MICROCHIMICA ACTA
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2019
·Vol. 186
·期 7
·1-10
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IF 5.479
Zhang Yanshu,Hu Yufei,Li Gongke,Zhang Runkun
Core-shell nanoparticles (NPs) consisting of a gold core and a metal-organic framework shell (type MOF-74) were synthesized via one-pot synthesis. The NPs exhibit highly sensitive and stable SERS activity for the detection of 4-nitrothiophenol, with a specific band at 1337 cm −1 . The method has a linear response in 0.10–10 μmol·L −1 analyte concentration range and a lower detection limit of 69 nmol·L −1 . The potential application of this novel SERS substrate was evaluated by two model reactions involving 4-nitrothiophenol. The first involves in-situ SERS monitoring of the surface plasmon-induced nitration of aromatic rings without adding conventional acid catalyst. The second involves the photocatalytic reduction of 4-nitrothiophenol to 4-thioaminophenol in the presence of Au/MOF-74 under 785-nm laser irradiation. The plasmon-assisted dimerization of 4-nitrothiophenol to form 4,4′-dimercaptoazobenzene can also be monitored simultaneously.
Schematic presentation of a nanoparticle SERS substrate consisting of gold core and MOF-74 shell, which was applied to detection of 4-nitrothiophenol. The Au/MOF-74 was successfully used for in-situ monitoring of two model reactions involving 4-nitrothiophenol by SERS.
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Nature Communications
·
2019
·Vol. 10
·期 1
·1-7
·
IF 11.878
Chen Chao,Gao Liang,Gao Wanru,Ge Cong,Du Xinyuan,Li Zha,Yang Ying,Niu Guangda,Tang Jiang
Circularly polarized light (CPL) detection is required in various fields such as drug screening, security surveillance and quantum optics. Conventionally, CPL photodetector needs the installation of optical elements, imposing difficulties for integrated and flexible devices. The established CPL detectors without optical elements rely on chiral organic semiconductor and metal metamaterials, but they suffer from extremely low responsivity. Organic-inorganic hybrid materials combine CPL-sensitive absorption induced by chiral organics and efficient charge transport of inorganic frameworks, providing an option for direct CPL detection. Here we report the CPL detector using chiral organic-inorganic hybrid perovskites, and obtain a device with responsivity of 797 mA W -1 , detectivity of 7.1 × 10 11 Jones, 3-dB frequency of 150 Hz and one-month stability, a competitive combined feature for circularly polarized light detection. Thanks to the solution processing, we further demonstrate flexible devices on polyethylene terephthalate substrate with comparable performance.
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International Journal of Implant Dentistry
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2024
·Vol. 10
·期 1
·1-11
·
IF 3.1
Cui Boyu,Bai Tianyi,Wu Qiyou,Hu Yibo,Liu Yihong
Purpose Osteoporotic individuals who have dental implants usually require a prolonged healing time for osseointegration due to the shortage of bone mass and the lack of initial stability. Although studies have shown that intermittent teriparatide administration can promote osseointegration, there is little data to support the idea that pre-implantation administration is necessary and beneficial. Methods Sixty-four titanium implants were placed in the bilateral proximal tibial metaphysis in 32 female SD rats. Bilateral ovariectomy (OVX) was used to induce osteoporosis. Four major groups ( n = 8) were created: PRE (OVX + pre-implantation teriparatide administration), POST (OVX + post-implantation administration), OP (OVX + normal saline (NS)) and SHAM (sham rats + NS). Half of rats ( n = 4) in each group were euthanized respectively at 4 weeks or 8 weeks after implantation surgery, and four major groups were divided into eight subgroups (PRE4 to SHAM8). Tibiae were collected for micro-CT morphometry, biomechanical test and undecalcified sections analysis. Results Compared to OP group, rats in PRE and SHAM groups had a higher value of insertion torque ( p < 0.05). The micro-CT analysis, biomechanical test, and histological data showed that peri-implant trabecular growth, implants fixation and bone-implant contact (BIC) were increased after 4 or 8 weeks of teriparatide treatment ( p < 0.05). There was no statistically difference in those parameters between PRE4 and POST8 subgroups ( p > 0.05). Conclusions In osteoporotic rats, post-implantation administration of teriparatide enhanced peri-implant bone formation and this effect was stronger as the medicine was taken longer. Pre-implantation teriparatide treatment improved primary implant stability and accelerated the osseointegration process.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
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IF 15.7
Bai Lishun,Xu Yan,Liu Yue,Zhang Danni,Zhang Shibin,Yang Wujie,Chang Zhi,Zhou Haoshen
The rapid evolution of portable electronics and electric vehicles necessitates batteries with high energy density, robust cycling stability, and fast charging capabilities. High-voltage cathodes, like LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM-811), promise enhanced energy density but are hampered by poor stability and sluggish lithium-ion diffusion in conventional electrolytes. We introduce a metal-organic framework (MOF) liquid-infusion technique to fully integrate MOF liquid into the grain boundaries of NCM-811, creating a thoroughly coated cathode with a thin, rigid MOF Glass layer. The surface electrically non-conductive MOF Glass layer with 2.9 Å pore windows facilitating Li-ion pre-desolvation and enabling highly aggregative electrolyte formation inside the Glass channels, suppressing solvated Li-ion co-insertion and solvent decomposition. While the inner Glass layer composes of Li-ion conducting components and enhancing fast Li-ion diffusion. This functional structure effectively shields the cathode from particle cracking, CEI rupture, oxygen loss, and transition metal migration. As a result, Li | |Glass@NCM-811 cells demonstrate good rate capability and cycling stability even under high-charge rates and elevated voltages. Furthermore, we also achieve a 385 Wh kg -1 pouch-cell (19.579 g, for pouch-cell), showcasing the practical potential of this method. This straightforward and versatile strategy can be applied to other high-voltage cathodes like Li-rich manganese oxides and LiCoO 2 .
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
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2025
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IF 2
Xue Jianyu,Li Yingchun,Wang Wensheng,Yuan Chengke,Mi Jia,Zhang Yinzhu
Recycled acrylonitrile–butadiene–styrene (rABS) and recycled high impact polystyrene (rHIPS) are vital components of waste electrical and electronic equipment (WEEE) plastics, playing crucial roles in the recycling process. This paper utilized sodium chlorite (NaClO 2 ) to modify the surfaces of rABS and rHIPS, followed by flotation to separate the two types of plastics. X-ray photoelectron spectroscopy (XPS) test confirmed that the number of hydrophilic groups introduced on the rABS surface was more than that of rHIPS after surface modification. Through contact angle measurements, scanning electron microscope (SEM), and atomic force microscopy (AFM), it was confirmed that the modification on the rABS sample surface altered its microstructure and enhanced its surface wettability. The sodium chlorite concentration, modification temperature, and modification time significantly affected the floating percentage of rABS and rHIPS. The optimal surface modification conditions were determined to be a sodium chlorite concentration of 0.08 mol L -1 , a modification temperature of 70 °C, and a modification time of 60 min. Under these conditions, efficient separation of rABS and rHIPS was achieved, with floating percentage of 3.62 and 96.39%, respectively. Therefore, surface modification using sodium chlorite can be utilized to facilitate the flotation separation of rABS and rHIPS.
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Scientific Reports
·
2017
·
IF 4.259
Kunpeng Li,Rongzhen Zhang,Yan Xu,Zhimeng Wu,Jing Li,Xiaotian Zhou,Jiawei Jiang,Haiyan Liu,Rong Xiao
(S)-carbonyl reductase II (SCRII) from Candida parapsilosis is a short-chain alcohol dehydrogenase/reductase. It catalyses the conversion of 2-hydroxyacetophenone to (S)-1-phenyl-1,2-ethanediol with low efficiency. Sortase was reported as a molecular "stapler" for site-specific protein conjugation to strengthen or add protein functionality. Here, we describe Staphylococcus aureus sortase A-mediated crosslinking of SCRII to produce stable catalysts for efficient biotransformation. Via a native N-terminal glycine and an added GGGGSLPETGG peptide at C-terminus of SCRII, SCRII subunits were conjugated by sortase A to form crosslinked SCRII, mainly dimers and trimers. The crosslinked SCRII showed over 6-fold and 4-fold increases, respectively, in activity and k cat /K m values toward 2-hydroxyacetophenone compared with wild-type SCRII. Moreover, crosslinked SCRII was much more thermostable with its denaturation temperature (T m ) increased to 60 °C. Biotransformation result showed that crosslinked SCRII gave a product optical purity of 100% and a yield of >99.9% within 3 h, a 16-fold decrease in transformation duration with respect to Escherichia coli/pET-SCRII. Sortase A-catalysed ligation also obviously improved T m s and product yields of eight other short-chain alcohol dehydrogenases/reductases. This work demonstrates a generic technology to improve enzyme function and thermostability through sortase A-mediated crosslinking of oxidoreductases.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
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2025
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IF 3.1
Li Kaiqian,Zhang Xupeng,Li Xianghong,Chang Qiaowen,Deng Shuduan,Zhu Gang
Introducing novel bimetallic metal–organic frameworks (Cu/Zr-MOF) into wood cellulose scaffolds via an in situ growth strategy represents an effective approach to enhance the fire retardancy of wooden products. This work evaluates the effects of Cu/Zr-MOF loading content embedded in wood composite on the MOF morphology and flame retardancy of natural wood (NW). We discovered that MOF loading has a significant impact on the morphology of Cu/Zr-MOF. Specifically, with an increase in the amount of MOF precursors, the morphological transformation is from spherical to regular octahedra. Furthermore, the incorporation of high MOF loading remarkably enhanced the thermal stability at the early stage and exhibited significantly improved residual content. With 24 mass% loading of Cu/Zr bimetallic MOF, the highly flame-retardant wood composite (Cu-U-W-3) was obtained. Compared to pure NW, the peak heat release rate (pHRR) and total heat release (THR) were reduced to 25.25 W g −1 and 5.0 kJ g −1 , respectively. The limiting oxygen index (LOI) of the treated sample reached 24.81%, showing outstanding self-extinguishing ability. According to the char residue analysis, it was found that Cu-Zr bimetallic MOF anchored on the cell wall exhibited catalytic carbon-forming effect, thereby facilitating the generation of high-quality residual char. The enhanced fire safety of natural wood can be attributed to the oxygen barrier and the reduced heat transfer characteristics of the dense carbon layer. This work presents a novel methodology for the fabrication of bimetallic MOF hybrid flame retardants, with the objective of enhancing the flame retardancy of wooden products.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
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IF 15.7
Yu Shu-Yang,Wang Xiao-Yan,Sun Xiu-Li,Gao Yanshan,Zhao Yanan,Ning Xiao-Shan,Ji Gang,Lu Yuan,Yang Jie,Liu Zhi-Pan,Tang Yong
Synthesizing functionalized polyethylenes via ethylene coordination copolymerization with fundamental low-cost vinyl polar monomers provides a very attractive approach. However, it is also very challenging as the functional group (FG) to be introduced onto the polyolefin chain is directly derived from the corresponding vinyl polar monomers (CH 2 = CH-FG), which often cause catalyst poisoning due to the FG coordination to active metal center and β-X elimination during catalysis, etc. It is especially true for the synthesis of cyano-functionalized polyethylenes (PEs) via ethylene/acrylonitrile copolymerization, which can only rely on Pd catalysis with low activity. Here we present an approach utilizing binuclear Ni catalysis for ethylene/acrylamide copolymerization and the synthesis of cyano-functionalized PEs (>99%) with great activity up to 4.1 × 10 6 g/(mol cat·h). Extensive polymer characterizations (NMR, GPC, model experiments, etc) confirm significant chain transfer and the conversion of amide to nitrile during catalysis. Mechanistic investigations, including comprehensive control experiments, deuterium labeling and computational studies, support an isomerization-mediated chain transfer polymerization (ICTP) mechanistic pathway, which include tandem acrylamide enchainment, amido group conversion into CN group, and active catalyst regeneration by Et 2 AlCl. Catalyst poisoning could be largely circumvented by this catalyst system.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-10
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IF 17.694
Zhao Yixuan,Song Yuqing,Hu Zhaoning,Wang Wendong,Chang Zhenghua,Zhang Yan,Lu Qi,Wu Haotian,Liao Junhao,Zou Wentao,Gao Xin,Jia Kaicheng,Zhuo La,Hu Jingyi,Xie Qin,Zhang Rui,Wang Xiaorui,Sun Luzhao,Li Fangfang,Zheng Liming,Wang Ming,Yang Jiawei,Mao Boyang,Fang Tiantian,Wang Fuyi,Zhong Haotian,Liu Wenlin,Yan Rui,Yin Jianbo,Zhang Yanfeng,Wei Yujie,Peng Hailin,Lin Li,Liu Zhongfan
The availability of graphene and other two-dimensional (2D) materials on a wide range of substrates forms the basis for large-area applications, such as graphene integration with silicon-based technologies, which requires graphene on silicon with outperforming carrier mobilities. However, 2D materials were only produced on limited archetypal substrates by chemical vapor deposition approaches. Reliable after-growth transfer techniques, that do not produce cracks, contamination, and wrinkles, are critical for layering 2D materials onto arbitrary substrates. Here we show that, by incorporating oxhydryl groups-containing volatile molecules, the supporting films can be deformed under heat to achieve a controllable conformal contact, enabling the large-area transfer of 2D films without cracks, contamination, and wrinkles. The resulting conformity with enhanced adhesion facilitates the direct delamination of supporting films from graphene, providing ultraclean surfaces and carrier mobilities up to 1,420,000 cm 2 V −1 s −1 at 4 K.
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Reaction Kinetics Mechanisms and Catalysis
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2024
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IF 1.7
Gao Xinglong,Qiu Feifei,Xie Hongzhao,Chen Xiaopeng,Wu Chenghong,Chen Yutong,Liang Jiezhen,Wang Linlin
In the present work, efficient catalytic hydrogenation of acrylic rosin (AR) were extensively investigated. Qualitative and quantitative analysis of AR and hydrogenated acrylic rosin (HAR) were carried out by GC and GC–MS, and the reaction pathway network about catalytic hydrogenation of AR was constructed. In addition, a Pd/C catalyst with well-dispersed ultrafine nano-palladium was prepared by impregnation method using Pd(NO 3 ) 2 ·2H 2 O precursor and put into use for the catalytic hydrogenation of AR. The structural properties of the catalyst were measured via XRD, TEM, ICP-OES, XPS, and BET. The characterizations showed that the ultrafine Pd nanoparticles (NPs) with an average Pd NPs size of 2.29 nm and consisting of 3.1% Pd were equably loaded on the surface of activated carbon. Benefiting from well-dispersed ultrafine Pd NPs, the catalyst exhibits outstanding activity in the hydrogenation of AR at 180 °C and 5 MPa, which shows 1.9 times superior activity than a commercial 10% Pd/C. The quality of prepared HAR is similar to the commercial HAR (Gardner color < 1, acid value of 235 mg KOH/g, softening point of 129 °C, 35% conversion rate of acrylpimaric acids). Graphical abstract
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ACTA PHARMACOLOGICA SINICA
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2025
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IF 8.4
Wang Hao,Zhang Li,Yang Wan-yue,Ji Xiao-yi,Gao An-qi,Wei Yi-hong,Ding Xin,Kang Yue,Ding Jian-hua,Fan Yi,Lu Ming,Hu Gang
Obesity increases the risk of depression. Evidence shows that peripheral inflammation, glycemic dysregulation, and hyperactivity within the hypothalamic-pituitary-adrenal axis are implicated in both obesity and depression. In this study we investigated the impact of visceral adipose tissue (VAT), a crucial characteristic of obesity, on stress susceptibility in obese mice. Age-matched mice were fed with chow diet (CD) or high-fat diet (HFD), respectively, for 12 weeks. CD mice were deprived of VAT and received transplantation of VAT from HFD mice (TransHFD) or CD mice (TransCD). Extracellular vesicles (EVs) were prepared from VAT of CD or HFD mice, and intravenously injected (100 μg, 4 times in 2 weeks) in naïve mice or injected into hippocampus (5 μg, 4 times in 2 weeks) through implanted bilateral cannula. Depression-like behaviors were assessed 14 days after transplantation. We showed that HFD mice exhibited significantly higher body weight gain and impaired insulin and glucose tolerance, accompanied by increased stress susceptibility. Transplantation of VAT or VAT-derived EVs from HFD mice caused synaptic damage and promoted stress susceptibility in recipient mice. Through inhibiting miRNA biogenesis in the VAT and miRNA sequencing analysis, we demonstrated that miR-140-5p was significantly upregulated in both VAT-EVs and hippocampus of HFD mice. Overexpression of hippocampal miR-140-5p in naïve mice not only facilitated acute stress-induced depression-like behaviors, but also decreased hippocampal CREB-BDNF signaling cascade and synaptic plasticity. Conversely, knockdown of miR-140-5p in the VAT, VAT-EVs or hippocampus of HFD mice protected against acute stress, reducing stress susceptibility that were mediated via CREB-BDNF pathway. In summary, VAT-EVs or the cargo miRNAs in obese mice promote synaptic damage and stress susceptibility, providing potential therapeutic targets for metabolism-related affective disorders.
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INFLAMMATION
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2012
·Vol. 35
·期 5
·1676-1684
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IF 1.747
Liu Tengfei,Li Jing,Liu Yuxin,Xiao Nan,Suo Haitao,Xie Kun,Yang Chunliu,Wu Chen
Short-chain fatty acids (SCFAs) produced by the colonic bacterial fermentation of dietary fiber contribute a significant proportion of daily energy requirement. Furthermore, these compounds are modulators of macrophage function and potential targets for the development of new drugs. The aims of this study were to evaluate the effects of three types of SCFAs (sodium acetate (NaAc), sodium propionate (NaP), and sodium butyrate (NaB)) on the production of NO and inducible nitric oxide synthase (iNOS) and proinflammatory and antiinflammatory cytokines (tumor necrosis factor-α (TNF-α) and interleukin (IL-1, IL-6, and IL-10)) and to observe the effect of NaAc on inhibiting lipopolysaccharide (LPS)-induced NF-κB activation in LPS-stimulated RAW264.7 cells. The results show that three types of SCFAs (acetate, propionate, and butyrate) reduced the production of proinflammatory factors, including TNF-α, IL-1β, IL-6, and NO, and inhibited the vitality of iNOS. Meanwhile, SCFAs enhanced the production of antiinflammatory cytokine IL-10 in lower concentrations (1–1,200 μmol/L). Like NaB, NaAC inhibited LPS-induced NF-κB activation. These results may hold promise on the role that SCFAs have on the prevention and treatment of various inflammatory conditions.
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