Nature Communications
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2022
·Vol. 13
·期 1
·1-8
·
IF 17.694
Li Ming-Ding,Shen Xiao-Quan,Chen Xin,Gan Jia-Ming,Wang Fang,Li Jian,Wang Xiao-Liang,Shen Qun-Dong
With speeding up development of 5 G chips, high-efficient thermal structure and precise management of tremendous heat becomes a substantial challenge to the power-hungry electronics. Here, we demonstrate an interpenetrating architecture of electrocaloric polymer with highly thermally conductive pathways that achieves a 240% increase in the electrocaloric performance and a 300% enhancement in the thermal conductivity of the polymer. A scaled-up version of the device prototype for a single heat spot cooling of 5 G chip is fabricated utilizing this electrocaloric composite and electromagnetic actuation. The continuous three-dimensional (3-D) thermal conductive network embedded in the polymer acts as nucleation sites of the ordered dipoles under applied electric field, efficiently collects thermal energy at the hot-spots arising from field-driven dipolar entropy change, and opens up the high-speed conduction path of phonons. The synergy of two components, thus, tackles the challenge of sluggish heat dissipation of the electroactive polymers and their contact interfaces with low thermal conductivity, and more importantly, significantly reduces the electric energy for switching the dipolar states during the electrocaloric cycles, and increases the manipulable entropy at the low fields. Such a feasible solution is inevitable to the precisely fixed-point thermal management of next-generation smart microelectronic devices.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-10
·
IF 17.694
Deng Wenjie,Zheng Zilong,Li Jingzhen,Zhou Rongkun,Chen Xiaoqing,Zhang Dehui,Lu Yue,Wang Chongwu,You Congya,Li Songyu,Sun Ling,Wu Yi,Li Xuhong,An Boxing,Liu Zheng,Wang Qi jie,Duan Xiangfeng,Zhang Yongzhe
Miniaturized spectrometers are of considerable interest for their portability. Most designs to date employ a photodetector array with distinct spectral responses or require elaborated integration of micro & nano optic modules, typically with a centimeter-scale footprint. Here, we report a design of a micron-sized near-infrared ultra-miniaturized spectrometer based on two-dimensional van der Waals heterostructure (2D-vdWH). By introducing heavy metal atoms with delocalized electronic orbitals between 2D-vdWHs, we greatly enhance the interlayer coupling and realize electrically tunable infrared photoresponse (1.15 to 1.47 μm). Combining the gate-tunable photoresponse and regression algorithm, we achieve spectral reconstruction and spectral imaging in a device with an active footprint < 10 μm. Considering the ultra-small footprint and simple fabrication process, the 2D-vdWHs with designable bandgap energy and enhanced photoresponse offer an attractive solution for on-chip infrared spectroscopy.
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FIBERS AND POLYMERS
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2024
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IF 2.2
Huang Fei,Huang Chen,Meng Fenye,Aw Kean Chin,Yan Xiong,Hu Jiyong
Yarn-based strain sensors are breaking the boundaries between flexible wearable electronics and smart clothing due to their unique functionality and weavability. The sensing strain range of most flexible strain sensors is less than its tensile range, and it is easy to exceed its sensing strain range during use, resulting in unstable performance and failure of the sensor. An effective-strain-range-controllable and wear-resistant yarn strain sensor was developed with a core-sheath braided structure with the sensing yarn as the core and the braided yarn as the shell. This design strain allows for control over the effective strain range by adjusting the core sensing yarn’s pre-stretch ratio and the outer braided layer’s structure. This prevents damage to the conductive network and sensor failure caused by excessive stretching during use. The sensitivity, linear sensing range, and hysteresis of the braided strain sensors are effectively adjusted by changing the braiding yarns’ braiding angle and the sensing yarn’s pre-stretch ratio. Additionally, the sensors’ appearance and texture can be customized by changing the colour and material of the braiding yarns, allowing these sensors to integrate seamlessly with the garment and enhance their aesthetics. Furthermore, when combined with elastic fabric bands, these sensors can be attached to various parts of the human body to monitor physiological information, such as respiration and movement. The braided structure design presents a versatile strategy that could be applied to other types of strain sensors, achieving stability, durability, and aesthetics simultaneously.
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Journal of Translational Medicine
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2025
·Vol. 23
·期 1
·1-19
·
IF 7.5
Han Ning,Yu Na,Yu Li
Background Diabetic retinopathy (DR) is the common cause of diabetic vascular complications and it causes blindness. Until now, there are still some patients with DR who lack effective treatment. Tripartite motif containing 44 (TRIM44) has been shown to play a significant role in endothelial cells. However, the role of TRIM44 in DR remains unknown. Methods Diabetes was induced in rats through the administration of an intraperitoneal injection of 65 mg/kg of streptozotocin (STZ). Rat retinal microvascular endothelial cells (RMECs) were subjected to stimulation under high glucose (HG) conditions. A thorough proteomic investigation and bioinformatic analysis were performed to identify the differentially expressed proteins (DEPs) in rat RMECs after blocking TRIM44. A dual luciferase reporter assay was employed to assess the luciferase activity of TRIM44. Results TRIM44 was highly expressed in the retinal tissues of rats with diabetes and HG-induced RMECs. In vivo assays suggested that TRIM44 silencing improved the pathological alterations of DR rats as demonstrated by the downregulated expression of isolectin-B4 and VEGFA, along with a decrease in acellular capillaries within the retinal tissues. Knockdown of TRIM44 markedly reduced cell viability, proliferation, migration, invasion, and angiogenesis in HG-evoked RMECs. Mechanistically, TRIM44 was demonstrated to be activated transcriptionally by KLF transcription factor 9 (KLF9), a known facilitator of angiogenesis in DR. In HG-induced cells, the loss of TRIM44 resulted in the reverse of the endothelial cell function caused by KLF9 overexpression. After the comprehensive analysis, 64 upregulated and 38 downregulated DEPs were screened out for a series of functional enrichment analyses. Conclusions Collectively, this study demonstrates that TRIM44 knockdown suppressed diabetes-induced retinal vascular dysfunction in DR.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
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IF 15.7
Duan Peng,Wang Chenxing,Huang Yinpeng,Fu Chunqiao,Lu Xulei,Zhang Yong,Yao Yuming,Chen Lei,He Qi-Chang,Qian Linmao,Yang Tingting
Harvesting the energy from the interaction between hygroscopic materials and atmospheric water can generate green and clean energy. However, the ion diffusion process of moisture-induced dissociation leads to the disappearance of the ion concentration gradient gradually, and there is still a lack of moisture-based power generation devices with truly continuous operation, especially the duration of the current output still needs to be extended. Here, we propose a design for reconstructing the ion concentration gradient by coupling photocatalytic hydrogen evolution reaction with hydrovoltaic effect, to report a moisture-enabled electric generator (MEG) with continuous current output. We show that the introduction of the photocatalytic layer not only absorbs light energy to greatly increase the power generation of the MEG (500% power density enhancement), but more importantly, the photocatalytic hydrogen evolution process consumes the pre-stacked ions to restore the ion concentration gradient, allowing the MEG to continuously output current for more than 600 hours, which is 1 to 2 orders of magnitude higher than the great majority of existed MEGs in terms of the current output duration.
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Journal of Central South University
·
2025
·Vol. 31
·期 12
·4449-4459
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IF 4.4
Wu Zhuang-zhi,Han Cheng,Wang Jia-sen,Li Xue-bao,Fei Hao,Wang De-zhi
Sulfide solid electrolytes (S-SEs) are widely preferred for their high ionic conductivity and processability. However, the further development of S-SEs is hindered by the excessive price of its critical raw materials of Li 2 S. Herein, a low-cost and environmentally friendly method is proposed to synthesize Li 2 S by the carbothermal reduction reaction of Li 2 SO 4 in one step, and the effects of various factors are also discussed. As a result, a purity of 99.67% is obtained over the self-prepared Li 2 S. More importantly, the cost of the self-prepared Li 2 S is only about 50 $/kg, which is significantly lower than that of the commercial counterpart (10000–15000 dollar/kg). Moreover, the ionic conductivity of Li 5.5 PS 4.5 Cl 1.5 prepared using self-prepared Li 2 S as raw materials is 4.19 mS/cm at room temperature, which is a little higher than that of Li 5.5 PS 4.5 Cl 1.5 using commercial Li 2 S (4.05 mS/cm). And the all-solid-state lithium batteries (ASSLBs) with the as-prepared electrolytes could maintain a discharge capacity of 109.9 mA·h/g with an average coulombic efficiency (CE) of 98% after 100 cycles at 0.2 C , which is equivalent to that using commercial Li 2 S, demonstrating that the preparation strategy of Li 2 S proposed in this work is feasible.
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International Journal of Metalcasting
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2025
·
IF 2.5
Du Danfeng,Nie Xinfeng,Sun Chaowei,Liu Zexin,Guo Xiurong
Aluminum foam often collapses during the foaming process, adversely affecting its pore structure and resulting in suboptimal compression and energy absorption performance. To address this issue and enhance the mechanical properties of aluminum foam for broader applications in the automotive industry and other fields, this study developed an Al/TaC foam composite (AT-FC) using powder metallurgy. The composite incorporates tantalum carbide (TaC) as reinforcement particles, titanium powder as a combustion aid, titanium hydride as a foaming agent, and wood fiber as a space-holder material. The effects of varying TaC content on the pore structure and distribution of the aluminum foam composite were systematically investigated, alongside axial quasi-static compression tests. The results reveal that TaC content significantly influences the porosity and pore distribution of aluminum foam, while the inclusion of wood fiber as a spatial support material effectively prevents collapse. Compression tests showed that the mechanical properties were optimized with 10% TaC content, achieving a compressive strength of 10.223 MPa and an energy absorption capacity of 3.977 MJ/m 3 before reaching the densification strain. Graphical
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RARE METALS
·
2025
·
IF 11
Liu Wan-Ping,Liu Jun,Li Xue-Lei,Li Qing-Wen,Xu Zhi-Hui,Liu Hui-Rong,Cao Jia-Feng,Bayaguud Aruuhan,Baoyin Hexi
In sulfide-based all-solid-state lithium batteries (ASLBs), the development of high-capacity anode materials with stable interfaces to sulfide solid-state electrolytes (SSEs) is critical. Here, In 2 O 3 is explored as an anode material for ASLBs for the first time, demonstrating exceptional interfacial stability and electrochemical performance. The In 2 O 3 anode, with a substantial mass loading of 7.64 mg cm −2 , sustains a charge-specific capacity of 528.0 mAh g −1 (4.03 mAh cm −2 ) at a current density of 0.76 mA cm −2 over 500 cycles, with a capacity retention of 81.2%. Additionally, it exhibits remarkable long-term cycling stability (2900 cycles) under a high current density of 3.82 mA cm −2 , with an exceptionally low decay rate of 0.016% per cycle. The charge–discharge mechanism of the In 2 O 3 anode is elucidated in detail, revealing that the electrochemical evolution of In 2 O 3 in ASLBs involves not only the alloying/dealloying process of indium (In) but also a conversion reaction between In and Li 2 O. Notably, as cycling progresses, the conversion reaction of In and Li 2 O diminishes, with the reversible alloying/dealloying process becoming predominant. This work offers valuable insights for advancing oxide anode materials in sulfide-based ASLBs. Graphical abstract
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CLINICAL RHEUMATOLOGY
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2025
·
IF 2.8
Wang Xin,Sun Chao,Yang Xinmeng,Xu Guixia,Pei Lijia,Tang Lin,Xu Shengqian,Xie Changhao
Objective To explore the role of gut microbiota and plasma metabolites in the therapeutic mechanism of tofacitinib in ankylosing spondylitis (AS). Method Ten AS patients and ten matched healthy controls (HC) were enrolled in this study. 16S rRNA sequencing and LC–MS profiling was conducted to investigate the gut microbiota and plasma metabolite before and after tofacitinib therapy. An AS mouse model was established to validate the effect of tofacitinib in vivo via H&E staining, western blot, and ELISA. Results Tofacitinib improved clinical symptoms in AS patients. Microbiota analysis revealed Microbiota analysis revealed reduced α-diversity (ACE, Chao1) and altered community structure in AS patients compared to HC, which partially normalized post-treatment. LEfSe identified 84 taxa biomarkers; Barnesiella , Coprobacter , Lachnospira , and Lactobacillus tended to return to normal after tofacitinib treatment. Plasma metabolomics uncovered 3 key metabolies, including choline metabolism, glycerophospholipid metabolism, and phenylalanine metabolism. Spearman analysis revealed that the gut microbiota were closely related to the changes in differential plasma metabolites. Combinated tofacitinib and trichostatin therapy attenuated inflammation, restored metabolism caused by AS in mice in vivo . Conclusion AS patients suffer from dysbiosis of gut microbiota, and the mechanism of tofacitinib treatment of AS may be related to the modulation of gut microbiota and alteration of plasma metabolites.
Key Points • Tofacitinib improves clinical symptoms in patients with AS . • Tofacitinib regulates gut microbiota in AS patients . • Tofacitinib regulates plasma metabolites in patients with AS . • Tofacitinib regulates the choline metabolism .
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Stem Cell Research & Therapy
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2025
·Vol. 16
·期 1
·1-17
·
IF 7.3
Du Dongdong,Wang Ting,Sun Yaodong,Zhang Yi,Zhang Bufan,Shao Jingrong,Yang Mengxue,Huang Chuan,Zuo Shengkai,Wu Naishi
Background The poor viability and paracrine function of transplanted mesenchymal stem cells (MSCs) hamper their therapeutic efficacy in ischemic heart injury treatment. Protein arginine methyltransferases (PRMTs) mediate arginine methylation and have important functions in cellular responses. However, the role of PRMTs in MSC-based therapies for ischemic heart injury remains unclear. The aim of this study was to investigate the effect of PRMT1 on MSC function and therapeutic efficacy using a mouse myocardial infarction (MI) model.Methods We isolated, cultured, and identified mouse adipose tissue-derived mesenchymal stromal cells (ADSCs). We used Furamidine, a PRMT1 inhibitor, and adenoviral shPRMT1 to study the effects of PRMT1 inhibition on ADSC proliferation, migration, and viability. We performed RNA sequencing and biochemical experiments to elucidate the molecular mechanisms of PRMT1 in ADSCs. Finally, we infected ADSCs with adenoviral shPRMT1 and administered an intramyocardial injection after MI. Cardiac function was evaluated using echocardiography and pathological staining, and ADSCs survival rates, cardiomyocyte apoptosis, and capillary density were evaluated using immunofluorescence staining.Results We found that PRMT1 was highly expressed in ADSCs and markedly upregulated in response to H2O2 challenge. Inhibition of PRMT1 by Furamidine or adenoviral shPRMT1 promoted ADSC proliferation and migration and reduced H2O2-induced ADSCs apoptosis. Mechanistically, PRMT1 inhibition significantly increased the expression of matrix metallopeptidase (MMP)-10, placenta growth factor (PlGF) and transforming growth factor (TGF)-β2 in ADSCs through transcription factor RUNX1. Blockage of RUNX1 abolished the proliferative and migratory effects of PRMT1 inhibition in ADSCs. Compared to ADSCs infected with the adenovirus-control, PRMT1 knockdown adenovirus markedly increased the survival and retention of transplanted ADSCs in injured hearts after MI. ADSCs with PRMT1 knockdown markedly improved cardiac function and alleviated cardiac fibrosis in mice after MI by reducing cardiomyocyte apoptosis and increasing capillary density.Conclusion sPRMT1 inhibition enhances the cardioprotective effect of ADSCs against MI through RUNX1-mediated production of MMP-10/PlGF/TGF-β2. Overall, PRMT1 inhibition is a promising strategy for augmenting MSCs therapeutic efficacy in ischemic cardiomyopathy.
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MICROCHIMICA ACTA
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2025
·Vol. 192
·期 6
·1-11
·
IF 5.3
Zhang Xingping,Feng Yujun,Chen Xiaowei,Wang Yuanyuan,Guo Yingli,Yang Xin,Yang Hualin
A sensitive fluorescence and colorimetric dual-mode detection method based on Eu 3+ and Fe 3 O 4 @MoS 2 nanocomposites was constructed. In this technique, tetracycline antibiotics (TCs) chelated with Eu 3+ to form a Eu 3+ -TCs complex which emits red fluorescence at 620 nm through the antenna effect. At the same time, Eu 3+ -TCs complex enhances the peroxidase-like activity of Fe 3 O 4 @MoS 2 to catalyze the oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB) that can produce a colorimetric signal. This proposed strategy has been used to detect three antibiotics including oxytetracycline (OTC), tetracycline (TC), and chlortetracycline hydrochloride (HCl-CTC). The linear ranges of the new assay for OTC, TC, and HCl-CTC were 0.1–25 μM, 0.5–25 μM, and 0.05–5 μM with the detection limits of 0.016 μM, 0.039 μM, and 0.036 μM, respectively. Meanwhile, this new method was fast and convenient which can complete the detection in 22 min. The assay has been effectively applied to TCs detection in tap water, lake water and honey with satisfactory recoveries of 90.55–109.86%. Graphical
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 15
·1-17
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IF 2.8
Wang Renjie,Hu Mengmeng,Zhu Yifan,Jin Xiaxue,Ge Siying,Cai Runjing,Wang Tongliang,Cheng Qiaohuan,Ran Huijuan,Peng Fei
Dopamine is a critical neurotransmitter, and its dysfunction is strongly linked to various neurological disorders, including Parkinson’s disease, depression, and schizophrenia. Current detection techniques exhibit limitations in clinical applications; therefore, developing a method with high sensitivity and rapid response for dopamine detection holds significant importance. In this study, poly(3,4-ethylenedioxythiophene) (PEDOT) was synthesized via the solvent method, and a novel electrochemical sensor was constructed by integrating titanium metal–organic framework (Ti-MOF) with PEDOT through an in-situ synthesis strategy. This sensor combines the REDOX properties of Ti-MOF with the high conductivity of PEDOT, demonstrating exceptional sensitivity toward dopamine. The linear detection range spans from 8 to 400 μM, with a detection limit of 3.815 μM. In the presence of ascorbic acid (AA), dopamine (DA), and uric acid (UA), the sensor exhibits remarkable selectivity for DA. Repeatability testing reveals that the relative standard deviation of the sample response current is less than 5%, indicating high data consistency. Furthermore, after one month of storage, the senso’s response to DA decreases by only 12%, reflecting excellent reproducibility. Additionally, this study provides an in-depth analysis of the sensor’s REDOX mechanism, offering theoretical support for its optimization and practical application. The successful development of this sensor introduces an innovative, efficient, and highly sensitive approach for dopamine detection, thereby expanding the application scope of Ti-MOF in the field of electrochemical sensing.
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