MICROCHIMICA ACTA
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2021
·Vol. 188
·期 11
·1-10
·
IF 5.833
Zhou Shiying,Wang Xianfeng,Zhao Peng,Zheng Jilin,Yang Mei,Huo Danqun,Hou Changjun
ZIF-67-derived Co nanoparticles supported on N-doped carbon skeletons have been prepared from melamine foam (Co-NPs/NCs) for non-enzymatic electrochemical H 2 O 2 detection. The synthesis of Co-NPs/NCs was demonstrated via calcination treatment using melamine foam (MF) and ZIF-67 as precursors. The experimental results show that Co-NPs/NCs composites exhibit eminent catalytic activity toward specific determination of H 2 O 2 with high selectivity and sensitivity (252.43 and 203.88 μA mM −1 cm −2 ), low LOD (0.12 μM), and wide linear ranges (10–2080 and 2080–11,800 μM). The excellent performance might be ascribed to the synergetic effects of MOF and N-doped carbon skeletons. The carbon skeletons serve as a conductive bridge and provide a large specific surface area, which can facilitate electron transfer and well disperse nanoparticles. This non-enzymatic electrochemical sensor based on Co-NPs/NCs can successfully detect H 2 O 2 secreted by living cells, indicating its great potential in the early diagnosis and pathological exploration of disease. Graphical abstract
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Science China-Life Sciences
·
2021
·Vol. 65
·期 6
·1198-1212
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IF 6.038
Zhang Qi,Li Danyang,Dong Xue,Zhang Xiaowen,Liu Junwu,Peng Lili,Meng Bo,Hua Qi,Pei Xinyu,Zhao Lu,Hu Xiaoxi,Zhang Yang,Pan Zhenwei,Lu Yanjie,Yang Baofeng
Diabetic cardiomyopathy (DCM) is a common complication in diabetic patients. The molecular mechanisms of DCM remain to be fully elucidated. The intronic long noncoding RNA of DACH1 (lncDACH1) has been demonstrated to be closely associated with heart failure and cardiac regeneration. In this study, we investigated the role of lncDACH1 in DCM and the underlying molecular mechanisms. The expression of lncDACH1 was increased in DCM hearts and in high glucose-treated cardiomyocytes. Knockout of lncDACH1 reduced mitochondrial oxidative stress, cell apoptosis, cardiac fibrosis and hypertrophy, and improved cardiac function in DCM mice. Overexpression of lncDACH1 exacerbated mitochondria-derived reactive oxygen species (ROS) level and apoptosis, decreased activity of manganese superoxide dismutase (Mn-SOD); while silencing of lncDACH1 attenuated ROS production, mitochondrial dysfunction, cell apoptosis, and increased the activity of Mn-SOD in cardiomyocytes treated with high glucose. LncDACH1 directly bound to sirtuin3 (SIRT3) and facilitated its degradation by ubiquitination, therefore promoting mitochondrial oxidative injury and cell apoptosis in mouse hearts. In addition, SIRT3 silencing abrogated the protective effects of lncDACH1 deficiency in cardiomyocytes. In summary, lncDACH1 aggravates DCM by promoting mitochondrial oxidative stress and cell apoptosis via increasing ubiquitination-mediated SIRT3 degradation in mouse hearts. Inhibition of lncDACH1 represents a novel therapeutic strategy for the intervention of diabetic cardiomyopathy.
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Nano-Micro Letters
·
2021
·Vol. 13
·期 1
·1-14
·
IF 16.419
Lin Xiuzhu,Li Fan,Bing Yu,Fei Teng,Liu Sen,Zhao Hongran,Zhang Tong
A printable multifunctional electronic skin (e-skin) with an excellent self-healing ability was developed via a simple, clean and universally applicable method.
Water served as both the only solvent throughout the fabrication process and the trigger of the self-healing process. Each e-skin component was biocompatible.
Combined with conventional electronics, signals collected by the e-skin could be transmitted to smartphones via Bluetooth for post-processing.
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Chinese Medicine
·
2021
·Vol. 16
·期 1
·1-14
·
IF 5.455
Zhang Chen,Chen Zhejie,He Yanan,Xian Jing,Luo Ruifeng,Zheng Chuan,Zhang Jinming
Background The oral colon-targeting drug delivery vehicle is vital for the efficient application of curcumin (Cur) in ulcerative colitis (UC) treatment because of its lipophilicity and instability in the gastrointestinal tract.Methods The core–shell microparticle (MP) system composed of eco-friendly materials, zein and shellac, was fabricated using a coaxial electrospray technique. In this manner, Cur was loaded in the zein core, with shellac shell coating on it. The colon-targeting efficiency and accumulation capacity of shellac@Cur/zein MPs were evaluated using a fluorescence imaging test. The treatment effects of free Cur, Cur/zein MPs, and shellac@Cur/zein MPs in acute experimental colitis were compared.Results With the process parameters optimized, shellac@Cur/zein MPs were facilely fabricated with a stable cone-jet mode, exhibiting standard spherical shape, uniform size distribution (2.84 ± 0.15 µm), and high encapsulation efficiency (95.97% ± 3.51%). Particularly, with the protection of shellac@zein MPs, Cur exhibited sustained drug release in the simulated gastrointestinal tract. Additionally, the in vivo fluorescence imaging test indicated that the cargo loaded in shellac@zein MPs improves the colon-targeting efficiency and accumulation capacity at the colonitis site. More importantly, compared with either free Cur or Cur/zein MPs, the continuous oral administration of shellac@Cur/zein MPs for a week could efficiently inhibit inflammation in acute experimental colitis.Conclusion The shellac@Cur/zein MPs would act as an effective oral drug delivery system for UC management.
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EXPERIMENTS IN FLUIDS
·
2021
·Vol. 62
·期 10
·1-11
·
IF 2.48
Li Mengqi,Liu Zhaomiao,Pang Yan,Wang Ju,Lu Yao,Ren Yanlin,Zhao Siyu,Gao Shanshan
In this paper, the internal flow characteristics of shear thinning xanthan gum (0.02–0.08 wt %) non-Newtonian droplets moving in rectangular microchannels were studied by means of micro-PIV. When the capillary number Ca is less than 4.05 × 10 –3 , there are four eddies inside droplets running in the low depth-to-width ratio channel. Once the aspect ratio gets higher, more oil film resistance would result in a pair of eddies inside droplets near the channel wall at the plane of half the channel height, which means six eddies exist inside droplets in total. As Ca gradually increased to 5.06 × 10 –2 , due to the shear stress of continuous phase and the shear thinning of dispersed phase, the flow topologies inside droplets would change to symmetric butterfly wing double vortex and \(\dot{\mathrm{M}}\) structure. The uneven distribution of interfacial tension caused by the inertial aggregation of surfactants at the back end of the droplet transforms long droplets into a teardrop-like under continuous phase extrusion. Because of the continuous phase reflux in the middle of the droplet horizontal axis, an obvious pressure fluctuation is observed. At high xanthan gum concentration, the increase of viscosity leads to four eddies inside teardrop-like droplet. The essence of the flow fields inside non-Newtonian droplets is the redistribution of dispersed phase velocity with different degrees of shear thinning. The results are beneficial to the development of microfluidic flow cytometry, the control of biochemical reaction process inside droplets and the understanding of the complex logic behavior of non-Newtonian droplets in microchannels. Graphic abstract
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JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 32
·18162-18173
·
IF 4.22
Xu Yongjie,Liu Qifan,You Hui,Zang Limin,Xiao Yayue,Wang Xue,Yang Chao
The exploration of future energy storage devices with lightweight, flexible, and highly efficient energy management strategy has attracted increased interest in recent years. The design and implementation of unique supercapacitor electrodes are expected to overcome these challenges. Herein, we report a facile electrochemical polymerization method to prepare sandpaper-based conductive polymer flexible supercapacitors. The prepared electrodes present hollow barnacle-like structure, and the maximum specific capacitance of the assembled supercapacitor is 303.3 mF cm −2 . After 10,000 charge–discharge cycles, the capacitance retention maintains 92.7%. Moreover, the device has good flexibility, and the capacitance retention is as high as 92.5% after 2000 bending cycles, which is of great significance to applications. Graphical abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 29
·期 7
·10858-10864
·
IF 4.223
Li Min,Wang Yayao,Ma Lu,Yan Xingfu,Lei Qian
Many quinoline (QL) derivatives are present in the environment and pose potential threats to human health and ecological safety. The acute toxicity of 30 haloquinolines (HQs) was examined using the photobacterium Vibrio fischeri. IC 50 values (inhibitory concentration for 50% luminescence elimination) were in the range 5.52 to >200 mg·L −1 . The derivative 5-BrQL exhibited the highest toxicity, with 3-ClQL, 3-BrQL, 4-BrQL, 5-BrQL, 6-BrQL, and 6-IQL all having IC 50 values below 10 mg·L −1 . Comparative molecular field analysis modeling based on the steric and electrostatic field properties of the HQs was used to quantify the impact of halogen substituents on their toxicity. QL derivative rings with larger substituents at the 2/8-positions and less negative charge at the 4/5/6/8-positions were positively correlated with acute toxicity towards V. fischeri .
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Journal of Translational Medicine
·
2019
·Vol. 17
·期 1
·1-12
·
IF 4.098
Liu Dandan,Lv Hang,Liu Qi,Sun Yanli,Hou Shenglong,Zhang Lu,Yang Mengyue,Han Baihe,wang Gang,Wang Xuedong,Du Wenjuan,Nie Honggang,Zhang Ruoxi,Huang Xingtao,Hou Jingbo,Yu Bo
Background Atherosclerosis preferentially develops in regions of disturbed flow (DF). Emerging evidence indicates that yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which are both effectors of the Hippo pathway, sense different blood flow patterns and regulate atherosclerotic lesions. We previously found that methotrexate (MTX) reduces in-stent neoatherosclerosis, decreases the plaque burden, and has an effect on local fluid shear stress. Here, we investigated the atheroprotective effect of MTX under DF and the mechanisms underlying these properties. Methods Human umbilical vein endothelial cells (HUVECs) were subjected to biomechanical stretch using a parallel-plate flow system and treated with or without MTX at therapeutically relevant concentrations. Additionally, an extravascular device was used to induce DF in the left common carotid artery of C57BL/6 mice, followed by treatment with MTX or 0.9% saline. The artery was then assessed histopathologically after 4 weeks on a Western diet. Results We observed that MTX significantly inhibited DF-induced endothelial YAP/TAZ activation. Furthermore, it markedly decreased pro-inflammatory factor secretion and monocyte adhesion in HUVECs but had no effect on apoptosis. Mechanistically, AMPKa1 depletion attenuated these effects of MTX. Accordingly, MTX decreased DF-induced plaque formation, which was accompanied by YAP/TAZ downregulation in vivo. Conclusions Taken together, we conclude that MTX exerts protective effects via the AMP-dependent kinase (AMPK)-YAP/TAZ pathway. These results provide a basis for the prevention and treatment of atherosclerosis via the inhibition of YAP/TAZ.
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CELLULOSE
·
2019
·Vol. 27
·期 2
·743-753
·
IF 3.917
Chen Junyu,Mao Liucheng,Qi Hongxu,Xu Dazhuang,Huang Hongye,Liu Meiying,Wen Yuanqing,Deng Fengjie,Zhang Xiaoyong,Wei Yen
Abstract In recent years, cellulose nanocrystal (CNC) based materials have attracted great research attention for different applications owing to their unique properties and facile modification chemistry. In this work, CNC based thermo-responsive fluorescent composites were successfully prepared via the metal-free surface-initiated atom transfer radical polymerization (ATRP) of NIPAAm and a Schiff base containing dye (HDPAP). Results demonstrated CNC-poly (NIPAAm–HDPAP) composites display sensitive temperature-responsive coil-to-globule transition behavior at the temperature of lower critical solution temperature. The bright fluorescence offered by the Schiff base dye (HDPAP) was also confirmed by fluorescence spectra. Moreover, the preparation method of light meditated ATRP was proved to become the promising way in fabrication of multifunctional nanomaterials for its incomparable advantages, including low energy consumption, high efficiency, good monomer adaptation, free of transition metal ions. Graphic abstract
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 12
·1-10
·
IF 5.479
Gan Xiaorong,Zhao Huimin,Schirhagl Romana,Quan Xie
A non-enzymatic fluorometric assay is described for the determination of glucose. The method is based on the use of g-C 3 N 4 quantum dots (QDs) that have good water solubility. The QDs were synthesized by a one-step solvothermal process using formamide as precursor. The QDs possess an average size of ~5 nm, a band gap of 3.0~3.5 eV, and strong blue fluorescence (with excitation/emission maxima at 400/447 nm). Fluorescence is quenched by glucose (which acts as the electron acceptor) via an electron transfer mechanism. Comprehensive spectroscopy and density functional theory calculations show that the selectivity of the fluorescent probe can be attributed to the presence of N-H bonds that are formed between the QDs (mainly at plane edges) and glucose. The interaction forces lead to the formation of localized states for capturing hot electrons. This results in a decrease in the band gap and a reduction in fluorescence intensity. The probe is selective over some typical interfering species (such as cysteine and albumin) which often are present in the urine of diabetics. The method has a linear response in the 0.2 to 5.0 mM glucose concentration range and a 0.2 mM detection limit.
Schematic representation of the synthesis of g-C 3 N 4 quantum dots (QDs) as a fluorescent nanoprobe for selective detection of glucose.
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JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 55
·期 3
·1148-1156
·
IF 3.442
Chen He,Yu Lanyong,Lin Zifeng,Zhu Qizhen,Zhang Peng,Qiao Ning,Xu Bin
MXenes are 2D transition metal carbides or nitrides with high electrical conductivity that have attracted great attention as promising electrode materials that supersede carbon-based material designed for supercapacitors. However, the aggregation and self-restacking of MXene 2D nanosheets limit their high-rate performance. In this work, flexible and conductive Ti 3 C 2 T x MXene/carbon nanotubes (CNTs) composite film was prepared through a simple vacuum filtration of the Ti 3 C 2 T x MXene and CNTs suspension mixture. The CNTs integrated MXene nanosheets can effectively prevent the restacking while creating fast ion transport channels for enhanced capacitance. The designed films exhibit excellent performance as supercapacitor electrodes with high capacitance of 300 F g −1 at 1 A g −1 with superior rate performance of 199 F g −1 even at 500 A g −1 , together with excellent cyclic stability of 92% capacitance retention after 10000 cycles at 20 A g −1 . The excellent workability demonstrates potential application of the system for flexible, portable and highly integrated supercapacitors.
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Nano Research
·
2019
·Vol. 12
·期 11
·2766-2773
·
IF 8.515
Fang Dahui,Wan Lei,Jiang Qike,Zhang Hongjie,Tang Xuejun,Qin Xiaoping,Shao Zhigang,Wei Zidong
Bimetallic platinum-copper (Pt-Cu) alloy nanowires have emerged as a novel class of fuel cell electrocatalysts for oxygen reduction reaction (ORR) due to their intrinsic high catalytic activity and durability, but preparing such electrocatalysts with clean surface via facile method is still a challenge. Herein, PtCu alloy with nanowire networks (NWNs) structure is obtained by a simple modified polyol method accompanied with a salt-mediated self-assembly process in a water/ethylene glycol (EG) mixing media. The formation mechanism of PtCu NWNs including the morphological evolution and the relevant experimental parameters has been investigated systematically. We propose that a micro-interface in H2O-EG media formed with the assistance of disodium dihydrogen pyrophosphate (Na 2 H 2 P 2 O 7 ) and its unique nature of coordinating with Pt 2+ or Cu 2+ play critical roles in the formation of NWNs. When tested as ORR catalyst, the PtCu NWNs /C exhibits much higher activity and durability than that of Pt NWNs /C and commercial Pt/C, even exceeding the target of DOE in 2020. The excellent performance of PtCu NWNs /C could be attributed to the unique structure of NWNs with 2.4 nm ultrathin wavy nanowires and plentiful surface defects and the modified electronic effect caused by alloying with Cu atoms.
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