International Journal of Nanomedicine
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2026
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IF 8.7
Luting Lin,Guowei Wang,Jie Zhang,Jingming Luo,Xudong Fan,Jianqing Gao,Xinjun Cai
Background The efficacy of chemotherapy for treating lung cancer is hindered by insufficient intracellular drug utilisation. Moreover, non-targeted distribution often leads to severe side effects, resulting in poor prognosis and low patient compliance. Therefore, a more effective strategy is required to achieve effective treatment. In this study, we aimed to develop a pH-responsive nanoplatform for intratracheal administration to enhance drug accumulation in lung cancer tissues and promote the accumulation of drugs within tumour cells.Results A self-assembled nanomicelle named SN-38@PEG-PMMSD (PPM) was constructed using a cinnamaldehyde synthetic carrier material loaded with SN-38 and nanoprecipitation. Intratracheal administration enhanced the accumulation of PPM within the lungs and tumors (the fold increase in lung accumulation following intratracheal (i.t.) were 49.63-fold higher than intravenous (i.v.) delivery at the 48-hour timepoint). Owing to its small size, PPM can easily penetrate deep into tumour tissues. The micro-acidic environment characteristic of tumours increases the efficiency of tumour cell uptake of PPM. This triggered a pH-responsive reaction in the acidic lysosomal milieu, leading to dissociation of PPM and the regeneration of cinnamaldehyde while releasing SN-38. Cinnamaldehyde acted as a reactive oxygen species (ROS) amplifier, facilitating ROS generation. Elevated ROS levels, in conjunction with SN-38, resulted in strong antitumor effects.Conclusion In summary, Intratracheal administration of pH-responsive PPM is anticipated to enhance drug accumulation in tumour tissues, improve drug uptake by tumour cells, and achieve effective treatment of lung cancer.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Peili Li,Siyu Zhang,Haoran Xu,Xiangxiang Wu,Xiaoqing Yu,Wenxin Wang,Ran Ding,Da Zhang,Junhua Chen,Xiang Ke,Zirong Li
Bacterial infections associated with biofilm formation hinder wound healing via enhanced antibiotic resistance and impaired tissue repair. Herein, we fabricated dandelion herb-derived carbon dots (DH-CDs) through a green solvothermal-extraction method, developing a biocompatible antimicrobial agent with synergistic wound healing potential. Physicochemical characterization showed that DH-CDs are quasi-spherical (4.87 nm), partially graphitized nanoparticles with abundant surface functional groups and pH-responsive charge-switching capability. In vitro studies demonstrated that DH-CDs exhibit broad-spectrum antibacterial activity against S. aureus and E. coli, with minimum inhibitory concentrations (MICs) of 62.5 μg/mL at pH 7.4 and 31.25 μg/mL at pH 5.5. The antibacterial effect is mediated by a multimodal mechanism involving electrostatically driven bacterial membrane disruption, energy metabolism inhibition, intracellular reactive oxygen species (ROS) generation, and antioxidant enzyme inactivation. Moreover, DH-CDs achieve complete disruption of mature S. aureus biofilms at 300 μg/mL. Notably, DH-CDs possess excellent biocompatibility, with a 10% hemolysis concentration (HC10) exceeding 4000 μg/mL and over 95% viability of NIH 3T3 fibroblasts at 2000 μg/mL. A unique dual ROS-modulating capability was identified that DH-CDs generate excessive ROS to eradicate bacteria while scavenging deleterious ROS in mammalian cells, thereby preserving redox homeostasis. In vivo evaluations in a murine S. aureus-infected full-thickness wound model demonstrated that DH-CDs significantly accelerate wound closure by promoting re-epithelialization, granulation tissue maturation, collagen deposition, and hair follicle regeneration, outperforming a commercial wound healing spray. Collectively, DH-CDs integrate green synthesis, pH-responsive antibacterial/antibiofilm activity, dual ROS regulation, and biocompatibility, representing a promising translational candidate for bacteria-infected wounds and a paradigm for multifunctional biomass-derived nanomaterials.
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Small
·
2026
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IF 11.8
Hang Zhang,Yinuo Wu,Zhen Zhang,Ying Hou,Peizhi Liu,Ting Liao,Bingshe Xu,Yanhui Song,Haixia Zhang,Junjie Guo,Ziqi Sun
M-N-C single-atom catalysts have been demonstrated to be a promising class of non-noble-metal based catalysts, but their activity is largely constrained by the symmetrical electronic density distribution of the M-N 4 moieties. Herein, a ZIF-8 derived Fe/Fe dual-center catalyst (FeN 4 /FeO 5 @NC) is constructed by introducing a O-FeO 4 configuration adjacent to the Fe-N 4 sites to form asymmetric dumbbell-shaped FeN 4 -O-FeO 4 active sites, resulting in improved intrinsic activity of Fe─N─C catalyst. The dumbbell FeN 4 -O-FeO 4 dual-center catalyst features an electron transfer pathway of “FeN 4 → bridged O → FeO 4 ”, which breaks the symmetry of the electronic density distribution of the Fe moiety and regulates the position of the d-band center, increasing the electron transfer efficiency, reducing the desorption energy barrier of the rate-determining step, and enhancing the activation ability of O 2 molecules. The obtained FeN 4 -O-FeO 4 dual-center catalyst exhibits excellent ORR performance in a pH-universal range. The liquid-state Zn-air battery (ZAB) with this FeN 4 -O-FeO 4 dual-center catalyst delivers an outstanding open circuit voltage of 1.502 V and a peak power density of 246 mW cm −2 , superior to the Pt/C-cathode ZAB. This work represents an exploration of ways to improve the ORR performance of Fe─N─C catalysts and provides a paradigm for rationally designing low-cost, highly catalytic, and stable non-noble metal catalysts.
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高影响因子
APOPTOSIS
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2026
·Vol. 31
·期 6
·150
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IF 9
Xu Jiang,Liu Longyan,Liu Shuheng,He Zesong,Meng Wei
To overcome resistance to MEK inhibitors such as selumetinib in neurofibroma, we developed a metabolism-targeted nanotherapeutic based on a pH-responsive silver nanoparticle platform (AgNP-PEG-TC) for delivering Triacsin C (TC), an inhibitor of long-chain acyl-CoA synthetases, to disrupt tumor-associated lipid metabolism. AgNP-PEG-TC was synthesized and characterized for its physicochemical properties, drug-loading efficiency, and pH-responsive release behavior. Its antitumor effects were assessed in human neurofibroma cells, including selumetinib-resistant cells, and in normal Schwann cells by examining proliferation, apoptosis, migration, and invasion. In vivo therapeutic efficacy and biosafety were evaluated in neurofibroma xenograft models. Bulk RNA sequencing, lipidomics, and protein analyses were performed to investigate the underlying mechanisms. AgNP-PEG-TC demonstrated stable colloidal properties and successful pH-sensitive release. It selectively reduced neurofibroma cell growth, migration, and invasion while promoting apoptosis, with minimal effects on normal cells. In xenograft models, AgNP-PEG-TC significantly inhibited tumor growth and showed good biocompatibility. Multi-omics analyses indicated that its antitumor activity was associated with ACSL4 downregulation, remodeling of arachidonic-acid-enriched phospholipids, enhanced lipid peroxidation, and increased lipid-droplet accumulation, suggesting heightened ferroptosis susceptibility. Notably, AgNP-PEG-TC synergized with MEK inhibitors and restored antitumor responses in resistant neurofibroma cells. These findings establish a metabolism-nanotechnology synergy in which AgNP-PEG-TC-mediated ACSL4 inhibition and lipid metabolic reprogramming resensitize MEK inhibitor-resistant neurofibromas to therapy. The platform functions as both a targeted drug carrier and a modulator of tumor lipid homeostasis, offering a promising combinatorial strategy. Graphical abstract The alternative text for this image may have been generated using AI.
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JOURNAL OF THE TEXTILE INSTITUTE
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2024
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IF 1.5
Shuyu Chen,Yongfang Qian,Ying Wang,Lihua Lyu,Xinghai Zhou
Aiming to improve the low stability of blueberry anthocyanins (BA) and moisture absorption of the ethylene vinyl alcohol copolymer (EVOH), BA was encapsulated in EVOH and then dispersed in PVA solution to form water in water (W/W) emulsion, and further electrospun into nanofibers. The stability of the emulsion was analyzed by bio microscopy and zeta potential particle size analyzer. The successful encapsulation of BA/EVOH in the continuous phase of PVA was verified by infrared spectroscopy. The incorporation of BA significantly improved the oxidation resistance and UV resistance of the membranes, which could completely block UVB region and most of the UVA region. In addition, water vapor transmission rate and mechanical properties were effectively enhanced after thermal crosslinking. Finally, the potential application of the membrane in shrimp spoilage monitoring was explored, where the color of the indicator changed from mauve to grayish blue during indoor sealed storage. The results suggest that the membrane can monitor shrimp spoilage in real time through pH changes and the developed index membrane would be a good candidate as intelligent food package material.
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MICROPOROUS AND MESOPOROUS MATERIALS
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2019
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IF 4.182
Chen Yuan,Pengfei Cheng,Jing Li,Xianlu Gao,Xingsen Gao,Xin Wang,Mingliang Jin,Richard Nötzel,Guofu Zhou,Zhang Zhang,Junming Liu
Zeolite imidazolate frameworks (ZIFs) are a novel kind of zeolite materials with regular porous network structures, belonging to mental-organic frameworks (MOFs). Thanks to their high porosity and large specific surface area , ZIFs could have potential applications in the field of photocatalysis . In this paper, visible light responsive photocatalyst of ZIF-67 was synthesized by a one-step hydrothermal method under a mild condition. We explored three organic dyes in aqueous solutions were degraded under visible light irradiation . And corresponding photocatalytic performances of ZIF-67 with controllable synthetic conditions were evaluated systematically. It was found that ZIF-67(9 h) had the highest degradation efficiency. Besides, the ZIF-67(9 h) were heated in Ar can maintain their crystal structure and microporous form, but exposed more sites to improve photocatalytic activity with partial bond breakage . More than 75% methyl orange (MO), 85% methyl blue (MB) and 54% Rhodamine B (RhB) can be degraded with a 0.5 g L −1 ZIF-67(9 h)(Ar) under visible light irradiation. Moreover, the ZIF-67(9 h)(Ar) demonstrates a strong pH changing tolerance in both acid and alkaline aqueous solutions, the degradations can be well performed in a wide pH range from 3.0 to 11.0.
研究领域:
材料科学
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光催化
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环境化学
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纳米材料
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化学工程
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高影响因子
DYES AND PIGMENTS
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2022
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IF 5.122
Zhong Lin,Heru Pan,Yong Tian,Jia Tang,Chonghua Zhang,Peisheng Zhang,Heping Yang,Jian Chen
Stimuli-responsive fluorescent polymeric nanoparticles are widely used in bioimaging, anti-counterfeiting and data encryption due to their advantages of simple preparation, good water-dispersibility, high brightness and photostability. In this paper, novel photo-pH dual stimuli-responsive multicolor fluorescent polymeric nanoparticles (SMFPNs) were fabricated via combination of one-pot miniemulsion polymerization and surface modification. Based on fluorescence resonance energy transfer (FRET) principle, 4-ethoxy-9-allyl-1,8-naphthalimide (EANI), fluorescein isothiocyanate (FITC) and spiropyran-linked methacrylate (SPMA) can be used to constitute three pairs of FRET systems. In the nanoparticles , the blue fluorescence of EANI (energy donor) decreases and the green fluorescence of FITC (energy receptor) increases via increasing pH. While pH decreases, it can return to blue fluorescence. Meanwhile, after UV light irradiation , SPMA converts from non-fluorescent spiropyrans (SP) state to red fluorescent merocyanine (MC) state, the transformation from blue or green emission to red emission can be realized. When irradiated with visible light, it reverts to its original blue or green fluorescence. Therefore, the system can achieve the multi-color transformation of blue, green and red under changing pH and illumination conditions. In addition, the as-prepared nanoparticles also exhibited high fluorescence contrast, rapid photo-responsiveness and excellent photoreversibility. Therefore, SMFPNs displayed great potential in the fields of multicolor security ink, advanced anti-counterfeiting, multilevel data encryption and in vivo bioimaging.
研究领域:
材料科学
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纳米技术
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光学加密
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生物医学成像
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高分子化学
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传感器与探测器
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
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IF 4.8
Dechan Lu,Rubing Bai,Jingwen Lin,Tao Wang,Chaofan Lv,Rongmao Qiu
Lung cancer mortality remains high due to the difficulty in accurately distinguishing early-stage lung cancer (LC) from benign lung disease (BLD) via conventional diagnostic approaches, and DNA methylation serves as an ideal early epigenetic marker for LC diagnosis while lacking efficient detection technologies. Herein, we developed a multi-pH fused surface-enhanced Raman scattering (SERS) strategy for label-free DNA methylation detection, enabling preliminary discrimination potential between early-stage LC and BLD. We first identified pH-dependent methylation-associated spectral markers by investigating SERS characteristics of cytosine/5-methylcytosine and methylated/unmethylated DNA standards under acidic (pH 3), neutral (pH 7) and alkaline (pH 9) conditions, and validated the specificity and universality of these markers at cellular level (A549/BEAS-2B cells). For clinical formalin-fixed paraffin-embedded (FFPE) samples, we quantified the pH-responsive intensity variations of core methylation-associated peaks in LC and BLD DNA, and further constructed a principal component analysis-linear discriminant analysis (PCA-LDA) model to compare the diagnostic efficacy of single-pH and multi-pH fused SERS spectra. Single-pH SERS detection showed limitations with low diagnostic performance, while the multi-pH spectral fusion strategy integrated complementary methylation feature information across different pH conditions, achieving a diagnostic accuracy of 0.93 for LC-BLD discrimination in clinical FFPE samples, with excellent sensitivity and specificity. This study presents a multi-pH fused SERS method for DNA methylation-associated spectral analysis, which improves the capture of complementary spectral information compared with single-pH detection and provides a label-free exploratory approach for differentiating early-stage LC from BLD.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Qian Rui,Jun Gao,Zheng-Zhi Yin,Junyao Li,Wenrong Cai,Datong Wu,Yong Kong
A simple and smart drug controlled delivery system is developed in this work. Biodegradable mesoporous silica nanoparticles (BMSN) were first synthesized by introducing disulfide during the synthesis of mesoporous silica nanoparticles (MSN), which were used for the loading of methotrexate (MTX), an anti-cancer drug. The MTX loaded BMSN (BMSN-MTX) was then encapsulated in the hydrogels of carboxymethyl chitosan (CMCS)/oxidized pullulan (OPL) generated through Schiff base reaction. The acylhydrazone bonds (–N=CH–) between CMCS and OPL are prone to be hydrolyzed in acidic medium while the disulfide linkage (–S–S–) in the BMSN can be cleaved in the presence of glutathione (GSH), and thus the delivery of MTX from the BMSN-MTX-gel can be triggered by both pH and GSH. The results of release kinetics reveal that the delivery of MTX from the biodegradable hydrogels is controlled by Higuchi model. Finally, good biocompatibility and pronounced cytotoxicity of the developed BMSN-MTX-gel are confirmed by cytotoxicity test .
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FOOD CHEMISTRY
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2023
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IF 8.8
Jingyu Zhang,Zhihui Zhang,Liping Yao,Mingrong Qian,Zuguang Li,Yulin Han,Shanshan Bai,Mawrong Lee
The existing QuEChERS-combined analytical pretreatment methods are limited by large reagent consumption, high environmental burden, and mediocre effects. To provide an efficient and green pretreatment method, this study developed pH-responsive switchable deep eutectic solvents (SDESs) to extract triazole fungicides (TFs) from fruit peel wastes, which could enhance the preconcentration effect of target compounds in food waste samples with complex matrices. The mechanisms of pH-induced phase transition and hydrophobicity-hydrophilicity conversion of pH-responsive SDESs were investigated by pH phase diagrams and chemical characterization techniques, respectively. We validated the established method by high-performance liquid chromatography-diode array detector (HPLC-DAD), and lower LOD (0.089–0.351 ng mL −1 ), LOQ (0.297–1.172 ng mL −1 ), RSD (≤8.8 %) and satisfactory recoveries (90.6 %-110.9 %) and preconcentration factors (389–512) were obtained in rotting grape peel, watermelon peel, and orange peel samples. Our findings highlight the potential of pH-responsive SDESs in the extraction and analysis of various natural food products.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2023
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IF 5.8
Jidong Wang,Yating Zhang,Min Dong,Zhaopeng Liu,Binbin Guo,Haipeng Zhang,Liming Gao
Detecting and analyzing circulating tumor cells(CTCs) is significant for early diagnosis, management, and personalized treatment of tumors. Herein, a smart magnetic aptamer modified Fe 3 O 4 @ZIF-8 core/shell structured nanoparticle (NPs) was successfully constructed using for capture and simultaneous pH- and NIR-irradiation responsive release of CTCs. Taking MCF-7 as model CTCs, it could be captured ca. 60 % in low-concentration artificial blood by aptamer (SYL3C) on the surface of Fe 3 O 4 @ZIF-8 NPs. After magnetic separation, the ZIF-8 shell in aptamer-modified Fe 3 O 4 @ZIF-8 NPs carrying captured CTCs would disintegrate within 20 min under the synergistic effect of an acidic environment (pH=6.0) and NIR irradiation leading to the release of CTCs with high cell viability , which was benefited for the subsequent culture and analysis. This magnetic and core/shell structured device integrated high-efficiency capture, quick isolation and perfect release into one system, which showed great potential s for the detection of CTCs in the clinic.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2023
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IF 5.8
Wanling Cai,Wei Zhang,Zuliang Chen
Metal-organic frameworks (MOFs) have a high specific surface area and inherent biodegradability due to their unique structure and composition . As well, owing to the properties of nanomaterials and especially their magnetic features, Fe 3 O 4 nanoparticles and MOFs composite materials have great potential in the design and application of drug release. The present work: firstly, investigated norfloxacin loading in magnetic metal organic framework (Fe 3 O 4 @ZIF-8); and secondly, studied the release of norfloxacin and its antibacterial activity . Results showed the release efficiencies reached 97 % at 310 K after 84 h (pH 7.4). Drug release behavior was tested at various pH levels and it was found that Fe 3 O 4 @ZIF-8 has pH-sensitive properties. Furthermore, the release model calculation illustrated that the release process fitted well to the Bhaskar model. The magnetic properties of Fe 3 O 4 @ZIF-8 confirmed that the composite has potential application for a targeted drug delivery system. The mechanism of pH-responsive norfloxacin release was combined with diffusion , ion exchange and electrostatic repulsion. Furthermore, the antibacterial activities of Fe 3 O 4 @ZIF-8 and NOR-Fe 3 O 4 @ZIF-8 were tested against Escherichia coli . Results showed that Fe 3 O 4 @ZIF-8 had good biocompatibility while NOR-Fe 3 O 4 @ZIF-8 can deter or inhibit the actions of microorganisms .
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高影响因子
危险品化学品经营许可证（带存储）