Cl2 as a single catalyst. The block copolymerization was demonstrated to proceed in a living/controlled chain-growth manner, affording the desired block copolymers in high yields with tunable compositions, controlled molecular weight, and narrow molecular weight distributions. The resulting block copolymer was revealed to self-assemble into various well-defined supramolecular structures depending on the solvents used such as nano-fibril and spherical nanoparticles. Very interestingly, such a block copolymer displayed highly selective visual detection for cobalt over most other competing metal ions by changing its orange color to light green and bright orange emission to deep green. The detection limit was estimated to be down to 1.0 × 10−7 M and the interference of the other competing metal ions is negligible. Furthermore, such a block copolymer can be applied using test strips, making it a practical, sensitive, and selective probe for cobalt ions.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Zhu Yin,Xing Liu,Fengzhen Wu,Beili Lu,Biao Huang,Yandan Chen,Guanfeng Lin
Based on low-cost, N-containing biomass waste peanut shells and phosphoric acid, the P element was successfully introduced into the carbon skeleton to obtain P-doped porous carbon materials, with inherent N functionality. In comparison to carbon catalysts functionalized with just N or P (NC-800 or PC), the as-prepared P-doped, N-containing porous carbon materials (NPC-T) possessed superior catalytic activity toward the aerobic oxidation of benzyl alcohol (BA). According to these findings, a synergistic effect of N and P species on the catalytic efficiency of carbon materials was observed. The amounts of graphitic N and C3PO species on the surface of NPC-T were shown to be correlated with catalytic activity. In the case of NPC-800, 100% conversion and 99.7% selectivity could be achieved along with a high TOF value (2.49 × 10–3 mol·g–1·h–1). Even when applied to various alcohols, the NPC-800 still showed good catalytic activity. Based upon the mechanistic investigations, both radical and nonradical reaction pathways occurred during the aerobic oxidation of BA over the NPC-800. Furthermore, to facilitate catalyst recycling, the granular P-doped, N-containing carbon (granular NPC-800) was generated, utilizing a kneading heat treatment and extrusion molding technique that did not require the addition of any extra adhesive. This work highlighted the potential high-value utilization of biomass waste in constructing P-doped, N-containing carbon materials and the application as metal-free catalysts in the aerobic selective oxidation reactions.
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高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2022
·
IF 8.91
Sufeng Wang,Xiaojuan Lv,Mingwei Fu,Zijing Wang,Dan Zhang,Qina Sun
Artemia egg shell loaded with nano-magnesium (shell-Mg) can be used to recover phosphorus from wastewater. The exhausted Artemia egg shell-Mg (denoted as shell-Mg-P) can be used as a slow-release fertilizer for phosphorus reuse. However, due to the coexistence of heavy metal ions in the environment, the application of slow-release fertilizer for phosphorus removal and reuse may have potential risks. In this paper, the potential risks of Pb 2+ , Cd 2+ , Zn 2+ and Cu 2+ in phosphorus wastewater and soil were studied from the formation and application process of shell-Mg-P. The result showed that shell-Mg adsorbed Pb 2+ , Cd 2+ , Zn 2+ and Cu 2+ in phosphate wastewater during the formation of shell-Mg-P and became shell-Mg-P-metal hybrid biomaterial . Although the experiment proved that the existence of heavy metal ions did not affect the phosphorus slow-release behavior of slow-release fertilizer, but the heavy metal ions in the shell-Mg-P-metal were also slow released. The pot experiment results confirmed that the slow-release phosphorus fertilizers (shell-Mg-P and shell-Mg-P-metal) in the soil polluted in low concentration of heavy metals can reduce the amount of heavy metals in whole wheat seedlings and promote wheat seedling growth. However, the application of slow-release fertilizers increased the translocation efficiency (T FR to SL ) of metal from root (R) to aboveground part (stem and leaves, SL), promoted the transportation of heavy metals from roots to the stems and leaves, and increased the safety risk of the wheat seedling edible. Therefore, besides the positive role of slow-release fertilizers in retaining heavy metals and reducing the amount of heavy metals in whole seedlings, the risk that it may aggravate the translocation of heavy metals to stems and leaves should be paid more attention, so as to ensure the safe and reliable application of slow-release fertilizers.
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PubMed
高影响因子
ANTICANCER RESEARCH
·
2021
·Vol. 41
·期 3
·1213-1218
·
IF 2.48
SHUIMING WANG,XIAOFENG WANG,YU WANG,QIANG LENG,YU SUN,ROBERT M. HOFFMAN,HEIYING JIN
Background/Aim: Overexpression of inflammatory cytokines and oxidative stress increase the risk of colorectal cancer (CRC) in obesity and hyperlipidemia. The aim of this study was to investigate whether the monoterpene antioxidant p-cymene would reduce the incidence of CRC in a rat model of hyperlipidemia. Materials and Methods: The hyperlipidemic CRC rat model was established by a high-fat diet and dimethyl hydrazine (DMH) induction. All rats received 30 mg/kg DMH to induce CRC, and were then assigned to groups with a normal diet or high-fat diet with/without 30 mg/kg/day p-cymene orally during the entire experimental period. Tumor incidence in each group, and the level of serum inflammatory cytokines and oxidative stress-related markers in intestinal tissues were measured. Results: p-Cymene significantly inhibited CRC occurrence in hyperlipemic rats (p=0.024) by reducing the expression of serum inflammatory cytokines (interleukin-1 by 54.5%; interleukin-6 by 28.3%; adiponectin by 26.3%; cyclo-oxygenase-2 by 48.4%) and intestinal oxidative-stress cytokines (total antioxidant capacity by 30.4%; superoxide dismutase by 30.3%; malondialdehyde by 47.1%). Conclusion: p-Cymene has clinical potential to reduce the incidence of CRC in hyperlipemia.
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PubMed
高影响因子
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