Communications Earth & Environment
·
2026
·
IF 9.3
Zhu Lang,Chen Na,Zou Rui,Ren Luyao,Xie Jia,Hao Zelin,Jiang Haoyang,Jia Hanzhong
Frozen regions sequester dissolved organic carbon (DOC) in ice, yet its transformation, especially coupled with other elements, remains unexplored. We found that freezing accelerated DOC transformation when coupled with nitrite, and the transformation pathway varies with carbon source. At pH 3.0, dissolved black carbon (DBC) underwent oxidative degradation with decreasing molecular weight and aromaticity, whereas leached DOC (LDOC) exhibited humification, increasing the humification index from 0.38 to 0.65. The difference arises from nitrite protonation to HNO 2 and NO + under the strongly acidic conditions induced by the freeze concentration effect. HNO 2 amplified the oxidative capacity of H 2 O 2 for DBC decomposition, where H 2 O 2 concentration in the DBC system was 6.9-fold higher than LDOC. However, NO + converts electron-rich phenols within LDOC (2.65-fold higher than DBC) into phenyl radicals, triggering polymerization to humus. These findings reveal different nitrite-induced DOC turnover during freezing, providing valuable insights into carbon source-sink dynamics during carbon-nitrogen coupling in ice. The alternative text for this image may have been generated using AI.
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Stress Biology
·
2026
·Vol. 6
·期 1
·63
·
IF 6.4
Adam Saber Y.,Ennab Wael,Zhu Cuipeng,Yuan Long,Ahmed Abdelkareem A.,Essa Mohamed Osman Abdalrahem,Husien Hosameldeen Mohamed,Saleh Ahmed A.,Kim In Ho,Liu Hao-Yu,Cai Demin
T-2 toxin is a trichothecene mycotoxin produced by Fusarium species and can cause disease after contaminated food or feed ingestion. This study aimed to investigate the impact of lycopene (Ly) on systemic inflammation, oxidative stress, and dysbiosis in mice exposed to T-2 toxin. A total of 20 male BALB/c mice (6 weeks old, weighing 23.5 ± 0.32 g) randomly divided into four groups ( n = 5): Control (Cont), Ly, T-2, and T-2 + Ly groups. Findings revealed that Ly enhanced the body weight, feedd, and water intake that have been reduced by T-2. Ly increased the villus height (VH) and VH: crypt depth (CD) and decreased CD and villus width (VW) in ileum compared to the T-2 group. In alpha diversity, Staphylococcus and Corynebacterium were the most prevalent in Cont group; Staphylococcus , and Lactobacillus , were the most prevalent in T-2 group; Candidatus-Arthromitus and Staphylococcus were the most prevalent in T-2 + Ly group. Moreover, T-2 mice had significantly ( p < 0.05) greater levels of interleukin-1 beta (IL-1β), interferon gamma (IFN-γ), Interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-α) than Cont, while the Ly significantly ( p < 0.05) lowered their concentration. The T-2 mice had significantly ( p < 0.05) higher levels of reactive oxygen species (ROS) and malondialdehyde (MDA), while their catalase (CAT),, glutathione (GSH), adenosine triphosphate (ATP), and superoxide dismutase 1(SOD1) activities were significantly ( p < 0.05) lower than Cont. Ly significantly ( p < 0.05) restored their concentration. Moreover, there was a significant reduction ( p < 0.05) of hexanoic, butyric, acetic, pentanoic, and Heptanoic acids in the T-2 mice compared to Cont. In contrast, treatment with Ly was found to significantly restore their levels compared to T-2 group. We conclude that Ly administration in the context of T-2–induced toxicity may help attenuate systemic oxidative stress and inflammation, possibly through modulation of gut microbiota and fecal short-chain fatty acids (SCFAs).
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Advanced Composites and Hybrid Materials
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2026
·
IF 15.5
He Jiachen,Wu Jianjun,Wang Lin,Yin Siwei,Yu Kun,Liu Yanyun,Xu Dejia,Ji Tuo,Gao Yuzhi,Du Yikuan,Gao Xuzhu,Cai Limin,Xie Chaoming,Lu Xiong
Resection of bone-metastatic tumors is often accompanied by severe bone erosion and structural defects. Three‐dimensional (3D) printed hydrogel scaffolds with tailorable architectures and mechanical robustness are increasingly employed to restore bone integrity after tumor removal. Here, a 3D-printed sodium alginate/GelMA hydrogel scaffold is engineered to remodel the local microenvironment for simultaneous tumor ablation and bone repair, aiming to overcome the persistent challenge of functionally modifying hydrogel scaffolds to achieve both effective tumor eradication and bone regeneration. The scaffold encapsulates dendritic cell-derived exosomes loaded with the STING agonist Cyclic dinucleotide (Dex-CDN), together with methacrylated osteogenic growth peptide (OGP-MA), while a dopamine–manganese coordination nanozyme (DM) forms a mussel‐inspired catalytic coating on the surface. Under the acidic tumor milieu, DM exhibits peroxidase‐like activity to trigger Fenton reactions, deplete glutathione, and induce oxidative stress–mediated tumor cell death. Under physiological conditions, DM displays superoxide dismutase‐ and catalase‐like activities, scavenging reactive oxygen species and maintaining redox homeostasis to promote osteogenesis. Sustained Dex‐CDN release activates STING signaling and elicits potent antitumor immunity, whereas OGP‐MA triggers BMP/Smad‐mediated osteogenic differentiation. This integrated scaffold unites catalytic therapy, immune activation, and osteoinduction, offering a promising strategy for localized tumor control and bone regeneration following bone metastatic tumor resection.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2026
·Vol. 132
·期 10
·974
·
IF 3
Liu Guanlin,Zhou Lei,Xiao Yongshuang,Cao Yan,Wang Jiaxiang,Liu Yidong,Lei Jiyu,Shi Hainan,Huang Jintao,Min Yonggang
Traditional polyimides (PI) have poor solubility in common organic solvents due to the high rigidity of the main chain and strong intermolecular forces. Consequently, the traditional negative photosensitive polyimides (PSPIs) processing needs to use a large amount of DMF, NMP and other toxic organic solvents to dissolve the poly(amic acid) (PAA), which causes the problems of volatile organic compounds emission, difficult recovery and high cost. With increasing environmental concerns, it is essential to fundamentally address the solubility limitations of PIs to reduce their dependence on hazardous solvents and improve environmental compatibility. 3,5-diaminobenzoic acid (DABA) was used to improve the solubility of PI. The carboxyl groups in DABA molecules were introduced as pendant groups along the PI main chains, which greatly increased the polarity of the polymer and provided more reactive sites for the photosensitive compound, thus significantly improving the solubility of PAA in a milder and more environmentally friendly solvent system. In this study, a series of photosensitive poly(amic acid) (PSPAA) samples with varying DABA contents were synthesized. The structure, mechanical properties, thermal properties, and morphology of PI were investigated by FTIR, DMA, TGA, and SEM, respectively, through which the optimal DABA ratio was obtained.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2026
·Vol. 132
·期 9
·968
·
IF 3
Shahbaz Muhammad Ali Hamza,Nasir Hamid,Afzal Amir Muhammad,Imran Muhammad,Chine Zied,Mumtaz Sohail,Kumar Abhinav,Kamran Muhammad Arshad
Developing multifunctional electrode materials that integrate high energy storage capacity with catalytic activity is essential for next-generation energy systems. Herein, a hierarchically engineered NiSnSe₂@r-GO@Ni-MOF composite was synthesized by the use of a two-step hydrothermal process, combining the high conductivity of r-GO, the porous framework of Ni-MOF, and the redox activity of NiSnSe₂. Structural and morphological investigations (SEM, XRD, Raman, XPS, and BET–BJH) confirmed the formation of a well-integrated mesoporous architecture with a large available electroactive sites and effective electron–ion transport. Electrochemical evaluation exhibited a high specific capacity of 1297.8 C g⁻¹. The assembled asymmetric device (NiSnSe₂@r-GO@Ni-MOF//AC) achieved an energy density of 44.8 Wh kg⁻¹ and a power density of 1120 W kg⁻¹, with 90% capacity retention over 7,000 cycles. Additionally, the composite exhibited excellent HER response and delivered a low overpotential of 49 mV and a Tafel slope of 52 mV dec⁻¹. The boosted bifunctional enactment is accredited to strong interfacial coupling and stabilizes the electrode structure, which highlights a scalable strategy for designing efficient multifunctional heterostructure to overcome the energy crisis in the present era.
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Journal of Food Measurement and Characterization
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2026
·
IF 3.6
Zhou Lin,Tang Honggang,Xu Teng,Wang Ziyuan,Zhao Ke,Li Shuangxi,Fang Siyi,Peng Xinyan,Li Huanhuan
This study aimed to evaluate the improvement effects of native Staphylococcus simulans HZ01 and S. equorum SL05 on the physicochemical features, microbial parameters, volatile organic compounds (VOCs) and microbial diversity of the fermented sausages. The results demonstrated that individual inoculation of the two strains, as well as combined inoculation, significantly improved the color and inhibited lipid and protein oxidation of the fermented sausages. There were no significant differences among the three inoculating groups. The combined inoculation group significantly increased the nitrite content, compared with the individual inoculated groups. Quantitative PCR (qPCR) analysis results showed that inoculation groups significantly increased the amount of total Staphylococcus , while having no effect on the amount of total bacteria. A total of 46 VOCs were identified in the fermented sausages, and the inoculation groups significantly increased the combined proportions of aldehydes and alcohols to more than 53%, compared with 45% in the control group. Inoculation groups significantly increased the relative abundance of Staphylococcus to more than 6.90%, compared with that of the control (0.22%). In addition, inoculation of S. equorum in fermented sausages significantly reduced the relative abundance of Brochothrix thermosphacta and all six lactic acid bacteria species, while S. simulans had no corresponding effects. Pearson correlation analysis indicated S. simulans and S. equorum had obvious differences in flavor formation. This study provided a theoretical basis for the scientific use of coagulase-negative staphylococci alone or in combination.
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Nature Nanotechnology
·
2026
·
IF 37.5
Zhang Mingqian,Li Ziyi,Hao Wenying,Yi Yakun,Zhou Ke,Liu Lei,Wu Hai-Chen
Catecholamines, including dopamine, noradrenaline (also known as norepinephrine) and adrenaline (also known as epinephrine), are essential regulators of neural and endocrine function. Although they are synthesized through a branched phenylalanine metabolic pathway, direct and dynamic monitoring of the enzymatic processes governing their production has remained challenging. Here we reconstitute the complete catecholamine biosynthetic pathway from phenylalanine to adrenaline in vitro using purified enzymes and cofactors, and couple this system with nanopore-based single-molecule sensing. By integrating two orthogonal molecular recognition modalities within a single nanopore platform, we achieve highly specific detection of all metabolic intermediates and end products throughout the pathway. Real-time monitoring enables direct observation of pathway progression and regulatory perturbations at single-molecule resolution. Using this approach, we show that 6-methylisothiocyanate disrupts catecholamine biosynthesis, providing mechanistic insight into how iodotyrosine dehalogenase 1 (DEHAL1) deficiency may compromise catecholamine production. Together, this integrated enzymology and label-free nanopore sensing platform enables time-resolved dissection of neurotransmitter metabolism and regulation, and offers a general framework for studying complex biochemical pathways with single-molecule resolution.
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JOURNAL OF NANOPARTICLE RESEARCH
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2025
·Vol. 27
·期 10
·1-16
·
IF 2.6
Zhu Junqiao,Tang Wei,Sun Zhiting,Zhu Xinhai,Quan Qiang,Yin Jiaxin,Huang Qiugui,Jia Guoxia,Zhao Yang,Tang Yuqin,Zhang Yan,Xie Linhao,Zhao Jianfu
Multiple cycles of transarterial embolization chemotherapy for hepatocellular carcinoma (HCC) can easily cause the overexpression of P-glycoprotein (P-gp), leading to multidrug resistance (MDR) of HCC. Herein, we linked PLA (polylactic acid) with doxorubicin (DOX) through acid-sensitive hydrazone bonds to prepare PLA-ADH/DOX. Then, PLA-ADH/DOX and disulfiram (DSF) were physically encapsulated into PLGA-PEG (polylactic-co-glycolic acid-polyethylene glycol) as the backbone to fabricate a drug delivery system (DOX/DSF NPs) by nanoprecipitation and emulsion solvent evaporation method. The data of physicochemical characterization showed that DOX/DSF NPs enabled excellent stability at room temperature and pH sensitivity in an acidic environment. More importantly, DOX/DSF NPs could avoid P-gp-mediated efflux through endocytosis pathways and inhibit the function of P-gp by DSF, which increases cellular uptake of DOX in HepG2/DOX cells (hepatocellular DOX-resistant cancer cell line) and promotes DOX to enter the nucleus of HepG2/DOX cells for exerting the therapeutic effect in vitro. In addition, DOX/DSF NPs could increase intracellular reactive oxygen species (ROS) levels and reduce intracellular adenosine triphosphate (ATP) levels, thereby further inhibiting the function of P-gp, increasing intracellular concentration of drugs, and ultimately overcoming MDR in HCC. Hence, the combination of DOX and DSF delivered by DOX/DSF NPs with pH-sensitive and sequentially controlled drug release may provide a new way for MDR of HCC.
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 15
·1-24
·
IF 3
Zang Shuyan,Wang Shuai,Li Xue,Chen Xinru,Wang Qian,Wang Juan
The removal of both organic and inorganic arsenic is crucial for safeguarding the environment and human health, which constitutes a key aspect of sustainable development. In this study, a novel method integrating Fenton oxidation with ZIF-8 adsorption was developed for the simultaneous treatment of roxarsone (ROX) and arsenite (As(III)) from wastewater. ZIF-8 was hydrothermally synthesized and characterized using X-ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Elemental Mapping (EM), Brunauer–Emmett–Teller (BET) surface area analysis, and zeta potential analysis. Comprehensive characterization demonstrated that the synthesized ZIF-8 exhibited a well-defined rhombic dodecahedral morphology with smooth crystal surfaces and an exceptionally high specific surface area of 1836.23 m 2 /g. Under the optimized conditions for Fenton oxidation (4.90 mmol/L H 2 O 2 , 0.1380 g/L FeSO 4 ·7H 2 O, pH 3, 30 min) and ZIF-8 adsorption (0.1 g/L ZIF-8, pH 6, 180 min, 25℃), the integrated system exhibited remarkable removal efficiencies of 92.32% for ROX (20 mg/L) and 95.16% for As(III) (1 mg/L). Specifically, compared to the individual processes, the removal efficiency of ROX was increased by 20.59% (versus Fenton-only) and 52.63% (versus ZIF-8-only), while that of As(III) was enhanced by 29.17% and 35.51%, respectively. Additionally, the integrated system exhibited maximum adsorption capacities of 107.76 mg/g for ROX and 17.70 mg/g for As(III), further confirming the presence of synergistic effects between Fenton oxidation and ZIF-8 adsorption. The adsorption processes for ROX and As(III) followed pseudo-second-order kinetics and were best described by the Langmuir adsorption model, suggesting chemisorption and monolayer adsorption on a homogeneous surface. The removal mechanism in the synergistic method involved three primary pathways: oxidation reactions (•OH), electrostatic interactions (-OH/-NH 2 ), and precipitation (FeAsO 4 ). This study demonstrates that the proposed synergistic method (Fenton@ZIF-8) is a promising technology for the simultaneous removal of both organic and inorganic arsenic species from contaminated water, with strong potential for practical application in wastewater remediation.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Li Xuefei,Jiang Pan,Wu Zumin,Yu Wei,Guo Zhiwei
The severe wear of friction pairs in water-lubricated bearings, resulting from lubricating film instability under boundary lubrication, has hindered their development and application. Enhancing surface wettability to improve interfacial adsorption capacity for water molecules and promote stable water film formation under harsh operating conditions represents an effective approach for ameliorating lubrication performance in water-lubricated bearings. Hydrophilic-modified Si 3 N 4 /polyurethane (PU) composite materials were fabricated utilizing Si 3 N 4 ceramic/PU composite material fabrication technology combined with PMPC and β-cyclodextrin surface grafting techniques. Surface characteristics, mechanical properties, and tribological performance were systematically evaluated, specifically elucidating the influence mechanisms of hydrophilic groups on wettability and lubrication behavior. Results demonstrate that distinct hydrophilic groups differentially affect composite material performance, with β-cyclodextrin exhibiting more pronounced effects. Compared to the control group, the contact angles of PMPC and β-cyclodextrin-modified composite materials were decreased by 5.69% and 10.53%, respectively. Surface-bound hydrophilic groups lowered water-lubricated friction coefficients and effectively suppressed friction-induced vibration. Superior enhancement of tribological properties was provided by β-cyclodextrin modification relative to PMPC, with optimal performance achieved at solution –OH concentrations of 0.6 mol/L. This work presents a viable strategy for mitigating tribological challenges in water-lubricated bearing materials operating under boundary lubrication state. Graphical abstract
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Nature Protocols
·
2025
·
IF 16
Dong Zhen,Wu Chunlong,Chen Jiayi,Jiang Wenhao,Piatkevich Kiryl D.,Zhu Yi,Guo Tiannan
Filter-aided expansion proteomics (FAXP) is a spatial proteomics approach designed for high-resolution analysis of formalin-fixed, paraffin-embedded (FFPE) tissues. Here we describe the integration of hydrogel-based tissue expansion with mass spectrometry, enabling isotropic expansion and robust protein retention while preserving spatial features. The FAXP workflow consists of several sequential steps, including tissue section dewaxing, in situ protein anchoring, hydrogel embedding, homogenization, staining, isotropic expansion, microdissection and filter-aided in-gel digestion to maximize peptide recovery. The Protocol integrates laser capture microdissection, enabling the precise isolation of single cells and subcellular components for subcellular spatial proteomics analysis. The approach achieves up to a fivefold linear expansion factor of FFPE tissue, including extracellular matrix-rich samples such as colorectal cancer, with less than 6% distortion, enabling the identification of an average of 2,368 proteins from single mouse liver nucleus shape and 3,312 proteins from single mouse liver cell shape using an Astral mass spectrometer. The method is compatible with diverse tissue types, including extracellular matrix-rich specimens, and integrates seamlessly with imaging workflows, such as immunostaining, for spatially resolved proteomic analysis. FAXP enables researchers to obtain comprehensive proteomic profiles with strong reproducibility and high sensitivity. The entire workflow takes ~27 h and requires only commercially available reagents and supplies and is thus accessible for researchers with intermediate expertise in tissue processing, microscopy and proteomics. FAXP can advance spatial proteomics-based studies, in particular of cancer heterogeneity, neurodegenerative diseases and cellular microenvironments within FFPE tissues, including archival clinical samples.
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PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 30
·1912
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IF 2.8
Wen Jiawei,Zhang Songyang,Chen Jian-an,Zhang Xiaoming,Wang Xin,Huang Guoyong
Titanium niobium oxide (TiNb 2 O 7 , TNO) has become a high-performance anode material for fast-charging lithium-ion batteries due to its high specific capacity, safety advantages and stable cycling performance. Nevertheless, the material’s low electronic/ionic conductivity remains a critical challenge for commercial implementation. The present study presents a novel Ni-doping strategy for TNO that optimizes the electronic structure, achieving a remarkable improvement in lithium-ion storage performance through enhanced charge transfer and ionic diffusion. The Ni 0.02 -TNO anode exhibits a reversible capacity of 240.7 mAh g −1 after 150 cycles at 1C, while retaining 172.9 mAh g −1 even after 1000 cycles under an ultra-high rate of 10C, demonstrating exceptional long-term stability and rate capability. Furthermore, the assembled LiFePO 4 (LFP) ||Ni 0.02 -TNO pouch cell demonstrates outstanding cycling stability, with 86.9% capacity retention over 500 cycles at 1C. Density functional theory calculations reveal that Ni doping reduces the bandgap from 2.193 eV to 0.765 eV, thereby enhancing electronic conductivity and facilitating faster charge transfer kinetics. This work provides a viable pathway for designing advanced lithium-ion batteries with rapid-charging capability and long-term cyclability.
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