JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2026
·
IF 2.6
Bian Meihua,He Yuyin,Deng Shanquan,Zhu Junwei,Peng Jianing
To overcome the inherent limitations of Ag–SnO 2 electrical contact materials, this study employed a combined strategy of In 2 O 3 doping and hot pressing sintering, establishing a direct interrelationship among material composition, microstructural evolution, electrical conductivity, and microstrain. Four Ag–SnO 2 –In 2 O 3 powder compositions were synthesized, and the effects of conventional sintering versus hot pressing sintering on microstructure and functional properties were systematically investigated. Results show that hot pressing sintering enables near-complete densification (99% relative density) and significantly improves hardness by 42.5% (57.3HV), primarily by suppressing interfacial porosity and refining microstructural uniformity. Optimal In 2 O 3 addition (4 wt%) not only facilitates homogeneous phase distribution but also minimizes bulk resistivity (2.52 × 10 −6 O·cm), leading to the highest electrical conductivity (3.98 × 10 5 S/cm). Rietveld refinement reveals a pronounced reduction in microstrain (0.01% for In 2 O 3 , 1.7% for SnO 2 ) in the best-performing samples, directly linking lattice relaxation and phase stability to enhanced electron mobility. This mechanistic insight provides a foundation for the rational design and optimization of advanced Ag-based electrical contact materials.
✓ 已验证
产品关联
DOI
高影响因子
WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 10
·572
·
IF 3.5
Zhang Jian,Wang Ningruo,Xie Xuewen,Liao Siyi,Zhong Biao,Feng Bo,Tian Chunxiang,Xu Yajun,Chen Yuhan,Xiao Jiewen
This study systematically evaluates the efficiency and mechanism of Mn–Co bimetallic oxides for peroxymonosulfate (PMS) activation to degrade bisphenol AF (BPAF). A series of spherical Mn a Co (1-a) O x catalysts were synthesized via a facile hydrothermal method. Among them, Mn 0.2 Co 0.8 O x exhibited the highest catalytic activity, outperforming other ratios. Under optimized conditions ([BPAF] = 5 mg/L, [PMS] = 0.2 mM, [Mn 0.2 Co 0.8 O x ] = 400 mg/L, pH = 7.85), the Mn 0.2 Co 0.8 O x /PMS system achieved 97.7% BPAF removal. Quenching tests and EPR spectroscopy confirmed SO 4 •⁻ and •OH as the predominant reactive oxygen species, with SO 4 •⁻ playing the dominant role. XPS and mechanism analysis indicated that the synergistic Co(III)/Co(II) and Mn(III)/Mn(II) redox cycles drive the efficient PMS activation and BPAF degradation.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2026
·
IF 4.1
Mao Shuai,An Zhoujian,Du Xiaoze,Ding Yong,Zhang Dong,Fu Jian
Nanofluids obtained by the incorporation of nanoparticles into ternary carbonates be capable of enhancing the low heat transfer and the capacity for thermal storage as well as the poor fluidity of carbonate. In this study, 31.5 mass% Na 2 CO 3 -31.5 mass% Li 2 CO 3 -37 mass% K 2 CO 3 was used as the ternary carbonate. Nanofluids were prepared utilize the high-temperature melting technique by dispersing nanoparticles of different particle sizes, concentrations, and types in carbonate solution. The thermophysical properties of nanofluids were measured employing X-ray diffractometer, viscosity analyzer, scanning electron microscopy, etc. The findings indicated that among the selected nanoparticles, SiO 2 containing 1.0 mass% magnitude of particles of 30 nm was the most effective in enhancing the heat transfer, heat storage, and flow properties of the ternary carbonate. From the fitted curves, the incorporation of SiO 2 increased the solid state specific heat capacity with 6.25%, the liquid form by 6.0%. The liquid phase exhibited a 27.8% improvement of thermal conductivity, and the viscosity of nanofluids was below 10 cp with increasing temperature, and the viscosity was less than 3 cp at 500 °C. After undergoing 100 h of high-temperature insulation and 100 cycles of thermal shock with large temperature difference, nanofluids exhibited a melting temperature change of only 1.39% and 1.19%, demonstrating excellent initial stability. Subsequent testing will involve extended periods of high-temperature insulation and thermal shock cycles with large temperature differences to ensure this nanofluid truly meets practical application requirements.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 4
·233
·
IF 5.4
Gao Xiang,Hou Yujiao,Lin Fang,Wen Limei,Guo Yali,Kong Weijun,Hu Junping,Yang Jianhua
An electrochemical (EC) molecularly imprinted polymer (MIP) sensor for therapeutic drug monitoring of olanzapine (OLZ) has been developed. A “rime-like” gold-platinum nanostructured film (Au-Pt NF) was fabricated on a screen-printed carbon electrode (SPCE) via an one-step hydrogen bubble dynamic template (HBDT) method, followed by electropolymerization of a polyaniline-based MIP. The Au-Pt NF/SPCE served as an ideal three-dimensional conductive substrate with a large active area and enhanced electron-transfer capability, endowing the specific MIP sensor with high sensitivity. Using [Fe(CN) 6 ] 3−/4− as a redox probe, the sensor quantified OLZ by the decrease in differential pulse voltammetry current caused by target binding. It exhibited two linear ranges (0.005–0.4 µM and 0.4–10 µM) with a detection limit of 0.94 nM, and demonstrated high selectivity, reproducibility, and stability. The sensor achieved recoveries of 96.7–102.7% for OLZ in tablets, urine, and whole blood. This work provides a reliable, all-EC sensing platform with strong potential for rapid OLZ monitoring in clinical settings.
Section
Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Hou Chaojie,Xu Hang,Zhang Bingbing,Zhao Yuan,Wu Fengmin
A flower-like core–shell MnO 2 @CeO 2 composite was synthesized via hydrothermal method. Characterization by X-ray diffraction, Brunauer–Emmett–Teller, scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy confirmed a micro-spherical morphology with a high specific surface area (266.4 m 2 g −1 ) and well-defined mesoporous structure (average pore size: 7.4 nm), facilitating active site exposure and reactant adsorption. Under optimal conditions (25 mg catalyst, 1.5 mL 25 wt% peroxymonosulfate, 2 mL acetonitrile, 600 ppm initial sulfur, 40℃), the desulfurization efficiency for dibenzothiophene reached 81.26%. It maintained 71% efficiency after 5 cycles, with stable chemical structure and morphology. Quenching experiments confirm that the primary oxidation of dibenzothiophene to dibenzothiophene sulfoxide is predominantly mediated by sulfate radicals (·SO 4 ⁻), while the subsequent oxidation of dibenzothiophene sulfoxide to dibenzothiophene sulfone relies primarily on hydroxyl radicals (·OH). Kinetic analysis showed tandem reaction behavior with rate constants k 1 = 0.213 min⁻ 1 and k 2 = 0.187 min⁻ 1 . This catalyst offers promising potential for industrial production of ultra-low-sulfur fuels. Graphical
✓ 已验证
产品关联
DOI
高影响因子
TRANSITION METAL CHEMISTRY
·
2026
·Vol. 51
·期 3
·35
·
IF 2.8
Liu Chao,Bi Xue-bin,Xu Jia-yu,Liu Rui-xue,Zhang Shu-feng
Two new metal complexes 9-AIH-Co and 9-AIH-Zn, were synthesized using ( Z )-2-(2-(anthracen-9-ylmethylene)hydrazineyl)-4,5-dihydro-1 H -imidazole (9-AIH) as the ligand and evaluated as anticancer agents. Their structures were determined by single-crystal X-ray diffraction, elemental analysis and mass spectroscopy. The 9-AIH ligand crystallized in acetate form within the orthorhombic crystal system with space group P na2 1 . The cobalt complex, 9-AIH-Co, is a mononuclear complex with chloride counterions, adopting a tetrahedral coordination geometry and crystallizing in the monoclinic system with space group P2 1 /n. Similarly, the zinc complex, 9-AIH-Zn, with acetate counterions, also exhibits a tetrahedral configuration but crystallizes in the monoclinic system with space group C2/c. Anticancer activity assays revealed that 9-AIH-Co demonstrated significant inhibitory effects against three representative tumor cell lines, MGC-803 (gastric cancer), SK-OV-3 (ovarian cancer), and HepG-2 (liver cancer), which were selected for their clinical relevance as models for prevalent and challenging solid tumors. The IC 50 values were 6.45 ± 0.78, 8.28 ± 0.80 and 8.87 ± 2.26 µM, respectively, showing superior activity compared to both the free ligand 9-AIH and the 9-AIH-Zn. In vitro antibacterial tests indicated that 9-AIH-Co possessed antimicrobial properties similar to those of 9-AIH against four common pathogenic bacteria, including Bacillus subtilis , with MIC values ranging from 3.9 to 7.8 µg/mL. Conversely, 9-AIH-Zn showed markedly diminished antibacterial effects, with the MIC value of 125 µg/mL. These findings collectively suggest that metal ions play a pivotal role in modulating the comprehensive biological activities of metal complexes. The coordination of imidazole with Co(II) synergistically enhances both anticancer and antibacterial activities, whereas Zn(II) appears more appropriate for developing complexes with lower cytotoxicity. This research provides fundamental insights into the metal-ion-specific behavior of anthrahydrazone complexes, highlighting cobalt coordination as a promising strategy for developing dual-functional metallodrugs.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Ocean University of China
·
2026
·Vol. 25
·期 2
·586-598
·
IF 1.6
Zeng Chu,Lyu Likang,Liu Mengqun,Yang Xiaodong,Zhao Hongkui,Wen Haishen,Li Jifang,Qi Xin
Caspase-9, the most intensively studied caspase, plays a crucial role in mitochondrial or intrinsic apoptosis of mammals as a protease. To explore the role of caspase-9 in fish, we cloned casp9 gene from rainbow trout ( Oncorhynchus mykiss ) and studied its characteristic and functions. Our in vivo experiments revealed that casp9 expression was significantly upregulated 24 h after bacterial challenge in the gills, accompanied by notable histopathological changes and apoptosis signals. Gene cloning identified that rainbow trout caspase-9 is a 455 amino acid protein encoded by a 1368 bp gene, characterized by a conserved CARD domain, as well as prominent large (P20) and small (P10) subunits. Functional assays of recombinant rainbow trout caspase-9 (rcaspase-9) showed dose-dependent proteolytic activity, with significantly higher activity at 2 mg/mL than at 0.2 mg/mL. Conversely, the CARD domain-deleted version exhibited minimal activity even at 2 mg/mL, demonstrating that the CARD domain is indispensable for homodimerization and self-activation. Additionally, RT-qPCR results indicated that casp9 was mainly expressed in gills and spleen. In vitro studies demonstrated significant upregulation of casp9, apaf-1 and cyt c , along with downregulation of bcl-2 in primary gill cells in response to LPS, peptidoglycan and poly I:C stimulation. Furthermore, rcaspase-9 induced upregulation of casp6 and casp7 in these cells. These findings underscore the importance of caspase-9 in immune defense and apoptosis triggered by pathogens in rainbow trout.
✓ 已验证
产品关联
DOI
高影响因子
IONICS
·
2026
·
IF 3.4
Hou Kangwei,Chang Xinhao,Li Xiaolin,Wang Li,Liang Guangchuan
The development of high-performance anode materials is crucial for lithium-ion battery. This work presents a strategic design of carbon quantum dots (CQDs) modified amorphous-dominated high-entropy oxide (FeCoNiCrMn) 3 O 4 (FCNCMO) synthesized via a combined hydrothermal and calcination approach as anode material for lithium-ions batteries. Systematic characterization reveals that CQDs form conductive bridges between particles, not only enhancing interparticle electron transport but also acting as an elastic buffer layer to suppress volume variations during cycling, while simultaneously refining the particle size from 433.6 nm (pristine FCNCMO) to 254.8 nm (FCNCMO/CQDs-10) and preventing particle aggregation to provide larger specific surface area 330.38 m 2 g − 1 , thereby providing more active sites for electrochemical reactions. Electrochemical tests demonstrate that the optimal FCNCMO/CQDs-10 composite delivers a high discharge capacity of 515.9 mAh g − 1 after 200 cycles at 200 mA g − 1 , significantly surpassing pristine FCNCMO (302.1 mAh g − 1 ). This composite also exhibits outstanding rate capability, delivering 190.2 mAh g − 1 at high current density of 2 A g − 1 while recovering to 831.6 mAh g − 1 when current density returns to 0.1 A g − 1 . This study provides a valuable strategy of stabilizing amorphous-dominated structures for developing high-performance HEO anodes.
✓ 已验证
产品关联
DOI
高影响因子
Clinical Oral Investigations
·
2026
·Vol. 30
·期 3
·96
·
IF 3.6
Zhang Suqin,Yang Xinyu,Liu Ting,Xie Haifeng,Chen Chen
Objectives This study aims to investigate how the molecular weight, steric hindrance, number of phenolic hydroxyl groups, and their spatial arrangement in four polyphenols influence the inhibition of matrix metalloproteinase (MMP) activity and the promotion of collagen cross-linking and remineralization through polyphenol pre-treatment, and further analyze how these effects enhance the stability of the hybrid layer. Materials and methods Resin-dentin bonding specimens, collagen membranes, and demineralized dentin slices were prepared with/without pretreatment using four polyphenols: myricetin, resveratrol, proanthocyanidins (PA), and tannic acid, representing stilbenes, flavonoids, condensed tannins, and tannins. Then the microtensile bond strength (µTBS), nanoleakage, and in situ zymography were evaluated. The ability of polyphenols to inhibit MMP activity, promote collagen cross-linking and remineralization was assessed through quantitative MMP activity assays, hydroxyproline assays, cross-linking degree measurements, transmission electron microscopy (TEM), Zeta potential measurements, X-ray diffraction (XRD), and attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR). Results Among the four polyphenols, PA and myricetin demonstrated the strongest bonding enhancement by significantly increasing µTBS, reducing nanoleakage, and inhibiting MMP-9. PA and tannic acid were the most effective in promoting collagen cross-linking, while PA and myricetin showed the best remineralization capacity. Conclusions All four polyphenols promoted collagen cross-linking, inhibited MMP activity, and enhanced remineralization; PA and myricetin ultimately led to more significant increases in µTBS and reductions in nanoleakage. Clinical relevance PA and myricetin have better capabilities for enhancing bonding durability, which is very valuable for future screening of suitable polyphenols and even designing and synthesizing better-performing polyphenol structures artificially.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BREAST CANCER RESEARCH
·
2026
·
IF 6.2
Jianwen Wang,Longdi Yao,Yuming Chen,Qiang Zhu,Wenjing Xu,An Xu,Xiang Li,Zhi Chen,Min Cheng,Qi Leng,Chunlian Li,Xintao Deng,Deyuan Fu
Background: Breast cancer (BC) is one of the most common malignant tumors in women worldwide, with metastasis and recurrence constituting major therapeutic challenges. F-Box Protein 5(FBXO5), a core component of the E3 ubiquitin ligase complex, is overexpressed in multiple cancers, but its specific role and underlying mechanism in BC remain unclear and require further investigation. Methods: We screened E3 ubiquitin ligase-related cancer dependency genes by integrating data from the DepMap and UniProt databases, and further analyzed transcriptomic data from TCGA and GEO to identify the candidate gene FBXO5. We then validated its expression at the mRNA and protein levels in BC tissues from two independent centers and in cell lines, employing qRT-PCR, Western blot, and immunohistochemistry.The effects of FBXO5 on the proliferation, migration, and invasion abilities of BC cells were evaluated in vitro and in vivo through colony formation, CCK8, Transwell assays, wound healing assays, IHC, and subcutaneous tumor formation in nude mice. The interactions between FBXO5 and proteins, as well as its main functions and pathways, were investigated using Co-IP, mass spectrometry, immunofluorescence confocal microscopy, molecular docking and bioinformatics analysis, with results validated by rescue experiments. Results: The mRNA and protein expression levels of FBXO5 were significantly upregulated in BC tissues from two centers, high expression of FBXO5 was significantly correlated with adverse clinicopathological features, including larger tumor size, positive nodal status, and elevated Ki-67, and was associated with poor overall survival (OS) and disease-free survival (DFS).In vitro and in vivo experiments confirmed that FBXO5 significantly affected the proliferation, invasion, and migration abilities of BC cells. Mechanistically, Co-IP, mass spectrometry, molecular docking and immunofluorescence confocal microscopy experiments confirmed that FBXO5 directly interacts with ribosomal protein L23a (RPL23A) and promotes its polyubiquitination at the K48 chain, thereby regulating its degradation. Further experiments showed that the ubiquitination-mediated degradation of RPL23A led to a decrease in the stability of Tumor Protein p53(p53) and facilitated its degradation by Proto-Oncogene MDM2 (MDM2). Conclusion: Our study establishes the existence of a novel FBXO5/RPL23A/MDM2/p53 oncogenic axis in BC. These findings thereby nominate FBXO5 as a promising therapeutic target for BC intervention.
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF THERMOPHYSICS
·
2026
·Vol. 47
·期 5
·88
·
IF 3.6
Zuo Yingying,Zhou Rui,Zhang Yanli,Guo Jianli,Wang Jian,Wang Jiao,Zang Shuyan
A ternary eutectic solvent (TDES [TBAB:EG:OA]) was prepared with a molar ratio of 1:1:1, using tetrabutylammonium bromide (TBAB) as the hydrogen-bond acceptor and ethylene glycol (EG) and oxalic acid (OA) as hydrogen-bond donors. Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and density functional theory (DFT) calculations confirmed that its formation originates from a complex noncovalent interaction network dominated by O–H…Br hydrogen bonds between components. The density, viscosity, and refractive index of the [TBAB:EG:OA] system mixed with water/acetonitrile were systematically measured over the full mole fraction range from 298.15 to 328.15 K. Based on experimental data, excess properties such as excess molar volume, viscosity deviation, and refractive index deviation were further investigated. The activation energy for viscous flow in the mixture was derived using the Arrhenius equation. The results indicate that TDES exhibits strong intermolecular interactions with both solvents, leading to negative excess volume and negative viscosity deviation in the mixed systems. Among them, the acetonitrile system demonstrates a more pronounced volume contraction effect and viscosity-reducing capability. Analysis of the refractive index deviation further confirms the presence of stronger hydrogen-bonding interactions between water and TDES. This work provides critical fundamental physical property data and molecular insights for understanding the structure–activity relationships in TDES/molecular solvent mixtures, thereby advancing process design and optimization for such green solvents in fields such as extraction and separation.
✓ 已验证
DOI
高影响因子
Systems Microbiology and Biomanufacturing
·
2026
·Vol. 6
·期 4
·116
·
IF 3.5
Zhang Quancheng,Sun Ruobin,Yu Xiaowei,Zheng Pu,Chen Pengcheng,Wu Dan
Enzymatic preparation of high value-added chitooligosaccharides still faces challenges including uncontrollable product polymerization degrees and insufficient catalytic specificity of enzymes. In this study, three mutants, namely C41A, I17A/T47A, and S155A/T200A, were constructed via rational enzyme design, and the control mechanism of product specificity through differential conformational dynamics was systematically studied. Specifically, the C41A mutant located in the catalytic pocket modified the flexibility of the key loop structure, thus enhancing the selective cleavage toward chitosan. The proportion of chitoheptaose in the product reached 4.5%, which was 11.25-fold higher than that of the parental enzyme Csn46-Mut4. The I17A/T47A double mutant at the substrate channel entrance triggered rigid contraction of the channel entrance, restricting the entry of long-chain substrates and simplifying the hydrogen bond network. Consequently, the proportion of chitopentaose was improved to 22.5%, representing an 11.8-fold improvement compared with the parental enzyme. In contrast, the S155A/T200A double mutant formed a binding pocket compatible with larger long-chain substrates, enabling the biosynthesis of chitooctaose with a proportion of 0.88%, which represented a crucial breakthrough from zero detection. Molecular dynamics simulations and intermolecular interaction analyses confirmed that all three superior mutants followed the regulatory mechanism of “conformational dynamics-product specificity”. The T m values of the mutants were increased by 0.16⁓2.30 °C relative to Csn46-Mut4. On the premise of maintaining enzyme activity, this work established a novel and efficient method for the precise preparation of chitooligosaccharides with specific high polymerization degrees, providing a solid foundation for technological innovation in this field and further promoting the application and development of high-polymer chitooligosaccharides in biomedicine and other related fields. Graphical abstract
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）