Inorganics
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2022
·Vol. 10
·期 11
·202
·
IF 3.149
Liang Qin,Fenglan Liang,Yan Li,Jiana Wu,Shiyuan Guan,Meiyin Wu,Shiling Xie,Manshi Luo,Deyun Ma
A hydrostable 2D Zn-based MOF, {[Zn(5-PIA)(imbm)]·2H2O}n(1) (5-H2PIA = 5-propoxy-isophthalic acid, imbm = 1,4-di(1H-imidazol-1-yl)benzene), was synthesized and structurally characterized. Complex1shows good water and thermal stability based on the TGA and PXRD analyses and displays a 2D framework with 1D channels of 4.8 × 13.8 and 10.0 × 8.3 Å2along theaaxis. The 5-fluorouracil (5-FU) payload in activated complex1(complex1a) is 19.3 wt%, and the cumulative release value of 5-FU at 120 h was about 70.04% in PBS (pH 7.4) at 310 K. In vitro MTT assays did not reveal any cytotoxic effect of NIH-3T3 and HEK-293 cells when the concentration of1was below 500 μg/mL and 5 μg/mL, respectively. No morphological abnormalities were observed on zebrafish exposed to complex1.Keywords:zinc-organic framework;drug delivery;5-fluorouracil;MTT assays;zebrafish toxicity
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JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 61
·期 4
·346-354
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IF 3.046
Die Li,Mei Hong,Yan Wang,Chunyang Bao,Xiaoling Xu,Jing Chen,Bin Peng,Jingyu Zhang,Bingyu Wang,Qiang Zhang
Porous carbon nanospheres have attracted extensive attention due to their excellent advantages in specific surface area, pore distribution, and electronic conductivity. Herein, boron-doped hollow carbon nanospheres with mesoporous walls have been successfully synthesized via a combination of hard/soft templating and boronic acid/sugar ligation. Surface-initiated Cu(0) mediated reversible deactivation radical polymerization was used to initiate the polymerization of 2-hydroxyethyl acrylate and poly(ethylene glycol) methyl ether acrylate from the surface of silica. 4-carboxy-3-fluorophenylboronic acid was introduced as a boron precursor by N -(3-dimethylaminopropyl)- N ′-ethylcarbodiimide hydrochloride coupling and fructose was introduced as a carbon precursor by boronic esters. After carbonization and template etching, boron-doped porous carbon spheres could be obtained. We believe such in-situ heteroatom-doped method has great potential in preparing hollow mesoporous carbon nanospheres with excellent properties. Graphical
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2022
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IF 24.319
Kexuan Gao,Li-an Hou,Xiaoqiang An,Doudou Huang,Yu Yang
The rapid recombination rate of photogenerated charges make the rational design of high-performance stable photocatalysts challenging. Herein, the features of heterojunctions, oxygen vacancies (OVs), and MXene quantum dots (MQDs) were simultaneously collected in CBM (gC 3 N 4 /BiOBr/MXene) using a simple solvothermal method for the first time. OVs promoted the chemisorption of O 2 , MQDs not only accelerated electron transport but also promoted a photogenerated charge to selectively generate singlet oxygen, 99% of the tetracycline hydrochloride (TC-HCl) was degraded by CBM within 30 min under visible light irradiation. Thirteen intermediates and possible photocatalytic degradation pathways were proposed. It was discovered that CBM is nontoxic to the environment but can swiftly produce an excellent antibacterial effect when exposed to visible light irradiation. This research provides fresh insights into the effective removal of organic pollutants from water by combining cutting-edge defect engineering and quantum dot doping technology in photocatalytic heterojunctions.
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Genes & Genomics
·
2022
·Vol. 45
·期 1
·1-11
·
IF 2.164
Cao Qingfei,Ma Jiaji,Li Weitao,Hong Peng,Shen Tong,Tong Ming
Background Guanine nucleotide-binding protein 2 (GNBP2) is a GTPase that has critical roles in host immunity and some types of cancer, but its function in clear cell renal cell carcinoma (ccRCC) is not fully understood. Objective This work explored the role of GNBP2 in ccRCC progression and the underlying molecular mechanism. Methods Two public human cancer databases TNMplot and TISIDB were employed to analyze the expression pattern of GNBP2 during ccRCC progression and the correlation between GNBP2 expression and clinical features of ccRCC patients. GNBP2 functions in ccRCC cells were determined by EdU staining, flow cytometry, scratch wound assay, transwell assay, and xenograft model. Gene expression was evaluated using qPCR, Western blot, immunofluorescence staining, and immunohistochemical staining. Results GNBP2 expression was significantly elevated in ccRCC tissues and increased gradually with the increasing tumor grades. Patients with higher GNBP2 expression had shorter overall survival times. Knockdown of GNBP2 suppressed tumor cell proliferation and cell cycle progression and reduced the capability of migration and invasion, while GNBP2 overexpression exhibited protumor effects. GNBP2 silencing by RNA interference significantly inhibited the tumor growth of tumor-bearing nude mice and decreased the proliferation marker Ki67. Mechanistically, GNBP2 downregulation suppressed the STAT3 signaling transduction, as it reduced the phosphorylation of STAT3 and modulated the expression of the target genes, including c-Myc, MMP2, N-cadherin, and E-cadherin. Conclusion These findings reveal that GNBP2 promotes ccRCC progression by regulating STAT3 signaling transduction, indicating that GNBP2 might be a promising molecular target for ccRCC therapy.
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高影响因子
Biomaterials Research
·
2022
·Vol. 26
·期 1
·1-20
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IF 15.863
Luan Zhaohui,Liu Shuang,Wang Wei,Xu Kaige,Ye Shaosong,Dan Ruijue,Zhang Hong,Shu Zhenzhen,Wang Tongchuan,Fan Chaoqiang,Xing Malcolm,Yang Shiming
Background Wound closure in the complex body environment places higher requirements on suture’s mechanical and biological performance. In the scenario of frequent mechanical gastric motility and extremely low pH, single functional sutures have limitations in dealing with stomach bleeding trauma where the normal healing will get deteriorated in acid. It necessitates to advance suture, which can regulate wounds, resist acid and intelligently sense stomach pH. Methods Based on fish swim bladder, a double-stranded drug-loaded suture was fabricated. Its cytotoxicity, histocompatibility, mechanical properties, acid resistance and multiple functions were verified. Also, suture’s performance suturing gastric wounds and Achilles tendon was verified in an in vivo model. Results By investigating the swim bladder’s multi-scale structure, the aligned tough collagen fibrous membrane can resist high hydrostatic pressure. We report that the multi-functional sutures on the twisted and aligned collagen fibers have acid resistance and low tissue reaction. Working with an implantable “capsule robot”, the smart suture can inhibit gastric acid secretion, curb the prolonged stomach bleeding and monitor real-time pH changes in rabbits and pigs. The suture can promote stomach healing and is strong enough to stitch the fractured Achilles tendon. Conclusions As a drug-loaded absorbable suture, the suture shows excellent performance and good application prospect in clinical work.
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高影响因子
Reaction Kinetics Mechanisms and Catalysis
·
2022
·Vol. 135
·期 6
·3331-3342
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IF 1.843
Zhang Ning,Zheng Yu,Li Jianfeng,Du Zhiping,Cheng Fangqin
A reduced graphene oxide-P25 (rGO-P25) composite was synthesized by one-step hydrothermal method. The photocatalytic degradation of Rhodamine B (RhB) by the rGO-P25 composite and its settling performance was investigated with P25 as a control. The results showed that the rGO-P25 composite has a mesoporous structure, with the average particle size increased from 4.99 to 399.0 µm, and the specific surface area of the composite increased from 54.0 to 74.3 m 2 /g. The rGO-P25 composite has a much better photocatalytic and settling performance as compared to P25, which were 1.56 and 2.4 times higher. The increased photocatalytic performance by the rGO-P25 composite was mainly attributed to the increased adsorption capacity and charge transfer ability due to the introduction of rGO flakes in the composite. However, the improved settling performance mainly lies on the increase of the average particle size. The electron spin resonance (ESR) results shows that hydroxyl radical, superoxide radical and photogenerated hole were all generated in the degradation of RhB but the hydroxyl radicals are the leading reactive oxygen species. The as-synthesized rGO-P25 composite showed a good recycling ability as RhB degradation rate could still reach 98.6% after five times reuse. This study indicates that the rGO-P25 composite is a promising photocatalyst for practical wastewater treatment. Graphical abstract
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BIOMATERIALS
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2022
·
IF 15.304
Qin Zeng,Xipeng Li,Si Xie,Da Xing,Tao Zhang
Developing single molecule-assembled nanoprodrugs that can reverse the glutathione (GSH)–mediated drug resistance of tumors provides promising potentials for precision and effective cancer theranostics. Herein, we developed a novel single molecule-assembled nanoprodrug for effective photodynamic/chemotherapeutic eradication of drug-resistant tumors via the multistage GSH-depletion. The nanoprodrug MSSP-NP could be fancily fabricated by self-assembly of an amphiphilic activatable molecular MSSP, which is synthesized by covalently conjugating the photosensitizer methylene blue (MB) with a GSH-sensitive cisplatin prodrug via a tumor targeting thiolated polypeptide . Upon the nanoprodrug MSSP-NP systematic administrated, its photoactivities and pharmacological effects can be thoroughly switched on by intracellular GSH to produce the photosensitizer MB and chemotherapeutic drug cisplatin, along with the multi-step consumption of GSH, which could remarkably boost oxidative stress and reverse the drug resistance. As a result, the nanoprodrug could effectively disrupt the tumor GSH-defense system to afford high-efficiency photodynamic/chemotherapeutic inhibition of drug resistance tumors (96.4%) with minimum side effects.
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高影响因子
FOOD CHEMISTRY
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2022
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IF 9.231
Xinsheng Qin,Qingli Bo,Panzhu Qin,Sufang Wang,Kaiyong Liu
In this study, we demonstrated the role of whey protein isolate (WPI)/(−)-epigallocatechin-3-gallate (EGCG) covalent conjugates/gellan gum double network emulsion gels by duo-induction of glucono-δ-lactone (GDL) and CaCl 2 on the digestion viability of Lactobacillus Plantarum powders. We employed a novel one-step continuous cold gelation strategy to product double network emulsion gels. The gellan gum in continuous phase was first induced by CaCl 2 to form a gel in a short time. Besides, the GDL was improved covalent cross-linking between WPI-EGCG covalent conjugate Pickering particles or particle-coated oil droplets because of the slowly pH reduction. The first cross-linked gellan gum gels could be more closely integrated into the GDL-induced second gel networks with synergistic role, which promoted the formation of compact and homogeneous networks through hydrophobic interactions and disulfide bonds. Thus, the results provide a promising strategy for probiotic powders encapsulation of double network emulsion gels in oral applications of gel type foods.
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高影响因子
Frontiers in Nutrition
·
2022
·
IF 6.59
Du Qi,Fang Chuangdong,Qi He,Benjakul Soottawat,Aubourg Santiago P.,Zhang Bin
Phosphates and trehalose are widely accepted additives in animal muscle products. In this study, the effects of pre-soaking with sodium tripolyphosphate (STPP) and trehalose under vacuum permeation (VP) conditions on the physicochemical properties of shrimp muscle were evaluated over 120 d of frozen storage. The results indicate the STPP/trehalose-VP treatments significantly reduced the thawing loss and prevented changes in the texture, myofibrillar protein (MP) content, and Ca2+-ATPase activity of shrimp muscle during frozen storage compared with results of control and individual STPP or trehalose soaking treatments. The histological structure analysis revealed the permeated STPP/trehalose distinctly inhibited the dissociation of muscle fibers and reduced physical damage to connective tissues during storage. Furthermore, analysis of the thermal properties indicated STPP/trehalose treatment increased the Tg’ values of shrimp muscle tissues, likely by restricting the mobility of water molecules in muscle tissues and embedding proteins in the glassy matrix. Thus, the physical destruction caused by ice crystal growth was greatly reduced, due to the absence of water molecules around muscle proteins during frozen storage. Accordingly, the combined STPP/trehalose-VP treatment significantly enhanced the stability of frozen shrimp, and the results support the application of traditional cryoprotective additives. The treated shrimp can be stored at comparatively higher temperatures with limited physicochemical reactions during frozen storage.
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高影响因子
MOLECULES
·
2022
·Vol. 27
·期 18
·5742
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IF 4.927
Yang Liu,Xue Zhou,Dan Zhou,Yongxing Jian,Jingfu Jia,Fahuan Ge
Diabetes is a chronic metabolic disease, whereas α-glucosidases are key enzymes involved in the metabolism of starch and glycogen. There is a long history of the use of mulberry leaf (the leaf ofMorus alba) as an antidiabetic herb in China, and we found that chalcomoracin, one of the specific Diels–Alder adducts in mulberry leaf, had prominent α-glucosidase inhibitory activity and has the potential to be a substitute for current hypoglycemic drugs such as acarbose, which have severe gastrointestinal side effects. In this study, chalcomoracin was effectively isolated from mulberry leaves, and its α-glucosidase inhibition was studied via enzymatic kinetics, isothermal titration (ITC) and molecular docking. The results showed that chalcomoracin inhibited α-glucosidase through both competitive and non-competitive manners, and its inhibitory activity was stronger than that of 1-doxymycin (1-DNJ) but slightly weaker than that of acarbose. ITC analysis revealed that the combination of chalcomoracin and α-glucosidase was an entropy-driven spontaneous reaction, and the molecular docking results also verified this conclusion. During the binding process, chalcomoracin went into the “pocket” of α-glucosidase via hydrophobic interactions, and it is linked with residues Val544, Asp95, Ala93, Gly119, Arg275 and Pro287 by hydrogen bonds. This study provided a potential compound for the prevention and treatment of diabetes and a theoretical basis for the discovery of novel candidates for α-glycosidase inhibitors.Keywords:mulberry leaf;chalcomoracin;α-glucosidase inhibitor;enzymatic kinetics;molecular docking
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BIOMATERIALS
·
2022
·
IF 15.304
Xiaohui Xiao,Yupeng Wang,Jieyao Chen,Peng Qin,Peiyao Chen,Dongfang Zhou,Yue Pan
Chemoradiotherapy is a widely used treatment for patients with malignancies such as hepatocellular carcinoma (HCC). However, it remains challenging to realize safe and synergistic chemotherapy and radiation sensitization . Herein, we design a self-targeting nano-assembly (STNA) based on platinum(IV)-lactose amphiphilic prodrug for synergistic and safe chemoradiotherapy of HCC. The Pt STNA would improve the tumor accumulation due to the targeting ability of lactose to HCC cells. After receptor-mediated endocytosis , Pt STNA would release cisplatin(II) in cancer cells to form DNA-binding, thus inducing DNA damage and cell apoptosis. Meanwhile, the DNA-binding also causes cell cycle arrest in the radiation-sensitive G2/M phase by the up-regulation of phosphorylated checkpoint kinase 1 (p-Chk1) expression. Furthermore, under X-ray irradiation, Pt STNA as radiosensitizer possesses a strong X-ray attenuation ability to deposit more energy, thus elevating the level of reactive oxygen species (ROS) to amplify the cell-killing effect of radiotherapy in the G2/M phase with increased DNA damage. As a result, Pt STNA exhibits significant synergistic therapeutic effects in chemoradiotherapy with no adverse effects in vitro and in vivo . Overall, we present a novel self-targeting nano-assembly strategy based on widely used Pt drugs for synergistic chemotherapy and radiation sensitization of HCC treatment.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 38
·18251-18261
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IF 3.925
Jiabao Sun,Qiang Li,Dajie Zhang,Dongsheng Xia
Oxytetracycline (OTC) is a typical antibiotic that poses a serious threat to the environment. However, traditional treatment methods suffer from low treatment efficiencies and potential secondary contamination. Therefore, there is a need to develop efficient, convenient, and environmentally friendly removal technology. In this paper, magnetic nano-Cu/Fe composites were successfully synthesized and used as the activator of peroxymonosulfate (PMS) to degrade OTC. The obtained catalysts with different ratios showed excellent degradation effects, especially the Cu/Fe-1 catalysts. The highest removal efficiency of OTC (93%) was achieved with 0.2 g L−1 PMS and 0.1 g L−1 catalyst in 60 min. The impacts of the catalyst and PMS dosages, initial temperature and pH, coexisting anions, microplastics, and real-life water samples were investigated. To explore the mechanism for OTC degradation, radical scavenging and electron spin resonance (EPR) experiments were carried out, and non-radical 1O2 was identified to be the main radical. TEM and XRD results show the presence of CuFe2O4 composites in Cu/Fe-1, which can promote the production of 1O2 and thus improve the OTC degradation efficiency. This work provides a new efficient, stable, low-cost, and environmentally friendly approach for the degradation of oxytetracycline.
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