CELLULOSE
·
2022
·Vol. 29
·期 3
·1473-1485
·
IF 6.123
Xia Yuanyuan,Li Xinping,Yuan Yue,Zhuang Jingshun,Wang Wenliang
The preparation of cellulose beads has attracted much attention in the application of advanced green materials. Herein, the uniform and controllable cellulose beads were prepared by first dissolving the pulp into N-methylmorpholine N-oxide (NMMO), and then regenerated in various coagulation baths (water, alcohol, acid, NMMO, etc.). Results showed that the crystalline structure of regenerated cellulose changed from cellulose I to cellulose II. Besides, the cellulose beads regenerated in Methanol (MT-cellulose bead) had the highest porosity (90.51%) and crystallinity (62.59%). Laser confocal microscopy was employed to reveal the coagulation mechanism of cellulose beads, and the solidification process was carried out from the inside to the outside. This is a green and facile method for preparing cellulose beads with different structures and properties that can be widely used in absorbent materials, energy storage materials, and protein chromatography. Graphical abstract
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NEUROTOXICITY RESEARCH
·
2022
·Vol. 40
·期 1
·78-88
·
IF 3.978
Ji Na,Wu Lirong,Shi Hui,Li Qianlu,Yu Anyong,Yang Zhao
Intracerebral hemorrhage (ICH) is a fatal cerebrovascular disease. Neuroinflammation plays an important pathological role in brain injury after ICH. NLRP3 contributes to the pathogenesis of ICH, but the underlying mechanisms regulating of NLRP3 remain elusive. V-set and immunoglobulin domain containing 4 (VSIG4), specifically expressed in resting tissue-resident macrophages, can deliver anti-inflammatory signals into various inflammatory diseases. However, the interaction between VSIG4 and NLRP3, as well as the underlying mechanisms after ICH have not been reported. C57BL/6 mice were subjected to the autologous blood injection ICH model. VSIG4 and NLRP3 levels of macrophages were detected following ICH. Ad-VSIG4 or controls were administered via intracerebroventricular (i.c.v) injection before ICH induction. STAT3 inhibitor (S31-201), JAK2 inhibitor (TG101348), or Ad-A20 RNAi was administered to investigate the role of JAK2-STAT3-A20 pathway in VSIG4-mediated neuroinflammation after ICH. Pro-inflammatory cytokine production, BBB disruption, brain water content, and neurological test were examined in ICH mice. VSIG4 levels were significantly decreased, and NLRP3 levels were significantly increased in the perihematomal brain tissues after ICH. Ad-VSIG4 attenuated NLRP3 levels and inhibited inflammation, as well as improved neurological function and reduced BBB disruption and brain water content. Furthermore, Ad-VSIG4 increased the protein levels of phosphorylated JAK2 and STAT3, and A20 levels at 24 h after ICH. STAT3 inhibitor, JAK2 inhibitor, and A20 RNAi abolished the beneficial effects of Ad-VSIG4 after ICH. In summary, these data suggested that VSIG4 attenuated NLRP3 and ameliorated neuroinflammation via JAK2-STAT3-A20 pathway after intracerebral hemorrhage in mice. VSIG4 might be an ideal therapeutic target for ICH patients.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-18
·
IF 9.429
Li Jiankai,Zhang Tianshuai,Pan Mingmang,Xue Feng,Lv Fang,Ke Qinfei,Xu He
Impaired angiogenesis is one of the predominant reasons for non-healing diabetic wounds. Herein, a nanofiber/hydrogel core–shell scaffold with three-dimensional (3D) multilayer patterned structure (3D-PT-P/GM) was introduced for promoting diabetic wound healing with improved angiogenesis. The results showed that the 3D-PT-P/GM scaffolds possessed multilayered structure with interlayer spacing of about 15–80 μm, and the hexagonal micropatterned structures were uniformly distributed on the surface of each layer. The nanofibers in the scaffold exhibited distinct core–shell structures with Gelatin methacryloyl (GelMA) hydrogel as the shell and Poly (d, l-lactic acid) (PDLLA) as the core. The results showed that the porosity, water retention time and water vapor permeability of the 3D-PT-P/GM scaffolds increased to 1.6 times, 21 times, and 1.9 times than that of the two-dimensional (2D) PDLLA nanofibrous scaffolds, respectively. The in vitro studies showed that the 3D-PT-P/GM scaffolds could significantly promote cell adhesion, proliferation, infiltration and migration throughout the scaffolds, and the expression of cellular communication protein-related genes, as well as angiogenesis-related genes in the same group, was remarkably upregulated. The in vivo results further demonstrated that the 3D-PT-P/GM scaffolds could not only effectively absorb exudate and provide a moist environment for the wound sites, but also significantly promote the formation of a 3D network of capillaries. As a result, the healing of diabetic wounds was accelerated with enhanced angiogenesis, granulation tissue formation, and collagen deposition. These results indicate that nanofiber/hydrogel core–shell scaffolds with 3D multilayer patterned structures could provide a new strategy for facilitating chronic wound healing.Graphical Abstract
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Biomass Conversion and Biorefinery
·
2022
·
IF 4.05
Li Xiao,Zhao Qingqing,Han Ming,Zhang Ke,Guo Zhongya,Li Bin,Wang Wei,Wei Xuhe,Liang Miao
In the present study, the effects of pretreatments with different solvents (hydrochloric acid, sodium hydroxide, and ethanol) on the physicochemical structure and pyrolysis behavior of tobacco stem (TS) were investigated. Elemental compositions analysis showed that acid washing increased the carbon content and exhibited a high removal percentage for the inorganic species. SEM, BET, and FTIR analysis showed that the pretreatments exerted different effect on the surface and microstructure. Furthermore, the pyrolysis characteristics analysis indicated that solvent pretreatment increased the initial pyrolysis temperature due to the removal of unstable volatile components, especially for the acid and alkali washing samples. Meanwhile, hydrochloric acid pretreatment increased the maximum pyrolysis rate temperature of cellulose decomposition stage and decreased the char residues due to the large removal of inorganic species, while alkali treatment produced the opposite result. Pyrolysis kinetic analysis based on Coats-Redfern method showed that F1.5 chemical reaction model can be used to describe the pyrolysis stages of TS samples and a decreased activation energy was observed during the decomposition of cellulose stage for the acid and alkali washed samples. The released gaseous products during the pyrolysis process were also monitored by using TG-FTIR technique, and the gaseous release behavior was different from each other.
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Scientific Reports
·
2022
·Vol. 12
·期 1
·1-16
·
IF 4.996
Lu Yi-heng,Chen Zong-lin,Lu Yu-wei
To inhibit the agglomeration of nanotitanium dioxide, a poly (vinyl chloride) (PVC) composite film doped with folic acid-modified titanium dioxide was synthesized and characterized using X-ray powder diffraction, X-ray photoelectron spectroscopy and thermogravimetric analysis coupled with Fourier transform infrared spectroscopy. The average grain size of the folic acid-modified titanium dioxide was found to decrease by 1.3 nm, indicating that the cohesiveness of the nanoparticles is decreased. The lowest temperature for 1.0% thermal decomposition of PVC was determined to be 230.0 °C. The decomposition rate at the peak temperature is found to be 39.6% lower than that of a control sample. The stability of the PVC is improved due to a lower number of surface chlorine atoms as well intermolecular attraction. A mechanism for folic acid modification of titanium dioxide-doped PVC is proposed. After doping, the ester groups in the plasticizer show a significant decrease in the vibration peak intensities observed at 1264 cm −1 , 1736 cm −1 and 1106 cm −1 . The doped PVC film suppresses the release of CO 2 , and the strongest vibration peak at 1264 cm −1 is found to be 17.2% lower than that for the blank sample, indicating that doping is beneficial for plasticizer recovery.
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TRANSACTIONS OF THE INDIAN INSTITUTE OF METALS
·
2022
·Vol. 75
·期 5
·1211-1231
·
IF 1.391
Subedi Ayush,Hu Enzhu,Guo Jianhua,Chen Yenjie,Wang Jianping,Hu Kunhong,Hu Xianguo
Rice husk ceramic (RHC) can be used as a reinforcing agent in metal matrix composites (MMC) to improve the tribological properties because of their remarkable mechanical and tribological properties. This research scrutinizes the role of RHC to enhance tribological properties of Ni-MMC (Nickel metal matrix composite). Ni-MMC with additives RHC, Al, Cu, MoS 2 , and graphite in different content were prepared by powder metallurgy method. The wear and friction mechanism of Ni-MMC was investigated using a ball-disk tribometer at room temperature. SEM/EDS and optical microscope were used to examine the wear properties, distribution of reinforcement, and micro structural phases, respectively. Results indicated that the addition of RHC particles can strengthen the anti-wear and friction reduction properties of Ni-MMC. The addition of 3 wt% RHC resulted in the lowest value for the coefficient of friction and wear rate. Further expansion of MoS 2 and graphite along 3 wt% RHC, both the wear rate and coefficient of friction all decrease. At the same time, the value depends on the content of elements like aluminum and copper in MMCs.
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JOURNAL OF CLUSTER SCIENCE
·
2022
·Vol. 34
·期 1
·385-394
·
IF 3.447
Zhang Ziwei,Wells Connor J. R.,Liang Ruizheng,Davies Gemma-Louise,Williams Gareth R.
In this study, gadolinium (Gd) doped MgAl layered double hydroxides (LDHs) were synthesized via a ‘bottom-up’ method and fully characterized by X-ray diffraction, infrared spectroscopy and relaxivity measurements. Two cytotoxic agents were then intercalated via ion-exchange. X-ray diffraction patterns exhibit expanded interlayer spacings as a result of successful drug intercalation. Infrared spectra also showed characteristic peaks of the incorporated methotrexate (MTX) or 5-fluorouracil (5-FU). The LDHs were found to be highly stable under physiological conditions, while in acidic conditions a small proportion of Gd was freed into the immersion medium. Dissolution tests revealed that both 5FU and MTX were rapidly released from the LDH carrier. The longitudinal relaxivity of Gd-LDHs remains largely stable during drug release over 24 h, and was higher in acidic environments. Overall, the drug-loaded Gd-LDH systems prepared in this study could serve as pH-sensitive theranostic platforms for MRI-guided anti-cancer therapy.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 27
·40734-40744
·
IF 5.19
Zhu Bo,Xu Jiangyan,Xu Zhihui,Wu Meisheng,Jiang Hongmei
A facile soft-template solvent thermal strategy was developed to prepare mesoporous carbon–silica composite (MMCS) by using furfuryl alcohol (FA) as carbon precursor, Pluronic copolymer P123 as template, hydrated iron nitrate as iron source, and teraethylorthosilicate as silicon source and it was applied for the removal of methyl orange (MO). The as-synthesized MMCS with abound of hydrophilic groups processed a high specific surface area, large pore volume, and good magnetic response. With the increased amount of FA, the surface area and functional groups increased, promoting the adsorption effect. The maximum adsorption capacity of MO on MMCS can be high to 113.1 mg g −1 at pH 4 with 150 mg L −1 initial MO concentration. The adsorption isotherm, kinetic, and thermodynamics were all studied and the results showed the adsorption process well fitted Langmuir adsorption isotherm and pseudo-second-order model. Additionally, it was shown that the adsorption process could not be interfered by the co-existence of PO 4 3− , NO 3 − , CO 3 2− , SO 4 2− , and real water matrix. And the proposed adsorbent can remove MO in three practical water samples with satisfied removal rates ranging from 92.8 to 99.8%. Thus, the MMCS prepared in this study could be utilized as an alternative adsorbent for the removal of methyl orange from practical aqueous solution.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2022
·Vol. 331
·期 2
·889-902
·
IF 1.754
Fu Xibiao,Liu Jun,Ren Zheng,Zhang Siqin,Xiao Fangzhu,Peng Guowen
Metal-organic frameworks (MOFs) MIL-101(Cr)-PMIDA with phosphate groups were prepared for the adsorption of U(VI). The morphology and structure of the samples were characterized by SEM, TEM, FT-IR, BET, XPS and XRD. This study investigated the effects of the initial U(VI) concentration, contact time, pH, adsorption temperature and coexisting ions on the adsorption of U(VI) by MIL-101(Cr)-PMIDA. The experimental results showed that the adsorption capacity of MIL-101(Cr)-PMIDA was 267.92 mg g −1 at C 0 (U) = 40 mg L −1 , pH = 6.0 and T = 298 K, which was much higher than that of MIL-101(Cr)-NH 2 (71.10 mg g −1 ). More importantly, the material exhibited excellent selective removal performance for U(VI) in an aqueous solution. Furthermore, adsorption thermodynamics and kinetic studies showed that the adsorption was spontaneous (∆G < 0) and exothermic (∆H ˃ 0), following the pseudo-second-order kinetic model (R 2 > 0.99). Graphical abstract
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JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-15
·
IF 9.429
Liu Yu,Shang Wenting,Liu Heng,Hui Hui,Wu Jun,Zhang Wei,Gao Pengli,Guo Kunxiong,Guo Yanli,Tian Jie
Pro-tumoral and immunosuppressive M2-like tumor-associated macrophages (TAMs) contribute to tumor progression, recurrence and distal metastasis. However, current TAMs-modulating therapeutic strategies often encounter challenges including insufficient immune activation, weak antigen presentation ability and unsatisfactory antitumor immune performance. Herein, cyclic RGD peptide functionalized and manganese doped eumelanin-like nanocomposites (RMnMels) are reported for combined hyperthermia-immunotherapy against PC3 prostate cancer. The RMnMels could promote M2-to-M1 macrophage repolarization via scavenging multiple reactive oxygen species and remodeling the immunosuppressive tumor microenvironment. Following near-infrared light irradiation, RMnMels-mediated thermal ablation not only could destroy tumor cells directly, but also elicit the release of damage associated molecular patterns and tumor-associated antigens, provoking robust tumor immunogenicity and strong antitumor immune responses. The results showed that RMnMels could effectively scavenge reactive oxygen species and promote M2-to-M1 macrophage repolarization both in vitro and in vivo. Synergistically enhanced anti-tumor therapeutic efficacy was achieved following single administration of RMnMels plus single round of laser irradiation, evidenced by decreased primary tumor sizes and decreased number of distant liver metastatic nodules. The as-developed RMnMels may represent a simple and high-performance therapeutic nanoplatform for immunomodulation and enhanced antitumor immune responses.Graphical Abstract
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Drug Delivery and Translational Research
·
2022
·Vol. 12
·期 11
·2678-2692
·
IF 5.671
Chen Xinru,Li Quandong,Huang Zipeng,Lin Wen,Ma Yan
The limited tissue penetration depth and tumor hypoxic microenvironment have become the two pivotal obstacles that alleviate the antineoplastic efficacy in tumor photodynamic therapy (PDT). In the research, MnO 2 -decorated upconversion nanoparticles (UCSMn) have been designed to generate certain oxygen within the solid tumor, and also increase the light penetrating depth due to the optical conversion ability derived from upconversion nanoparticles. Furthermore, upconversion nanoparticles as the inner core are coated by mesoporous silica for the loading of curcumin as photosensitizer and chemotherapeutics, and then a MnO 2 shell is proceeding to grow via redox method. When reaching the tumor tissue, the MnO 2 nanoshells of UCSMn could be rapidly degraded into manganese ions (Mn 2+ ) owing to the reaction with H 2 O 2 in acidic tumor microenvironment, meanwhile producing oxygen and facilitating curcumin release. Once the tumor is illuminated by 980 nm light, the upconversion nanoparticles can transform the infrared light to visible light of 450 nm and 475.5 nm, which can be efficiently absorbed by curcumin, and then produce singlet oxygen to induce tumor cell apoptosis. Curcumin played a dual role which can not only be acted as a photosensitizer, but also a chemotherapeutic agent to further reinforce the antitumor activity. In short, the intelligent nanostructure has the potential to overcome the above-mentioned shortcomings existed in PDT and eventually do work well in the hypoxia tumors. Graphical abstract MnO 2 -decorated upconversion nanoparticle to solve the tissue penetration and tumor hypoxic microenvironment for tumor photodynamic therapy
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NATURE
·
2022
·Vol. 605
·期 7908
·69-75
·
IF 69.504
Liu Lei,Li Taotao,Ma Liang,Li Weisheng,Gao Si,Sun Wenjie,Dong Ruikang,Zou Xilu,Fan Dongxu,Shao Liangwei,Gu Chenyi,Dai Ningxuan,Yu Zhihao,Chen Xiaoqing,Tu Xuecou,Nie Yuefeng,Wang Peng,Wang Jinlan,Shi Yi,Wang Xinran
Two-dimensional transition-metal dichalcogenides (TMDs) are of interest for beyond-silicon electronics 1 , 2 . It has been suggested that bilayer TMDs, which combine good electrostatic control, smaller bandgap and higher mobility than monolayers, could potentially provide improvements in the energy-delay product of transistors 3 , 4 , 5 . However, despite advances in the growth of monolayer TMDs 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , the controlled epitaxial growth of multilayers remains a challenge 15 . Here we report the uniform nucleation (>99%) of bilayer molybdenum disulfide (MoS 2 ) on c -plane sapphire. In particular, we engineer the atomic terrace height on c -plane sapphire to enable an edge-nucleation mechanism and the coalescence of MoS 2 domains into continuous, centimetre-scale films. Fabricated field-effect transistor (FET) devices based on bilayer MoS 2 channels show substantial improvements in mobility (up to 122.6 cm 2 V −1 s −1 ) and variation compared with FETs based on monolayer films. Furthermore, short-channel FETs exhibit an on-state current of 1.27 mA μm −1 , which exceeds the 2028 roadmap target for high-performance FETs 16 .
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