Nature Communications
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2026
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IF 18.1
Wang Huihui,Gu Jianfeng,Li Chao,Li Donghui,Zhan Weiqing,Zhang Xinmin,Ji Xinyi,Chen Yongsheng,Liang Jiajie
MXenes enable high-performance fibers with strength, toughness, and conductivity, yet weak edge-to-edge interactions between nanosheets remain a critical challenge. Inspired by the cord-bound architecture of lamellar armor, we use molecular cords of carboxymethyl cellulose-wrapped single-walled carbon nanotubes to bridge adjacent MXene nanosheets via ionic coordination. Through mild and continuous wet-spinning, crosslinking, and hot-pressing, we fabricate MXene fibers containing only 0.12 wt% of the molecular cords that deliver enhanced mechanical properties: a tensile strength of 1.48 ± 0.06 GPa (peak: 1.55 GPa), ductility of 17.7 ± 0.8%, and toughness of 131.0 ± 8.7 MJ m −3 (peak: 140 MJ m −3 ), representing enhancements of 480%, 300%, and 1620% over pristine MXene fibers, while retaining electrical conductivity above 10,400 S cm −1 and a volumetric capacitance of 1645 F cm −3 . These molecular cords reinforce interlayer bonding and in-plane bridges, enabling efficient stress transfer and crack inhibition in 2D nanosheet fibers. This molecular cord strategy could potentially be applied to maximize the mechanical performance of fibers derived from other two-dimensional nanosheets.
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Nature Communications
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2026
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IF 18.1
Li Qing-Xiu,Li Hua-Xin,Sun Tao,Jiang Ming-Hao,Leng Yan-Bing,Lv Zi-Yu,Zhou You,Zhou Ye,Wong Wai-Yeung,Han Su-Ting
The demand for bio-inspired neuromorphic systems drives research on artificial neuronal devices with dual excitatory/inhibitory capabilities. Although perovskite memristors show promise, interfacial barriers and rapid ion migration hinder modulation. This study addresses these challenges through atomic-scale cathode engineering, developing perovskite-based memristor (Au/Ni 1 -rGO/MAPbI 3 /ITO) with nickel single-atom modified reduced graphene oxide (Ni 1 -rGO) cathode. The Ni–O configuration of Ni 1 -rGO with a single Ni atom anchored on rGO, modulates the electronic properties of rGO, reducing Schottky barrier via energy band alignment for bipolar current symmetry and spatially confining iodide ion migration through a high diffusion energy barrier (2.912 eV), conferring 780 ms relaxation. The device achieves 1,000 distinct conductance states and emulates interlayer connections and bidirectional signal transmission in feedback neuronal networks. We demonstrate neuromorphic functionalities: unsupervised competitive learning exceeds 50% clustering accuracy, while cooperative learning solves NP-hard problem 6× faster than simulated annealing, establishing an atomic-engineered approach for high-efficiency neuromorphic hardware.
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Journal of Saudi Chemical Society
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2026
·Vol. 30
·期 2
·12
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IF 5.2
Liu Xiaobing,Su Shi,Feng Faxiang,Dong Guilin,Shi Chuxuan,Zhu Zanming,Han Runlin
The photocatalytic degradation of organic pollutants has been demonstrated to be both cost-effective and efficient. However, catalysts are prone to loss and migration during use, and recycling them still presents a series of complex and urgent problems. In this work, silver nanoparticles/polyvinylidene fluoride (AgNPs/PVDF) hybrid photocatalytic membrane was prepared in-situ by introducing AgNO₃ into a PVDF casting solution, employing the immersion phase inversion method, and applying UV post-treatment. The membrane exhibits high efficiency in photocatalytically degrading organic compounds, including dyes and antibiotics. Degradation of methylene blue (MB) was found to reach 99.9% within 5 h, and the membrane exhibited excellent cyclic stability over 4 cycles. Photocatalytic degradation of MB was mainly found to be induced by superoxide radicals (·O 2 – ), and the photocatalytic degradation mechanism was explored. The AgNPs/PVDF photocatalytic membrane also demonstrated high antibacterial efficacy against E. coli , impeding bacterial proliferation during application. The highly convenient preparation of photocatalytic membrane offers a new option for efficiently treating wastewater contaminated with organic pollutants. Graphical
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Shen Fei,Tang Yuzhe,Meng Xiangzhi,Hou Juan,Sun Jing
Iron regulates redox processes and maintains cellular functions. In this study, a CDs@AuNCs-based ratiometric fluorescence probe was established for selective visual recognition and quantitative analysis of Fe 2+ . The probe combines blue-emitting carbon dots (CDs) and red-emitting gold nanoclusters (AuNCs), generating dual fluorescence emissions with distinct peaks at 435 nm and 610 nm. The I 610 /I 435 ratio was optimized for Fe 2+ detection, achieving excellent sensitivity with a detection limit as low as 3.5 nM. The proposed probe demonstrated superior photostability, high environmental tolerance, and remarkable selectivity towards Fe 2+ over other metal ions and small molecules. Real sample analysis, including ferrous succinate tablets, environmental water, and juice, showed satisfactory recoveries and low RSDs, confirming the reliability and accuracy of the method. CDs@AuNCs ratiometric probe is a promising tool for practical applications in clinical diagnostics, pharmaceutical quality control, and environmental monitoring, offering advantages such as simplicity, rapid response, and cost-effectiveness for Fe 2+ ion detection in complex real samples. Graphical
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Nature Communications
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2026
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IF 18.1
Song Jing,Pan Yongqi,Xin Ruobing,Yan Zifei,Tang Tianyao,Wang Kai,Wang Yujun,Deng Jian,Luo Guangsheng
Aromatic nitration, a hazardously complex process, poses serious risks. A major challenge for the reaction is the trade-off effect between spatiotemporal conversion rate and selectivity, particularly the over-nitration side reactions that have plagued the field for nearly 200 years. We propose a countercurrent microflow mode between two microreactors, which boosts spatiotemporal conversion rate by over five times compared to the normal single-stage co-current microflow mode, and two orders of magnitude compared to traditional batch reactors. Meanwhile, we identify an inhibition mechanism of over-nitration. The generated H 2 O in the main reaction can in situ reduce the dissolution of nitroaromatics in the aqueous phase and effectively prevent over-nitration. Through synergistic control of both kinetics and thermodynamics in the microreaction process, high spatiotemporal conversion and selectivity are achieved simultaneously, overcoming the trade-off effect. Furthermore, we demonstrate the broad applicability of the microflow strategy across various aromatic nitration processes.
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Advanced Fiber Materials
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2026
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IF 22.6
Zhou Xueli,Chen Yansong,Zhang Jifeng,Liu Qingping,Ren Lei,Ren Luquan
The development of strain-insensitive conductive fibers (SICFs) is crucial for wearable electronics; however, existing methods often involve complex processes and lack scalability. Here, we propose a novel strategy integrating rotational co-extrusion with wet spinning to fabricate helical conductive fibers with exceptional strain insensitivity and temperature sensing capabilities. By dynamically controlling the nozzle rotation speed (0–100 r/min), we achieve programmable helical architectures in the conductive layer, which synergistically dissipate mechanical stress through geometric deformation and maintain conductive pathways via dynamic ion redistribution in porous structures. The resulting fibers exhibit ultra-low resistance variation (Δ R / R 0 = 3.81% at 100% strain) and outstanding stability under bending (90°), twisting (720°), and cyclic stretching (1000 cycles). Simultaneously, the embedded ionic liquid endows the fibers with high thermal sensitivity (71.78% resistance drop at 20–70 °C), enabling precise temperature monitoring even during motion. Notably, the fibers demonstrate a linear response in the physiologically critical 30–40 °C range (18.5% resistance change), outperforming existing SICFs in strain–temperature decoupling. This study not only innovatively proposes a scalable process that integrates helical structure programming, material compounding, and fiber forming into a single operation but also extends the application of rotational co-extrusion technology to the field of wet spinning. It provides novel insights for multifunctional conductive fibers in areas such as wearable health monitoring and soft robotics sensing. Graphical
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EUROPEAN JOURNAL OF MEDICAL RESEARCH
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2026
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IF 4.8
Li Ma,Jing Wang,Jin Zhao,Jingrong Wang,Xiaolian Wen,Meijing Zheng,Liping Su
Background Current understanding of B cell heterogeneity in diffuse large B cell lymphoma (DLBCL) and its functional impact on disease progression remains incomplete. This study applies single-cell RNA sequencing to identify and characterize a distinct proliferation-related B cell subpopulation in DLBCL, aiming to address this knowledge gap. Methods We utilized dataset GSE182434 from the Gene Expression Omnibus (GEO) database for the analysis, with the aim of identifying genes that are specifically highly expressed in different cell clusters. The copy number variation analysis was performed using B cells of normal samples as the control. Thereafter, the cell–cell communication analysis was implemented to reveal the potential ligand–receptor pairs, and the functional enrichment analysis was performed to uncover the enriched pathways. Further, the potential transcription factors–target genes networks were plotted via SCENIC analysis, and a series of validation assays were implemented using DLBCL cells. Results The single-cell landscape of DLBCL revealed a reduced proportion of B cells, CD8 + T cells, and naïve T cells. Malignant B cells exhibited chr1q amplification and chr6 deletion, with genes in these regions linked to immune suppression and impaired antigen presentation, respectively. Further subclustering identified a proliferative B cell subcluster (subcluster 2) enriched in nucleotide metabolism and cell cycle pathways. This subcluster was characterized by elevated XBP1 activity, regulating ER stress response, and downregulation of SPIB, RELB, and IRF factors involved in lymphocyte activation and interferon signaling. Functionally, XBP1 silencing suppressed DLBCL cells proliferation and invasion. Cell communication analysis revealed crosstalk between this B cell subpopulation and CD8+ T/NK cells via MIF-(CD74+CXCR4) and LTA-TNFRSF pathways. Conclusion This analysis has identified and characterized the proliferation-related B cells in DLBCL, which may provide some ideas for the treatment strategies in immune-oncology and cellular therapies. Supplementary Information The online version contains supplementary material available at 10.1186/s40001-025-03673-2.
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Nature Communications
·
2026
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IF 18.1
Chen Hui,Feng Shuo,Wang Yutong,Zhong Leheng,Liang Wei,Shi Kangning,Li Dedi,Zhu Jiaxiong,Cui Huiling,Tang Zijie,Zhang Haofan,Li Ran,Zhi Chunyi,Lyu Haiming Lv
The electrolytes of aqueous batteries are mostly acidic or alkaline, resulting in inevitable side reactions. More importantly, when batteries are disposed of, strongly acidic and alkaline solutions harm the environment. In this study, we synthesized covalent organic polymers as negative electrode materials for aqueous divalent ion (Mg 2+ and Ca 2+ ) storage, which exhibit favorable performance in electrolytes with a pH of 7.0 (the electrolytes are environmentally benign and can even be “brine” in tofu production). Polymers containing electron-donating linking bonds exhibit fast kinetics and low potential for use in aqueous Mg 2+ /Ca 2+ batteries. In neutral electrolytes (pH = 7.0), Hexaketone-tetraaminodibenzo-p-dioxin covalent organic polymers exhibit 120,000 cycles and deliver specific capacities (up to 112.8 mA h g -1 ). The negative electrode was paired with a positive electrode, creating a full cell that has a voltage interval of 2.2 V and achieves a specific energy of up to 48.3 Wh kg -1 , which is calculated on the basis of the total mass of the negative electrode, positive electrode, and electrolyte at the full cell level, together with long-term cycling stability over 120,000 cycles at a specific current of 20 A g -1 . The full cells are environmentally benign and nontoxic and can be directly discarded to environments according to various standards (GB 18599-2020, ISO 14001, Resource Conservation and Recovery Act RCRA, US).
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 3
·163
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IF 5.4
Yi Fei,Li Zhixin,Jiang Fan,Zhang Zhule,Chen Yingmei,Zhao Zhe,Deng Xiaoyu,Chen Hao,Xu Shaohua,Tao Yingzhou
Aflatoxin B 1 (AFB 1 ), a potent mycotoxin, poses a critical threat to global food safety, demanding analytical methods with exceptional sensitivity. Here, we introduce a homogeneous electrochemiluminescence (ECL) biosensor that operates on a novel CRISPR-actuated electrostatic gating mechanism. The core of our strategy relies on controlling the access of ECL reporters to a positively charged electrode surface (PAH-ITO). In the absence of AFB 1 , cationic Ru(phen) 3 2+ reporters are electrostatically repelled from the electrode, resulting in a low background signal. The presence of AFB 1 triggers a CRISPR/Cas12a enzymatic cascade, which activates its trans-cleavage activity to release a highly anionic hybridization chain reaction (HCR) scaffold from magnetic beads (MB). This scaffold serves as a nanocarrier, capturing the Ru(phen) 3 2+ reporters and, by virtue of its strong negative charge, shuttling them to the electrode through potent electrostatic attraction. This action effectively “opens” the electrostatic gate, switching on a robust ECL signal. By synergistically integrating the high specificity of the aptamer-CRISPR system with the immense signal amplification of the HCR scaffold, all under the control of a charge-dominant switch, our biosensor achieves an outstanding limit of detection of 0.121 fg/mL and a broad linear range from 1 fg/mL to 100 pg/mL. Its successful application in spiked food samples validates its practicality and robustness, presenting a powerful new paradigm for designing minimal-background, high-gain ECL sensors for mycotoxin determination.
Section
Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·Vol. 24
·期 1
·327
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IF 15
Chen Xiaoyu,Hu Yubo,Xu Chenyu,Lian Tengye,Li Haocong,Sun Lu,Sun Shiduo,Hu Meilin,Wang Yinsong,Liu Dayong
Background Periodontitis is a chronic inflammatory disease characterized by excessive oxidative stress, persistent bacterial biofilms, and progressive destruction of periodontal tissues. Current clinical treatments primarily focus on controlling bacterial infection but often show limited long-term efficacy due to unresolved immune dysregulation. Therefore, therapeutic strategies that simultaneously target microbial biofilms and the pathological immune microenvironment are urgently needed. In this study, we developed an injectable dual-drug hydrogel incorporating curcumin (CUR) and glycyrrhizic acid (GL) for the treatment of periodontitis. Methods CUR was dissolved in melted polyethylene glycol distearate and then dispersed in an aqueous medium to form micelles (CURM). Compared to CUR, CURM exhibited improved solubility and stability, thereby displaying greatly enhanced antioxidative, anti-inflammatory, and antibacterial activities. CURM were subsequently embedded within a hydrogel self-assembled from glycyrrhizic acid and polyvinyl alcohol (GLH) to form a dual-drug hydrogel system (CURM@GLH). Experimental periodontitis was established in mice to test their in vivo effects. Results Owing to the intrinsic anti-inflammatory and antioxidative properties of glycyrrhizic acid, the hydrogel exhibited combined effects in regulating immune dysregulation. The CURM@GLH effectively protected cells from oxidative damage, reduced intracellular reactive oxygen species levels, promoted macrophage polarization from the proinflammatory M1 phenotype toward the pro-regenerative M2 phenotype, and downregulated proinflammatory cytokine expression. In a ligature-induced rat model of periodontitis, local administration of the hydrogel significantly alleviated periodontal oxidative stress and inflammation and markedly reduced alveolar bone resorption. Conclusions This study presents an injectable dual-drug hydrogel, CURM@GLH, that integrates biofilm inhibition with immunomodulatory regulation, offering a promising host-directed therapeutic strategy for periodontitis. The proposed approach provides new insights into the design of multifunctional biomaterials for the treatment of chronic inflammatory diseases associated with biofilm persistence and immune imbalance. Graphical
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2026
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IF 4.7
Gao Xiaobo,Lei Bocheng,Zhao Xiaomin,Zhang Ying
Many active ingredients from traditional Chinese medicine (TCM) have been applied in bone tissue engineering. However, the fuzzy mechanism of these ingredients limits their application. In this study, a novel biomimetic bone scaffold functionalized with two TCM ingredients, nano deer bone meals (nBM) and neferine (Nef), as well as collagen-binding IGF-1 (CBD-IGF-1) was fabricated via a combination of phase inversion and particle leaching methods. The biomimetic CIGF1&Nef@PLGA/nBM scaffold mimicked cancellous bone in terms of its porous structure and bone matrix composition rich in collagen. Both Nef contained in the scaffold and CBD-IGF-1 bound to collagen matrix could be slowly released from the scaffold, exerting long-term and safe bioactivity. In vitro tests showed that the CIGF1&Nef@PLGA/nBM composite significantly enhanced the adhesion, proliferation and osteogenic differentiation of MC3T3-E1 cells on the material. Nef and IGF-1 in CIGF1&Nef@PLGA/nBM scaffold exerted a synergistic effect on IGF-1-mediated osteogenic differentiation via IGF-1R axis to ensure the osteogenic activity of the biomimetic scaffold. In vivo skull defect repair experiment confirmed that CIGF1&Nef@PLGA/nBM could promote the neocortical bone formation and osseous maturation, further accelerating the bone defect repair. The findings of this research demonstrated that the biomimetic CIGF1&Nef@PLGA/nBM scaffold is a promising implantation in bone defect therapy.
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BULLETIN OF MATERIALS SCIENCE
·
2026
·Vol. 49
·期 2
·67
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IF 2.1
Gao Yu,Han Qiang,Chen Yuan,Jia Dongdong,Sun Yongyue
To develop high performance with wide pH adaptability catalysts for advanced oxidation processes, Co/N Co-doped carbon nanotubes encapsulating cobalt nanoparticles (Co@N-CNTs-x/y) were prepared by pyrolysis of dicyandiamide (DCD)-coated bimetallic zeolitic imidazole frameworks (Co x Zn y -ZIF) rapidly synthesized in supercritical carbon dioxide (sc-CO 2 ). The in situ growth of carbon nanotubes resulted in a more uniform distribution of cobalt atoms, forming abundant Co-N x structures, and effectively encapsulating cobalt nanoparticles within the nanotubes, thereby reducing cobalt leakage. The doping of zinc and its subsequent volatilization at high temperatures significantly impacted the Co-N x doping ratio, the diameter of the nanotubes, and the size and dispersion of cobalt nanoparticles (Co NPs). A non-radical catalytic mechanism dominated by electron transfer was proposed for hollow-structured Co@N-CNTs-1/1, enabling it to exhibit high bisphenol A (BPA) degradation efficiency across a pH range of 3–11 and tolerate various inorganic anions.
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